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Anup Maiti - One of the best experts on this subject based on the ideXlab platform.
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Swietenine, Big Leaf Mahogany ( Swietenia macrophylla ) Seed Extract as a Hypoglycemic Agent
Nuts and Seeds in Health and Disease Prevention, 2011Co-Authors: Saikat Dewanjee, Anup MaitiAbstract:Publisher Summary This chapter presents a research approach to isolating a novel antidiabetic molecule from Swietenia macrophylla seeds. The seeds of Swietenia macrophylla have been reported to possess hypotensive, antiinflammatory, antimutagenic, antitumor, and antibabesial activities. Petroleum ether extract of Swietenia macrophylla seeds has been reported to produce significant antidiarrheal activity and its aqueous extract has been reported to be effective against Plasmodium falciparum. The ethno-medicinal literature reveals that the Swietenia macrophylla seeds were used as a folk medicine in Indonesia for the treatment of diabetes. Preliminary pharmacological assay revealed that Swietenia macrophylla seeds possess significant hypoglycemic activity in experimental diabetic rats. Subsequent work was carried out to isolate the chemical constituent from seed, employing the bioassay-guided fractionation method. In vitro peripheral glucose utilization assay, using the isolated rat hemidiaphragm method, was employed to isolate lead from Swietenia macrophylla seeds. In vivo antidiabetic bioassay of swietenine revealed that it exhibited significant hypoglycemic and hypolipidemic activity at doses of 25 and 50 mg/kg p.o. Acute and subacute toxicity studies revealed that swietenine is non-toxic at its therapeutic dose in experimental animals.
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isolation of hypoglycemic phytoconstituent from Swietenia macrophylla seeds
Phytotherapy Research, 2009Co-Authors: Anup Maiti, Saikat Dewanjee, Ranabir SahuAbstract:The present study was undertaken to isolate a novel antidiabetic molecule from Swietenia macrophylla seeds. The hydroalcohol extract of Swietenia macrophylla seeds was subjected for bioassay guided isolation employing glucose utilization assay by the isolated rat hemi-diaphragm method in vitro. One tetranortriterpenoid, swietenine, isolated from the chloroform fraction exhibited significant (p<0.01) activity and the effect was comparable to that of human insulin (p<0.01).
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Isolation of hypoglycemic phytoconstituent from Swietenia macrophylla seeds.
Phytotherapy research : PTR, 2009Co-Authors: Anup Maiti, Saikat Dewanjee, Ranabir SahuAbstract:The present study was undertaken to isolate a novel antidiabetic molecule from Swietenia macrophylla seeds. The hydroalcohol extract of Swietenia macrophylla seeds was subjected for bioassay guided isolation employing glucose utilization assay by the isolated rat hemi-diaphragm method in vitro. One tetranortriterpenoid, swietenine, isolated from the chloroform fraction exhibited significant (p <
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Swietenine: A potential oral hypoglycemic from Swietenia macrophylla seed
Fitoterapia, 2009Co-Authors: Saikat Dewanjee, Anup Maiti, Subhash C. Mandal, Anup Kumar Das, Sankar P. DeyAbstract:Swietenine, a tetranortriterpenoid, was isolated from the Swietenia macrophylla seeds. The in vivo hypoglycemic activity was evaluated against neonatal-streptozotocin induced type 2 diabetic rats. Oral administration of swietenine at 25 and 50 mg/kg body weight per day to diabetic rats was found to possess significant dose dependant hypoglycemic and hypolipidemic activity in type 2 diabetic rats.
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Hypoglycemic effect of Swietenia macrophylla seeds against type II diabetes
International Journal of Green Pharmacy, 2008Co-Authors: Anup Maiti, Saikat Dewanjee, Goutam Kumar Jana, Subhash C. MandalAbstract:Th e antidiabetic eff ect of Swietenia macrophylla seeds was evaluated in Streptozotocin and Nicotinamide induced type II diabetic rats. Methanol extract of Swietenia macrophylla seeds was administered orally at doses of 150 and 300 mg/kg body weight for 12 consecutive days. Fasting blood sugar (FBG) was estimated on overnight fasted rats on day 1, 5 and 12 days. Lipid profi les, liver glycogen levels and changes in body weight were also measured. Th e extract was found more eff ective at the dose of 300 mg/kg body weight and it lowered FBG levels was statistically signifi cant P < 0.01 (32.78%) in diabetic rats at day 12. Extract at the same dose also signifi cantly reduced P < 0.01 the elevated level of serum total cholesterol (18.56%) and triglyceride (10.41%), and increased P < 0.01 (46.27%) the reduced liver glycogen level. Th ough statistically non-signifi cant the extract at both the doses was found to improve the body weight of diabetic rats. Th e observation concludes that the methanol extract of seeds of Swietenia macrophylla has hypoglycemic as well as hypolipidemic eff ect. Key words: Swietenia macrophylla, Streptozotocin, Nicotinamide, type II diabetes
Saikat Dewanjee - One of the best experts on this subject based on the ideXlab platform.
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Swietenine, Big Leaf Mahogany ( Swietenia macrophylla ) Seed Extract as a Hypoglycemic Agent
Nuts and Seeds in Health and Disease Prevention, 2011Co-Authors: Saikat Dewanjee, Anup MaitiAbstract:Publisher Summary This chapter presents a research approach to isolating a novel antidiabetic molecule from Swietenia macrophylla seeds. The seeds of Swietenia macrophylla have been reported to possess hypotensive, antiinflammatory, antimutagenic, antitumor, and antibabesial activities. Petroleum ether extract of Swietenia macrophylla seeds has been reported to produce significant antidiarrheal activity and its aqueous extract has been reported to be effective against Plasmodium falciparum. The ethno-medicinal literature reveals that the Swietenia macrophylla seeds were used as a folk medicine in Indonesia for the treatment of diabetes. Preliminary pharmacological assay revealed that Swietenia macrophylla seeds possess significant hypoglycemic activity in experimental diabetic rats. Subsequent work was carried out to isolate the chemical constituent from seed, employing the bioassay-guided fractionation method. In vitro peripheral glucose utilization assay, using the isolated rat hemidiaphragm method, was employed to isolate lead from Swietenia macrophylla seeds. In vivo antidiabetic bioassay of swietenine revealed that it exhibited significant hypoglycemic and hypolipidemic activity at doses of 25 and 50 mg/kg p.o. Acute and subacute toxicity studies revealed that swietenine is non-toxic at its therapeutic dose in experimental animals.
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isolation of hypoglycemic phytoconstituent from Swietenia macrophylla seeds
Phytotherapy Research, 2009Co-Authors: Anup Maiti, Saikat Dewanjee, Ranabir SahuAbstract:The present study was undertaken to isolate a novel antidiabetic molecule from Swietenia macrophylla seeds. The hydroalcohol extract of Swietenia macrophylla seeds was subjected for bioassay guided isolation employing glucose utilization assay by the isolated rat hemi-diaphragm method in vitro. One tetranortriterpenoid, swietenine, isolated from the chloroform fraction exhibited significant (p<0.01) activity and the effect was comparable to that of human insulin (p<0.01).
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Isolation of hypoglycemic phytoconstituent from Swietenia macrophylla seeds.
Phytotherapy research : PTR, 2009Co-Authors: Anup Maiti, Saikat Dewanjee, Ranabir SahuAbstract:The present study was undertaken to isolate a novel antidiabetic molecule from Swietenia macrophylla seeds. The hydroalcohol extract of Swietenia macrophylla seeds was subjected for bioassay guided isolation employing glucose utilization assay by the isolated rat hemi-diaphragm method in vitro. One tetranortriterpenoid, swietenine, isolated from the chloroform fraction exhibited significant (p <
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Swietenine: A potential oral hypoglycemic from Swietenia macrophylla seed
Fitoterapia, 2009Co-Authors: Saikat Dewanjee, Anup Maiti, Subhash C. Mandal, Anup Kumar Das, Sankar P. DeyAbstract:Swietenine, a tetranortriterpenoid, was isolated from the Swietenia macrophylla seeds. The in vivo hypoglycemic activity was evaluated against neonatal-streptozotocin induced type 2 diabetic rats. Oral administration of swietenine at 25 and 50 mg/kg body weight per day to diabetic rats was found to possess significant dose dependant hypoglycemic and hypolipidemic activity in type 2 diabetic rats.
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Hypoglycemic effect of Swietenia macrophylla seeds against type II diabetes
International Journal of Green Pharmacy, 2008Co-Authors: Anup Maiti, Saikat Dewanjee, Goutam Kumar Jana, Subhash C. MandalAbstract:Th e antidiabetic eff ect of Swietenia macrophylla seeds was evaluated in Streptozotocin and Nicotinamide induced type II diabetic rats. Methanol extract of Swietenia macrophylla seeds was administered orally at doses of 150 and 300 mg/kg body weight for 12 consecutive days. Fasting blood sugar (FBG) was estimated on overnight fasted rats on day 1, 5 and 12 days. Lipid profi les, liver glycogen levels and changes in body weight were also measured. Th e extract was found more eff ective at the dose of 300 mg/kg body weight and it lowered FBG levels was statistically signifi cant P < 0.01 (32.78%) in diabetic rats at day 12. Extract at the same dose also signifi cantly reduced P < 0.01 the elevated level of serum total cholesterol (18.56%) and triglyceride (10.41%), and increased P < 0.01 (46.27%) the reduced liver glycogen level. Th ough statistically non-signifi cant the extract at both the doses was found to improve the body weight of diabetic rats. Th e observation concludes that the methanol extract of seeds of Swietenia macrophylla has hypoglycemic as well as hypolipidemic eff ect. Key words: Swietenia macrophylla, Streptozotocin, Nicotinamide, type II diabetes
Ming-hua Qiu - One of the best experts on this subject based on the ideXlab platform.
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Limonoids from the leaves of Swietenia macrophylla
Natural product research, 2011Co-Authors: Jie-qing Liu, Cui-fang Wang, Jian-chao Chen, Ming-hua QiuAbstract:One new limonoid of the phragmalin type (1) named Swietenine J with nine known compounds methyl-6-β-hydroxy angolensate (2), 1-O-acetylkhayanolide A(3), Khayanolide E (4), Khayalactone (5), Khayanone (6), 1-O-Acetylkhayanolide B (7), 1-O-Deacetylkhayanolide E (8), Khayanolide A (9), Khayanolide B (10) were isolated from Swietenia macrophylla. The structure of 1 was elucidated on the basis of 1D and 2D- NMR spectroscopic analysis.
Utpal Raychaudhuri - One of the best experts on this subject based on the ideXlab platform.
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Reduced Erythrocyte Carbonic Anhydrase Activity by Swietenia macrophylla Seeds in Diabetic Rats
Journal of Diabetes Metabolic Disorders & Control, 2015Co-Authors: Moumita Dutta, Utpal Kumar Biswas, Runu Chakraborty, Piyasa Banerjee, Arun Kumar, Utpal RaychaudhuriAbstract:Background: We have previously reported that the CA activity is associated with advance glycation end product in insulin resistance condition. Our earlier report also revealed that Swietenia macrophylla effectively reduces the blood glucose levels in streptozotocin induced diabetic rats. Aim: The present study aims to find out if there is any effect of these plant extract on CA activity in Diabetic rat model. Materials and Methods: Streptozotocin was used to induce diabetes except in the control group.The activities of the Carbonic anhydrase in plasma and other biochemical parameters were estimated using standardized methods. Results: Our Results demonstrate the erythrocyte CA activity is positively correlated with the blood glucose as well as total cholesterol, triglyceride, LDL cholesterol levels. There is reduction of CA activity under the effect of these extract along with effective lowering of blood glucose and the above lipid parameters. Conclusions: The extract of Swietenia macrophylla seeds effectively inhibits erythrocyte CA activity and has potential for use to control Diabetes Mellitus and prevent complications.
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Evaluation of plasma H2S levels and H2S synthesis in streptozotocin induced Type-2 diabetes-an experimental study based on Swietenia macrophylla seeds
Asian Pacific journal of tropical biomedicine, 2014Co-Authors: Moumita Dutta, Utpal Kumar Biswas, Runu Chakraborty, Piyasa Banerjee, Utpal Raychaudhuri, Arun KumarAbstract:Objective To evaluate the plasma H2S levels and H2S synthesis activity in streptozotocin induced type 2 diabetes rats compared to the healthy controls and also to observe the effect of the aqueous extract of Swietenia macrophylla (S. macrophylla) seeds on the experimental groups.
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Antidiabetic and antioxidant effect of Swietenia macrophylla seeds in experimental type 2 diabetic rats
International Journal of Diabetes in Developing Countries, 2013Co-Authors: Moumita Dutta, Utpal Kumar Biswas, Runu Chakraborty, Piyasa Banerjee, Debasish Maji, Mohan Chandra Mondal, Utpal RaychaudhuriAbstract:The detrimental effects of diabetic complications are mainly mediated through oxidative stress. Despite considerable progress in the treatment of diabetes by insulin and oral hypoglycemic agents, search for newer drugs continue. Many studies have been carried out in search of a suitable plant drug that would be effective in diabetes mellitus. The present investigation was undertaken to evaluate the effect of aqueous extract of Swietenia macrophylla seeds on blood glucose levels and oxidative stress in streptozotocin induced type 2 diabetic rats. The Albino rat (Wister Strain) weighing 200–250 g were divided into five groups of six rats each and streptozotocin was used to induce diabetes except in the control group. The control group (I) and diabetic control group (II) received redistilled water. Group III and V diabetic rats were administered with aqueous extract of Swietenia macrophylla seeds (2 gm/kg body weight) daily for 30 days. Peptide was mixed with extract as adjuvant in the latter group (1:1, 2 g / kg body weight/ day for 30 days). Group IV diabetic rats were fed with aqueous extract of established drug Metformin (10 mg/kg body weight). The oral administration of extract alone (2 g / kg body) and extract plus soya peptide (1:1, 2 g / kg body weight) per day for 30 days to diabetic rats was found to possess significant hypoglycemic activity. The antioxidant activity in the blood of Swietenia macrophylla seeds extract-treated diabetic rats and aqueous extract of Swietenia macrophylla seeds, estimated by modified FORD test and expressed as Torlox equivalents also revealed significant antioxidant activity. The present study demonstrates that the aqueous extract of Swietenia macrophylla seeds have substantial anti-diabetic and antioxidant properties. An extensive population based study is required in this direction, to establish this natural product as a therapeutic agent for diabetes mellitus.
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Regeneration of pancreatic β-cells on streptozotocin induced diabetic rats under the effect of Swietenia macrophylla seeds
International Journal of Green Pharmacy, 2012Co-Authors: Utpal Raychaudhuri, Moumita Dutta, Utpal Kumar Biswas, Runu Chakraborty, Piyasa BanerjeeAbstract:Background: Diabetes mellitus is one of the major killers these days and has a profound effect in the quality of life. Despite considerable progress in the treatment of diabetes, search for newer drugs continues, especially from the natural resources. We have previously reported that the seed of the plant. Swietenia macrophylla is nontoxic. Aim: The current study was undertaken to investigate the effect of Swietenia macrophylla seeds on histopathological changes of pancreatic, hepatic and renal tissues, besides to observe its effect on the blood glucose level and lipid parameters in experimental diabetic rats. Materials and Methods: The Albino rat (Wister Strain) weighing 200-250 gm were divided into five groups of seven rats each and streptozotocin was used to induce diabetes except in the control group. The control group (I) and diabetic control group (II) received redistilled water. Group III and V diabetic rats were administered with aqueous extract of Swietenia macrophylla seeds (2 gm/kg body weight) daily for 30 days. Peptide was mixed with extract as adjuvant in the latter group (1:1, 2 gm/kg body weight/day for 30 days). Group IV diabetic rats were fed with aqueous extract of standard drug Metformin (10 mg/kg body weight). Statistical Analysis: Statistical analysis was done using Microsoft Excel, Office 2003 and SPSS 16 software. Values were expressed by mean ± SD. P value
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Regeneration of pancreatic b‑cells on streptozotocin induced diabetic rats under the effect of Swietenia macrophylla seeds
International Journal of Green Pharmacy, 2012Co-Authors: Moumita Dutta, Utpal Kumar Biswas, Runu Chakraborty, Piyasa Banerjee, Utpal RaychaudhuriAbstract:Background: Diabetes mellitus is one of the major killers these days and has a profound effect in the quality of life. Despite considerable progress in the treatment of diabetes, search for newer drugs continues, especially from the natural resources. We have previously reported that the seed of the plant. Swietenia macrophylla is nontoxic. Aim: The current study was undertaken to investigate the effect of Swietenia macrophylla seeds on histopathological changes of pancreatic, hepatic and renal tissues, besides to observe its effect on the blood glucose level and lipid parameters in experimental diabetic rats. Materials and Methods: The Albino rat (Wister Strain) weighing 200‑250 gm were divided into five groups of seven rats each and streptozotocin was used to induce diabetes except in the control group. The control group (I) and diabetic control group (II) received redistilled water. Group III and V diabetic rats were administered with aqueous extract of Swietenia macrophylla seeds (2 gm/kg body weight) daily for 30 days. Peptide was mixed with extract as adjuvant in the latter group (1:1, 2 gm/kg body weight/day for 30 days). Group IV diabetic rats were fed with aqueous extract of standard drug Metformin (10 mg/kg body weight). Statistical Analysis: Statistical analysis was done using Microsoft Excel, Office 2003 and SPSS 16 software. Values were expressed by mean ± SD. P value
Michel Vennetier - One of the best experts on this subject based on the ideXlab platform.
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Le Mahogany à grandes feuilles (Swietenia macrophylla King)
1998Co-Authors: Michel VennetierAbstract:Cet article donne une description de Swietenia macrophylla en indiquant notamment les proprietes de son bois, son aire de repartition et son autecologie. Apres avoir souligne la sensibilite de cette espece a Hypsipyla grandella, la mineuse des pousses, l'auteur precise la place du mahogany aux Antilles.
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Le mahogany à grandes feuilles (Swietenia macrophylla King)
Bulletin technique de l'ONF, 1998Co-Authors: Michel VennetierAbstract:Après avoir rappelé les principales caractéristiques botaniques de Swietenia macrophylla King, l'auteur présente son aire de répartition, les qualités technologiques de son bois et ses exigences écologiques. Puis il décrit le comportement et la reproduction de son principal ennemi parasitaire, le lepidoptère Hypsipyla grandella Zeller, et les conséquences physiques et économiques des attaques.
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Contribution des dispositifs expérimentaux de Martinique à la sylviculture du mahogany à grandes feuilles (Swietenia macrophylla King)
Bulletin technique de l'ONF, 1998Co-Authors: Michel Vennetier, J. PlanAbstract:Les auteurs présentent les résultats de recherches, menées en Martinique, sur la sylviculture du mahogany à grande feuilles (Swietenia macrophylla King). Sont abordés l'élevage en pépinière, les méthodes de plantation et d'entretien des jeunes boisements, les traitements contre la mineuse des pousses, les éclaircies, et la régénération naturelle des peuplements.
