The Experts below are selected from a list of 99 Experts worldwide ranked by ideXlab platform
Shitij Kapur - One of the best experts on this subject based on the ideXlab platform.
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is desire for social relationships mediated by the serotonergic system in the prefrontal cortex an 18f Setoperone pet study
Social Neuroscience, 2010Co-Authors: Philip Gerretsen, Sylvain Houle, Shitij Kapur, Ariel Graffguerrero, Mahesh Menon, Bruce G Pollock, Neil Vasdev, David C MamoAbstract:Social behavior and desire for social relationships have been independently linked to the serotonergic system, the prefrontal cortex, especially the orbitofrontal cortex (OFC), and the anterior cingulate cortex (ACC). The goal of this study was to explore the role of serotonin 5HT2A receptors in these brain regions in forming and maintaining close interpersonal relationships. Twenty-four healthy subjects completed the Temperament and Character Inventory (TCI) prior to undergoing [18F]Setoperone brain positron emission tomography (PET) to measure serotonin 5HT2A receptor availability within the OFC (BA 11 and 47) and ACC (BA 32). We explored the relationship between desire for social relationships, as measured by the TCI reward dependence (RD) scale, and 5HT2A receptor non-displaceable binding potential (BPnd) in these regions. Scores of RD were negatively correlated with 5HT2A BPnd in the ACC (BA 32, r = –.528, p = .012) and OFC (BA 11, r = –.489, p = .021; BA 47, r = –.501, p = .017). These correlations ...
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differential effects of aripiprazole on d 2 5 ht 2 and 5 ht 1a receptor occupancy in patients with schizophrenia a triple tracer pet study
American Journal of Psychiatry, 2007Co-Authors: David C Mamo, Chekkera Shammi, Ariel Graff, Romina Mizrahi, Francoise Romeyer, Shitij KapurAbstract:Objective: Aripiprazole has a unique pharmacological profile that includes partial agonism at D 2 receptors, antagonism at 5-HT 2 receptors, and partial agonism at 5-HT 1A receptors. The authors conducted a positron emission tomography (PET) study to characterize the simultaneous effects of aripiprazole at the D 2 , 5-HT 2 , and 5-HT 1A receptors in patients with schizophrenia or schizoaffective disorder. Method: Twelve patients who had previously received antipsychotic treatment were randomly assigned to receive 10 mg, 15 mg, 20 mg, or 30 mg of aripiprazole. After at least 14 days of treatment, participants underwent high-resolution PET scans using [ 11 C]raclopride, [ 18 F]Setoperone, and [ 11 C]WAY100635. Results: Very high occupancy was observed at striatal D 2 receptors (average putamen, 87%; caudate, 93%; and ventral striatum, 91%), lower occupancy at 5-HT 2 receptors (54%–60%), and even lower occupancy at 5-HT 1A receptors (16%). D 2 occupancy levels were significantly correlated with plasma drug c...
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a pet study of dopamine d2 and serotonin 5 ht2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone
American Journal of Psychiatry, 2004Co-Authors: David C Mamo, Shitij Kapur, Chekkera Shammi, George Papatheodorou, Steve Mann, Francois Therrien, Gary RemingtonAbstract:OBJECTIVE: Ziprasidone is an atypical antipsychotic drug that shows a higher affinity for serotonin 5-HT2 receptors compared with dopamine D2 receptors in vitro. The affinity of ziprasidone for these receptors in vivo in patients was examined in a positron emission tomography (PET) study. METHOD: The authors conducted a PET study to evaluate D2 occupancy (using [11C]raclopride) and 5-HT2 occupancy (using [18F]Setoperone) in brain regions of interest in 16 patients with schizophrenia or schizoaffective disorder randomly assigned to receive 40, 80, 120, or 160 mg/day of ziprasidone, which reflected the recommended dose range. PET scanning was done after 3 weeks of administration and at trough plasma levels, i.e., 12–16 hours after the last dose. RESULTS: The mean 5-HT2 receptor occupancy was significantly higher than the mean D2 receptor occupancy (mean=76%, SD=15%, and mean=56%, SD=18%, respectively). The estimated plasma ziprasidone concentration associated with 50% maximal 5-HT2 receptor occupancy was al...
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a pet study of dopamine d2 and serotonin 5 ht2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone
American Journal of Psychiatry, 2004Co-Authors: David C Mamo, Shitij Kapur, Chekkera Shammi, George Papatheodorou, Steve Mann, Francois Therrien, Gary RemingtonAbstract:OBJECTIVE: Ziprasidone is an atypical antipsychotic drug that shows a higher affinity for serotonin 5-HT2 receptors compared with dopamine D2 receptors in vitro. The affinity of ziprasidone for these receptors in vivo in patients was examined in a positron emission tomography (PET) study. METHOD: The authors conducted a PET study to evaluate D2 occupancy (using [11C]raclopride) and 5-HT2 occupancy (using [18F]Setoperone) in brain regions of interest in 16 patients with schizophrenia or schizoaffective disorder randomly assigned to receive 40, 80, 120, or 160 mg/day of ziprasidone, which reflected the recommended dose range. PET scanning was done after 3 weeks of administration and at trough plasma levels, i.e., 12–16 hours after the last dose. RESULTS: The mean 5-HT2 receptor occupancy was significantly higher than the mean D2 receptor occupancy (mean=76%, SD=15%, and mean=56%, SD=18%, respectively). The estimated plasma ziprasidone concentration associated with 50% maximal 5-HT2 receptor occupancy was al...
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the effect of paroxetine on 5 ht 2a receptors in depression an 18 f Setoperone pet imaging study
American Journal of Psychiatry, 2001Co-Authors: Jeffrey H. Meyer, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, Beata S Eisfeld, Shahryar Rafitari, Helen S Mayberg, Sidney H. KennedyAbstract:OBJECTIVE: In the cortex of animals, serotonin (5-HT) levels increase after several weeks of treatment with selective serotonin reuptake inhibitors (SSRIs). Studies using an intrasubject design to examine the effects of SSRI treatment on 5-HT2A receptors in the cortex of drug-free depressed patients are needed. In theory, agonist stimulation of 5-HT2A receptors could be relevant to SSRI treatment by promoting neuronal growth and survival as well as direct elevation of mood. The objective of this study was to evaluate the effect of 6 weeks of paroxetine treatment on 5-HT2A receptors in depressed patients. METHOD: After a medication-free period of at least 3 months, 19 depressed patients were treated for 6 weeks with paroxetine, 20 mg/day. The authors used [18F]Setoperone and positron emission tomography to assess 5-HT2A receptor binding potential in the patients before and after treatment and in 19 age-matched healthy subjects. RESULTS: 5-HT2A binding potential declined with age in all cortical regions in ...
Sylvain Houle - One of the best experts on this subject based on the ideXlab platform.
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is desire for social relationships mediated by the serotonergic system in the prefrontal cortex an 18f Setoperone pet study
Social Neuroscience, 2010Co-Authors: Philip Gerretsen, Sylvain Houle, Shitij Kapur, Ariel Graffguerrero, Mahesh Menon, Bruce G Pollock, Neil Vasdev, David C MamoAbstract:Social behavior and desire for social relationships have been independently linked to the serotonergic system, the prefrontal cortex, especially the orbitofrontal cortex (OFC), and the anterior cingulate cortex (ACC). The goal of this study was to explore the role of serotonin 5HT2A receptors in these brain regions in forming and maintaining close interpersonal relationships. Twenty-four healthy subjects completed the Temperament and Character Inventory (TCI) prior to undergoing [18F]Setoperone brain positron emission tomography (PET) to measure serotonin 5HT2A receptor availability within the OFC (BA 11 and 47) and ACC (BA 32). We explored the relationship between desire for social relationships, as measured by the TCI reward dependence (RD) scale, and 5HT2A receptor non-displaceable binding potential (BPnd) in these regions. Scores of RD were negatively correlated with 5HT2A BPnd in the ACC (BA 32, r = –.528, p = .012) and OFC (BA 11, r = –.489, p = .021; BA 47, r = –.501, p = .017). These correlations ...
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the effect of paroxetine on 5 ht 2a receptors in depression an 18 f Setoperone pet imaging study
American Journal of Psychiatry, 2001Co-Authors: Jeffrey H. Meyer, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, Beata S Eisfeld, Shahryar Rafitari, Helen S Mayberg, Sidney H. KennedyAbstract:OBJECTIVE: In the cortex of animals, serotonin (5-HT) levels increase after several weeks of treatment with selective serotonin reuptake inhibitors (SSRIs). Studies using an intrasubject design to examine the effects of SSRI treatment on 5-HT2A receptors in the cortex of drug-free depressed patients are needed. In theory, agonist stimulation of 5-HT2A receptors could be relevant to SSRI treatment by promoting neuronal growth and survival as well as direct elevation of mood. The objective of this study was to evaluate the effect of 6 weeks of paroxetine treatment on 5-HT2A receptors in depressed patients. METHOD: After a medication-free period of at least 3 months, 19 depressed patients were treated for 6 weeks with paroxetine, 20 mg/day. The authors used [18F]Setoperone and positron emission tomography to assess 5-HT2A receptor binding potential in the patients before and after treatment and in 19 age-matched healthy subjects. RESULTS: 5-HT2A binding potential declined with age in all cortical regions in ...
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Prefrontal Cortex 5-HT2 Receptors in Depression: An [18F]Setoperone PET Imaging Study
American Journal of Psychiatry, 1999Co-Authors: Jeffrey H. Meyer, Beata Owczarek, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, Sidney H. KennedyAbstract:OBJECTIVE: Widespread disturbances of serotonin (5-HT) are implicated in the pathophysiology of depression. Of 5-HT receptor abnormalities reported, the most replicated finding is increased 5-HT2 receptor binding in the postmortem prefrontal cortex of depressed suicide victims. The extent to which these findings exist in depressed persons without recent suicide attempts is uncertain. The objective of this study was to evaluate 5-HT2 receptors in depressed patients who were medication-free and who had not made recent suicide attempts. METHOD: With the use of [18F]Setoperone and positron emission tomography (PET), 5-HT2 receptor binding potential was assessed in 14 depressed and 19 healthy subjects. Exclusion criteria for depressed patients included use of antidepressant medication within the past 6 months, a history of suicide attempts within the past 5 years, other current axis I disorders including bipolar disorder, and the presence of psychotic symptoms. The 5-HT2 (Setoperone) binding potential in the t...
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serotonin 5 ht2 receptors in schizophrenia a pet study using 18f Setoperone in neuroleptic naive patients and normal subjects
American Journal of Psychiatry, 1999Co-Authors: Ralph Lewis, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, C Jones, Robert B ZipurskyAbstract:OBJECTIVE: Several postmortem studies have reported a decreased density of serotonin 5-HT2 receptors in the prefrontal cortex in schizophrenia. The purpose of this study was to investigate this in patients with schizophrenia by means of [18F]Setoperone and positron emission tomography (PET) imaging. METHOD: Thirteen neuroleptic-free patients with schizophrenia, 10 of whom were also neuroleptic-naive, were compared with a group of 26 normal subjects in the same age range. The density of 5-HT2 receptors was assessed with the use of [18F]Setoperone and PET in standardized cortical regions of interest. RESULTS: Increasing age was associated with similar declines in 5-HT2 receptors in all cortical regions in the patient group and in the normal comparison group. After control for the effect of age, there was no statistically significant difference between the patients and the comparison subjects in 5-HT2 receptor density in any of the cortical regions. CONCLUSIONS: This study failed to find the decrease in 5-HT...
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prefrontal cortex 5 ht 2 receptors in depression an 18 f Setoperone pet imaging study
1999Co-Authors: Jeffrey H. Meyer, Beata Owczarek, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, Sidney H. KennedyAbstract:Objective: Widespread disturbances of serotonin (5-HT) are implicated in the pathophysiology of depression. Of 5-HT receptor abnormalities reported, the most replicated finding is increased 5-HT2 receptor binding in the postmortem prefrontal cortex of depressed suicide victims. The extent to which these findings exist in depressed persons without recent suicide attempts is uncertain. The objective of this study was to evaluate 5HT2 receptors in depressed patients who were medication-free and who had not made recent suicide attempts. Method: With the use of [ 18 F]Setoperone and positron emission tomography (PET), 5-HT2 receptor binding potential was assessed in 14 depressed and 19 healthy subjects. Exclusion criteria for depressed patients included use of antidepressant medication within the past 6 months, a history of suicide attempts within the past 5 years, other current axis I disorders including bipolar disorder, and the presence of psychotic symptoms. The 5-HT2 (Setoperone) binding potential in the two groups of subjects was compared by analysis of covariance with age as the covariate. Results: Age had a significant effect on 5-HT2 binding potential, but depression did not. The interaction of age and depression was not significant. Conclusions: The 5-HT2 binding potential is not increased in untreated depressed subjects who have not made recent suicide attempts. This negative finding does not rule out the possibility that there is a role for 5-HT2 receptors in treatment or that 5-HT2 receptors are increased in highly suicidal states.
David C Mamo - One of the best experts on this subject based on the ideXlab platform.
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is desire for social relationships mediated by the serotonergic system in the prefrontal cortex an 18f Setoperone pet study
Social Neuroscience, 2010Co-Authors: Philip Gerretsen, Sylvain Houle, Shitij Kapur, Ariel Graffguerrero, Mahesh Menon, Bruce G Pollock, Neil Vasdev, David C MamoAbstract:Social behavior and desire for social relationships have been independently linked to the serotonergic system, the prefrontal cortex, especially the orbitofrontal cortex (OFC), and the anterior cingulate cortex (ACC). The goal of this study was to explore the role of serotonin 5HT2A receptors in these brain regions in forming and maintaining close interpersonal relationships. Twenty-four healthy subjects completed the Temperament and Character Inventory (TCI) prior to undergoing [18F]Setoperone brain positron emission tomography (PET) to measure serotonin 5HT2A receptor availability within the OFC (BA 11 and 47) and ACC (BA 32). We explored the relationship between desire for social relationships, as measured by the TCI reward dependence (RD) scale, and 5HT2A receptor non-displaceable binding potential (BPnd) in these regions. Scores of RD were negatively correlated with 5HT2A BPnd in the ACC (BA 32, r = –.528, p = .012) and OFC (BA 11, r = –.489, p = .021; BA 47, r = –.501, p = .017). These correlations ...
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differential effects of aripiprazole on d 2 5 ht 2 and 5 ht 1a receptor occupancy in patients with schizophrenia a triple tracer pet study
American Journal of Psychiatry, 2007Co-Authors: David C Mamo, Chekkera Shammi, Ariel Graff, Romina Mizrahi, Francoise Romeyer, Shitij KapurAbstract:Objective: Aripiprazole has a unique pharmacological profile that includes partial agonism at D 2 receptors, antagonism at 5-HT 2 receptors, and partial agonism at 5-HT 1A receptors. The authors conducted a positron emission tomography (PET) study to characterize the simultaneous effects of aripiprazole at the D 2 , 5-HT 2 , and 5-HT 1A receptors in patients with schizophrenia or schizoaffective disorder. Method: Twelve patients who had previously received antipsychotic treatment were randomly assigned to receive 10 mg, 15 mg, 20 mg, or 30 mg of aripiprazole. After at least 14 days of treatment, participants underwent high-resolution PET scans using [ 11 C]raclopride, [ 18 F]Setoperone, and [ 11 C]WAY100635. Results: Very high occupancy was observed at striatal D 2 receptors (average putamen, 87%; caudate, 93%; and ventral striatum, 91%), lower occupancy at 5-HT 2 receptors (54%–60%), and even lower occupancy at 5-HT 1A receptors (16%). D 2 occupancy levels were significantly correlated with plasma drug c...
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a pet study of dopamine d2 and serotonin 5 ht2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone
American Journal of Psychiatry, 2004Co-Authors: David C Mamo, Shitij Kapur, Chekkera Shammi, George Papatheodorou, Steve Mann, Francois Therrien, Gary RemingtonAbstract:OBJECTIVE: Ziprasidone is an atypical antipsychotic drug that shows a higher affinity for serotonin 5-HT2 receptors compared with dopamine D2 receptors in vitro. The affinity of ziprasidone for these receptors in vivo in patients was examined in a positron emission tomography (PET) study. METHOD: The authors conducted a PET study to evaluate D2 occupancy (using [11C]raclopride) and 5-HT2 occupancy (using [18F]Setoperone) in brain regions of interest in 16 patients with schizophrenia or schizoaffective disorder randomly assigned to receive 40, 80, 120, or 160 mg/day of ziprasidone, which reflected the recommended dose range. PET scanning was done after 3 weeks of administration and at trough plasma levels, i.e., 12–16 hours after the last dose. RESULTS: The mean 5-HT2 receptor occupancy was significantly higher than the mean D2 receptor occupancy (mean=76%, SD=15%, and mean=56%, SD=18%, respectively). The estimated plasma ziprasidone concentration associated with 50% maximal 5-HT2 receptor occupancy was al...
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a pet study of dopamine d2 and serotonin 5 ht2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone
American Journal of Psychiatry, 2004Co-Authors: David C Mamo, Shitij Kapur, Chekkera Shammi, George Papatheodorou, Steve Mann, Francois Therrien, Gary RemingtonAbstract:OBJECTIVE: Ziprasidone is an atypical antipsychotic drug that shows a higher affinity for serotonin 5-HT2 receptors compared with dopamine D2 receptors in vitro. The affinity of ziprasidone for these receptors in vivo in patients was examined in a positron emission tomography (PET) study. METHOD: The authors conducted a PET study to evaluate D2 occupancy (using [11C]raclopride) and 5-HT2 occupancy (using [18F]Setoperone) in brain regions of interest in 16 patients with schizophrenia or schizoaffective disorder randomly assigned to receive 40, 80, 120, or 160 mg/day of ziprasidone, which reflected the recommended dose range. PET scanning was done after 3 weeks of administration and at trough plasma levels, i.e., 12–16 hours after the last dose. RESULTS: The mean 5-HT2 receptor occupancy was significantly higher than the mean D2 receptor occupancy (mean=76%, SD=15%, and mean=56%, SD=18%, respectively). The estimated plasma ziprasidone concentration associated with 50% maximal 5-HT2 receptor occupancy was al...
Jeffrey H. Meyer - One of the best experts on this subject based on the ideXlab platform.
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the effect of paroxetine on 5 ht 2a receptors in depression an 18 f Setoperone pet imaging study
American Journal of Psychiatry, 2001Co-Authors: Jeffrey H. Meyer, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, Beata S Eisfeld, Shahryar Rafitari, Helen S Mayberg, Sidney H. KennedyAbstract:OBJECTIVE: In the cortex of animals, serotonin (5-HT) levels increase after several weeks of treatment with selective serotonin reuptake inhibitors (SSRIs). Studies using an intrasubject design to examine the effects of SSRI treatment on 5-HT2A receptors in the cortex of drug-free depressed patients are needed. In theory, agonist stimulation of 5-HT2A receptors could be relevant to SSRI treatment by promoting neuronal growth and survival as well as direct elevation of mood. The objective of this study was to evaluate the effect of 6 weeks of paroxetine treatment on 5-HT2A receptors in depressed patients. METHOD: After a medication-free period of at least 3 months, 19 depressed patients were treated for 6 weeks with paroxetine, 20 mg/day. The authors used [18F]Setoperone and positron emission tomography to assess 5-HT2A receptor binding potential in the patients before and after treatment and in 19 age-matched healthy subjects. RESULTS: 5-HT2A binding potential declined with age in all cortical regions in ...
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a voxel by voxel analysis of 18f Setoperone pet data shows no substantial serotonin 5 ht2a receptor changes in schizophrenia
Psychiatry Research-neuroimaging, 2000Co-Authors: Nicholaas Paul L G Verhoeff, Jeffrey H. Meyer, Robert B Zipursky, Ralph Lewis, A Kecojevic, Douglas Hussey, J Tauscher, Shitij KapurAbstract:Several postmortem studies have reported regionally localized decreases in serotonin(2A) receptors (5-HT(2A)R) in schizophrenia. This was not confirmed by two recent [18F]Setoperone positron emission tomography (PET) studies. In these two studies relatively large regions of interest (ROIs) were used; hence, 5-HT(2A)R changes may have been missed in some brain areas. Therefore, data from one study were analyzed on a voxel-by-voxel basis using Statistical Parametric Mapping (SPM). We also used this method to examine the relationship between 5-HT(2A)R binding potential (BP) and five PANSS-derived factors: negative, positive, activation, dysphoric and autistic preoccupation. Thirteen schizophrenic patients (10 antipsychotic-naive, 3 antipsychotic-free; 11 M, 2 F; age 31+/-7 years) and 35 age-matched control subjects (15 M, 20 F; age 30+/-7 years) were scanned. The 5-HT(2A)R BP was determined for each voxel using the pseudoequilibrium ratio method on PET data obtained between 65 and 90 min after [18F]Setoperone bolus injection. The resulting parametric 5-HT(2A)R BP images were spatially normalized using a ligand specific template. Analyses of covariance were done using SPM99 with age as covariate. In tests for the effect of schizophrenia and for partial correlations between 5-HT(2A)R BP and the five factors, corrected P values <0.05 at cluster or voxel level were considered significant. No significant differences were detected between patients and control subjects, and no significant correlations were observed between 5-HT(2A)R BP and any of the five factors. Thus, in agreement with the previous ROI studies, voxel-by-voxel analysis confirmed the lack of substantial 5-HT(2A)R BP differences between schizophrenic patients and control subjects.
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Prefrontal Cortex 5-HT2 Receptors in Depression: An [18F]Setoperone PET Imaging Study
American Journal of Psychiatry, 1999Co-Authors: Jeffrey H. Meyer, Beata Owczarek, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, Sidney H. KennedyAbstract:OBJECTIVE: Widespread disturbances of serotonin (5-HT) are implicated in the pathophysiology of depression. Of 5-HT receptor abnormalities reported, the most replicated finding is increased 5-HT2 receptor binding in the postmortem prefrontal cortex of depressed suicide victims. The extent to which these findings exist in depressed persons without recent suicide attempts is uncertain. The objective of this study was to evaluate 5-HT2 receptors in depressed patients who were medication-free and who had not made recent suicide attempts. METHOD: With the use of [18F]Setoperone and positron emission tomography (PET), 5-HT2 receptor binding potential was assessed in 14 depressed and 19 healthy subjects. Exclusion criteria for depressed patients included use of antidepressant medication within the past 6 months, a history of suicide attempts within the past 5 years, other current axis I disorders including bipolar disorder, and the presence of psychotic symptoms. The 5-HT2 (Setoperone) binding potential in the t...
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the effects of single dose nefazodone and paroxetine upon 5 ht2a binding potential in humans using 18f Setoperone pet
Psychopharmacology, 1999Co-Authors: Jeffrey H. Meyer, Sidney H. Kennedy, Raymond Y Cho, Shitij KapurAbstract:Rationale: Alterations in 5-HT2A receptor binding are implicated in suicidality and depression. 5-HT2A receptors may also be involved in the therapeutic effects of antidepressants. Objectives: The purpose of this study was to assess the effect of paroxetine and nefazodone on 5-HT2A receptors after a single dose. Methods: Seven subjects received a single dose of nefazodone 200 mg and five subjects received a single dose of paroxetine 20 mg. Before and after the dose, 5-HT2A binding potentials (Bmax/Kd) were determined in each subject using [18F]-Setoperone PET. Results: Nefazodone induced a significant change in 5-HT2A binding potential (−39 ± 17%, P = 0.003) while paroxetine showed no significant alteration of 5-HT2A binding potential (+3 ± 13%, P = 0.73). Conclusions: The change in 5-HT2A binding potential seen with nefazodone represents blockade of 5-HT2A receptors by the drug. We do not find evidence for acute downregulation of 5-HT2A receptors with paroxetine within 9 h.
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prefrontal cortex 5 ht 2 receptors in depression an 18 f Setoperone pet imaging study
1999Co-Authors: Jeffrey H. Meyer, Beata Owczarek, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, Sidney H. KennedyAbstract:Objective: Widespread disturbances of serotonin (5-HT) are implicated in the pathophysiology of depression. Of 5-HT receptor abnormalities reported, the most replicated finding is increased 5-HT2 receptor binding in the postmortem prefrontal cortex of depressed suicide victims. The extent to which these findings exist in depressed persons without recent suicide attempts is uncertain. The objective of this study was to evaluate 5HT2 receptors in depressed patients who were medication-free and who had not made recent suicide attempts. Method: With the use of [ 18 F]Setoperone and positron emission tomography (PET), 5-HT2 receptor binding potential was assessed in 14 depressed and 19 healthy subjects. Exclusion criteria for depressed patients included use of antidepressant medication within the past 6 months, a history of suicide attempts within the past 5 years, other current axis I disorders including bipolar disorder, and the presence of psychotic symptoms. The 5-HT2 (Setoperone) binding potential in the two groups of subjects was compared by analysis of covariance with age as the covariate. Results: Age had a significant effect on 5-HT2 binding potential, but depression did not. The interaction of age and depression was not significant. Conclusions: The 5-HT2 binding potential is not increased in untreated depressed subjects who have not made recent suicide attempts. This negative finding does not rule out the possibility that there is a role for 5-HT2 receptors in treatment or that 5-HT2 receptors are increased in highly suicidal states.
Sidney H. Kennedy - One of the best experts on this subject based on the ideXlab platform.
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the effect of paroxetine on 5 ht 2a receptors in depression an 18 f Setoperone pet imaging study
American Journal of Psychiatry, 2001Co-Authors: Jeffrey H. Meyer, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, Beata S Eisfeld, Shahryar Rafitari, Helen S Mayberg, Sidney H. KennedyAbstract:OBJECTIVE: In the cortex of animals, serotonin (5-HT) levels increase after several weeks of treatment with selective serotonin reuptake inhibitors (SSRIs). Studies using an intrasubject design to examine the effects of SSRI treatment on 5-HT2A receptors in the cortex of drug-free depressed patients are needed. In theory, agonist stimulation of 5-HT2A receptors could be relevant to SSRI treatment by promoting neuronal growth and survival as well as direct elevation of mood. The objective of this study was to evaluate the effect of 6 weeks of paroxetine treatment on 5-HT2A receptors in depressed patients. METHOD: After a medication-free period of at least 3 months, 19 depressed patients were treated for 6 weeks with paroxetine, 20 mg/day. The authors used [18F]Setoperone and positron emission tomography to assess 5-HT2A receptor binding potential in the patients before and after treatment and in 19 age-matched healthy subjects. RESULTS: 5-HT2A binding potential declined with age in all cortical regions in ...
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Prefrontal Cortex 5-HT2 Receptors in Depression: An [18F]Setoperone PET Imaging Study
American Journal of Psychiatry, 1999Co-Authors: Jeffrey H. Meyer, Beata Owczarek, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, Sidney H. KennedyAbstract:OBJECTIVE: Widespread disturbances of serotonin (5-HT) are implicated in the pathophysiology of depression. Of 5-HT receptor abnormalities reported, the most replicated finding is increased 5-HT2 receptor binding in the postmortem prefrontal cortex of depressed suicide victims. The extent to which these findings exist in depressed persons without recent suicide attempts is uncertain. The objective of this study was to evaluate 5-HT2 receptors in depressed patients who were medication-free and who had not made recent suicide attempts. METHOD: With the use of [18F]Setoperone and positron emission tomography (PET), 5-HT2 receptor binding potential was assessed in 14 depressed and 19 healthy subjects. Exclusion criteria for depressed patients included use of antidepressant medication within the past 6 months, a history of suicide attempts within the past 5 years, other current axis I disorders including bipolar disorder, and the presence of psychotic symptoms. The 5-HT2 (Setoperone) binding potential in the t...
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the effects of single dose nefazodone and paroxetine upon 5 ht2a binding potential in humans using 18f Setoperone pet
Psychopharmacology, 1999Co-Authors: Jeffrey H. Meyer, Sidney H. Kennedy, Raymond Y Cho, Shitij KapurAbstract:Rationale: Alterations in 5-HT2A receptor binding are implicated in suicidality and depression. 5-HT2A receptors may also be involved in the therapeutic effects of antidepressants. Objectives: The purpose of this study was to assess the effect of paroxetine and nefazodone on 5-HT2A receptors after a single dose. Methods: Seven subjects received a single dose of nefazodone 200 mg and five subjects received a single dose of paroxetine 20 mg. Before and after the dose, 5-HT2A binding potentials (Bmax/Kd) were determined in each subject using [18F]-Setoperone PET. Results: Nefazodone induced a significant change in 5-HT2A binding potential (−39 ± 17%, P = 0.003) while paroxetine showed no significant alteration of 5-HT2A binding potential (+3 ± 13%, P = 0.73). Conclusions: The change in 5-HT2A binding potential seen with nefazodone represents blockade of 5-HT2A receptors by the drug. We do not find evidence for acute downregulation of 5-HT2A receptors with paroxetine within 9 h.
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prefrontal cortex 5 ht 2 receptors in depression an 18 f Setoperone pet imaging study
1999Co-Authors: Jeffrey H. Meyer, Beata Owczarek, Gregory M. Brown, Sylvain Houle, Alan A Wilson, Shitij Kapur, Jean N. Dasilva, Sidney H. KennedyAbstract:Objective: Widespread disturbances of serotonin (5-HT) are implicated in the pathophysiology of depression. Of 5-HT receptor abnormalities reported, the most replicated finding is increased 5-HT2 receptor binding in the postmortem prefrontal cortex of depressed suicide victims. The extent to which these findings exist in depressed persons without recent suicide attempts is uncertain. The objective of this study was to evaluate 5HT2 receptors in depressed patients who were medication-free and who had not made recent suicide attempts. Method: With the use of [ 18 F]Setoperone and positron emission tomography (PET), 5-HT2 receptor binding potential was assessed in 14 depressed and 19 healthy subjects. Exclusion criteria for depressed patients included use of antidepressant medication within the past 6 months, a history of suicide attempts within the past 5 years, other current axis I disorders including bipolar disorder, and the presence of psychotic symptoms. The 5-HT2 (Setoperone) binding potential in the two groups of subjects was compared by analysis of covariance with age as the covariate. Results: Age had a significant effect on 5-HT2 binding potential, but depression did not. The interaction of age and depression was not significant. Conclusions: The 5-HT2 binding potential is not increased in untreated depressed subjects who have not made recent suicide attempts. This negative finding does not rule out the possibility that there is a role for 5-HT2 receptors in treatment or that 5-HT2 receptors are increased in highly suicidal states.