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Akemi Tomoda - One of the best experts on this subject based on the ideXlab platform.

  • School Phobia and childhood chronic fatigue syndrome ccfs
    Nihon rinsho. Japanese journal of clinical medicine, 2007
    Co-Authors: Akemi Tomoda
    Abstract:

    Chronic fatigue occurring in previously healthy children and adolescents is a vexing problem encountered by pediatric practitioners and the impact of fatigue in youngsters should not be underestimated. In its severe form, it is often associated with mood disorders. Findings in children and adolescent cases suggest that severe unexplained fatigue might precede the development of fatigue-related illness, such as childhood chronic fatigue syndrome (CCFS). This is a disabling condition characterized by severe disabling fatigue and a combination of symptoms, the prominent features being self-reported impairments in concentration and short-term memory, sleep disturbances and autonomic symptoms that cannot be explained by medical or psychiatric illness. We have encountered such patients with these complaints; their major symptoms include: general fatigue, fever, headache (not migraine), and memory disturbance. From our clinical experience, we have inferred that patients with CCFS might experience changes in brain function levels, which induce an autonomic imbalance and engender symptoms such as general fatigue, higher-order level cognitive dysfunction, and memory disturbance.

  • learning and memorization impairment in childhood chronic fatigue syndrome manifesting as School Phobia in japan
    Brain & Development, 2004
    Co-Authors: Teruhisa Miike, Akemi Tomoda, Takako Jhodoi, Noritaka Iwatani, Hiroyo Mabe
    Abstract:

    For the last 15 years, we have tried to understand the pathophysiology of childhood chronic fatigue syndrome (CCFS) in Japan. In this condition, two major symptoms are important: easy fatigability and disturbed learning and memorization. In CCFS patients we clinically evaluated autonomic nervous system function, circadian rhythm of hormonal secretion (melatonin, cortisol and 3-endorphin), core body temperature, and sleep-wake pattern. Most patients showed autonomic nervous system dysfunction and circadian rhythm disturbances, similar to those observed in jet lag. Radiological imaging studies (SPECT, Xe-CT, and MRS) revealed decreased blood flow in the frontal and thalamic areas, and accumulation of choline in the frontal lobe. We analyzed the relationship between the laboratory data and clinical symptoms in CCFS.

  • single photon emission computed tomography for cerebral blood flow in School Phobia
    Current Therapeutic Research-clinical and Experimental, 1995
    Co-Authors: Akemi Tomoda, Teruhisa Miike, Takako Honda, Keiko Fukuda, Yumiko Kai, Mitsuko Nabeshima, Mutsumasa Takahashi
    Abstract:

    Abstract To investigate the correlation between abnormalities of regional cerebral blood flow and psychosomatic symptoms in School Phobia, we examined cerebral blood flow in 55 patients with School Phobia using single-photon emission computed tomography (SPECT) with 111 MBq 123 I-iodoamphetamine. The relationship between neuropsychological examination scores and SPECT findings was also examined. None of our patients exhibited evidence of focal structural abnormalities on magnetic resonance imaging. Blood flow, expressed as the corticocerebellar ratio (CCR) in the frontal, temporal, and occipital lobes, was markedly lower in patients with general fatigue, headache, and memory disturbance than in healthy adult subjets studied by another investigator and used as reference values in this study. However, parietal CCRs were higher in children with School Phobia than in adult volunteers. These findings suggest that in patients with School Phobia, the clinical psychosomatic symptoms may be closely related to decrease cerebral blood flow, especially in the frontal lobe. The relationship between symptoms of depression in our patients, measured using the self-rating depression scale score, and CCR was not significant.

Teruhisa Miike - One of the best experts on this subject based on the ideXlab platform.

  • learning and memorization impairment in childhood chronic fatigue syndrome manifesting as School Phobia in japan
    Brain & Development, 2004
    Co-Authors: Teruhisa Miike, Akemi Tomoda, Takako Jhodoi, Noritaka Iwatani, Hiroyo Mabe
    Abstract:

    For the last 15 years, we have tried to understand the pathophysiology of childhood chronic fatigue syndrome (CCFS) in Japan. In this condition, two major symptoms are important: easy fatigability and disturbed learning and memorization. In CCFS patients we clinically evaluated autonomic nervous system function, circadian rhythm of hormonal secretion (melatonin, cortisol and 3-endorphin), core body temperature, and sleep-wake pattern. Most patients showed autonomic nervous system dysfunction and circadian rhythm disturbances, similar to those observed in jet lag. Radiological imaging studies (SPECT, Xe-CT, and MRS) revealed decreased blood flow in the frontal and thalamic areas, and accumulation of choline in the frontal lobe. We analyzed the relationship between the laboratory data and clinical symptoms in CCFS.

  • single photon emission computed tomography for cerebral blood flow in School Phobia
    Current Therapeutic Research-clinical and Experimental, 1995
    Co-Authors: Akemi Tomoda, Teruhisa Miike, Takako Honda, Keiko Fukuda, Yumiko Kai, Mitsuko Nabeshima, Mutsumasa Takahashi
    Abstract:

    Abstract To investigate the correlation between abnormalities of regional cerebral blood flow and psychosomatic symptoms in School Phobia, we examined cerebral blood flow in 55 patients with School Phobia using single-photon emission computed tomography (SPECT) with 111 MBq 123 I-iodoamphetamine. The relationship between neuropsychological examination scores and SPECT findings was also examined. None of our patients exhibited evidence of focal structural abnormalities on magnetic resonance imaging. Blood flow, expressed as the corticocerebellar ratio (CCR) in the frontal, temporal, and occipital lobes, was markedly lower in patients with general fatigue, headache, and memory disturbance than in healthy adult subjets studied by another investigator and used as reference values in this study. However, parietal CCRs were higher in children with School Phobia than in adult volunteers. These findings suggest that in patients with School Phobia, the clinical psychosomatic symptoms may be closely related to decrease cerebral blood flow, especially in the frontal lobe. The relationship between symptoms of depression in our patients, measured using the self-rating depression scale score, and CCR was not significant.

Hiroyo Mabe - One of the best experts on this subject based on the ideXlab platform.

  • learning and memorization impairment in childhood chronic fatigue syndrome manifesting as School Phobia in japan
    Brain & Development, 2004
    Co-Authors: Teruhisa Miike, Akemi Tomoda, Takako Jhodoi, Noritaka Iwatani, Hiroyo Mabe
    Abstract:

    For the last 15 years, we have tried to understand the pathophysiology of childhood chronic fatigue syndrome (CCFS) in Japan. In this condition, two major symptoms are important: easy fatigability and disturbed learning and memorization. In CCFS patients we clinically evaluated autonomic nervous system function, circadian rhythm of hormonal secretion (melatonin, cortisol and 3-endorphin), core body temperature, and sleep-wake pattern. Most patients showed autonomic nervous system dysfunction and circadian rhythm disturbances, similar to those observed in jet lag. Radiological imaging studies (SPECT, Xe-CT, and MRS) revealed decreased blood flow in the frontal and thalamic areas, and accumulation of choline in the frontal lobe. We analyzed the relationship between the laboratory data and clinical symptoms in CCFS.

Mutsumasa Takahashi - One of the best experts on this subject based on the ideXlab platform.

  • single photon emission computed tomography for cerebral blood flow in School Phobia
    Current Therapeutic Research-clinical and Experimental, 1995
    Co-Authors: Akemi Tomoda, Teruhisa Miike, Takako Honda, Keiko Fukuda, Yumiko Kai, Mitsuko Nabeshima, Mutsumasa Takahashi
    Abstract:

    Abstract To investigate the correlation between abnormalities of regional cerebral blood flow and psychosomatic symptoms in School Phobia, we examined cerebral blood flow in 55 patients with School Phobia using single-photon emission computed tomography (SPECT) with 111 MBq 123 I-iodoamphetamine. The relationship between neuropsychological examination scores and SPECT findings was also examined. None of our patients exhibited evidence of focal structural abnormalities on magnetic resonance imaging. Blood flow, expressed as the corticocerebellar ratio (CCR) in the frontal, temporal, and occipital lobes, was markedly lower in patients with general fatigue, headache, and memory disturbance than in healthy adult subjets studied by another investigator and used as reference values in this study. However, parietal CCRs were higher in children with School Phobia than in adult volunteers. These findings suggest that in patients with School Phobia, the clinical psychosomatic symptoms may be closely related to decrease cerebral blood flow, especially in the frontal lobe. The relationship between symptoms of depression in our patients, measured using the self-rating depression scale score, and CCR was not significant.

Boris Birmaher - One of the best experts on this subject based on the ideXlab platform.

  • psychometric properties of the screen for child anxiety related emotional disorders scared a replication study
    Journal of the American Academy of Child and Adolescent Psychiatry, 1999
    Co-Authors: Boris Birmaher, David A Brent, Laurel Chiappetta, Jeffrey A Bridge, Suneeta Monga, Marianne Baugher
    Abstract:

    ABSTRACT Objective To replicate and extend work on the psychometric properties of the Screen for Child Anxiety Related Emotional Disorders (SCARED), a child and parent self-report instrument used to screen for children with anxiety disorders. Method The 41-item version of the SCARED was administered to a new sample of 190 outpatient children and adolescents and 166 parents. The internal consistency, discriminant, and convergent validity were assessed. In addition, using discriminant function analysis, a briefer version of the SCARED was developed. Results Using item analyses and factor analyses on the 41-item version, 5 factors were obtained: panic/somatic, generalized anxiety, separation anxiety, social Phobia, and School Phobia. In general, the total score and each of the 5 factors for both the child and parent SCARED demonstrated good internal consistency and discriminant validity (both between anxiety and depressive and disruptive disorders and within anxiety disorders). A reduced version of the SCARED yielded 5 items and showed similar psychometrics to the full SCARED. Conclusions In a new sample, the authors replicated their initial psychometric findings that the SCARED is a reliable and valid instrument to screen for childhood anxiety disorders in clinical settings. Furthermore, pending future research, the 5-item SCARED appears to be a promising brief screening inventory for anxiety disorders in epidemiological studies.

  • the screen for child anxiety related emotional disorders scared scale construction and psychometric characteristics
    Journal of the American Academy of Child and Adolescent Psychiatry, 1997
    Co-Authors: Boris Birmaher, Suneeta Khetarpal, David A Brent, Marlane Cully, Lisa Balach, Joan Kaufman, Sandra Mckenzie Neer
    Abstract:

    ABSTRACT Objective To develop a reliable and valid child and parent self- report instrument to screen children with anxiety disorders. Method An 85-item questionnaire was administered to 341 outpatient children and adolescents and 300 parents. Utilizing item analyses and factor analyses, the original scale was reduced to 38 items. A subsample of children ( n = 88) and parents ( n = 86) was retested an average of 5 weeks (4 days to 15 weeks) after the initial screening. Results The child and parent Screen for Child Anxiety Related Emotional Disorders (SCARED) both yielded five factors: somatic/panic, general anxiety, separation anxiety, social Phobia, and School Phobia. For the total score and each of the five factors, both the child and parent SCARED demonstrated good internal consistency (α = .74 to .93), test-retest reliability (intraclass correlation coefficients=.70 to .90), discriminative validity (both between anxiety and other disorders and within anxiety disorders), and moderate parent-child agreement ( r = .20 to .47, p Conclusions The SCARED shows promise as a screening instrument for anxiety disorders. Future studies using the SCARED in community samples are indicated.