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Sabine Brandt - One of the best experts on this subject based on the ideXlab platform.
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isolation of treponema and tannerella spp from equine odontoclastic Tooth Resorption and hypercementosis related periodontal disease
Equine Veterinary Journal, 2014Co-Authors: Sabine Sykora, K Pieber, V Hackl, D Brodesser, H Simhofer, Sabine BrandtAbstract:Summary Reasons for performing study Red complex bacteria, i.e. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, are involved in the onset and progression of periodontal disease in man, yet seldom inhabit the oral cavity of healthy individuals. Periodontal disease is also encountered in horses, with equine odontoclastic Tooth Resorption and hypercementosis (EOTRH) constituting a particular form of disease. However, only little is known about the oral microbiome of healthy and periodontitis-affected equids. Objective We aimed to test the hypothesis that red complex bacteria are also associated with EOTRH-related periodontal disease. Study design Controlled cross-sectional study. Methods We screened DNA purified from crevicular fluid derived from 23 EOTRH-affected and 21 disease-free horses for the presence of Treponema spp., Tannerella spp. and Porphyromonas gingivalis DNA by polymerase chain reaction. Subsequently, amplified DNA was bidirectionally sequenced and identified via BLAST analysis. Results Treponema and/or Tannerella DNA was detected in 100% of periodontitis-related samples and in 52.2% of DNA derived from healthy horses. Twenty-six amplicon sequences were 98–100% homologous to published bacterial sequences, which mostly corresponded to Treponema pectinovorum, oral Treponema clones JU025 and OMZ 840, and Tannerella forsythia. P. gingivalis DNA was only found in 3 EOTRH-related samples. Forty-three amplicon sequences revealed weaker homologies ranging between 80% and 97% to known Treponema or Tannerella strains, partly because of their heterogeneity, partly because they obviously represented so far unknown types. Conclusions This is the first report in which known and novel Treponema and Tannerella spp. were isolated in association with EOTRH-related periodontal disease.
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isolation of treponema and tannerella spp from equine odontoclastic Tooth Resorption and hypercementosis related periodontal disease
Equine Veterinary Journal, 2014Co-Authors: Sabine Sykora, K Pieber, V Hackl, D Brodesser, H Simhofer, Sabine BrandtAbstract:Summary Reasons for performing study Red complex bacteria, i.e. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, are involved in the onset and progression of periodontal disease in man, yet seldom inhabit the oral cavity of healthy individuals. Periodontal disease is also encountered in horses, with equine odontoclastic Tooth Resorption and hypercementosis (EOTRH) constituting a particular form of disease. However, only little is known about the oral microbiome of healthy and periodontitis-affected equids. Objective We aimed to test the hypothesis that red complex bacteria are also associated with EOTRH-related periodontal disease. Study design Controlled cross-sectional study. Methods We screened DNA purified from crevicular fluid derived from 23 EOTRH-affected and 21 disease-free horses for the presence of Treponema spp., Tannerella spp. and Porphyromonas gingivalis DNA by polymerase chain reaction. Subsequently, amplified DNA was bidirectionally sequenced and identified via BLAST analysis. Results Treponema and/or Tannerella DNA was detected in 100% of periodontitis-related samples and in 52.2% of DNA derived from healthy horses. Twenty-six amplicon sequences were 98–100% homologous to published bacterial sequences, which mostly corresponded to Treponema pectinovorum, oral Treponema clones JU025 and OMZ 840, and Tannerella forsythia. P. gingivalis DNA was only found in 3 EOTRH-related samples. Forty-three amplicon sequences revealed weaker homologies ranging between 80% and 97% to known Treponema or Tannerella strains, partly because of their heterogeneity, partly because they obviously represented so far unknown types. Conclusions This is the first report in which known and novel Treponema and Tannerella spp. were isolated in association with EOTRH-related periodontal disease.
Frank Verstraete - One of the best experts on this subject based on the ideXlab platform.
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dental and temporomandibular joint pathology of the california mountain lion puma concolor couguar
Journal of Comparative Pathology, 2017Co-Authors: A Aghashani, Philip H Kass, Frank VerstraeteAbstract:Summary Skulls from 91 California mountain lions ( Puma concolor couguar ) were examined macroscopically and radiographically. The majority of the skulls were from young adult animals (57.1%). The skull specimens were from 42 male (46.1%) and 34 female (37.4%) animals, while the gender was unknown for the remainder. The majority (94.5%) of teeth were present for examination. Only 11 teeth were identified as absent congenitally; five of these teeth were maxillary first molar teeth and three were maxillary second premolar teeth. Abnormal Tooth morphology was identified in 3.5% of teeth. The most common abnormality in Tooth form was abnormally large crowns of the maxillary first molar teeth. Teeth with an abnormal number of roots were uncommon ( n = 21). Ninety-one teeth were found to have an abnormal number of roots, most often two-rooted maxillary first molar teeth instead of the expected one root. The most prevalent dental lesions found in the California mountain lion were attrition/abrasion (93.4%), Tooth fractures (80.2%) and periodontitis (38.5%). Less common dental lesions were Tooth Resorption ( n = 32 teeth) and endodontal disease ( n = 29 teeth).
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clinical application of cone beam computed tomography of the rabbit head part 2 dental disease
Frontiers in Veterinary Science, 2017Co-Authors: G G Riggs, Boaz Arzi, Philip H Kass, Derek D Cissell, David C Hatcher, Amy Zhen, Frank VerstraeteAbstract:Domestic rabbits are increasing in popularity as household pets; therefore veterinarians need to be familiar with the most common diseases afflicting rabbits including dental disease. Current diagnostic approaches include gross oral examination, endoscopic oral examination, skull radiography, and computed tomography (CT). Cone-beam CT (CBCT), a new oral and maxillofacial imaging modality that has the capability to produce high-resolution images, has not yet been described for use in evaluating dental disease in rabbits. A total of fifteen client-owned rabbits had CBCT, oral examination, dental charting, and dental treatment performed under general anesthesia. Images were evaluated using transverse and custom multi-planar (MPR), tridimensional (3D), and panoramic reconstructed images. The CBCT findings were grouped into abnormalities that could be detected on conscious oral examination vs. abnormalities that could not be detected by conscious oral examination. Potential associations between the two categories were examined by pairwise Fisher’s exact test with statistical significance determined by P<0.05. The most common findings identified on CBCT images were periodontal ligament space widening (14/15), premolar and molar malocclusion (13/15), apical elongation (13/15), coronal elongation (12/15), inflammatory Tooth Resorption (12/15), periapical lucency (11/15), moth-eaten pattern of osteolysis of the alveolar bone (9/15), ventral mandibular border contour changes (9/15), and missing teeth (8/15). Of the CBCT abnormalities likely to be observed on oral examination, coronal elongation (detectable on oral examination) was significantly associated with apical elongation (P=0.029). There were no other significant associations between CBCT findings that are also clinically detectable and CBCT findings that are not be detectable on oral examination. This suggests that pathology often exists that is not apparent upon oral examination. This study establishes the common CBCT findings associated with dental disease in rabbits and demonstrates the feasibility of this technology to diagnose and plan treatment in dental disorders in this species.
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Radiographic evaluation in clinical practice of the types and stage of incisor Tooth Resorption and hypercementosis in horses.
Equine veterinary journal, 2016Co-Authors: Travis J Henry, Sarah M. Puchalski, Boaz Arzi, Philip H Kass, Frank VerstraeteAbstract:SummaryBackground There are several reports of incisor Tooth Resorption and hypercementosis in horses but to date studies have been limited in case numbers and to advanced lesions. Tooth Resorption in other species is a radiographic diagnosis of types of Resorption that are often identified before clinical signs. Our goal was to evaluate radiographically incisor Tooth Resorption in a large population of horses, utilising interpretation criteria from canine and human dentistry. Objective To document and classify incisor Tooth Resorption and hypercementosis. Study design Retrospective descriptive case series. Methods Horses presented for routine dental care, >5 years old were included only if owners were unaware of incisor pathology. Radiographs (3 views) were obtained of the incisor teeth and incisor teeth Resorption was classified according to the radiographic criteria described for humans and dogs. Hypercementosis and its location were recorded. Results Tooth Resorption was detected in 149 of 169 (88.2%) horses and 951 of 1952 (48.7%) of incisor teeth. The classification system used was applicable in 926 (97.2%) of 951 affected teeth. Hypercementosis was detected in 34 (20.1%) horses and 148 (7.6%) teeth. As horses increased in age, Resorption and hypercementosis was more frequent; no significant differences were found among sex or breed categories. All horses with hypercementosis had Resorption, but only 23.4% of horses with Resorption had hypercementosis. Advanced (stage ≥3) Resorption was detected in 159 (8.1%) teeth and 54 (32.0%) horses in an otherwise clinically healthy population. Main limitations Certain horses’ anatomy precluded isolation of the mandibular third incisor teeth from the canine teeth due to superimposition. Conclusions Incisor Tooth Resorption, in particular external replacement Resorption and external inflammatory Resorption, is common in horses. Hypercementosis is consistently associated with Resorption but the inverse association is inconsistent. This article is protected by copyright. All rights reserved.
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dental pathology of the california bobcat lynx rufus californicus
Journal of Comparative Pathology, 2016Co-Authors: A Aghashani, Philip H Kass, A S Kim, Frank VerstraeteAbstract:Skulls from 277 California bobcats (Lynx rufus californicus) were examined macroscopically and by radiography. The majority of the skulls were from adult animals (79.8%). The skulls were from 128 male (46.2%) and 114 female (41.2%) animals and gender was unknown for the remainder. The majority (95.6%) of teeth were present for examination. Only 16 teeth were identified as absent congenitally and 15 of these were incisor teeth. Teeth with abnormal morphology were rare (0.5%). The two most common abnormalities were unusually large crowns of the maxillary first molar teeth and bigemination of the mandibular incisor teeth. Teeth with an abnormal number of roots were uncommon (n = 68). Sixty-three teeth had abnormal roots, mostly the presence of two roots instead of one for the maxillary first molar Tooth. The most prevalent dental lesions found in the California bobcat were attrition/abrasion (85.2%), periodontitis (56.0%) and Tooth fractures (50.9%). Less common dental lesions were endodontal disease (n = 114 teeth) and Tooth Resorption (n = 73 teeth).
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radiographic evaluation of the types of Tooth Resorption in dogs
American Journal of Veterinary Research, 2010Co-Authors: Santiago Peralta, Frank Verstraete, Philip H KassAbstract:Objective—To determine the prevalence of Tooth Resorption in dogs and to evaluate whether a classification system for Tooth Resorption in humans is applicable in this species. Animals—224 dogs > 1 year old admitted for periodontal treatment or other dental procedures in 2007 Procedures—Full-mouth radiographs of all dogs were reviewed for evidence of Tooth Resorption. Tooth Resorption was classified in accordance with radiographic criteria described for use in humans. Patient signalment and concurrent dental conditions were recorded and tabulated. Results—Tooth Resorption was detected in 120 of 224 (53.6%) dogs and 943 of 8,478 (11.1%) teeth. The classification system for use in humans was applicable in 908 of 943 (96.3%) affected teeth. Tooth Resorption was more frequent among older and large-breed dogs; no significant differences were found among sex categories. The 2 most common types of Tooth Resorption were external replacement Resorption (77/224 [34.4%] dogs and 736/8,478 [8.7%] teeth) and external i...
Joanna S Price - One of the best experts on this subject based on the ideXlab platform.
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identifying early osteoclastic resorptive lesions in feline teeth a model for understanding the origin of multiple idiopathic root Resorption
Journal of Periodontal Research, 2009Co-Authors: A Delaurier, A Boyde, Michael A Horton, B F Jackson, Joanna S PriceAbstract:Background and Objective: Domestic cats commonly suffer from external osteoclastic Tooth Resorption, a disease with many similarities to human multiple idiopathic root Resorption. In both diseases, it is unclear whether anatomical features of the Tooth surface are associated with a predisposition for resorptive lesions. The aim of the present study was to investigate the origin and progression of early feline osteoclastic resorptive lesions in teeth exhibiting no clinical signs of disease. Material and Methods: The entire surfaces of 138 teeth from 13 adult cats were analysed using back-scattered electron microscopy. The distribution of lesions was assessed by Tooth type, location and between individuals. Results: Seventy-three (53%) teeth showed at least one resorptive lesion. Eleven (85%) cats had lesions, and there was a significant association between increasing age and incidence of resorptive lesions. The highest frequency occurred in mandibular molars (82%). On average, there were 3.5 lesions per Tooth. Fifty-two (38%) teeth featured resorptive lesions at the cemento–enamel junction. Twenty-three per cent of teeth with resorptive lesions showed evidence of repair of lesions that was limited to the root surface. There was no evidence of repair of resorptive lesions at the cemento–enamel junction. Conclusion: Resorption is prevalent without evidence of clinical disease, and occured at younger ages than previously reported. It can initiate anywhere on the root surface, but lack of repair of lesions at the cemento–enamel junction indicates that mechanisms of replacement are absent or compromised in this region. Whereas Resorption of the root may undergo repair, Resorption at the cervix may progress to clinically evident lesions.
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a scanning electron microscopy study of idiopathic external Tooth Resorption in the cat
Journal of Periodontology, 2005Co-Authors: April Delaurier, A Boyde, Michael A Horton, Joanna S PriceAbstract:Background: Multiple idiopathic root Resorption (MIRR) is a rare condition in man characterized by cervical Resorption leading to significant Tooth loss. A similar condition, feline osteoclastic resorptive lesions (FORL), affects up to 70% of domestic cats and thus provides a valuable model for investigating the etiopathogenesis of MIRR. The aim of the present study was to establish changes in the surface microanatomy of the Tooth in late stage FORL and to identify whether its location has a surface bias. Methods: Scanning electron microscopy (SEM) was used to analyze the surface features of enamel and cementum of feline teeth affected with advanced FORL. Results: Resorption involved the coronal root at the cementoenamel junction (CEJ) in 95% of teeth and focal Resorption of intact enamel was observed in 14% of teeth. In 55% of teeth, the main lesion was on the buccal surface and a distinct circumferential Resorption "front" was present at the apical margin of Resorption. The root surfaces of most affecte...
Sabine Sykora - One of the best experts on this subject based on the ideXlab platform.
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isolation of treponema and tannerella spp from equine odontoclastic Tooth Resorption and hypercementosis related periodontal disease
Equine Veterinary Journal, 2014Co-Authors: Sabine Sykora, K Pieber, V Hackl, D Brodesser, H Simhofer, Sabine BrandtAbstract:Summary Reasons for performing study Red complex bacteria, i.e. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, are involved in the onset and progression of periodontal disease in man, yet seldom inhabit the oral cavity of healthy individuals. Periodontal disease is also encountered in horses, with equine odontoclastic Tooth Resorption and hypercementosis (EOTRH) constituting a particular form of disease. However, only little is known about the oral microbiome of healthy and periodontitis-affected equids. Objective We aimed to test the hypothesis that red complex bacteria are also associated with EOTRH-related periodontal disease. Study design Controlled cross-sectional study. Methods We screened DNA purified from crevicular fluid derived from 23 EOTRH-affected and 21 disease-free horses for the presence of Treponema spp., Tannerella spp. and Porphyromonas gingivalis DNA by polymerase chain reaction. Subsequently, amplified DNA was bidirectionally sequenced and identified via BLAST analysis. Results Treponema and/or Tannerella DNA was detected in 100% of periodontitis-related samples and in 52.2% of DNA derived from healthy horses. Twenty-six amplicon sequences were 98–100% homologous to published bacterial sequences, which mostly corresponded to Treponema pectinovorum, oral Treponema clones JU025 and OMZ 840, and Tannerella forsythia. P. gingivalis DNA was only found in 3 EOTRH-related samples. Forty-three amplicon sequences revealed weaker homologies ranging between 80% and 97% to known Treponema or Tannerella strains, partly because of their heterogeneity, partly because they obviously represented so far unknown types. Conclusions This is the first report in which known and novel Treponema and Tannerella spp. were isolated in association with EOTRH-related periodontal disease.
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isolation of treponema and tannerella spp from equine odontoclastic Tooth Resorption and hypercementosis related periodontal disease
Equine Veterinary Journal, 2014Co-Authors: Sabine Sykora, K Pieber, V Hackl, D Brodesser, H Simhofer, Sabine BrandtAbstract:Summary Reasons for performing study Red complex bacteria, i.e. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, are involved in the onset and progression of periodontal disease in man, yet seldom inhabit the oral cavity of healthy individuals. Periodontal disease is also encountered in horses, with equine odontoclastic Tooth Resorption and hypercementosis (EOTRH) constituting a particular form of disease. However, only little is known about the oral microbiome of healthy and periodontitis-affected equids. Objective We aimed to test the hypothesis that red complex bacteria are also associated with EOTRH-related periodontal disease. Study design Controlled cross-sectional study. Methods We screened DNA purified from crevicular fluid derived from 23 EOTRH-affected and 21 disease-free horses for the presence of Treponema spp., Tannerella spp. and Porphyromonas gingivalis DNA by polymerase chain reaction. Subsequently, amplified DNA was bidirectionally sequenced and identified via BLAST analysis. Results Treponema and/or Tannerella DNA was detected in 100% of periodontitis-related samples and in 52.2% of DNA derived from healthy horses. Twenty-six amplicon sequences were 98–100% homologous to published bacterial sequences, which mostly corresponded to Treponema pectinovorum, oral Treponema clones JU025 and OMZ 840, and Tannerella forsythia. P. gingivalis DNA was only found in 3 EOTRH-related samples. Forty-three amplicon sequences revealed weaker homologies ranging between 80% and 97% to known Treponema or Tannerella strains, partly because of their heterogeneity, partly because they obviously represented so far unknown types. Conclusions This is the first report in which known and novel Treponema and Tannerella spp. were isolated in association with EOTRH-related periodontal disease.
K Pieber - One of the best experts on this subject based on the ideXlab platform.
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isolation of treponema and tannerella spp from equine odontoclastic Tooth Resorption and hypercementosis related periodontal disease
Equine Veterinary Journal, 2014Co-Authors: Sabine Sykora, K Pieber, V Hackl, D Brodesser, H Simhofer, Sabine BrandtAbstract:Summary Reasons for performing study Red complex bacteria, i.e. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, are involved in the onset and progression of periodontal disease in man, yet seldom inhabit the oral cavity of healthy individuals. Periodontal disease is also encountered in horses, with equine odontoclastic Tooth Resorption and hypercementosis (EOTRH) constituting a particular form of disease. However, only little is known about the oral microbiome of healthy and periodontitis-affected equids. Objective We aimed to test the hypothesis that red complex bacteria are also associated with EOTRH-related periodontal disease. Study design Controlled cross-sectional study. Methods We screened DNA purified from crevicular fluid derived from 23 EOTRH-affected and 21 disease-free horses for the presence of Treponema spp., Tannerella spp. and Porphyromonas gingivalis DNA by polymerase chain reaction. Subsequently, amplified DNA was bidirectionally sequenced and identified via BLAST analysis. Results Treponema and/or Tannerella DNA was detected in 100% of periodontitis-related samples and in 52.2% of DNA derived from healthy horses. Twenty-six amplicon sequences were 98–100% homologous to published bacterial sequences, which mostly corresponded to Treponema pectinovorum, oral Treponema clones JU025 and OMZ 840, and Tannerella forsythia. P. gingivalis DNA was only found in 3 EOTRH-related samples. Forty-three amplicon sequences revealed weaker homologies ranging between 80% and 97% to known Treponema or Tannerella strains, partly because of their heterogeneity, partly because they obviously represented so far unknown types. Conclusions This is the first report in which known and novel Treponema and Tannerella spp. were isolated in association with EOTRH-related periodontal disease.
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isolation of treponema and tannerella spp from equine odontoclastic Tooth Resorption and hypercementosis related periodontal disease
Equine Veterinary Journal, 2014Co-Authors: Sabine Sykora, K Pieber, V Hackl, D Brodesser, H Simhofer, Sabine BrandtAbstract:Summary Reasons for performing study Red complex bacteria, i.e. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia, are involved in the onset and progression of periodontal disease in man, yet seldom inhabit the oral cavity of healthy individuals. Periodontal disease is also encountered in horses, with equine odontoclastic Tooth Resorption and hypercementosis (EOTRH) constituting a particular form of disease. However, only little is known about the oral microbiome of healthy and periodontitis-affected equids. Objective We aimed to test the hypothesis that red complex bacteria are also associated with EOTRH-related periodontal disease. Study design Controlled cross-sectional study. Methods We screened DNA purified from crevicular fluid derived from 23 EOTRH-affected and 21 disease-free horses for the presence of Treponema spp., Tannerella spp. and Porphyromonas gingivalis DNA by polymerase chain reaction. Subsequently, amplified DNA was bidirectionally sequenced and identified via BLAST analysis. Results Treponema and/or Tannerella DNA was detected in 100% of periodontitis-related samples and in 52.2% of DNA derived from healthy horses. Twenty-six amplicon sequences were 98–100% homologous to published bacterial sequences, which mostly corresponded to Treponema pectinovorum, oral Treponema clones JU025 and OMZ 840, and Tannerella forsythia. P. gingivalis DNA was only found in 3 EOTRH-related samples. Forty-three amplicon sequences revealed weaker homologies ranging between 80% and 97% to known Treponema or Tannerella strains, partly because of their heterogeneity, partly because they obviously represented so far unknown types. Conclusions This is the first report in which known and novel Treponema and Tannerella spp. were isolated in association with EOTRH-related periodontal disease.