The Experts below are selected from a list of 219 Experts worldwide ranked by ideXlab platform
William D Willis - One of the best experts on this subject based on the ideXlab platform.
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the effect of a kainate glur5 receptor antagonist on responses of Spinothalamic Tract neurons in a model of peripheral neuropathy in primates
Pain, 2004Co-Authors: J Palecek, Susan M Carlton, Volker Neugebauer, Smriti Iyengar, William D WillisAbstract:AbsTractThe responses of antidromically identified Spinothalamic Tract (STT) neurons to mechanical and thermal stimuli were compared in anesthetized normal and neuropathic monkeys before and after administration of a GluR5 kainate receptor antagonist (LY382884) into the spinal cord dorsal horn throu
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effects of protein kinase a activation on the responses of primate Spinothalamic Tract neurons to mechanical stimuli
Journal of Neurophysiology, 2002Co-Authors: Jing Wu, William D WillisAbstract:Behavioral and anatomical studies by our group have suggested that the protein kinase A (PKA) signal transduction cascade contributes to long-term changes in nociceptive processing at the spinal cord level. In this study, we have examined the effects of activation of the PKA cascade on the responses of Spinothalamic Tract (STT) neurons to peripheral mechanical stimuli in anesthetized and paralyzed monkeys. PKA in the spinal cord was activated by intra-spinal infusion of forskolin, an activator of adenylate cyclase, by microdialysis. There was a consistent increase in responses to mechanical pressure and pinch stimuli in all STT cells tested when forskolin was administered. Enhanced responses remained at relatively high levels when forskolin had been washed out for 30 min. However, in most STT cells tested (65%), the responses to brushing stimuli were not obviously changed when forskolin was given. Background activity was slightly increased when forskolin was administered. An inactive isomer of forskolin,d...
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nitric oxide mediates the central sensitization of primate Spinothalamic Tract neurons
Journal of Neurophysiology, 1999Co-Authors: J Palecek, Veronika Paleckova, Yuan Bo Peng, Jing Wu, William D WillisAbstract:Nitric oxide mediates the central sensitization of primate Spinothalamic Tract neurons. Nitric oxide (NO) has been proposed to contribute to the development of hyperalgesia by activating the NO/gua...
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nitric oxide mediated spinal disinhibition contributes to the sensitization of primate Spinothalamic Tract neurons
Journal of Neurophysiology, 1999Co-Authors: Jing Wu, Yuan Bo Peng, William D WillisAbstract:Nitric oxide–mediated spinal disinhibition contributes to the sensitization of primate Spinothalamic Tract neurons. This study concentrated on whether an increase in spinal nitric oxide (NO) dimini...
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inhibition of primate Spinothalamic Tract neurons by spinal glycine and gaba is modulated by guanosine 3 5 cyclic monophosphate
Journal of Neurophysiology, 1999Co-Authors: Jing Wu, Yuan Bo Peng, William D WillisAbstract:Inhibition of primate Spinothalamic Tract neurons by spinal glycine and GABA is modulated by guanosine 3′,5′-cyclic monophosphate. Our recent work has suggested that the nitric oxide/guanosine 3′,5...
Robert D Foreman - One of the best experts on this subject based on the ideXlab platform.
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intrapericardiac injections of algogenic chemicals excite primate c1 c2 Spinothalamic Tract neurons
American Journal of Physiology-regulatory Integrative and Comparative Physiology, 2000Co-Authors: Margaret J Chandler, Jianhua Zhang, Yu Yuan, Robert D ForemanAbstract:Extracellular potentials of 38 C1-C2 Spinothalamic Tract (STT) neurons in anesthetized monkeys (Macaca fascicularis) were examined for responses to intrapericardiac injections of an algogenic chemi...
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convergence of trigeminal input with visceral and phrenic inputs on primate c1 c2 Spinothalamic Tract neurons
Brain Research, 1999Co-Authors: Margaret J Chandler, Yu Yuan, Robert D ForemanAbstract:AbsTract Trigeminal, spinal and vagal afferent fibers overlap in C1–C2 segments. We hypothesized that trigeminal input from the superior sagittal sinus (SSS) can excite C1–C2 Spinothalamic Tract (STT) neurons receiving thoracic visceral or phrenic inputs. Effects of SSS stimulation were evenly divided among cells responding to each nerve stimulus; magnitude of responses to ipsilateral vagal input was greater in neurons excited by SSS input. Somatic fields of 80% of neurons responding to SSS stimulation included face areas innervated by the trigeminal nerve, whereas somatic fields of 89% of neurons unaffected by SSS stimulation were located only on areas innervated by cervical spinal nerves. Results are consistent with the idea that pain referred to trigeminal areas could originate in thoracic organs.
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Cardiopulmonary sympathetic input excites primate cuneothalamic neurons: comparison with Spinothalamic Tract neurons.
Journal of Neurophysiology, 1998Co-Authors: Margaret J Chandler, Jianhua Zhang, Robert D ForemanAbstract:Chandler, Margaret J., Jianhua Zhang, and Robert D. Foreman. Cardiopulmonary sympathetic input excites primate cuneothalamic neurons: comparison with Spinothalamic Tract neurons. J. Neurophysiol. 80: 628–637, 1998. Stimulation of cardiopulmonary sympathetic afferent fibers excites thoracic and cervical Spinothalamic Tract (STT) cells that respond primarily to noxious somatic stimuli. Neurons in dorsal column nuclei respond primarily to innocuous somatic inputs, but noxious stimulation of pelvic viscera activates gracile neurons. The purpose of this study was to compare effects of thoracic visceral input on cuneothalamic and STT neurons. Stellate ganglia of 17 anesthetized monkeys (Macaca fascicularis) were stimulated electrically to activate cardiopulmonary sympathetic afferent fibers. Somatic receptive fields were manipulated with brush, tap, and pinch stimuli. Extracellular discharge rate was recorded for neurons antidromically activated from ventroposterolateral (VPL) thalamus. Stimulation of the ipsil...
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evidence that c1 and c2 propriospinal neurons mediate the inhibitory effects of viscerosomatic spinal afferent input on primate Spinothalamic Tract neurons
Journal of Neurophysiology, 1992Co-Authors: S F Hobbs, Margaret J Chandler, U T Oh, Q G Fu, D C Bolser, Robert D ForemanAbstract:1. Lumbosacral Spinothalamic Tract (STT) neurons can be inhibited by noxious pinch of the contralateral hindlimb or either forelimb and by electrical stimulation of cardiopulmonary sympathetic, spl...
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Inhibitory effects of phrenic afferent fibers on primate lumbosacral Spinothalamic Tract neurons
Brain Research, 1991Co-Authors: D C Bolser, Margaret J Chandler, S F Hobbs, Robert D ForemanAbstract:AbsTract Studies were conducted to determine if electrical or mechanical stimulation of phrenic afferent fibers (PHR) would inhibit the activity of lumbosacral Spinothalamic Tract (STT) neurons. Twelve monkeys were anesthetized, paralyzed, and artificially ventilated. Extracellular action potentials were recorded from 78 STT neurons located in L2-S3 spinal segments. Electrical stimulation of PHR reduced the activity of 65%, did not affect 33%, and excited 1% of STT neurons. Mechanical stimulation of the diaphragm reduced the activity of 63%, did not effect 34%, and excited 1% of lumbosacral STT neurons. Distention of the urinary bladder (UBD) inhibited 52%, did not affect 23%, excited 23%, and elicited a biphasic response in 1% of STT neurons. However, there was no correlation between the effect of PHR and UBD or somatic classification of the neurons. We conclude that electrical or mechanical stimulation of PHR can produce a generalized inhibition of lumbosacral STT neurons. This inhibitory effect of PHR is similar to inhibitory effects reported for a variety of other afferent systems.
Margaret J Chandler - One of the best experts on this subject based on the ideXlab platform.
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intrapericardiac injections of algogenic chemicals excite primate c1 c2 Spinothalamic Tract neurons
American Journal of Physiology-regulatory Integrative and Comparative Physiology, 2000Co-Authors: Margaret J Chandler, Jianhua Zhang, Yu Yuan, Robert D ForemanAbstract:Extracellular potentials of 38 C1-C2 Spinothalamic Tract (STT) neurons in anesthetized monkeys (Macaca fascicularis) were examined for responses to intrapericardiac injections of an algogenic chemi...
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convergence of trigeminal input with visceral and phrenic inputs on primate c1 c2 Spinothalamic Tract neurons
Brain Research, 1999Co-Authors: Margaret J Chandler, Yu Yuan, Robert D ForemanAbstract:AbsTract Trigeminal, spinal and vagal afferent fibers overlap in C1–C2 segments. We hypothesized that trigeminal input from the superior sagittal sinus (SSS) can excite C1–C2 Spinothalamic Tract (STT) neurons receiving thoracic visceral or phrenic inputs. Effects of SSS stimulation were evenly divided among cells responding to each nerve stimulus; magnitude of responses to ipsilateral vagal input was greater in neurons excited by SSS input. Somatic fields of 80% of neurons responding to SSS stimulation included face areas innervated by the trigeminal nerve, whereas somatic fields of 89% of neurons unaffected by SSS stimulation were located only on areas innervated by cervical spinal nerves. Results are consistent with the idea that pain referred to trigeminal areas could originate in thoracic organs.
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Cardiopulmonary sympathetic input excites primate cuneothalamic neurons: comparison with Spinothalamic Tract neurons.
Journal of Neurophysiology, 1998Co-Authors: Margaret J Chandler, Jianhua Zhang, Robert D ForemanAbstract:Chandler, Margaret J., Jianhua Zhang, and Robert D. Foreman. Cardiopulmonary sympathetic input excites primate cuneothalamic neurons: comparison with Spinothalamic Tract neurons. J. Neurophysiol. 80: 628–637, 1998. Stimulation of cardiopulmonary sympathetic afferent fibers excites thoracic and cervical Spinothalamic Tract (STT) cells that respond primarily to noxious somatic stimuli. Neurons in dorsal column nuclei respond primarily to innocuous somatic inputs, but noxious stimulation of pelvic viscera activates gracile neurons. The purpose of this study was to compare effects of thoracic visceral input on cuneothalamic and STT neurons. Stellate ganglia of 17 anesthetized monkeys (Macaca fascicularis) were stimulated electrically to activate cardiopulmonary sympathetic afferent fibers. Somatic receptive fields were manipulated with brush, tap, and pinch stimuli. Extracellular discharge rate was recorded for neurons antidromically activated from ventroposterolateral (VPL) thalamus. Stimulation of the ipsil...
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evidence that c1 and c2 propriospinal neurons mediate the inhibitory effects of viscerosomatic spinal afferent input on primate Spinothalamic Tract neurons
Journal of Neurophysiology, 1992Co-Authors: S F Hobbs, Margaret J Chandler, U T Oh, Q G Fu, D C Bolser, Robert D ForemanAbstract:1. Lumbosacral Spinothalamic Tract (STT) neurons can be inhibited by noxious pinch of the contralateral hindlimb or either forelimb and by electrical stimulation of cardiopulmonary sympathetic, spl...
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Inhibitory effects of phrenic afferent fibers on primate lumbosacral Spinothalamic Tract neurons
Brain Research, 1991Co-Authors: D C Bolser, Margaret J Chandler, S F Hobbs, Robert D ForemanAbstract:AbsTract Studies were conducted to determine if electrical or mechanical stimulation of phrenic afferent fibers (PHR) would inhibit the activity of lumbosacral Spinothalamic Tract (STT) neurons. Twelve monkeys were anesthetized, paralyzed, and artificially ventilated. Extracellular action potentials were recorded from 78 STT neurons located in L2-S3 spinal segments. Electrical stimulation of PHR reduced the activity of 65%, did not affect 33%, and excited 1% of STT neurons. Mechanical stimulation of the diaphragm reduced the activity of 63%, did not effect 34%, and excited 1% of lumbosacral STT neurons. Distention of the urinary bladder (UBD) inhibited 52%, did not affect 23%, excited 23%, and elicited a biphasic response in 1% of STT neurons. However, there was no correlation between the effect of PHR and UBD or somatic classification of the neurons. We conclude that electrical or mechanical stimulation of PHR can produce a generalized inhibition of lumbosacral STT neurons. This inhibitory effect of PHR is similar to inhibitory effects reported for a variety of other afferent systems.
Sung Ho Jang - One of the best experts on this subject based on the ideXlab platform.
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central pain due to injury of the Spinothalamic Tract misdiagnosed as complex regional pain syndrome a case report
Diagnostics (Basel Switzerland), 2019Co-Authors: Sung Ho Jang, Young Hyeon KwonAbstract:Objectives: We report on a patient with whiplash injury who had central pain, due to injury of the Spinothalamic Tract (STT), but who was misdiagnosed as complex regional pain syndrome (CRPS). Case description: While a minivan in which a 43-year-old female was seated in the passenger seat was stopped for a signal, a truck collided with the minivan from behind, and the minivan then repeatedly collided with trucks in front and behind the minivan. Her head repeatedly struck the minivan seat resulting in whiplash injuries. After onset, she felt pain in both legs with mild motor weakness in all four extremities and memory impairment. Eight years after onset, she was diagnosed at a university hospital as CRPS type 1 with the clinical features of hyperalgesia and mild edema and motor weakness of both legs. She visited another university hospital nine years after onset and complained of pain in the right arm and both legs, constant tingling and burning pain along with allodynia and hyperalgesia. She also showed mild weakness in the four extremities, mild edema of both legs, and memory impairment. On diffusion tensor Tractography (DTT), the left Spinothalamic Tract (STT) showed marked narrowing, and the right STT revealed mild narrowing and partial tearing. In addition, partial tears were observed in both corticospinal Tracts and the right corticoreticulospinal Tract. Discontinuations were observed in the left corticoreticulospinal Tract and the left fornical crus. Conclusion: Injury of the STT was demonstrated on DTT in a patient with central pain following whiplash injury. Previously, the patient was misdiagnosed as CRPS.
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diffusion tensor Tractography studies of central post stroke pain due to the Spinothalamic Tract injury a mini review
Frontiers in Neurology, 2019Co-Authors: Sung Ho JangAbstract:Elucidation of the pathophysiological mechanism of central post-stroke pain (CPSP) is essential to the development of effective therapeutic modalities for CPSP. However, the pathophysiological mechanism of CPSP has not yet been clearly elucidated. The recent development of diffusion tensor Tractography (DTT) derived from diffusion tensor imaging (DTI) has allowed visualization and estimation the Spinothalamic Tract (STT), which has been considered the most plausible neural Tract responsible for pathogenesis of CPSP. In this mini-review, six DTT studies in which CPSP due to STT injury in stroke patients was demonstrated are reviewed. The information provided in the reviewed studies suggests that DTT is useful to elucidation of the pathophysiological mechanism associated with CPSP. We believe that the reviewed studies will facilitate neurorehabilitation of stroke patients with CPSP. However, DTT studies of CPSP are still in the beginning stage because the total number (six studies) of the reviewed studies is very short and half were case reports. Therefore, further studies involving large numbers of subjects are warranted.
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Delayed-onset central poststroke pain due to degeneration of the Spinothalamic Tract following thalamic hemorrhage: A case report.
Medicine, 2018Co-Authors: Sung Ho JangAbstract:Rationale: Recent studies have used diffusion tensor Tractography (DTT) to demonstrate that central poststroke pain (CPSP) was related to Spinothalamic Tract (STT) injury in patients with stroke. However, few studies have been reported about delayed-onset CPSP due to degeneration of the STT following a stroke.
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central pain due to Spinothalamic Tract injury caused by indirect head trauma following a pratfall
Brain Injury, 2016Co-Authors: Sung Ho JangAbstract:AbsTractObjectives: This study reports on patients who showed central pain due to injury of the Spinothalamic Tract (STT) caused by fall without direct head trauma.Design: Prospective study.Participants: Two patients with mild traumatic brain injury (TBI) resulting from a fall were enrolled. Patient 1 was a 21-year-old female who had suffered a pratfall with no history of direct head trauma. She had begun to feel pain in both upper trunk and lower back and the left leg since ~ 5 days after onset: constant tingling and throbbing sensation with allodynia. Patient 2 was a 39-year-old male who had suffered a pratfall without direct head trauma. He had begun to feel pain in both arms and legs since ~ 4 days after the fall: constant tingling and pricking sensation without allodynia or hyperalgesia.Results: On diffusion tensor Tractograhpy (DTT) of patient 1, partial tearing of the right STT was observed at the subcortical white matter. On DTT of patient 2, partial tearing at the subcortical white matter was obs...
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degeneration of an injured Spinothalamic Tract in a patient with mild traumatic brain injury
Brain Injury, 2016Co-Authors: Sung Ho Jang, Hyeok Gyu KwonAbstract:AbsTractObjectives: This study reports on a patient who developed degeneration of an injured Spinothalamic Tract (STT) detected on diffusion tensor Tractography (DTT) following mild traumatic brain injury (TBI).Case description: A 56-year-old female had suffered from head trauma resulting from a pedestrian car accident. The patient did not experience loss of consciousness or post-traumatic amnesia and the patient’s Glasgow Coma Scale score was 15. She had begun to feel pain in her left hand and foot at ~ 7 days after onset. The characteristics and severity of pain were as follows: constant tingling and pricking sensation without allodynia or hyperalgesia (Visual Analogue Scale score: 3~4). No specific focal lesion was observed on brain and spine MRI and an electromyography study showed no evidence of peripheral nerve injury or radiculopathy. At 6 months after onset, the central pain in the left hand and foot became aggravated, with a Visual Analogue Scale score of 6.Results: On 1-month DTT, partial tearin...
Jing Wu - One of the best experts on this subject based on the ideXlab platform.
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effects of protein kinase a activation on the responses of primate Spinothalamic Tract neurons to mechanical stimuli
Journal of Neurophysiology, 2002Co-Authors: Jing Wu, William D WillisAbstract:Behavioral and anatomical studies by our group have suggested that the protein kinase A (PKA) signal transduction cascade contributes to long-term changes in nociceptive processing at the spinal cord level. In this study, we have examined the effects of activation of the PKA cascade on the responses of Spinothalamic Tract (STT) neurons to peripheral mechanical stimuli in anesthetized and paralyzed monkeys. PKA in the spinal cord was activated by intra-spinal infusion of forskolin, an activator of adenylate cyclase, by microdialysis. There was a consistent increase in responses to mechanical pressure and pinch stimuli in all STT cells tested when forskolin was administered. Enhanced responses remained at relatively high levels when forskolin had been washed out for 30 min. However, in most STT cells tested (65%), the responses to brushing stimuli were not obviously changed when forskolin was given. Background activity was slightly increased when forskolin was administered. An inactive isomer of forskolin,d...
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nitric oxide mediates the central sensitization of primate Spinothalamic Tract neurons
Journal of Neurophysiology, 1999Co-Authors: J Palecek, Veronika Paleckova, Yuan Bo Peng, Jing Wu, William D WillisAbstract:Nitric oxide mediates the central sensitization of primate Spinothalamic Tract neurons. Nitric oxide (NO) has been proposed to contribute to the development of hyperalgesia by activating the NO/gua...
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nitric oxide mediated spinal disinhibition contributes to the sensitization of primate Spinothalamic Tract neurons
Journal of Neurophysiology, 1999Co-Authors: Jing Wu, Yuan Bo Peng, William D WillisAbstract:Nitric oxide–mediated spinal disinhibition contributes to the sensitization of primate Spinothalamic Tract neurons. This study concentrated on whether an increase in spinal nitric oxide (NO) dimini...
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inhibition of primate Spinothalamic Tract neurons by spinal glycine and gaba is modulated by guanosine 3 5 cyclic monophosphate
Journal of Neurophysiology, 1999Co-Authors: Jing Wu, Yuan Bo Peng, William D WillisAbstract:Inhibition of primate Spinothalamic Tract neurons by spinal glycine and GABA is modulated by guanosine 3′,5′-cyclic monophosphate. Our recent work has suggested that the nitric oxide/guanosine 3′,5...
