The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
Saul Shiffman - One of the best experts on this subject based on the ideXlab platform.
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Within-day temporal patterns of smoking, withdrawal symptoms, and craving ☆
Drug and Alcohol Dependence, 2011Co-Authors: Siddharth Chandra, Deborah M. Scharf, Saul ShiffmanAbstract:We examined the temporal relationships between smoking frequency and craving and withdrawal. 351 heavy smokers (≥15 cigarettes per day) used ecological momentary assessment and electronic diaries to track smoking, craving, negative affect, arousal, Restlessness, and attention disturbance in real time over 16 days. The waking day was divided into 8 2-hour “bins” during which cigarette counts and mean levels of craving and withdrawal were computed. Cross-sectional analyses showed no association between Restlessness and smoking, and arousal and smoking, but craving (b=0.65, p
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Within-day temporal patterns of smoking, withdrawal symptoms, and craving.
Drug and alcohol dependence, 2011Co-Authors: Siddharth Chandra, Deborah Scharf, Saul ShiffmanAbstract:We examined the temporal relationships between smoking frequency and craving and withdrawal. 351 heavy smokers (≥15 cigarettes per day) used ecological momentary assessment and electronic diaries to track smoking, craving, negative affect, arousal, Restlessness, and attention disturbance in real time over 16 days. The waking day was divided into 8 2-h "bins" during which cigarette counts and mean levels of craving and withdrawal were computed. Cross-sectional analyses showed no association between Restlessness and smoking, and arousal and smoking, but craving (b=0.65, p
William G. Ondo - One of the best experts on this subject based on the ideXlab platform.
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Restless abdomen: a spectrum or a phenotype variant of restless legs syndrome?
2020Co-Authors: Xi-xi Wang, Xiao Ying Zhu, Zan Wang, Jian-wei Dong, William G. OndoAbstract:Abstract Background: With the growing awareness of restless legs syndrome (RLS), sensory disorders similar to RLS but initially confined to the arms, abdomen, and perineum have been reported. One of them is restless abdomen, which refers to a restless sensation in abdomen. Our study is designed to evaluate the clinical phenotype of restless abdomen and investigate its relationship with RLS.Methods: We enrolled 10 patients with restless abdomen according to RLS diagnostic criteria, excluding the requiring of leg involvement. Laboratory examinations were performed to exclude mimics and notable comorbidities.Results: All 10 patients had RLS like symptoms in the abdomen and otherwise satisfied all other RLS diagnostic criteria, and responded to dopaminergic therapy.Conclusions: Neurologists and gastroenterologists should be aware that RLS-related Restlessness can occur in extra-leg anatomy in the absence of episodes of worsening or augmentation of Restlessness.
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Restless abdomen: a spectrum or a phenotype variant of restless legs syndrome?
2020Co-Authors: Xi-xi Wang, Xiao Ying Zhu, Zan Wang, Jian-wei Dong, William G. OndoAbstract:Abstract Background: With the growing awareness of restless legs syndrome (RLS), sensory disorders similar to RLS initially confined to the arms, abdomen, and perineum are more and more being recognized. One of them is restless abdomen, which refers to a restless sensation in abdomen. Our study is designed to evaluate the clinical phenotype of restless abdomen and investigate its relationship with RLS. Methods: We enrolled 10 patients with restless abdomen according to the RLS diagnostic criteria. Laboratory examinations were performed to exclude mimics and notable comorbidities. Results: All 10 patients had RLS like symptoms in the abdomen and otherwise satisfied all other RLS diagnostic criteria, and responded to dopaminergic therapy. Conclusions: Neurologists should be aware of the RLS-related Restlessness that can occur in extra-leg anatomy in the absence of episodes of worsening or augmentation of Restlessness.
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Clinical characteristics of leg Restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome.
Journal of the Neurological Sciences, 2015Co-Authors: Xiao Ying Zhu, Ye Liu, Xiao Jin Zhang, Wen Hao Yang, Ya Feng, William G. Ondo, Eng-king TanAbstract:Abstract Objective There is limited data on motor Restlessness in Parkinson's disease (PD). Here we evaluate for clinical differences between cohorts of idiopathic Restless Legs Syndrome (iRLS), PD patients with leg Restlessness, and PD with RLS. Methods We examined 276 consecutive PD patients for leg Restlessness symptoms, we compared clinical features of PD patients with RLS, PD patients with leg Restlessness but not meeting RLS criteria, PD patient without RLS and iRLS. Results A total of 262 PD patients who satisfied the inclusion criteria were analyzed. After excluding 23 possible secondary RLS or mimics, 28 were diagnosed with RLS and 18 with leg motor Restlessness (LMR). Compared with iRLS patients, PD patients with RLS or LMR had older age of RLS/LMR onset, shorter duration of leg Restlessness, less positive family history, different seasonal trends and more unilaterality of leg Restlessness symptom (P Conclusion Clinical characteristics of PD patients with RLS and LMR were different from iRLS, differentiating these various subtypes can facilitate optimal treatment.
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Clinical characteristics of leg Restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome.
Journal of the neurological sciences, 2015Co-Authors: Xiao Ying Zhu, Ye Liu, Xiao Jin Zhang, Wen Hao Yang, Ya Feng, William G. Ondo, Eng-king TanAbstract:There is limited data on motor Restlessness in Parkinson's disease (PD). Here we evaluate for clinical differences between cohorts of idiopathic Restless Legs Syndrome (iRLS), PD patients with leg Restlessness, and PD with RLS. We examined 276 consecutive PD patients for leg Restlessness symptoms, we compared clinical features of PD patients with RLS, PD patients with leg Restlessness but not meeting RLS criteria, PD patient without RLS and iRLS. A total of 262 PD patients who satisfied the inclusion criteria were analyzed. After excluding 23 possible secondary RLS or mimics, 28 were diagnosed with RLS and 18 with leg motor Restlessness (LMR). Compared with iRLS patients, PD patients with RLS or LMR had older age of RLS/LMR onset, shorter duration of leg Restlessness, less positive family history, different seasonal trends and more unilaterality of leg Restlessness symptom (P<0.01) which were often in accordance with dominant Parkinsonism side and related with Parkinsonism severity. PD patients with RLS/LMR had lower daily dosage (P<0.01) and shorter duration (P<0.05) of dopaminergic medication when RLS/LMR symptom onset than PD without leg Restlessness. PD with LMR had less severe Parkinsonism (P<0.05) and leg Restlessness (P<0.01) symptoms than PD with RLS. Clinical characteristics of PD patients with RLS and LMR were different from iRLS, differentiating these various subtypes can facilitate optimal treatment. Copyright © 2015 Elsevier B.V. All rights reserved.
Siddharth Chandra - One of the best experts on this subject based on the ideXlab platform.
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Within-day temporal patterns of smoking, withdrawal symptoms, and craving ☆
Drug and Alcohol Dependence, 2011Co-Authors: Siddharth Chandra, Deborah M. Scharf, Saul ShiffmanAbstract:We examined the temporal relationships between smoking frequency and craving and withdrawal. 351 heavy smokers (≥15 cigarettes per day) used ecological momentary assessment and electronic diaries to track smoking, craving, negative affect, arousal, Restlessness, and attention disturbance in real time over 16 days. The waking day was divided into 8 2-hour “bins” during which cigarette counts and mean levels of craving and withdrawal were computed. Cross-sectional analyses showed no association between Restlessness and smoking, and arousal and smoking, but craving (b=0.65, p
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Within-day temporal patterns of smoking, withdrawal symptoms, and craving.
Drug and alcohol dependence, 2011Co-Authors: Siddharth Chandra, Deborah Scharf, Saul ShiffmanAbstract:We examined the temporal relationships between smoking frequency and craving and withdrawal. 351 heavy smokers (≥15 cigarettes per day) used ecological momentary assessment and electronic diaries to track smoking, craving, negative affect, arousal, Restlessness, and attention disturbance in real time over 16 days. The waking day was divided into 8 2-h "bins" during which cigarette counts and mean levels of craving and withdrawal were computed. Cross-sectional analyses showed no association between Restlessness and smoking, and arousal and smoking, but craving (b=0.65, p
Xiao Ying Zhu - One of the best experts on this subject based on the ideXlab platform.
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Restless abdomen: a spectrum or a phenotype variant of restless legs syndrome?
2020Co-Authors: Xi-xi Wang, Xiao Ying Zhu, Zan Wang, Jian-wei Dong, William G. OndoAbstract:Abstract Background: With the growing awareness of restless legs syndrome (RLS), sensory disorders similar to RLS but initially confined to the arms, abdomen, and perineum have been reported. One of them is restless abdomen, which refers to a restless sensation in abdomen. Our study is designed to evaluate the clinical phenotype of restless abdomen and investigate its relationship with RLS.Methods: We enrolled 10 patients with restless abdomen according to RLS diagnostic criteria, excluding the requiring of leg involvement. Laboratory examinations were performed to exclude mimics and notable comorbidities.Results: All 10 patients had RLS like symptoms in the abdomen and otherwise satisfied all other RLS diagnostic criteria, and responded to dopaminergic therapy.Conclusions: Neurologists and gastroenterologists should be aware that RLS-related Restlessness can occur in extra-leg anatomy in the absence of episodes of worsening or augmentation of Restlessness.
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Restless abdomen: a spectrum or a phenotype variant of restless legs syndrome?
2020Co-Authors: Xi-xi Wang, Xiao Ying Zhu, Zan Wang, Jian-wei Dong, William G. OndoAbstract:Abstract Background: With the growing awareness of restless legs syndrome (RLS), sensory disorders similar to RLS initially confined to the arms, abdomen, and perineum are more and more being recognized. One of them is restless abdomen, which refers to a restless sensation in abdomen. Our study is designed to evaluate the clinical phenotype of restless abdomen and investigate its relationship with RLS. Methods: We enrolled 10 patients with restless abdomen according to the RLS diagnostic criteria. Laboratory examinations were performed to exclude mimics and notable comorbidities. Results: All 10 patients had RLS like symptoms in the abdomen and otherwise satisfied all other RLS diagnostic criteria, and responded to dopaminergic therapy. Conclusions: Neurologists should be aware of the RLS-related Restlessness that can occur in extra-leg anatomy in the absence of episodes of worsening or augmentation of Restlessness.
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Clinical characteristics of leg Restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome.
Journal of the Neurological Sciences, 2015Co-Authors: Xiao Ying Zhu, Ye Liu, Xiao Jin Zhang, Wen Hao Yang, Ya Feng, William G. Ondo, Eng-king TanAbstract:Abstract Objective There is limited data on motor Restlessness in Parkinson's disease (PD). Here we evaluate for clinical differences between cohorts of idiopathic Restless Legs Syndrome (iRLS), PD patients with leg Restlessness, and PD with RLS. Methods We examined 276 consecutive PD patients for leg Restlessness symptoms, we compared clinical features of PD patients with RLS, PD patients with leg Restlessness but not meeting RLS criteria, PD patient without RLS and iRLS. Results A total of 262 PD patients who satisfied the inclusion criteria were analyzed. After excluding 23 possible secondary RLS or mimics, 28 were diagnosed with RLS and 18 with leg motor Restlessness (LMR). Compared with iRLS patients, PD patients with RLS or LMR had older age of RLS/LMR onset, shorter duration of leg Restlessness, less positive family history, different seasonal trends and more unilaterality of leg Restlessness symptom (P Conclusion Clinical characteristics of PD patients with RLS and LMR were different from iRLS, differentiating these various subtypes can facilitate optimal treatment.
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Clinical characteristics of leg Restlessness in Parkinson's disease compared with idiopathic Restless Legs Syndrome.
Journal of the neurological sciences, 2015Co-Authors: Xiao Ying Zhu, Ye Liu, Xiao Jin Zhang, Wen Hao Yang, Ya Feng, William G. Ondo, Eng-king TanAbstract:There is limited data on motor Restlessness in Parkinson's disease (PD). Here we evaluate for clinical differences between cohorts of idiopathic Restless Legs Syndrome (iRLS), PD patients with leg Restlessness, and PD with RLS. We examined 276 consecutive PD patients for leg Restlessness symptoms, we compared clinical features of PD patients with RLS, PD patients with leg Restlessness but not meeting RLS criteria, PD patient without RLS and iRLS. A total of 262 PD patients who satisfied the inclusion criteria were analyzed. After excluding 23 possible secondary RLS or mimics, 28 were diagnosed with RLS and 18 with leg motor Restlessness (LMR). Compared with iRLS patients, PD patients with RLS or LMR had older age of RLS/LMR onset, shorter duration of leg Restlessness, less positive family history, different seasonal trends and more unilaterality of leg Restlessness symptom (P<0.01) which were often in accordance with dominant Parkinsonism side and related with Parkinsonism severity. PD patients with RLS/LMR had lower daily dosage (P<0.01) and shorter duration (P<0.05) of dopaminergic medication when RLS/LMR symptom onset than PD without leg Restlessness. PD with LMR had less severe Parkinsonism (P<0.05) and leg Restlessness (P<0.01) symptoms than PD with RLS. Clinical characteristics of PD patients with RLS and LMR were different from iRLS, differentiating these various subtypes can facilitate optimal treatment. Copyright © 2015 Elsevier B.V. All rights reserved.
Koichi Hirata - One of the best experts on this subject based on the ideXlab platform.
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leg Restlessness preceding the onset of motor symptoms of parkinson disease a case series of 5 patients
Medicine, 2019Co-Authors: Keisuke Suzuki, Hiroaki Fujita, Yuji Watanabe, Takeo Matsubara, Taro Kadowaki, Hirotaka Sakuramoto, Mai Hamaguchi, Narihiro Nozawa, Koichi HirataAbstract:Patients with Parkinson disease (PD) often show restless legs syndrome (RLS), leg motor Restlessness (LMR) and other leg Restlessness (OLR) related to sensorimotor symptoms.Here, we describe 5 patients who presented with leg Restlessness as an early manifestation of PD.In case 1, the patient had leg Restlessness that was not LMR or RLS and preceded the onset of motor symptoms by 1 year. In case 2, LMR preceded motor symptoms by 2 years. Case 3 had unilateral RLS symptoms on the left side of the body for 33 years. Two and a half years after the spread of RLS symptoms to the right leg with increased frequency of left-sided RLS symptoms, the patient developed PD at the age of 58 years. In cases 4 and 5, RLS symptoms preceded motor symptoms by 3 months and 1 month, respectively. All patients developed Parkinsonism within 3 years (median, 1.0 year; range 0.083-2.5 years) after initial onset or exacerbation of leg Restlessness. All patients had frequent leg Restlessness symptoms (6-7 days per week). In our series, the preceding leg Restlessness was unilateral and confined to the dominant side of the subsequent Parkinsonism, or preceding leg Restlessness was bilateral but dominant on the dominant side of the subsequent Parkinsonism.Clinicians should be aware that late-onset leg Restlessness (>50 years of age) including RLS, LMR, and OLR, particularly if frequent and asymmetrical, can be an early nonmotor manifestation of PD.
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Restless legs syndrome, leg motor Restlessness and their variants in patients with Parkinson's disease and related disorders.
Journal of the neurological sciences, 2018Co-Authors: Takeo Matsubara, Keisuke Suzuki, Hiroaki Fujita, Yuji Watanabe, Hirotaka Sakuramoto, Masanori Matsubara, Koichi HirataAbstract:Abstract Objective The objective of this study was to investigate the prevalence of restless leg syndrome (RLS), leg motor Restlessness (LMR) and RLS/LMR variants and their relationship with clinical factors in patients with Parkinson's disease (PD) and related disorders. Methods Sixty-three PD patients, 17 multiple system atrophy (MSA) patients and 11 progressive supranuclear palsy (PSP) patients were included in this study. Through face-to-face interviews, the patients were diagnosed with RLS/LMR, or with RLS/LMR variants in which the symptoms occur predominantly in body parts other than the legs. Results The frequency of RLS, LMR, RLS variants and LMR variants was as follows: PD (12.7%, 11.1%, 0% and 1.6%); MSA (5.9%, 11.8%, 0% and 0%); and PSP (0%, 9.1%, 0% and 0%). Restlessness without the urge to move was observed in 25.4% of the PD patients, 11.8% of the MSA patients and 0% of the PSP patients. The PD patients with Restlessness exhibited higher Hoehn and Yahr stages and higher scores on the Scales for Outcomes in PD-Autonomic, PD sleep scale-2 and Beck Depression Inventory-II. The olfactory functioning, 123I-MIBG myocardial scintigraphy uptake and dopamine transporter single photon emission computed tomography findings did not differ between the PD patients with Restlessness and those without. The severity of RLS was correlated with the autonomic symptoms among the PD patients with Restlessness. Conclusion PD with Restlessness was characterized by increased autonomic, sleep and depressive symptoms. Further studies including a large sample are warranted to characterize Restlessness in PD and related disorders.
