The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Brett A King - One of the best experts on this subject based on the ideXlab platform.
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Development of the Scalp Hair Assessment PRO™ measure for alopecia areata.
The British journal of dermatology, 2020Co-Authors: Kathleen W Wyrwich, H Kitchen, Sarah Knight, Natalie V J Aldhouse, Jake Macey, Fabio P Nunes, Yves Dutronc, Natasha Atanaskova Mesinkovska, Brett A KingAbstract:Author(s): Wyrwich, KW; Kitchen, H; Knight, S; Aldhouse, NVJ; Macey, J; Nunes, FP; Dutronc, Y; Mesinkovska, N; Ko, JM; King, BA | Abstract: BackgroundValid patient-reported outcome (PRO) measures are required to evaluate alopecia areata (AA) treatments.ObjectivesTo develop a content-valid and clinically meaningful PRO measure to assess AA Scalp Hair loss with scores comparable with the five-response-level Alopecia Areata Investigator Global Assessment (AA-IGA™).MethodsA draft PRO measure was developed based on input from 10 clinical experts in AA. The PRO measure was cognitively debriefed, modified and finalized through two rounds of qualitative semistructured interviews with patients with AA who had experienced ≥ 50% Scalp Hair loss. Data were thematically analysed.ResultsAdults (round 1: n = 25; round 2: n = 15) and adolescents aged 15-17 years (round 1: n = 5) in North America participated. All patients named Scalp Hair loss as a key AA sign or symptom. Patients demonstrated the ability to self-report their current amount of Scalp Hair using percentages. In round 1 not all patients interpreted the measurement concept consistently; therefore, the PRO was modified to clarify the measurement concept to improve usability. Following modifications, patients in round 2 responded without difficulty to the PRO measure. Patients confirmed that they could use the five-level response scale to rate their Scalp Hair loss: no missing Hair, 0%; limited, 1-20%; moderate, 21-49%; large, 50-94%; nearly all or all, 95-100%. Almost all patients deemed Hair regrowth resulting in ≤ 20% Scalp Hair loss a treatment success.ConclusionsThe Scalp Hair Assessment PRO™ is a content-valid, clinically meaningful assessment of distinct gradations of Scalp Hair loss for evaluating AA treatment for patients with ≥ 50% Hair loss at baseline.
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development of the Scalp Hair assessment pro measure for alopecia areata
British Journal of Dermatology, 2020Co-Authors: Kathleen W Wyrwich, H Kitchen, Sarah Knight, Natalie V J Aldhouse, Jake Macey, Fabio P Nunes, Yves Dutronc, Natasha Atanaskova Mesinkovska, Brett A KingAbstract:Background Valid patient-reported outcome (PRO) measures are required to evaluate alopecia areata (AA) treatments. Objectives To develop a content-valid and clinically meaningful PRO measure to assess AA Scalp Hair loss with scores comparable with the five-response-level Alopecia Areata Investigator Global Assessment (AA-IGA™). Methods A draft PRO measure was developed based on input from 10 clinical experts in AA. The PRO measure was cognitively debriefed, modified and finalized through two rounds of qualitative semistructured interviews with patients with AA who had experienced ≥ 50% Scalp Hair loss. Data were thematically analysed. Results Adults (round 1: n = 25; round 2: n = 15) and adolescents aged 15-17 years (round 1: n = 5) in North America participated. All patients named Scalp Hair loss as a key AA sign or symptom. Patients demonstrated the ability to self-report their current amount of Scalp Hair using percentages. In round 1 not all patients interpreted the measurement concept consistently; therefore, the PRO was modified to clarify the measurement concept to improve usability. Following modifications, patients in round 2 responded without difficulty to the PRO measure. Patients confirmed that they could use the five-level response scale to rate their Scalp Hair loss: no missing Hair, 0%; limited, 1-20%; moderate, 21-49%; large, 50-94%; nearly all or all, 95-100%. Almost all patients deemed Hair regrowth resulting in ≤ 20% Scalp Hair loss a treatment success. Conclusions The Scalp Hair Assessment PRO™ is a content-valid, clinically meaningful assessment of distinct gradations of Scalp Hair loss for evaluating AA treatment for patients with ≥ 50% Hair loss at baseline.
Hassan Imran Afridi - One of the best experts on this subject based on the ideXlab platform.
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correlation of aluminum and manganese concentration in Scalp Hair samples of patients having neurological disorders
Environmental Monitoring and Assessment, 2015Co-Authors: Mariam Shahzadi Arain, Tasneem Gul Kazi, Hassan Imran Afridi, Farah Naz Talpur, Mohammad Balal Arain, Atif Kazi, Salma Aslam Arain, Jamshed AliAbstract:Neurodegenerative diseases are thought to be multifactorial, while metals (aluminum and manganese) can be involved as cofactors in abnormalities or suspected of being risk factors for this disorder. The aim of our study was to assess the aluminum (Al) and manganese (Mn) concentrations in Scalp Hair samples of 397 patients having different types of neurological disorder diseases. For comparative purpose, Scalp Hair samples of 201 control subjects does not have any neuro-disorders of same age group (30–60 years) and were selected as referents. The Al and Mn in Scalp Hair samples were assessed by the electrothermal atomic absorption spectrophotometry after microwave-assisted acid digestion. The validity of methodology was checked by the certified human Hair reference material (NCS ZC81002). The results of this study showed that the mean values of Al and Mn were significantly higher in Scalp Hair samples of all types of neurological disorder patients as compared to controls (p = 0.01–0.001). The high levels of Al and Mn may play a role in the development of neurological disorders. However, further work is suggested to examine the precise correlation between trace elemental level and the degree of disorders in neurological patients.
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Evaluated the Levels of Lead and Cadmium in Scalp Hair of Adolescent Boys Consuming Different Smokeless Tobacco Products with Related to Controls
Biological trace element research, 2014Co-Authors: Sadaf Sadia Arain, Tasneem Gul Kazi, Hassan Imran Afridi, Jamshed Ali, Asma J. Arain, Kapil Dev Brahman, Naeemullah, G. Zuhra MemonAbstract:The present study was aimed to evaluate the cadmium (Cd) and lead (Pb) levels in the Scalp Hair samples of adolescent boys age ranged 12–15 years, chewing different smokeless tobacco (SLT) products. For comparative purpose, boys of the same age group who did not consume any SLT products were selected as referents. The concentrations of Cd and Pb in SLT products and the Scalp Hair samples were measured by electrothermal atomic absorption spectrophotometer (ETAAS) after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by certified reference materials (CRMs). The difference between experimental and certified values of both elements was not significant (p > 0.05). The resulted data indicated that the adolescent boys who consumed different SLT products have two- to threefold higher levels of Cd and Pb in the Scalp Hair samples as compared to the referent boys (p < 0.01). The adolescent chewing different SLT products have 82.2–110 and 60.6–94.5 % higher levels of Cd and Pb, respectively, in their Scalp Hair as related to the referents.
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Investigation of Alteration in the Levels of Iron and Copper in Scalp Hair Samples of Patients Having Different Types of Viral Hepatitis
Biological Trace Element Research, 2013Co-Authors: Salma Aslam Arain, Hassan Imran Afridi, Faheem Shah, Farah Naz Talpur, Sadaf Sadia Arain, Tasneem G. Kazi, Abdul Haleem Panhwar, Kapil Dev BrahmanAbstract:The aim of this study was to measure the alterations of copper and iron contents in Scalp Hair samples of hepatitis A–E patients of both genders, same age group, and socioeconomic status. For comparative study, the Scalp Hair samples of healthy individuals of the same age and socioeconomic status were collected. The concentrations of copper and iron were measured using an atomic absorption spectrophotometer, after microwave-assisted acid digestion. The validity and accuracy of methodology was checked using a certified reference material. The results of this study showed that the mean values of copper and iron were higher in Scalp Hair samples of hepatitis patients than those of age-matched control subjects, while the difference was significant in the cases of patients having viral hepatitis B, C, and D as compared to those who have viral hepatitis A and E ( p
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Investigation of Alteration in the Levels of Iron and Copper in Scalp Hair Samples of Patients Having Different Types of Viral Hepatitis
Biological Trace Element Research, 2013Co-Authors: Salma Aslam Arain, Hassan Imran Afridi, Faheem Shah, Farah Naz Talpur, Sadaf Sadia Arain, Tasneem G. Kazi, Abdul Haleem Panhwar, Kapil Dev BrahmanAbstract:The aim of this study was to measure the alterations of copper and iron contents in Scalp Hair samples of hepatitis A–E patients of both genders, same age group, and socioeconomic status. For comparative study, the Scalp Hair samples of healthy individuals of the same age and socioeconomic status were collected. The concentrations of copper and iron were measured using an atomic absorption spectrophotometer, after microwave-assisted acid digestion. The validity and accuracy of methodology was checked using a certified reference material. The results of this study showed that the mean values of copper and iron were higher in Scalp Hair samples of hepatitis patients than those of age-matched control subjects, while the difference was significant in the cases of patients having viral hepatitis B, C, and D as compared to those who have viral hepatitis A and E ( p
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Comparative metal distribution in Scalp Hair of Pakistani and Irish referents and diabetes mellitus patients.
Clinica chimica acta; international journal of clinical chemistry, 2012Co-Authors: Hassan Imran Afridi, Tasneem Gul Kazi, Dermot Brabazon, Sumsun Naher, Farah Naz TalpurAbstract:Abstract Background The essential metals, chromium (Cr), magnesium (Mg), manganese (Mn) and zinc (Zn), are necessary for many metabolic processes and their homeostasis is crucial for life. The toxic metals, cadmium (Cd) and lead (Pb), have no beneficial role in human metabolism. The aim of this study was to investigate the levels of Cd, Cr, Mg, Mn, Pb, and Zn in Scalp Hair samples of type 2 diabetes mellitus patients of both genders, ages ranging from 30 to 50 y, and belong to urban areas of Ireland and Pakistan. For comparison purposes, age matched non-diabetic subjects of both countries were selected as referents. Methods The concentrations of metals in Scalp Hair samples were measured by inductively coupled plasma atomic emission spectrophotometer and atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by conventional wet-acid-digestion method and using certified reference materials. Results The mean values of Cd and Pb were significantly higher in Scalp Hair samples of both Pakistani and Irish diabetic patients as compared to referents of both countries (P Conclusion This study showed that, increased toxic elements and decreased essential elements are associated with diabetes mellitus. Therefore, these elements may play a role in the development and pathogenesis of diabetes mellitus.
Tasneem Gul Kazi - One of the best experts on this subject based on the ideXlab platform.
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Variation of Lithium Contents in Scalp Hair Samples of Different Male Psychiatric Patients Before and After Treatment with its Pharmaceutical Supplements
Pharmaceutica Analytica Acta, 2016Co-Authors: Tasneem Gul Kazi, Farah Naz Talpur, Shahnawaz Baloch, H. I. Afridi, Oan Muhammad SahitoAbstract:The biological, medical and environmental roles of lithium (Li) have attracted considerable attention over last many decades, especially as medications for treating bipolar disorder. The aim of this follow up study was to compare the Li concentration in Scalp Hair samples of male psychiatric patients (schizophrenia, depression and bipolar disorder), before and after treatment with Li therapy for different time intervals (six and twelve months). For comparative purpose, the Scalp Hair samples were also collected from healthy male subjects of same socioeconomic and age group. The Scalp Hair samples were oxidized by 65% HNO3: 30% H2O2 (2:1) in microwave oven. The digested Scalp Hair samples were analyzed for Li by flame atomic absorption spectrometry. The resulted data indicated that the contents of Li in Scalp Hair samples of different types of psychiatric patients (schizophrenia, depression and bipolar disorder) were 46.0-55.7% lower as compared to healthy individuals (p
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correlation of aluminum and manganese concentration in Scalp Hair samples of patients having neurological disorders
Environmental Monitoring and Assessment, 2015Co-Authors: Mariam Shahzadi Arain, Tasneem Gul Kazi, Hassan Imran Afridi, Farah Naz Talpur, Mohammad Balal Arain, Atif Kazi, Salma Aslam Arain, Jamshed AliAbstract:Neurodegenerative diseases are thought to be multifactorial, while metals (aluminum and manganese) can be involved as cofactors in abnormalities or suspected of being risk factors for this disorder. The aim of our study was to assess the aluminum (Al) and manganese (Mn) concentrations in Scalp Hair samples of 397 patients having different types of neurological disorder diseases. For comparative purpose, Scalp Hair samples of 201 control subjects does not have any neuro-disorders of same age group (30–60 years) and were selected as referents. The Al and Mn in Scalp Hair samples were assessed by the electrothermal atomic absorption spectrophotometry after microwave-assisted acid digestion. The validity of methodology was checked by the certified human Hair reference material (NCS ZC81002). The results of this study showed that the mean values of Al and Mn were significantly higher in Scalp Hair samples of all types of neurological disorder patients as compared to controls (p = 0.01–0.001). The high levels of Al and Mn may play a role in the development of neurological disorders. However, further work is suggested to examine the precise correlation between trace elemental level and the degree of disorders in neurological patients.
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Evaluated the Levels of Lead and Cadmium in Scalp Hair of Adolescent Boys Consuming Different Smokeless Tobacco Products with Related to Controls
Biological trace element research, 2014Co-Authors: Sadaf Sadia Arain, Tasneem Gul Kazi, Hassan Imran Afridi, Jamshed Ali, Asma J. Arain, Kapil Dev Brahman, Naeemullah, G. Zuhra MemonAbstract:The present study was aimed to evaluate the cadmium (Cd) and lead (Pb) levels in the Scalp Hair samples of adolescent boys age ranged 12–15 years, chewing different smokeless tobacco (SLT) products. For comparative purpose, boys of the same age group who did not consume any SLT products were selected as referents. The concentrations of Cd and Pb in SLT products and the Scalp Hair samples were measured by electrothermal atomic absorption spectrophotometer (ETAAS) after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by certified reference materials (CRMs). The difference between experimental and certified values of both elements was not significant (p > 0.05). The resulted data indicated that the adolescent boys who consumed different SLT products have two- to threefold higher levels of Cd and Pb in the Scalp Hair samples as compared to the referent boys (p < 0.01). The adolescent chewing different SLT products have 82.2–110 and 60.6–94.5 % higher levels of Cd and Pb, respectively, in their Scalp Hair as related to the referents.
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Comparative metal distribution in Scalp Hair of Pakistani and Irish referents and diabetes mellitus patients.
Clinica chimica acta; international journal of clinical chemistry, 2012Co-Authors: Hassan Imran Afridi, Tasneem Gul Kazi, Dermot Brabazon, Sumsun Naher, Farah Naz TalpurAbstract:Abstract Background The essential metals, chromium (Cr), magnesium (Mg), manganese (Mn) and zinc (Zn), are necessary for many metabolic processes and their homeostasis is crucial for life. The toxic metals, cadmium (Cd) and lead (Pb), have no beneficial role in human metabolism. The aim of this study was to investigate the levels of Cd, Cr, Mg, Mn, Pb, and Zn in Scalp Hair samples of type 2 diabetes mellitus patients of both genders, ages ranging from 30 to 50 y, and belong to urban areas of Ireland and Pakistan. For comparison purposes, age matched non-diabetic subjects of both countries were selected as referents. Methods The concentrations of metals in Scalp Hair samples were measured by inductively coupled plasma atomic emission spectrophotometer and atomic absorption spectrophotometer after microwave-assisted acid digestion. The validity and accuracy of the methodology were checked by conventional wet-acid-digestion method and using certified reference materials. Results The mean values of Cd and Pb were significantly higher in Scalp Hair samples of both Pakistani and Irish diabetic patients as compared to referents of both countries (P Conclusion This study showed that, increased toxic elements and decreased essential elements are associated with diabetes mellitus. Therefore, these elements may play a role in the development and pathogenesis of diabetes mellitus.
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Quantification of arsenic in dialysate solution and Scalp Hair samples of kidney failure patients by cloud point extraction and electrothermal atomic absorption spectroscopy.
Journal of AOAC International, 2012Co-Authors: Jameel Ahmed Baig, Tasneem Gul Kazi, Hassan Imran Afridi, Mohammad Balal Arain, Khalida Perveen MaharAbstract:A method has been developed for the determination of arsenic (As) in pharmaceutical and Scalp Hair samples of kidney failure patients by cloud point extraction (CPE). The Scalp Hair samples were subjected to microwave-assisted digestion in nitric acid-hydrogen peroxide (2 + 1, v/v). Then, dialysate and digested Scalp Hair solutions were preconcentrated by CPE using pyronine B as a complexing agent. The resulting complex was entrapped in nonionic surfactant (Triton X-114) prior to its determination by electrothermal atomic absorption spectroscopy. The validity of the CPE method for As was checked by analysis of a certified reference material of human Hair and a standard addition method for dialysate solution. The chemical variables affecting the analytical performance of the CPE methods were studied and optimized. After optimization of the complexation and extraction conditions, a preconcentration factor of 52 was obtained for As in 10 mL of dialysate solution and acid digested samples of Scalp Hair. Under the optimum experimental conditions, the LOD and LOQ of As for the preconcentration of 10 mL of solution were 0.022 and 0.073 microg/L, respectively. The level of As in Scalp Hair samples of kidney failure patients was higher than in healthy controls.
Won Soo Lee - One of the best experts on this subject based on the ideXlab platform.
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Phototrichogram analysis of normal Scalp Hair characteristics with aging.
European journal of dermatology : EJD, 2013Co-Authors: Jung Eun Kim, Won Soo Lee, Joo Hyun Lee, Kwang Hyun Choi, Gwang Seong Choi, Oh Sang Kwon, Moon-bum Kim, Chang Hun Huh, Chull Wan Ihm, Young Chul KyeAbstract:Background: Phototrichogram analysis of normal Scalp Hair characteristics in Asian populations is not well characterized. Objective: To investigate the normal Hair characteristics of South Koreans using a phototrichogram. Methods: We enrolled 674 males and 683 females between the ages of 10 and 69. Hair density, thickness and the white Hair percentage were measured via phototrichogram. Six Scalp sites, including front, top, the peak between top and back, back, and the right and left sides were targeted. Results: The mean Hair density, Hair thickness, and the white Hair percentages were not significantly different between genders at any Scalp site. The mean Hair density and thickness were significantly different according to Scalp sites. Hair density declined with age, especially at the peak between the top and back. Males and females showed different patterns of aging in Hair density. Hair thickness changed little with age. Mean Hair thickness generally tended to increase until the 20s, reach a plateau between the 20s and 50s, and decrease after the 50s. The mean white Hair percentages were 1.84 ± 4.24% in males and 1.66 ± 4.21% in females. The mean white Hair percentages were significantly increased in subjects over 40 years of age. Conclusion: We described the normal characteristics and aging patterns of Scalp Hair in a Korean population.
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Segmented heterochromia in Scalp Hair
Journal of the American Academy of Dermatology, 2003Co-Authors: Kyeong Han Yoon, Dae-hwan Kim, Seonghyang Sohn, Won Soo LeeAbstract:Abstract Segmented heterochromia of Scalp Hair is characterized by the irregularly alternating segmentation of Hair into dark and light bands and is known to be associated with iron deficiency anemia. The authors report the case of an 11-year-old boy with segmented heterochromia associated with iron deficiency anemia. After 11 months of iron replacement, the boy's segmented heterochromic Hair recovered completely.
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Diffuse heterochromia of Scalp Hair
Journal of the American Academy of Dermatology, 1996Co-Authors: Won Soo Lee, Wook Bin Lee, Sung Ku AhnAbstract:Heterochromia of Hair is the presence of more than one distinct color of Hair in the same person. A color difference between Scalp Hair and a mustache or sideburns is not uncommon. Pubic and axillary Hair and eyebrows and eyelashes are often darker than Scalp Hair in a fair-Haired person. Rarely, a circumscribed patch of Hair of different colors occurs. However, diffuse heterochromia of black and red Scalp Hair has not been previously reported. We describe a father and son with this condition.
Kathleen W Wyrwich - One of the best experts on this subject based on the ideXlab platform.
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Development of the Scalp Hair Assessment PRO™ measure for alopecia areata.
The British journal of dermatology, 2020Co-Authors: Kathleen W Wyrwich, H Kitchen, Sarah Knight, Natalie V J Aldhouse, Jake Macey, Fabio P Nunes, Yves Dutronc, Natasha Atanaskova Mesinkovska, Brett A KingAbstract:Author(s): Wyrwich, KW; Kitchen, H; Knight, S; Aldhouse, NVJ; Macey, J; Nunes, FP; Dutronc, Y; Mesinkovska, N; Ko, JM; King, BA | Abstract: BackgroundValid patient-reported outcome (PRO) measures are required to evaluate alopecia areata (AA) treatments.ObjectivesTo develop a content-valid and clinically meaningful PRO measure to assess AA Scalp Hair loss with scores comparable with the five-response-level Alopecia Areata Investigator Global Assessment (AA-IGA™).MethodsA draft PRO measure was developed based on input from 10 clinical experts in AA. The PRO measure was cognitively debriefed, modified and finalized through two rounds of qualitative semistructured interviews with patients with AA who had experienced ≥ 50% Scalp Hair loss. Data were thematically analysed.ResultsAdults (round 1: n = 25; round 2: n = 15) and adolescents aged 15-17 years (round 1: n = 5) in North America participated. All patients named Scalp Hair loss as a key AA sign or symptom. Patients demonstrated the ability to self-report their current amount of Scalp Hair using percentages. In round 1 not all patients interpreted the measurement concept consistently; therefore, the PRO was modified to clarify the measurement concept to improve usability. Following modifications, patients in round 2 responded without difficulty to the PRO measure. Patients confirmed that they could use the five-level response scale to rate their Scalp Hair loss: no missing Hair, 0%; limited, 1-20%; moderate, 21-49%; large, 50-94%; nearly all or all, 95-100%. Almost all patients deemed Hair regrowth resulting in ≤ 20% Scalp Hair loss a treatment success.ConclusionsThe Scalp Hair Assessment PRO™ is a content-valid, clinically meaningful assessment of distinct gradations of Scalp Hair loss for evaluating AA treatment for patients with ≥ 50% Hair loss at baseline.
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development of the Scalp Hair assessment pro measure for alopecia areata
British Journal of Dermatology, 2020Co-Authors: Kathleen W Wyrwich, H Kitchen, Sarah Knight, Natalie V J Aldhouse, Jake Macey, Fabio P Nunes, Yves Dutronc, Natasha Atanaskova Mesinkovska, Brett A KingAbstract:Background Valid patient-reported outcome (PRO) measures are required to evaluate alopecia areata (AA) treatments. Objectives To develop a content-valid and clinically meaningful PRO measure to assess AA Scalp Hair loss with scores comparable with the five-response-level Alopecia Areata Investigator Global Assessment (AA-IGA™). Methods A draft PRO measure was developed based on input from 10 clinical experts in AA. The PRO measure was cognitively debriefed, modified and finalized through two rounds of qualitative semistructured interviews with patients with AA who had experienced ≥ 50% Scalp Hair loss. Data were thematically analysed. Results Adults (round 1: n = 25; round 2: n = 15) and adolescents aged 15-17 years (round 1: n = 5) in North America participated. All patients named Scalp Hair loss as a key AA sign or symptom. Patients demonstrated the ability to self-report their current amount of Scalp Hair using percentages. In round 1 not all patients interpreted the measurement concept consistently; therefore, the PRO was modified to clarify the measurement concept to improve usability. Following modifications, patients in round 2 responded without difficulty to the PRO measure. Patients confirmed that they could use the five-level response scale to rate their Scalp Hair loss: no missing Hair, 0%; limited, 1-20%; moderate, 21-49%; large, 50-94%; nearly all or all, 95-100%. Almost all patients deemed Hair regrowth resulting in ≤ 20% Scalp Hair loss a treatment success. Conclusions The Scalp Hair Assessment PRO™ is a content-valid, clinically meaningful assessment of distinct gradations of Scalp Hair loss for evaluating AA treatment for patients with ≥ 50% Hair loss at baseline.
