The Experts below are selected from a list of 3171 Experts worldwide ranked by ideXlab platform
Zia Ahmad - One of the best experts on this subject based on the ideXlab platform.
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anti inflammatory activities of sieboldogenin from Smilax china linn experimental and computational studies
Journal of Ethnopharmacology, 2009Co-Authors: Inamullah Khan, Muhammad Nisar, Farooq Ebad, Said Nadeem, Muhammad Saeed, Haroon Khan, Fazli Khuda, Nasiara Karim, Zia AhmadAbstract:Abstract Ethnopharmacological relevance Smilax china Linn. is extensively used in traditional Chinese medicine (TCM) as well as in Pakistan for several medicinal purposes including their use in inflammatory disorders. Aim of the study The aims of the current study were to validate and assess the folk use of Smilax china Linn. on pharmacological grounds using the isolated compound at molecular, in vivo and computational levels. Materials and methods Seiboldogenin was isolated from ethyl acetate fraction of the plant crude extract. In vitro lipoxygenase and in vivo carrageenan-induced hind paw oedema models were used in experimental studies while molecular docking technique was used to conduct computational study. Results Sieboldogenin showed significant lipoxygenase inhibition (IC50: 38 μM). It also exhibited significant inhibition ( p Conclusions Sieboldogenin seems to be a potential new anti-inflammatory compound responsible for anti-inflammatory activities of Smilax china Linn. Its in vitro and in vivo inflammatory activities are in good agreement with the folk medicinal use of Smilax china Linn. in inflammatory disorders.
Chatzimanolis Stylianos - One of the best experts on this subject based on the ideXlab platform.
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FIGURES 5 – 8 in A revision of the myrmecophilous genus Smilax Laporte (Coleoptera: Staphylinidae: Staphylininae)
2018Co-Authors: Chatzimanolis StylianosAbstract:FIGURES 5 – 8. Head of Smilax Laporte. 5. Smilax deneinephyto Chatzimanolis. 6. Smilax kuntzeni (Scheerpeltz). 7. Smilax lynchi (Bruch). 8. Smilax pilosa (F.). Not to scale
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FIGURES 9 – 12 in A revision of the myrmecophilous genus Smilax Laporte (Coleoptera: Staphylinidae: Staphylininae)
2018Co-Authors: Chatzimanolis StylianosAbstract:FIGURES 9 – 12. Pronotum of Smilax Laporte. 9. Smilax deneinephyto Chatzimanolis. 10. Smilax kuntzeni (Scheerpeltz). 11. Smilax lynchi (Bruch). 12. Smilax pilosa (F.). Not to scale
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FIGURES 13 – 16 in A revision of the myrmecophilous genus Smilax Laporte (Coleoptera: Staphylinidae: Staphylininae)
2018Co-Authors: Chatzimanolis StylianosAbstract:FIGURES 13 – 16. Abdominal sternites VII – VIII of Smilax Laporte. 13. Smilax deneinephyto Chatzimanolis. 14. Smilax pilosa (F.). 15. Smilax kuntzeni (Scheerpeltz). 16. Smilax lynchi (Bruch). Not to scale
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FIGURES 3 – 4 in A revision of the myrmecophilous genus Smilax Laporte (Coleoptera: Staphylinidae: Staphylininae)
2018Co-Authors: Chatzimanolis StylianosAbstract:FIGURES 3 – 4. Habitus photographs of Smilax Laporte. 3. Smilax kuntzeni (Scheerpeltz), total length = 19.1 mm. 4. Smilax lynchi (Bruch), total length = 18.5 mm
Inamullah Khan - One of the best experts on this subject based on the ideXlab platform.
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anti inflammatory activities of sieboldogenin from Smilax china linn experimental and computational studies
Journal of Ethnopharmacology, 2009Co-Authors: Inamullah Khan, Muhammad Nisar, Farooq Ebad, Said Nadeem, Muhammad Saeed, Haroon Khan, Fazli Khuda, Nasiara Karim, Zia AhmadAbstract:Abstract Ethnopharmacological relevance Smilax china Linn. is extensively used in traditional Chinese medicine (TCM) as well as in Pakistan for several medicinal purposes including their use in inflammatory disorders. Aim of the study The aims of the current study were to validate and assess the folk use of Smilax china Linn. on pharmacological grounds using the isolated compound at molecular, in vivo and computational levels. Materials and methods Seiboldogenin was isolated from ethyl acetate fraction of the plant crude extract. In vitro lipoxygenase and in vivo carrageenan-induced hind paw oedema models were used in experimental studies while molecular docking technique was used to conduct computational study. Results Sieboldogenin showed significant lipoxygenase inhibition (IC50: 38 μM). It also exhibited significant inhibition ( p Conclusions Sieboldogenin seems to be a potential new anti-inflammatory compound responsible for anti-inflammatory activities of Smilax china Linn. Its in vitro and in vivo inflammatory activities are in good agreement with the folk medicinal use of Smilax china Linn. in inflammatory disorders.
Rong Tsao - One of the best experts on this subject based on the ideXlab platform.
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ultrafiltration lc esi msn screening of mmp 2 inhibitors from selected chinese medicinal herbs Smilax glabra roxb Smilax china l and saposhnikovia divaricata turcz schischk as potential functional food ingredients
Journal of Functional Foods, 2015Co-Authors: Huirong Zhang, Anqi Zhao, Binhua Han, Chunming Liu, Rong TsaoAbstract:Abstract In vitro Matrix metalloproteases-2 (MMP-2) inhibition assay and ultrafiltration liquid chromatography coupled to electrospray ionization tandem mass spectrometry (ultrafiltration LC-ESI-MS n ) were combined to screen MMP-2 inhibitors from three Chinese medicinal herbs, Smilax glabra Roxb., Smilax china L. and Saposhnikovia divaricata (Turcz.) Schischk as potential functional food ingredients. Results showed that extracts of two Smilax species and the three major components resveratrol, engelitin and asibinn, and extract of S. divaricata and its major component 4′-O-β-D-glucosyl-5-O-methylvisamminol and three other chromones were strong MMP-2 inhibitors. Resveratrol and 4′-O-β-D-glucosyl-5-O-methylvisamminol had the highest binding affinity to MMP-2 and were the main contributors to the MMP-2 activity of Smilax and Saposhnikovia extracts, respectively. The present results further suggest that ultrafiltration LC-ESI-MS n is a valid, selective and effective method, and can be used to screen MMP-2 inhibitors from other plants such as grapes that contain resveratrol as functional foods and nutraceuticals.
Haroon Khan - One of the best experts on this subject based on the ideXlab platform.
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anti inflammatory activities of sieboldogenin from Smilax china linn experimental and computational studies
Journal of Ethnopharmacology, 2009Co-Authors: Inamullah Khan, Muhammad Nisar, Farooq Ebad, Said Nadeem, Muhammad Saeed, Haroon Khan, Fazli Khuda, Nasiara Karim, Zia AhmadAbstract:Abstract Ethnopharmacological relevance Smilax china Linn. is extensively used in traditional Chinese medicine (TCM) as well as in Pakistan for several medicinal purposes including their use in inflammatory disorders. Aim of the study The aims of the current study were to validate and assess the folk use of Smilax china Linn. on pharmacological grounds using the isolated compound at molecular, in vivo and computational levels. Materials and methods Seiboldogenin was isolated from ethyl acetate fraction of the plant crude extract. In vitro lipoxygenase and in vivo carrageenan-induced hind paw oedema models were used in experimental studies while molecular docking technique was used to conduct computational study. Results Sieboldogenin showed significant lipoxygenase inhibition (IC50: 38 μM). It also exhibited significant inhibition ( p Conclusions Sieboldogenin seems to be a potential new anti-inflammatory compound responsible for anti-inflammatory activities of Smilax china Linn. Its in vitro and in vivo inflammatory activities are in good agreement with the folk medicinal use of Smilax china Linn. in inflammatory disorders.
