The Experts below are selected from a list of 93 Experts worldwide ranked by ideXlab platform
Masatoshi Tanaka - One of the best experts on this subject based on the ideXlab platform.
-
Comparative study of short-term anxiolytic potency of alprazolam and tandospirone in psychiatric outpatients with anxiety disorders.
Human psychopharmacology, 2001Co-Authors: Kouji Yamauchi, Shigeto Yamada, Hisao Maeda, Kiichirou Morita, Masatoshi TanakaAbstract:Anxiolytic potency of 1 week of treatment with alprazolam or tandospirone in psychiatric outpatients with anxiety disorders was evaluated by changes in the scores on the Hamilton Anxiety Scale and the State and Trait Anxiety Inventory and in the Saliva Level of free-3-methoxy-4-hydroxyphenylglycol (free-MHPG). Saliva Level of free-MHPG was significantly reduced by 1 week of treatment with alprazolam but not with tandospirone. Reductions in the HAS score after 1 week of drug treatment were greater in patients treated with alprazolam than in those treated with tandospirone. These results indicate that the short-term anxiolytic potency of alprazolam is greater than that of tandospirone and that the Saliva Level of MHPG would be a useful marker for the evaluation of the therapeutic potency of anxiolytic agents. Copyright © 2001 John Wiley & Sons, Ltd.
-
Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) as a biological index of anxiety disorders
Psychiatry Research, 2000Co-Authors: Shigeto Yamada, Junpei Yajima, Kohji Yamauchi, Hisao Maeda, Shinji Hisadomi, Kohji Toyomasu, Masatoshi TanakaAbstract:Abstract To access the Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) as a biological index of anxiety disorders, gender- or age-dependent changes in Saliva MHPG Level in patients with anxiety disorders were investigated. Saliva MHPG Levels in 196 normal volunteers (59 male, 137 female) and 42 outpatients with anxiety disorders (20 male, 22 female) at the initial consultation to the hospital were measured by gas chromatography-mass spectrometry. Saliva MHPG Levels in patients were higher than those in normal subjects. The increase in Saliva MHPG Levels in male patients was greater than that in female patients. Age-associated increase in the Saliva MHPG Level was greater in patients than in normal subjects. Especially, a significant interaction of age vs. patient effect was found in female subjects ( P =0.0005), but not in male subjects ( P =0.174). These data indicate that the measurement of Saliva MHPG would be valuable for detecting pathological anxiety in male patients regardless of age and in older female patients, but not in younger female patients.
-
Saliva Level of free-3-methoxy-4-hydroxyphenylglycol in patients with anxiety disorders
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1999Co-Authors: Shigeto Yamada, Akira Tsuda, Junpei Yajima, Kohji Yamauchi, Hisao Maeda, Masatoshi TanakaAbstract:The Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) in 16 outpatients with anxiety disorders was determined by gas chromatography-mass spectrometry. The anxiety Level of the patients was scored by the Hamilton Anxiety Scale (HAS) before and after a one-week drug treatment with alprazolam. The Saliva Level of free-MHPG at the subjects' first visit to the hospital was significantly higher than that of the control subjects and was reduced by the one-week alprazolam treatment. The post-treatment Level of MHPG in patients who showed good response to the treatment was significantly less than the pretreatment Level, but there was no significant difference between pre- and post-treatment Levels of MHPG in poor responders. There was no correlation between the MHPG Level and the HAS score at the first hospital visit. The MHPG Levels after the treatment correlated with the HAS scores. The reduction of the anxiety Level as scored by the HAS correlated with the reduction of the MHPG Level. These results indicate that the free Saliva MHPG Level may be a useful indicator for assessing not only the Level of anxiety but also the response to drug treatment for anxiety in these patients.
-
Saliva Level of free 3-methoxy-4-hydroxyphenylglycol in psychiatric outpatients with anxiety.
International clinical psychopharmacology, 1998Co-Authors: Shigeto Yamada, Akira Tsuda, Junpei Yajima, Hisao Maeda, Mutsuo Harano, K Miki, J Nakamura, H Shoji, Masatoshi TanakaAbstract:As a measurement of the Level of anxiety in psychiatric outpatients with anxiety, we determined the Saliva Level of free 3-methoxy-4-hydroxyphenyleglycol (MHPG) using gas chromatography- mass spectrometry and scored the Levels of anxiety with the Hamilton Anxiety Scale (HAS) in patients, before and after drug treatment with alprazolam for 1 week. The Saliva Level of free-MHPG at first visit to hospital was significantly higher than that of control individuals and disease control individuals and was reduced by alprazolam treatment for 1 week. There was no correlation between MHPG Level and the HAS score at the first hospital visit. The MHPG Levels after treatment correlated with the HAS scores. The reduction of the anxiety Level as scored by the HAS correlated with the reduction of MHPG Level. These results indicate that the free Saliva MHPG Level may be a useful indicator for assessing not only the Level of anxiety, but also the response to drug treatment for anxiety in these patients.
Shigeto Yamada - One of the best experts on this subject based on the ideXlab platform.
-
Relationship between Saliva Level of 3-methoxy-4-hydroxyphenylglycol and mental health in the elderly general population.
Psychiatry and Clinical Neurosciences, 2008Co-Authors: Itaru Watanabe, Yutaka Kunitake, Kazuhiro Sugataka, Toshifumi Muraoka, Naoki Kojima, Toshiro Kawashima, Shigeto YamadaAbstract:Aims: A large number of studies on the monoamine systems in Alzheimer's disease (AD) have found abnormalities of the noradrenergic system in the brain, but there has been no report concerning the relationship between noradrenergic activity and cognitive function in elderly living in a community. The aim of the present study was to explore the relationship between Saliva Level of 3-methoxy-4-hydroxyphenylglycol (sMHPG) and mental health in this population. Methods: The study was to examine the relationship between sMHPG and performance on the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Beck Depression Inventory (BDI) in 213 elderly people living in the local community. Results: sMHPG in female subjects was positively correlated with age (r = 0.24, P = 0.003) and negatively correlated with scores on the MMSE (r = −0.26, P = 0.0016) and FAB (r = −0.19, P = 0.024), even after controlling for the effect of age (MMSE r = −0.20, P = 0.013). Notably, sMHPG was correlated with the pentagon drawing score (P = 0.0008) of MMSE. sMHPG was significantly correlated with BDI score in male subjects, but negatively correlated in female subjects. A gender difference was found in the relationship between the sMHPG and BDI score. Conclusion: The measurement of sMHPG may be a useful marker of mental health in elderly community-dwelling subjects.
-
Association between the scores on the general health questionnaire-28 and the Saliva Levels of 3-methoxy-4-hydroxyphenylglycol in normal volunteers.
Biological psychology, 2006Co-Authors: H. Ueki, Y. Yamamoto, Shigeto YamadaAbstract:To access the Saliva Level of 3-methoxy-4-hydroxy-phenylglycol (sMHPG) as an index of mental health in normal volunteers, we investigated the relationship between the sMHPG and the scores on the general health questionnaire-28 (GHQ-28). A total of 270 normal volunteers answered the GHQ-28 and the sMHPG Levels were determined. The sMHPG Levels in women and men were comparable. There was a significant negative correlation between the social dysfunction score on the GHQ-28 and sMHPG Levels in women (P = 0.0035), but not in men. Moreover, the sMHPG Levels also correlated with the total GHQ-28 score (P = 0.0205), the anxiety and the insomnia score (P = 0.0306) in women. These data indicate a high social dysfunction score on the GHQ-28 to be associated with a reduced noradrenergic neuronal tone thus possibly reflecting psychomotor retardation in women.
-
Assessment of mental condition by Saliva Level of 3-methoxy-4-hydroxyphenylglycol
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2005Co-Authors: Shigeto YamadaAbstract:There is substantial evidence that the anxiety state in human is associated with a high Level of 3-methoxy-4-hydroxyphenylglycol (MHPG), noradrenaline metabolite, in the plasma, urine and cerebrospinal fluid. Moreover, the plasma Level of MHPG in some patients with depression has been reported to be lower than that in normal controls. Recently, the Saliva Level of MHPG was well correlated with a Level of plasma and CSF. Social dysfunction score of General Health Questionnaire (GHQ-28) was negatively correlated with the Saliva Level of MHPG in normal volunteers (n = 270, r = -0.213, p < 0.001). Lowered baseline Saliva MHPG Level was associated with the poor performance on a continuous task requiring effortful attention. These data indicate that reduced Saliva MHPG in general population would reflect a depressive state. The Saliva Level of MHPG at first visit to a hospital in patients with anxiety disorder was significantly higher than that of control individuals and was reduced by alprazolam treatment for 1 week. Thus, a Saliva MHPG would be a useful marker to assess some mental states in psychiatric patients as well as the general population.
-
Comparative study of short-term anxiolytic potency of alprazolam and tandospirone in psychiatric outpatients with anxiety disorders.
Human psychopharmacology, 2001Co-Authors: Kouji Yamauchi, Shigeto Yamada, Hisao Maeda, Kiichirou Morita, Masatoshi TanakaAbstract:Anxiolytic potency of 1 week of treatment with alprazolam or tandospirone in psychiatric outpatients with anxiety disorders was evaluated by changes in the scores on the Hamilton Anxiety Scale and the State and Trait Anxiety Inventory and in the Saliva Level of free-3-methoxy-4-hydroxyphenylglycol (free-MHPG). Saliva Level of free-MHPG was significantly reduced by 1 week of treatment with alprazolam but not with tandospirone. Reductions in the HAS score after 1 week of drug treatment were greater in patients treated with alprazolam than in those treated with tandospirone. These results indicate that the short-term anxiolytic potency of alprazolam is greater than that of tandospirone and that the Saliva Level of MHPG would be a useful marker for the evaluation of the therapeutic potency of anxiolytic agents. Copyright © 2001 John Wiley & Sons, Ltd.
-
Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) as a biological index of anxiety disorders
Psychiatry Research, 2000Co-Authors: Shigeto Yamada, Junpei Yajima, Kohji Yamauchi, Hisao Maeda, Shinji Hisadomi, Kohji Toyomasu, Masatoshi TanakaAbstract:Abstract To access the Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) as a biological index of anxiety disorders, gender- or age-dependent changes in Saliva MHPG Level in patients with anxiety disorders were investigated. Saliva MHPG Levels in 196 normal volunteers (59 male, 137 female) and 42 outpatients with anxiety disorders (20 male, 22 female) at the initial consultation to the hospital were measured by gas chromatography-mass spectrometry. Saliva MHPG Levels in patients were higher than those in normal subjects. The increase in Saliva MHPG Levels in male patients was greater than that in female patients. Age-associated increase in the Saliva MHPG Level was greater in patients than in normal subjects. Especially, a significant interaction of age vs. patient effect was found in female subjects ( P =0.0005), but not in male subjects ( P =0.174). These data indicate that the measurement of Saliva MHPG would be valuable for detecting pathological anxiety in male patients regardless of age and in older female patients, but not in younger female patients.
Hisao Maeda - One of the best experts on this subject based on the ideXlab platform.
-
Comparative study of short-term anxiolytic potency of alprazolam and tandospirone in psychiatric outpatients with anxiety disorders.
Human psychopharmacology, 2001Co-Authors: Kouji Yamauchi, Shigeto Yamada, Hisao Maeda, Kiichirou Morita, Masatoshi TanakaAbstract:Anxiolytic potency of 1 week of treatment with alprazolam or tandospirone in psychiatric outpatients with anxiety disorders was evaluated by changes in the scores on the Hamilton Anxiety Scale and the State and Trait Anxiety Inventory and in the Saliva Level of free-3-methoxy-4-hydroxyphenylglycol (free-MHPG). Saliva Level of free-MHPG was significantly reduced by 1 week of treatment with alprazolam but not with tandospirone. Reductions in the HAS score after 1 week of drug treatment were greater in patients treated with alprazolam than in those treated with tandospirone. These results indicate that the short-term anxiolytic potency of alprazolam is greater than that of tandospirone and that the Saliva Level of MHPG would be a useful marker for the evaluation of the therapeutic potency of anxiolytic agents. Copyright © 2001 John Wiley & Sons, Ltd.
-
Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) as a biological index of anxiety disorders
Psychiatry Research, 2000Co-Authors: Shigeto Yamada, Junpei Yajima, Kohji Yamauchi, Hisao Maeda, Shinji Hisadomi, Kohji Toyomasu, Masatoshi TanakaAbstract:Abstract To access the Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) as a biological index of anxiety disorders, gender- or age-dependent changes in Saliva MHPG Level in patients with anxiety disorders were investigated. Saliva MHPG Levels in 196 normal volunteers (59 male, 137 female) and 42 outpatients with anxiety disorders (20 male, 22 female) at the initial consultation to the hospital were measured by gas chromatography-mass spectrometry. Saliva MHPG Levels in patients were higher than those in normal subjects. The increase in Saliva MHPG Levels in male patients was greater than that in female patients. Age-associated increase in the Saliva MHPG Level was greater in patients than in normal subjects. Especially, a significant interaction of age vs. patient effect was found in female subjects ( P =0.0005), but not in male subjects ( P =0.174). These data indicate that the measurement of Saliva MHPG would be valuable for detecting pathological anxiety in male patients regardless of age and in older female patients, but not in younger female patients.
-
Saliva Level of free-3-methoxy-4-hydroxyphenylglycol in patients with anxiety disorders
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1999Co-Authors: Shigeto Yamada, Akira Tsuda, Junpei Yajima, Kohji Yamauchi, Hisao Maeda, Masatoshi TanakaAbstract:The Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) in 16 outpatients with anxiety disorders was determined by gas chromatography-mass spectrometry. The anxiety Level of the patients was scored by the Hamilton Anxiety Scale (HAS) before and after a one-week drug treatment with alprazolam. The Saliva Level of free-MHPG at the subjects' first visit to the hospital was significantly higher than that of the control subjects and was reduced by the one-week alprazolam treatment. The post-treatment Level of MHPG in patients who showed good response to the treatment was significantly less than the pretreatment Level, but there was no significant difference between pre- and post-treatment Levels of MHPG in poor responders. There was no correlation between the MHPG Level and the HAS score at the first hospital visit. The MHPG Levels after the treatment correlated with the HAS scores. The reduction of the anxiety Level as scored by the HAS correlated with the reduction of the MHPG Level. These results indicate that the free Saliva MHPG Level may be a useful indicator for assessing not only the Level of anxiety but also the response to drug treatment for anxiety in these patients.
-
Saliva Level of free 3-methoxy-4-hydroxyphenylglycol in psychiatric outpatients with anxiety.
International clinical psychopharmacology, 1998Co-Authors: Shigeto Yamada, Akira Tsuda, Junpei Yajima, Hisao Maeda, Mutsuo Harano, K Miki, J Nakamura, H Shoji, Masatoshi TanakaAbstract:As a measurement of the Level of anxiety in psychiatric outpatients with anxiety, we determined the Saliva Level of free 3-methoxy-4-hydroxyphenyleglycol (MHPG) using gas chromatography- mass spectrometry and scored the Levels of anxiety with the Hamilton Anxiety Scale (HAS) in patients, before and after drug treatment with alprazolam for 1 week. The Saliva Level of free-MHPG at first visit to hospital was significantly higher than that of control individuals and disease control individuals and was reduced by alprazolam treatment for 1 week. There was no correlation between MHPG Level and the HAS score at the first hospital visit. The MHPG Levels after treatment correlated with the HAS scores. The reduction of the anxiety Level as scored by the HAS correlated with the reduction of MHPG Level. These results indicate that the free Saliva MHPG Level may be a useful indicator for assessing not only the Level of anxiety, but also the response to drug treatment for anxiety in these patients.
Junpei Yajima - One of the best experts on this subject based on the ideXlab platform.
-
Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) as a biological index of anxiety disorders
Psychiatry Research, 2000Co-Authors: Shigeto Yamada, Junpei Yajima, Kohji Yamauchi, Hisao Maeda, Shinji Hisadomi, Kohji Toyomasu, Masatoshi TanakaAbstract:Abstract To access the Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) as a biological index of anxiety disorders, gender- or age-dependent changes in Saliva MHPG Level in patients with anxiety disorders were investigated. Saliva MHPG Levels in 196 normal volunteers (59 male, 137 female) and 42 outpatients with anxiety disorders (20 male, 22 female) at the initial consultation to the hospital were measured by gas chromatography-mass spectrometry. Saliva MHPG Levels in patients were higher than those in normal subjects. The increase in Saliva MHPG Levels in male patients was greater than that in female patients. Age-associated increase in the Saliva MHPG Level was greater in patients than in normal subjects. Especially, a significant interaction of age vs. patient effect was found in female subjects ( P =0.0005), but not in male subjects ( P =0.174). These data indicate that the measurement of Saliva MHPG would be valuable for detecting pathological anxiety in male patients regardless of age and in older female patients, but not in younger female patients.
-
Saliva Level of free-3-methoxy-4-hydroxyphenylglycol in patients with anxiety disorders
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1999Co-Authors: Shigeto Yamada, Akira Tsuda, Junpei Yajima, Kohji Yamauchi, Hisao Maeda, Masatoshi TanakaAbstract:The Saliva Level of free 3-methoxy-4-hydroxyphenylglycol (MHPG) in 16 outpatients with anxiety disorders was determined by gas chromatography-mass spectrometry. The anxiety Level of the patients was scored by the Hamilton Anxiety Scale (HAS) before and after a one-week drug treatment with alprazolam. The Saliva Level of free-MHPG at the subjects' first visit to the hospital was significantly higher than that of the control subjects and was reduced by the one-week alprazolam treatment. The post-treatment Level of MHPG in patients who showed good response to the treatment was significantly less than the pretreatment Level, but there was no significant difference between pre- and post-treatment Levels of MHPG in poor responders. There was no correlation between the MHPG Level and the HAS score at the first hospital visit. The MHPG Levels after the treatment correlated with the HAS scores. The reduction of the anxiety Level as scored by the HAS correlated with the reduction of the MHPG Level. These results indicate that the free Saliva MHPG Level may be a useful indicator for assessing not only the Level of anxiety but also the response to drug treatment for anxiety in these patients.
-
Saliva Level of free 3-methoxy-4-hydroxyphenylglycol in psychiatric outpatients with anxiety.
International clinical psychopharmacology, 1998Co-Authors: Shigeto Yamada, Akira Tsuda, Junpei Yajima, Hisao Maeda, Mutsuo Harano, K Miki, J Nakamura, H Shoji, Masatoshi TanakaAbstract:As a measurement of the Level of anxiety in psychiatric outpatients with anxiety, we determined the Saliva Level of free 3-methoxy-4-hydroxyphenyleglycol (MHPG) using gas chromatography- mass spectrometry and scored the Levels of anxiety with the Hamilton Anxiety Scale (HAS) in patients, before and after drug treatment with alprazolam for 1 week. The Saliva Level of free-MHPG at first visit to hospital was significantly higher than that of control individuals and disease control individuals and was reduced by alprazolam treatment for 1 week. There was no correlation between MHPG Level and the HAS score at the first hospital visit. The MHPG Levels after treatment correlated with the HAS scores. The reduction of the anxiety Level as scored by the HAS correlated with the reduction of MHPG Level. These results indicate that the free Saliva MHPG Level may be a useful indicator for assessing not only the Level of anxiety, but also the response to drug treatment for anxiety in these patients.
Naoki Kojima - One of the best experts on this subject based on the ideXlab platform.
-
Baseline Saliva Level of 3-methoxy-4-hydroxyphenylglycole (MHPG) associates with a consequent cognitive decline in non-demented elderly subjects: Three-years follow-up study
Psychiatry research, 2011Co-Authors: Itaru Watanabe, Yutaka Kunitake, Yoshiomi Imamura, Hiromi Nabeta, Hironobu Ishii, Masanori Haraguchi, Yuzo Furukawa, Hiroshi Tateishi, Naoki KojimaAbstract:The aim of the study was to explore the relation between Saliva Level of 3-methoxy-4-hydroxy-phenylglycol (MHPG) and a later cognitive decline in non-demented elderly subjects. We have reported that sMHPG in 214 elderly subjects living in the community (age 74.5 ± 5.9 years) was associated with scores on the Mini-Mental State Examination (MMSE) and the Frontal Assessment Battery (FAB) in 2004 to 2006 (Time A). The same cohort underwent these cognitive tests again from 2007 to 2009 (Time B). The cognitive function of the 147 of 214 subjects could be reassessed by the same cognitive tests. The score on the FAB, but not the MMSE, was significantly reduced at Time B (14.6 ± 2.6) compared with that of Time A (15.2 ± 1.9). There was a significant negative correlation between the baseline sMHPG and the changes in the FAB score subtracted from Time B to Time A or the scores on the FAB at Time B in men, but not at Time A. These correlations were not found in women. These data indicate that high sMHPG might be associated with subsequent cognitive decline assessed by the FAB in non-demented elderly men living in the community.
-
Relationship between Saliva Level of 3-methoxy-4-hydroxyphenylglycol and mental health in the elderly general population.
Psychiatry and Clinical Neurosciences, 2008Co-Authors: Itaru Watanabe, Yutaka Kunitake, Kazuhiro Sugataka, Toshifumi Muraoka, Naoki Kojima, Toshiro Kawashima, Shigeto YamadaAbstract:Aims: A large number of studies on the monoamine systems in Alzheimer's disease (AD) have found abnormalities of the noradrenergic system in the brain, but there has been no report concerning the relationship between noradrenergic activity and cognitive function in elderly living in a community. The aim of the present study was to explore the relationship between Saliva Level of 3-methoxy-4-hydroxyphenylglycol (sMHPG) and mental health in this population. Methods: The study was to examine the relationship between sMHPG and performance on the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Beck Depression Inventory (BDI) in 213 elderly people living in the local community. Results: sMHPG in female subjects was positively correlated with age (r = 0.24, P = 0.003) and negatively correlated with scores on the MMSE (r = −0.26, P = 0.0016) and FAB (r = −0.19, P = 0.024), even after controlling for the effect of age (MMSE r = −0.20, P = 0.013). Notably, sMHPG was correlated with the pentagon drawing score (P = 0.0008) of MMSE. sMHPG was significantly correlated with BDI score in male subjects, but negatively correlated in female subjects. A gender difference was found in the relationship between the sMHPG and BDI score. Conclusion: The measurement of sMHPG may be a useful marker of mental health in elderly community-dwelling subjects.
