The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Jurg Utzinger - One of the best experts on this subject based on the ideXlab platform.
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human and livestock trematode infections in a mobile pastoralist setting at lake chad added value of a one health approach beyond zoonotic diseases research
Transactions of The Royal Society of Tropical Medicine and Hygiene, 2017Co-Authors: Jurg Utzinger, Jan Hattendorf, Helena Greter, Annour A Batil, Bongo Nare Richard Ngandolo, Idriss O Alfaroukh, D D MotoAbstract:Background At Lake Chad in Central Africa, mobile pastoralists face economic losses due to livestock trematodiases. Fasciola gigantica and Schistosoma bovis-trematodes that affect livestock-share transmission ecology traits with Schistosoma haematobium and S. mansoni that cause human schistosomiasis. This project aimed at assessing treatment strategies and elucidating the predictive potential of human and livestock trematode infections. Methods Schistosomiasis and fascioliasis were investigated concurrently in humans and cattle by repeated cross-sectional surveys. Urine and stool samples from humans and faecal samples from cattle were examined for trematode eggs. Treatment strategies were assessed by means of focus group discussions and in-depth interviews. Results Mobile pastoralists of four ethnic groups participated. Prevalence of human schistosomiasis and livestock trematodiases showed considerable heterogeneity from one ethnic group to another, but correlated within ethnic groups. Effective trematocidal drugs were not available in the study area. Conclusions Mutual predictive potential of human schistosomiasis and livestock fascioliasis relates to distinct livestock husbandry practices. Introducing efficacious strategic treatment against human schistosomiasis and livestock fascioliasis might improve human and animal health and well-being. Our research provides evidence for the benefits of a One Health approach targeting diseases that share specific ecological traits.
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china s sustained drive to eliminate neglected tropical diseases
Lancet Infectious Diseases, 2014Co-Authors: Guojing Yang, Jurg Utzinger, Marcel Tanner, Sian M Griffiths, Robert Bergquist, Xiao-nong ZhouAbstract:Non-communicable diseases dominate the public health arena in China, yet neglected tropical diseases (NTDs) are still widespread and create a substantial burden. We review the geographical distribution, prevalence, and epidemic characteristics of NTDs identifi ed in China caused by helminths, protozoa, bacteria, and viruses. Lymphatic fi lariasis was eliminated in 2007, but schistosomiasis still aff ects up to 5% of local village residents in some endemic counties with around 300 000 people infected. China harbours more than 90% of the world’s burden of alveolar echinococcosis and food-borne zoonoses are emerging. In 2010, the overall prevalence of soil-transmitted helminth infections caused by Ascaris lumbricoides, Trichuris trichiura, and hookworm was 11·4%, with 6·8% of these infections caused by A lumbricoides. Corresponding fi gures for food-borne Trematodiasis, echinococcosis, and cysticercosis are more than 5%. Dengue, leishmaniasis, leprosy, rabies, and trachoma exist in many areas and should not be overlooked. Transmission of vector-borne diseases can be interrupted; nevertheless, epidemics occur in remote areas, creating a challenge for surveillance and control. Rigorous surveillance, followed by immediate and integrated response packages tailored to specifi c social and ecological systems, is essential for progress towards the elimination of NTDs in China.
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problem, particularly in Southeast Asia and the Western
2013Co-Authors: Emerging Foodborne Trematodiasis, Jennifer Keiser, Jurg UtzingerAbstract:Foodborne Trematodiasis is an emerging public healt
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trematode infections liver and lung flukes
Infectious Disease Clinics of North America, 2012Co-Authors: Thomas Furst, Jurg Utzinger, Urs Duthaler, Banchop Sripa, Jennifer KeiserAbstract:Food-borne trematodiases are an emerging public health problem in Southeast Asia and Latin America and of growing importance for travel clinics in Europe and North America. The disease is caused by chronic infections with liver, lung, and intestinal flukes. This article focuses on the most important liver and lung flukes that parasitize man, namely Clonorchis sinensis, Fasciola gigantica, Fasciola hepatica, Opisthorchis felineus, Opisthorchis viverrini, and Paragonimus spp. The article describes the epidemiology of major liver and lung fluke infections, including current distribution, burden, life cycle, clinical signs and symptoms, diagnostic approaches, and current tools for prevention, treatment, and control
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global burden of human food borne Trematodiasis a systematic review and meta analysis
Lancet Infectious Diseases, 2012Co-Authors: Jurg Utzinger, Thomas Furst, Jennifer KeiserAbstract:Summary Background Food-borne trematodiases are a group of neglected tropical diseases caused by liver, lung, and intestinal parasitic fluke infections. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD 2010 study) and a WHO initiative, we assessed the global burden of human food-borne Trematodiasis, as expressed in disability-adjusted life years (DALYs) for the year 2005. Methods We systematically searched electronic databases for reports about human food-borne Trematodiasis without language restriction, between Jan 1, 1980, and Dec 31, 2008. We used a broad search strategy with a combination of search terms and parasite and disease names. The initial search results were then screened on the basis of title, abstract, and, finally, full text. Relevant quantitative and qualitative data on human prevalence, morbidity, and mortality of food-borne Trematodiasis were extracted. On the basis of available information on pathological and clinical appearance, we developed simplified disease models and did meta-analyses on the proportions and odds ratios of specified sequelae and estimated the global burden of human food-borne Trematodiasis. Findings We screened 33 921 articles and identified 181 eligible studies containing quantitative information for inclusion in the meta-analyses. About 56·2 million people were infected with food-borne trematodes in 2005: 7·9 million had severe sequelae and 7158 died, most from cholangiocarcinoma and cerebral infection. Taken together, we estimate that the global burden of food-borne Trematodiasis was 665 352 DALYs (lower estimate 479 496 DALYs; upper estimate 859 051 DALYs). Furthermore, knowledge gaps in crucial epidemiological disease parameters and methodological features for estimating the global burden of parasitic diseases that are characterised by highly focal spatial occurrence and scarce and patchy information were highlighted. Interpretation Despite making conservative estimates, we found that food-borne trematodiases are an important cluster of neglected diseases. Funding Swiss National Science Foundation; Institute for Health Metrics and Evaluation.
Jennifer Keiser - One of the best experts on this subject based on the ideXlab platform.
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problem, particularly in Southeast Asia and the Western
2013Co-Authors: Emerging Foodborne Trematodiasis, Jennifer Keiser, Jurg UtzingerAbstract:Foodborne Trematodiasis is an emerging public healt
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trematode infections liver and lung flukes
Infectious Disease Clinics of North America, 2012Co-Authors: Thomas Furst, Jurg Utzinger, Urs Duthaler, Banchop Sripa, Jennifer KeiserAbstract:Food-borne trematodiases are an emerging public health problem in Southeast Asia and Latin America and of growing importance for travel clinics in Europe and North America. The disease is caused by chronic infections with liver, lung, and intestinal flukes. This article focuses on the most important liver and lung flukes that parasitize man, namely Clonorchis sinensis, Fasciola gigantica, Fasciola hepatica, Opisthorchis felineus, Opisthorchis viverrini, and Paragonimus spp. The article describes the epidemiology of major liver and lung fluke infections, including current distribution, burden, life cycle, clinical signs and symptoms, diagnostic approaches, and current tools for prevention, treatment, and control
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global burden of human food borne Trematodiasis a systematic review and meta analysis
Lancet Infectious Diseases, 2012Co-Authors: Jurg Utzinger, Thomas Furst, Jennifer KeiserAbstract:Summary Background Food-borne trematodiases are a group of neglected tropical diseases caused by liver, lung, and intestinal parasitic fluke infections. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD 2010 study) and a WHO initiative, we assessed the global burden of human food-borne Trematodiasis, as expressed in disability-adjusted life years (DALYs) for the year 2005. Methods We systematically searched electronic databases for reports about human food-borne Trematodiasis without language restriction, between Jan 1, 1980, and Dec 31, 2008. We used a broad search strategy with a combination of search terms and parasite and disease names. The initial search results were then screened on the basis of title, abstract, and, finally, full text. Relevant quantitative and qualitative data on human prevalence, morbidity, and mortality of food-borne Trematodiasis were extracted. On the basis of available information on pathological and clinical appearance, we developed simplified disease models and did meta-analyses on the proportions and odds ratios of specified sequelae and estimated the global burden of human food-borne Trematodiasis. Findings We screened 33 921 articles and identified 181 eligible studies containing quantitative information for inclusion in the meta-analyses. About 56·2 million people were infected with food-borne trematodes in 2005: 7·9 million had severe sequelae and 7158 died, most from cholangiocarcinoma and cerebral infection. Taken together, we estimate that the global burden of food-borne Trematodiasis was 665 352 DALYs (lower estimate 479 496 DALYs; upper estimate 859 051 DALYs). Furthermore, knowledge gaps in crucial epidemiological disease parameters and methodological features for estimating the global burden of parasitic diseases that are characterised by highly focal spatial occurrence and scarce and patchy information were highlighted. Interpretation Despite making conservative estimates, we found that food-borne trematodiases are an important cluster of neglected diseases. Funding Swiss National Science Foundation; Institute for Health Metrics and Evaluation.
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in vitro and in vivo trematode models for chemotherapeutic studies
Parasitology, 2010Co-Authors: Jennifer KeiserAbstract:Schistosomiasis and food-borne trematodiases are chronic parasitic diseases affecting millions of people mostly in the developing world. Additional drugs should be developed as only few drugs are available for treatment and drug resistance might emerge. In vitro and in vivo whole parasite screens represent essential components of the trematodicidal drug discovery cascade. This review describes the current state-of-the-art of in vitro and in vivo screening systems of the blood fluke Schistosoma mansoni, the liver fluke Fasciola hepatica and the intestinal fluke Echinostoma caproni. Examples of in vitro and in vivo evaluation of compounds for activity are presented. To boost the discovery pipeline for these diseases there is a need to develop validated, robust high-throughput in vitro systems with simple readouts.
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The Drugs We Have and the Drugs We Need Against Major Helminth Infections
Advances in parasitology, 2010Co-Authors: Jennifer Keiser, Jurg UtzingerAbstract:Parasitic worms (helminths) have accompanied humans for thousands of years and, still today, they are pervasive where poverty persists, including large parts of Southeast Asia and the Western Pacific Region. The global strategy for the control of helminth infections is morbidity control and elimination as a public health problem. Regular administration of anthelminthic drugs to at-risk populations (e.g. school-aged children) serves as the backbone of interventions in areas where helminth infections are highly endemic. In this review, we focus on soil-transmitted helminthiasis (ascariasis, hookworm disease, strongyloidiasis and trichuriasis) and food-borne Trematodiasis (clonorchiasis, fascioliasis, intestinal fluke infections, opisthorchiasis and paragonimiasis) and discuss the few drugs that are currently available for their treatment and control. Emphasis is placed on efficacy with new light shed on multiple dosing and combination therapy. We summarise recent advances made with anthelminthic drugs that might become the future armentarium for the control of major helminthiasis (e.g. artemisinins, cyclooctadepsipeptides, mefloquine, monepantel, nitazoxandide, synthetic peroxides and tribendimidine). Issuing from our review are current research gaps and the need for concerted efforts to discover, develop and deploy the next generation of anthelminthic drugs.
Per Westermark - One of the best experts on this subject based on the ideXlab platform.
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post mortem findings and their relation to aa amyloidosis in free ranging herring gulls larus argentatus
PLOS ONE, 2018Co-Authors: Désirée S. Jansson, Caroline Bröjer, Aleksija Neimanis, Torsten Mörner, Charles L. Murphy, Faruk Otman, Per WestermarkAbstract:Since the late 1990s, high mortality and declining populations have been reported among sea birds including Herring gulls (Larus argentatus) from the Baltic Sea area in Northern Europe. Repeated BoNT type C/D botulism outbreaks have occurred, but it remains unclear whether this is the sole and primary cause of mortality. Thiamine deficiency has also been suggested as a causal or contributing factor. With this study, we aimed to investigate gross and microscopic pathology in Herring gulls from affected breeding sites in Sweden in search of contributing diseases. Herring gulls from Iceland served as controls. Necropsies and histopathology were performed on 75 birds, of which 12 showed signs of disease at the time of necropsy. Parasites of various classes and tissues were commonly observed independent of host age, e.g. oesophageal capillariosis and nematode infection in the proventriculus and gizzard with severe inflammation, air sac larid pentastomes and bursal Trematodiasis in pre-fledglings. Gross and microscopic findings are described. Notably, amyloidosis was diagnosed in 93 and 33% of the adult birds from Sweden and Iceland, respectively (p<0.001), with more pronounced deposits in Swedish birds (p<0.001). Gastrointestinal deposits were observed in the walls of arteries or arterioles, and occasionally in villi near the mucosal surface. Amyloid was identified within the intestinal lumen in one severely affected gull suggesting the possibility of oral seeding and the existence of a primed state as previously described in some mammals and chickens. This could speculatively explain the high occurrence and previously reported rapid onset of amyloidosis upon inflammation or captivity in Herring gulls. Amyloid-induced malabsorbtion is also a possibility. The Herring gull SAA/AA protein sequence was shown to be highly conserved but differed at the N-terminus from other avian species.
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Microscopic parasite findings in Herring gulls (Larus argentatus).
2018Co-Authors: Désirée S. Jansson, Caroline Bröjer, Aleksija Neimanis, Torsten Mörner, Charles L. Murphy, Faruk Otman, Per WestermarkAbstract:(A) Nematode infection in the gizzard with disruption of the koilin layer, focal necroses and lymphoplasmacytic inflammation (bird no. 12, S1 Table). H&E, bar 100 μm. (B) Trematodiasis (Ichtyocotylarus platycephalus (Creplin, 1825) of the bursa of Fabricius. Lymphocyte and heterophilic granulocyte infiltration and effacement of lymphoid follicles can be observed adjacent to rostral parasite structures (bird no. 6, S1 Table). H&E, bar 100 μm. (C–D) Oesophageal mucosa infected by Capillaria sp. Parasite eggs are present in the mucosa and in the lumen in association with inflammatory cells and necrotic debris (bird no. 11, S2 Table). H&E, bar 100 μm (C), 50 μm (D). (E) Proventricular mucosa with a trematode present in a submucosal gland. Note compression of glandular epithelium and absence of an inflammatory reaction (bird no. 6, S2 Table). H&E, bar 50 μm. (F) Jejunal villi with large numbers of parasite larvae (bird no. 17, S2 Table). H&E, bar 50 μm.
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Post mortem findings and their relation to AA amyloidosis in free-ranging Herring gulls (Larus argentatus)
2018Co-Authors: Désirée S. Jansson, Caroline Bröjer, Aleksija Neimanis, Torsten Mörner, Charles L. Murphy, Faruk Otman, Per WestermarkAbstract:Since the late 1990s, high mortality and declining populations have been reported among sea birds including Herring gulls (Larus argentatus) from the Baltic Sea area in Northern Europe. Repeated BoNT type C/D botulism outbreaks have occurred, but it remains unclear whether this is the sole and primary cause of mortality. Thiamine deficiency has also been suggested as a causal or contributing factor. With this study, we aimed to investigate gross and microscopic pathology in Herring gulls from affected breeding sites in Sweden in search of contributing diseases. Herring gulls from Iceland served as controls. Necropsies and histopathology were performed on 75 birds, of which 12 showed signs of disease at the time of necropsy. Parasites of various classes and tissues were commonly observed independent of host age, e.g. oesophageal capillariosis and nematode infection in the proventriculus and gizzard with severe inflammation, air sac larid pentastomes and bursal Trematodiasis in pre-fledglings. Gross and microscopic findings are described. Notably, amyloidosis was diagnosed in 93 and 33% of the adult birds from Sweden and Iceland, respectively (p
Désirée S. Jansson - One of the best experts on this subject based on the ideXlab platform.
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post mortem findings and their relation to aa amyloidosis in free ranging herring gulls larus argentatus
PLOS ONE, 2018Co-Authors: Désirée S. Jansson, Caroline Bröjer, Aleksija Neimanis, Torsten Mörner, Charles L. Murphy, Faruk Otman, Per WestermarkAbstract:Since the late 1990s, high mortality and declining populations have been reported among sea birds including Herring gulls (Larus argentatus) from the Baltic Sea area in Northern Europe. Repeated BoNT type C/D botulism outbreaks have occurred, but it remains unclear whether this is the sole and primary cause of mortality. Thiamine deficiency has also been suggested as a causal or contributing factor. With this study, we aimed to investigate gross and microscopic pathology in Herring gulls from affected breeding sites in Sweden in search of contributing diseases. Herring gulls from Iceland served as controls. Necropsies and histopathology were performed on 75 birds, of which 12 showed signs of disease at the time of necropsy. Parasites of various classes and tissues were commonly observed independent of host age, e.g. oesophageal capillariosis and nematode infection in the proventriculus and gizzard with severe inflammation, air sac larid pentastomes and bursal Trematodiasis in pre-fledglings. Gross and microscopic findings are described. Notably, amyloidosis was diagnosed in 93 and 33% of the adult birds from Sweden and Iceland, respectively (p<0.001), with more pronounced deposits in Swedish birds (p<0.001). Gastrointestinal deposits were observed in the walls of arteries or arterioles, and occasionally in villi near the mucosal surface. Amyloid was identified within the intestinal lumen in one severely affected gull suggesting the possibility of oral seeding and the existence of a primed state as previously described in some mammals and chickens. This could speculatively explain the high occurrence and previously reported rapid onset of amyloidosis upon inflammation or captivity in Herring gulls. Amyloid-induced malabsorbtion is also a possibility. The Herring gull SAA/AA protein sequence was shown to be highly conserved but differed at the N-terminus from other avian species.
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Microscopic parasite findings in Herring gulls (Larus argentatus).
2018Co-Authors: Désirée S. Jansson, Caroline Bröjer, Aleksija Neimanis, Torsten Mörner, Charles L. Murphy, Faruk Otman, Per WestermarkAbstract:(A) Nematode infection in the gizzard with disruption of the koilin layer, focal necroses and lymphoplasmacytic inflammation (bird no. 12, S1 Table). H&E, bar 100 μm. (B) Trematodiasis (Ichtyocotylarus platycephalus (Creplin, 1825) of the bursa of Fabricius. Lymphocyte and heterophilic granulocyte infiltration and effacement of lymphoid follicles can be observed adjacent to rostral parasite structures (bird no. 6, S1 Table). H&E, bar 100 μm. (C–D) Oesophageal mucosa infected by Capillaria sp. Parasite eggs are present in the mucosa and in the lumen in association with inflammatory cells and necrotic debris (bird no. 11, S2 Table). H&E, bar 100 μm (C), 50 μm (D). (E) Proventricular mucosa with a trematode present in a submucosal gland. Note compression of glandular epithelium and absence of an inflammatory reaction (bird no. 6, S2 Table). H&E, bar 50 μm. (F) Jejunal villi with large numbers of parasite larvae (bird no. 17, S2 Table). H&E, bar 50 μm.
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Post mortem findings and their relation to AA amyloidosis in free-ranging Herring gulls (Larus argentatus)
2018Co-Authors: Désirée S. Jansson, Caroline Bröjer, Aleksija Neimanis, Torsten Mörner, Charles L. Murphy, Faruk Otman, Per WestermarkAbstract:Since the late 1990s, high mortality and declining populations have been reported among sea birds including Herring gulls (Larus argentatus) from the Baltic Sea area in Northern Europe. Repeated BoNT type C/D botulism outbreaks have occurred, but it remains unclear whether this is the sole and primary cause of mortality. Thiamine deficiency has also been suggested as a causal or contributing factor. With this study, we aimed to investigate gross and microscopic pathology in Herring gulls from affected breeding sites in Sweden in search of contributing diseases. Herring gulls from Iceland served as controls. Necropsies and histopathology were performed on 75 birds, of which 12 showed signs of disease at the time of necropsy. Parasites of various classes and tissues were commonly observed independent of host age, e.g. oesophageal capillariosis and nematode infection in the proventriculus and gizzard with severe inflammation, air sac larid pentastomes and bursal Trematodiasis in pre-fledglings. Gross and microscopic findings are described. Notably, amyloidosis was diagnosed in 93 and 33% of the adult birds from Sweden and Iceland, respectively (p
Pewpan M. Intapan - One of the best experts on this subject based on the ideXlab platform.
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Copyright © 2014 by The American Society of Tropical Medicine and Hygiene Short Report: Current Status of Human Hookworm Infections, Ascariasis, Trichuriasis, Schistosomiasis Mekongi and Other Trematodiases in Lao People’s Democratic Republic
2016Co-Authors: Sakhone Laymanivong, Oranuch Sanpool, Wanchai Maleewong, Bouasy Hangvanthong, Boualy Keokhamphavanh, Manisak Phommasansak, Baunphone Phinmal, Pewpan M. IntapanAbstract:Abstract. Soil-transmitted helminth (STH) infections, and schistosomiasis and other trematodiases often have a high prevalence in developing countries. Here, we present updated information on the prevalence of these parasites in the Lao People’s Democratic Republic (Lao PDR) in 2012, arising from the annual national helminthiasis survey. Fecal specimens were collected from 8,610 inhabitants of 12 provinces and one municipality (Bokeo, Houaphan, Luang Namtha, Luang Prabang, Oudomxay, and Phongsaly Provinces from northern Lao PDR; Bolikhamxay and Xieng Khouang Provinces and Vientiane Municipality from the central part of the country; and Attapeu, Champasak, Saravan, and Sekong Provinces from southern Lao PDR). The overall prevalence of three major STHs, Ascaris lumbricoides, Trichuris trichiura, and hookworms (Necator americanus and Ancylostoma duodenale) were 11.6%, 8.5%, and 25.0%, respectively. Prevalence of Schistosoma mekongi infection was 0.1%, and of miscellaneous trematodiases (including opisthorchiasis) was 14.0%. Clearly, the nationwide parasite control project is still necessary to reduce morbidity caused by helminthic diseases. Three major soil-transmitted helminths (STHs), i.e., round-worms (Ascaris lumbricoides), whipworms (Trichuris trichiura), and hookworms (Necator americanus and Ancylostoma duodenale) are important public health problems
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current status of human hookworm infections ascariasis trichuriasis schistosomiasis mekongi and other trematodiases in lao people s democratic republic
American Journal of Tropical Medicine and Hygiene, 2014Co-Authors: Sakhone Laymanivong, Bouasy Hangvanthong, Boualy Keokhamphavanh, Manisak Phommasansak, Baunphone Phinmaland, Pewpan M. IntapanAbstract:Soil-transmitted helminth (STH) infections, and schistosomiasis and other trematodiases often have a high prevalence in developing countries. Here, we present updated information on the prevalence of these parasites in the Lao People's Democratic Republic (Lao PDR) in 2012, arising from the annual national helminthiasis survey. Fecal specimens were collected from 8,610 inhabitants of 12 provinces and one municipality (Bokeo, Houaphan, Luang Namtha, Luang Prabang, Oudomxay, and Phongsaly Provinces from northern Lao PDR; Bolikhamxay and Xieng Khouang Provinces and Vientiane Municipality from the central part of the country; and Attapeu, Champasak, Saravan, and Sekong Provinces from southern Lao PDR). The overall prevalence of three major STHs, Ascaris lumbricoides, Trichuris trichiura, and hookworms (Necator americanus and Ancylostoma duodenale) were 11.6%, 8.5%, and 25.0%, respectively. Prevalence of Schistosoma mekongi infection was 0.1%, and of miscellaneous trematodiases (including opisthorchiasis) was 14.0%. Clearly, the nationwide parasite control project is still necessary to reduce morbidity caused by helminthic diseases.
