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Christopher J. Mcdougle - One of the best experts on this subject based on the ideXlab platform.
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multidisciplinary assessment and treatment of self injurious Behavior in autism spectrum disorder and intellectual disability integration of psychological and biological theory and approach
Journal of Autism and Developmental Disorders, 2015Co-Authors: Noha F Minshawi, Sarah Hurwitz, Danielle Morriss, Christopher J. McdougleAbstract:The objective of this review is to consider the psychological (largely Behavioral) and biological [neurochemical, medical (including genetic), and pharmacological] theories and approaches that contribute to current thinking about the etiology and treatment of Self-Injurious Behavior (SIB) in individuals with autism spectrum disorder and/or intellectual disability. Algorithms for the assessment and treatment of SIB in this context, respectively, from a multidisciplinary, integrative perspective are proposed and challenges and opportunities that exist in clinical and research settings are discussed.
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atypical antipsychotics in the treatment of children and adolescents with pervasive developmental disorders
Psychopharmacology, 2014Co-Authors: Laura C Politte, Christopher J. McdougleAbstract:Rationale Autism and related pervasive developmental disorders (PDD) are characterized by impairments in social interaction and communication, restricted interests, and repetitive and stereotyped patterns of Behavior. Individuals with PDD frequently display irritability and disruptive Behaviors including tantrums, Self-Injurious Behavior, and aggression. Atypical antipsychotics are currently the most efficacious pharmacological interventions available for treatment of irritability associated with PDD.
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examination of aggression and self injury in children with autism spectrum disorders and serious Behavioral problems
Child and Adolescent Psychiatric Clinics of North America, 2014Co-Authors: Devon Carroll, Christopher J. Mcdougle, Victoria Hallett, Michael G Aman, James T Mccracken, Elaine Tierney, Eugene L Arnold, Denis G Sukhodolsky, Luc Lecavalier, Benjamin L HandenAbstract:This study identified subtypes of aggression in a sample of 206 children with autism spectrum disorder (ASD) who participated in 2 risperidone trials. The narratives were derived from a parent interview about each child's 2 most pressing problems. Five subtypes of aggression emerged: hot aggression only, cold aggression only, Self-Injurious Behavior (SIB) only, aggression and SIB, and nonaggressive. All groups showed a high rate of positive response to risperidone with no differences across subtypes. These study findings extend understanding of aggression in ASD and may be useful to guide further study on biological mechanisms and individualized treatment in ASD.
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atypical antipsychotics in children and adolescents with autistic and other pervasive developmental disorders
The Journal of Clinical Psychiatry, 2008Co-Authors: Christopher J. Mcdougle, Craig A. Erickson, Kimberly A. Stigler, David J. PoseyAbstract:Atypical antipsychotics are emerging as the first-line pharmacologic treatment for irritability (i.e., aggression, Self-Injurious Behavior, and severe tantrums) in children and adolescents with autistic and other pervasive developmental disorders. Results from placebo-controlled and open-label studies of clozapine, risperidone, olanzapine, quetiapine, ziprasidone, and aripiprazole in this subject population are reviewed. Additional placebo-controlled trials and studies of longer-term safety and tolerability are needed.
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Pharmacotherapy of Irritability in Pervasive Developmental Disorders
Child and adolescent psychiatric clinics of North America, 2008Co-Authors: Kimberly A. Stigler, Christopher J. McdougleAbstract:Children and adolescents diagnosed with autism and related pervasive developmental disorders (PDDs) often sustain irritability, including aggression, Self-Injurious Behavior, and tantrums. Research to date supports the use of the atypical antipsychotics as a first-line pharmacologic treatment for this target symptom domain in PDDs. Currently, the atypical antipsychotic risperidone is the only medication approved by the US Food and Drug Administration for irritability in youth with autism. Additional large-scale, placebo-controlled studies of other medications are needed to determine their efficacy for the treatment of irritability in this diagnostic group.
Melinda A Novak - One of the best experts on this subject based on the ideXlab platform.
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rhesus macaques macaca mulatta with self injurious Behavior show less Behavioral anxiety during the human intruder test
American Journal of Primatology, 2017Co-Authors: Emily Peterson, Julie M Worlein, Grace H Lee, Amanda M Dettmer, Elana K Varner, Melinda A NovakAbstract:Self-Injurious Behavior (SIB) has been linked to anxiety in the human literature, but relatively few studies have explored this link in rhesus macaques. A widely used Behavioral assessment of anxiety, the human intruder test (HIT), employs the mildly stressful stimulus of an unfamiliar experimenter to assess anxious Behavior in macaques. The HIT was conducted on 59 (20 male) laboratory housed rhesus macaques, 30 with a record of SIB (10 male). If monkeys with SIB have a more anxious phenotype, they should show stronger reactions to the HIT. However, contrary to our predictions, monkeys with SIB did not show higher levels of anxious Behavior compared to controls. They spent significantly less time showing anxious Behavior and displayed little aggression in response to the stare of the intruder. SIB and control monkeys did not differ in a range score (number of unique Behaviors expressed per phase); however, SIB monkeys had a lower change score (total number of Behaviors expressed including repetitions) than controls. In general, monkeys that paced regardless of SIB status, showed a reduction in pacing when the intruder entered the room. Possible explanations for the failure of SIB monkeys to show increased anxiety in the HIT include greater exposure of SIB monkeys to unfamiliar humans because of their condition, evidence for a subtype of SIB which is not anxiety related, and/or the presence of comorbid depressive-like symptoms. Am. J. Primatol. 79:e22569, 2017. © 2016 Wiley Periodicals, Inc.
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tph2 5 and 3 regulatory polymorphisms are differentially associated with hpa axis function and self injurious Behavior in rhesus monkeys
Genes Brain and Behavior, 2010Co-Authors: Guolin Chen, Brian J Kelly, Melinda A Novak, Jerrold S Meyer, Eric J Vallender, Gregory M MillerAbstract:Tryptophan hydroxylase-2 (TPH2) synthesizes neuronal serotonin and is linked to numerous Behavioral traits. We have previously characterized the functionality of polymorphisms (especially 2051A>C) in 3’-untranslated region (3’-UTR) of rhesus monkey TPH2 (rhTPH2). This study further assessed the functionality of additional polymorphisms (–1605T>C, –1491Tn, –1485(AT)n, –1454A>G, –1325In>Del and –363T>G) in rhTPH2 5’-flanking region (5’-FR), and evaluated the effects of rhTPH2 5’ and 3’ genotypes on central serotonin turnover, hypothalamic–pituitary–adrenal (HPA) axis function and Self-Injurious Behavior (SIB) in 32 unrelated adult male monkeys of Indian origin. Haplotypes of the rhTPH2 5’-FR polymorphisms exert a significant, cell-dependent effect on reporter gene expression, primarily conferred by –1485(AT)n. The –1485(AT)n and 2051A>C polymorphisms interact to influence cerebrospinal fluid (CSF) 5-HIAA and plasma adrenocorticotropic hormone (ACTH) in the afternoon. While –1485(AT)n exerts significant main effects on the afternoon cortisol level and nocturnal HPA negative feedback, 2051A>C has significant main effects on the morning cortisol level and cortisol response to ACTH challenge, as well as marginally significant main effects on the daytime HPA negative feedback and self-biting rate. In addition, the genotype/allele frequency of the 5’-FR –1325Ins>Del differed significantly between the self-wounders and non-wounders, whereas 3’-UTR 2128S>L polymorphism differed significantly in genotype/allele frequency between the high- and low-frequency biters. This study shows the functionality of rhTPH2 5’-FR polymorphisms, and provides evidence for the differential association of rhTPH2 5’-FR and 3’-UTR polymorphisms with HPA axis function and SIB. Our findings shed light on the role of TPH2 gene variance in physiology and Behavioral traits, and also contribute to the understanding of the pathophysiology and genetics of SIB
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the anxiogenic drug fg7142 increases self injurious Behavior in male rhesus monkeys macaca mulatta
Life Sciences, 2009Co-Authors: Christine A Major, Brian J Kelly, Melinda A Novak, Matthew D Davenport, Karen M Stonemetz, Jerrold S MeyerAbstract:Aims Self-Injurious Behavior (SIB), which is deliberate infliction of self-injury without suicidal intent, is a significant human health problem. SIB is not unique to humans but is also manifested in a small percentage of captive macaques, typically as self-directed biting. Although the onset and maintenance of SIB have been linked to increased anxiety in both humans and nonhuman primates, no previous studies have directly tested the anxiety-SIB hypothesis. Here, we determined whether rhesus monkeys increase their self-directed biting following a challenge with the anxiogenic compound N-methyl-β-carboline-3-carboxamide (FG7142).
Richard E. Tessel - One of the best experts on this subject based on the ideXlab platform.
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cross sensitization between footshock stress and apomorphine on self injurious Behavior and neostriatal catecholamines in a rat model of lesch nyhan syndrome
Brain Research, 1998Co-Authors: Christopher J Stodgell, Pippa S Loupe, Stephen R Schroeder, Richard E. TesselAbstract:Abstract The effects of footshock sensitization (priming), apomorphine (APO) priming and their combination on Behavior and neostriatal and cortical catecholamines were examined in adult rats which had neonatally received bilateral intracerebroventricular injections with 6-hydroxydopamine (6-OHDA; a model of Lesch–Nyhan syndrome (LNS)) or vehicle (unlesioned rats). Lesioned (6-OHDA-treated) rats displayed self-biting (SB; 7/20 rats) and Self-Injurious Behavior (SIB; 1/20 rats) during APO priming, but not during footshock priming. During subsequent acute cumulative APO dosing, 20–30% of lesioned rats primed with APO alone or footshock alone displayed SB and SIB. However, SB and SIB incidence in APO+footshock-primed lesioned rats was nearly tripled. Dopamine (DA) synthesis, metabolism and extracellular concentrations (disposition) in unlesioned rats and in cortices of lesioned animals were unaffected by priming. In lesioned rats primed with APO alone or footshock alone, only neostriatal 3-methoxytyramine (3-MT) was significantly increased. However, neostriatal DA and metabolite concentrations (and norepinephrine (NE)) were all significantly elevated in lesioned rats primed with both APO and footshock. These results confirm that neonatal 6-OHDA-induced neostriatal catecholamine depletion can be antagonized by experiential change, suggest that Behavioral and neurochemical cross-sensitization between APO and footshock in such rats is unidirectional and support the view that stress can exacerbate the incidence of SIB in LNS.
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cross sensitization between footshock stress and apomorphine on self injurious Behavior and neostriatal catecholamines in a rat model of lesch nyhan syndrome
Brain Research, 1998Co-Authors: Christopher J Stodgell, Pippa S Loupe, Stephen R Schroeder, Richard E. TesselAbstract:Abstract The effects of footshock sensitization (priming), apomorphine (APO) priming and their combination on Behavior and neostriatal and cortical catecholamines were examined in adult rats which had neonatally received bilateral intracerebroventricular injections with 6-hydroxydopamine (6-OHDA; a model of Lesch–Nyhan syndrome (LNS)) or vehicle (unlesioned rats). Lesioned (6-OHDA-treated) rats displayed self-biting (SB; 7/20 rats) and Self-Injurious Behavior (SIB; 1/20 rats) during APO priming, but not during footshock priming. During subsequent acute cumulative APO dosing, 20–30% of lesioned rats primed with APO alone or footshock alone displayed SB and SIB. However, SB and SIB incidence in APO+footshock-primed lesioned rats was nearly tripled. Dopamine (DA) synthesis, metabolism and extracellular concentrations (disposition) in unlesioned rats and in cortices of lesioned animals were unaffected by priming. In lesioned rats primed with APO alone or footshock alone, only neostriatal 3-methoxytyramine (3-MT) was significantly increased. However, neostriatal DA and metabolite concentrations (and norepinephrine (NE)) were all significantly elevated in lesioned rats primed with both APO and footshock. These results confirm that neonatal 6-OHDA-induced neostriatal catecholamine depletion can be antagonized by experiential change, suggest that Behavioral and neurochemical cross-sensitization between APO and footshock in such rats is unidirectional and support the view that stress can exacerbate the incidence of SIB in LNS.
Christopher J Stodgell - One of the best experts on this subject based on the ideXlab platform.
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cross sensitization between footshock stress and apomorphine on self injurious Behavior and neostriatal catecholamines in a rat model of lesch nyhan syndrome
Brain Research, 1998Co-Authors: Christopher J Stodgell, Pippa S Loupe, Stephen R Schroeder, Richard E. TesselAbstract:Abstract The effects of footshock sensitization (priming), apomorphine (APO) priming and their combination on Behavior and neostriatal and cortical catecholamines were examined in adult rats which had neonatally received bilateral intracerebroventricular injections with 6-hydroxydopamine (6-OHDA; a model of Lesch–Nyhan syndrome (LNS)) or vehicle (unlesioned rats). Lesioned (6-OHDA-treated) rats displayed self-biting (SB; 7/20 rats) and Self-Injurious Behavior (SIB; 1/20 rats) during APO priming, but not during footshock priming. During subsequent acute cumulative APO dosing, 20–30% of lesioned rats primed with APO alone or footshock alone displayed SB and SIB. However, SB and SIB incidence in APO+footshock-primed lesioned rats was nearly tripled. Dopamine (DA) synthesis, metabolism and extracellular concentrations (disposition) in unlesioned rats and in cortices of lesioned animals were unaffected by priming. In lesioned rats primed with APO alone or footshock alone, only neostriatal 3-methoxytyramine (3-MT) was significantly increased. However, neostriatal DA and metabolite concentrations (and norepinephrine (NE)) were all significantly elevated in lesioned rats primed with both APO and footshock. These results confirm that neonatal 6-OHDA-induced neostriatal catecholamine depletion can be antagonized by experiential change, suggest that Behavioral and neurochemical cross-sensitization between APO and footshock in such rats is unidirectional and support the view that stress can exacerbate the incidence of SIB in LNS.
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cross sensitization between footshock stress and apomorphine on self injurious Behavior and neostriatal catecholamines in a rat model of lesch nyhan syndrome
Brain Research, 1998Co-Authors: Christopher J Stodgell, Pippa S Loupe, Stephen R Schroeder, Richard E. TesselAbstract:Abstract The effects of footshock sensitization (priming), apomorphine (APO) priming and their combination on Behavior and neostriatal and cortical catecholamines were examined in adult rats which had neonatally received bilateral intracerebroventricular injections with 6-hydroxydopamine (6-OHDA; a model of Lesch–Nyhan syndrome (LNS)) or vehicle (unlesioned rats). Lesioned (6-OHDA-treated) rats displayed self-biting (SB; 7/20 rats) and Self-Injurious Behavior (SIB; 1/20 rats) during APO priming, but not during footshock priming. During subsequent acute cumulative APO dosing, 20–30% of lesioned rats primed with APO alone or footshock alone displayed SB and SIB. However, SB and SIB incidence in APO+footshock-primed lesioned rats was nearly tripled. Dopamine (DA) synthesis, metabolism and extracellular concentrations (disposition) in unlesioned rats and in cortices of lesioned animals were unaffected by priming. In lesioned rats primed with APO alone or footshock alone, only neostriatal 3-methoxytyramine (3-MT) was significantly increased. However, neostriatal DA and metabolite concentrations (and norepinephrine (NE)) were all significantly elevated in lesioned rats primed with both APO and footshock. These results confirm that neonatal 6-OHDA-induced neostriatal catecholamine depletion can be antagonized by experiential change, suggest that Behavioral and neurochemical cross-sensitization between APO and footshock in such rats is unidirectional and support the view that stress can exacerbate the incidence of SIB in LNS.
Chris Oliver - One of the best experts on this subject based on the ideXlab platform.
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effects of social context on social interaction and self injurious Behavior in cornelia de lange syndrome
American Journal on Mental Retardation, 2006Co-Authors: Kate Arron, Scott S Hall, Chris Oliver, Jenny Sloneem, Debbie Forman, Karen McclintockAbstract:Abstract Cornelia de Lange syndrome is reported to be associated with Self-Injurious Behavior (SIB) and social avoidance. We used analog methodology to examine the effect of manipulating adult social contact on social communicative Behaviors and SIB in 16 children with this syndrome. For 9 participants engagement Behavior was related to levels of adult attention, and SIB showed significant variability across conditions for 3 participants. These findings indicate that SIB can be affected by environmental factors, even though it is thought to be part of the Behavioral phenotype of Cornelia de Lange syndrome and suggest that individuals with this syndrome show socially motivated attention-soliciting Behaviors. The implications for gene–environment interactions are discussed.
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self injurious Behavior self restraint and compulsive Behaviors in cornelia de lange syndrome
American Journal on Mental Retardation, 2002Co-Authors: P Hyman, Chris Oliver, Scott S HallAbstract:Abstract Researchers have argued that individuals who show self-restraint are more likely to show Self-Injurious Behavior (SIB) that is compulsive. Self-Injurious Behavior, self-restraint, and compulsive Behaviors have been described as features of Cornelia de Lange syndrome. We examined whether individuals with this syndrome displaying SIB and self-restraint exhibit more compulsive Behaviors than do those without SIB and self-restraint. Main caregivers of individuals with the syndrome completed questionnaires. A significant association was found between SIB and self-restraint, and those displaying both Behaviors displayed significantly more compulsions than did those not exhibiting them. Findings extend the compulsive Behavior theory and highlight areas for further research.
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self injurious Behavior in rett syndrome interactions between features of rett syndrome and operant conditioning
Journal of Autism and Developmental Disorders, 1993Co-Authors: Chris Oliver, Glynis H Murphy, Lissa Crayton, John CorbettAbstract:Operant and biological theories of the cause of Self-Injurious Behavior (SIB) in people with a mental handicap are often viewed as mutually exclusive. In this single case study, interactions between features of Rett syndrome and operant conditioning as determinants of SIB are examined. Functional analysis by analog methodology indicated different functions for two forms of SIB shown by the subject: automatic reinforcement by sensory stimulation and escape from social interactions. It is suggested that features of Rett syndrome established conditions under which operant conditioning of Self-Injurious responding was maximized. The implications of this interaction between features of syndromes and operant conditioning for the conceptualization of the cause of SIB are discussed and it is proposed that the notion of a unitary cause of SIB is inappropriate. It is more productive to consider operant conditioning as the process that maintains responding against a background of predisposing and mediating factors which may be biologically determined.