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Yasmeen Syeda - One of the best experts on this subject based on the ideXlab platform.
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An isoflavone glycoside from the seeds of Trichosanthes anguina.
Phytochemistry, 1994Co-Authors: R.n. Yadava, Yasmeen SyedaAbstract:Abstract A novel isoflavone glycoside; 5,6,6′-trimethoxy-3′,4′-methylenedioxyisoflavone 7- O -β- d -(2″- O - p -coumaroylglucopyranoside), has been characterized from the seeds of Trichosanthes anguina .
Zhuju Wang - One of the best experts on this subject based on the ideXlab platform.
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Trichosanthis Fructus: botany, traditional uses, phytochemistry and pharmacology.
Journal of Ethnopharmacology, 2018Co-Authors: Liying Tang, Xiao Zhang, Hanyan Luo, Rixin Guo, Hongjun Yang, Jianwei Fan, Zhuju WangAbstract:Abstract Ethnopharmacological relevance Trichosanthis Fructus (ripe fruits of Trichosanthes kirilowii Maxim. and Trichosanthes rosthornii Harms) is an essential traditional Chinese medicine to treat thoracic obstruction, angina, cardiac failure, myocardial infarction, pulmonary heart disease, some cerebral ischaemic diseases, etc. The present report reviews the advancements in research on the botany, traditional uses, phytochemistry and pharmacology of Trichosanthis Fructus. Finally, perspectives on future research and its possible directions are discussed. Aim of the study This review provides up-to-date information about the botany, traditional uses, phytochemistry, pharmacology, toxicity and quality control of Trichosanthis Fructus and discusses the perspectives on future research and possible directions of this traditional Chinese Medicine and its origin plants. Materials and methods The information on Trichosanthes kirilowii Maxim. and Trichosanthes rosthornii Harms was collected from published scientific materials, including books; monographs on medicinal plants; pharmacopoeia and electronic databases such as SCI finder, PubMed, Web of Science, ACS, Science Direct, Wiley, Springer, Taylor, CNKI and Google Scholar. Results Approximately 162 compounds, including terpenoids, phytosterols, flavonoids, nitrogenous compounds and lignans, have been isolated and identified from Trichosanthes kirilowii Maxim. and Trichosanthes rosthornii Harms. Numerous studies have shown that the extracts and compounds isolated from these two plants exhibit pharmacological activities, including protection against myocardial ischaemia, calcium antagonist, endothelial cell protection, anti-hypoxic, anti-platelet aggregation, expectorant, anti-inflammatory, cytotoxic and antioxidant. Conclusions Trichosanthis Fructus is an essential traditional Chinese medicine with pharmacological activities that mainly affect the cardiovascular system. This review summarises its botany, traditional uses, phytochemistry and pharmacology. Future research is needed to clarify the different uses of the seeds, pericarps and fruits. Quality control of investigations of the fruits should be improved, and the potential uses of the flesh, leaves and twigs should be further explored.
R.n. Yadava - One of the best experts on this subject based on the ideXlab platform.
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An isoflavone glycoside from the seeds of Trichosanthes anguina.
Phytochemistry, 1994Co-Authors: R.n. Yadava, Yasmeen SyedaAbstract:Abstract A novel isoflavone glycoside; 5,6,6′-trimethoxy-3′,4′-methylenedioxyisoflavone 7- O -β- d -(2″- O - p -coumaroylglucopyranoside), has been characterized from the seeds of Trichosanthes anguina .
Rugayah Rugayah - One of the best experts on this subject based on the ideXlab platform.
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THE STATUS OF Trichosanthes anguina L. (CUCURBITACEAE) ) [Status Trichosanthes anguina L. (Cucurbitaceae)]
'Indonesian Institute of Sciences', 2016Co-Authors: Rugayah RugayahAbstract:Perbedaan pendapat tentang status kedudukan taksonomi Trichosanthes anguina sebagai jenis yang berbeda dengan T. cucumerina,maupun sebagai anak jenis T. cucumerina subsp. anguina atau varietas T. cucumerina var. anguina memerlukan data pendukung.Anatomi daun dengan sayatan paradermal menunjukkan bahwa keduanya mempunyai bentuk stomata dan sel epidermis yang sama,tetapi berbeda hanya pada ukurannya. Stomata Trichosanthes anguina berukuran 15-17.5 x 10-12.5 urn dan sel epidermis 22.5-31.25 x 12.5-20 m, sedangkan Trichosanthes cucumerina mempunyai stomata 10-12.5 x 8.75-12.5 um dan epidermis sel 15-25 x 10-15 um. Data tersebut mendukung dalam menetapkan T.anguina sebagai T. cucumerina var.anguina
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THE STATUS OF Trichosanthes anguina L. (CUCURBITACEAE) )*[Status Trichosanthes anguina L. (Cucurbitaceae)]
2004Co-Authors: Rugayah RugayahAbstract:Perbedaan pendapat tentang status kedudukan taksonomi Trichosanthes anguina sebagai jenis yang berbeda dengan T. cucumerina,maupun sebagai anak jenis T. cucumerina subsp. anguina atau varietas T. cucumerina var. anguina memerlukan data pendukung.Anatomi daun dengan sayatan paradermal menunjukkan bahwa keduanya mempunyai bentuk stomata dan sel epidermis yang sama,tetapi berbeda hanya pada ukurannya. Stomata Trichosanthes anguina berukuran 15-17.5 x 10-12.5 urn dan sel epidermis 22.5-31.25 x 12.5-20 m, sedangkan Trichosanthes cucumerina mempunyai stomata 10-12.5 x 8.75-12.5 um dan epidermis sel 15-25 x 10-15 um. Data tersebut mendukung dalam menetapkan T.anguina sebagai T. cucumerina var.anguina.
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SPECIES DIVERSITY OF Trichosanthes IN GUNUNG HALIMUN NATIONAL PARK
2001Co-Authors: Rugayah RugayahAbstract:Inventory Trichosanthes L. in Gunung Halimun Nasional Park have been conducted. Seven species recorded occuring in TN Gn.Halimun namely, T. montana, T. ovigera, T. pubera, T. quinquangulata, T. tricuspidata, T. villosa, and T. wawrae.These species are found mostly in humid area in edge forest, or along river sides. Trichosanthes wawrae was found in Cikaniki,whereas the other six species found in Corridor Cianten. Trichosanthes quinquangulata has widelydistributed, it has found in Cibanteng and Leuwijamang as well. Exploration is still continuing to study the distribution of this genus in Gn. Halimun, to recollect the rare species and to do phylogenetic analysis.
Krishna G Mohan - One of the best experts on this subject based on the ideXlab platform.
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hepatoprotective effect of Trichosanthes cucumerina var cucumerina l on carbon tetrachloride induced liver damage in rats
Journal of Ethnopharmacology, 2009Co-Authors: Sathesh S Kumar, Ravi B Kumar, Krishna G MohanAbstract:Abstract Ethnopharmacological relevance Different parts of the plant Trichosanthes cucumerina Var cucumerina L. (cucurbitaceae) are used to treat liver disorders, traditionally. It is one among the constituents in various Ayurvedic formulations used for the treatment of liver disorders and other diseases. Aims of study The aim of the present study is to evaluate the protective effect of Trichosanthes cucumerina against experimentally induced liver injury. Materials and methods The methanolic extract of whole plant of Trichosanthes cucumerina (TCME) was evaluated for the hepatoprotective activity against carbon tetrachloride (CCl4) induced hepatotoxicity in rats. Various biochemical parameters like alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), total bilirubin (TB), total protein (TP) and albumin (ALB) levels were estimated in serum as well as the glutathione (GSH) and malondialdehyde (MDA) levels in the liver were determined. Histopathological changes in the liver of different groups were also studied. Results The pre-treatment of TCME at dose levels of 250 and 500 mg/kg b.w.p.o. had controlled the raise of AST, ALT, ALP, TB and MDA levels and the effects were comparable with standard drug (silymarin 100 mg/kg b.w.p.o.). The GSH, TP and ALB levels were significantly increased in the animals received pre-treatment of the extract. The animals received pre-treatment of the extract shown decreased necrotic zones and hepatocellular degeneration when compared to the liver exposed to CCl4 intoxication alone. Thus the histopathalogical studies also supported the protective effect of the extract. Conclusion This study demonstrates the hepatoprotective activity of Trichosanthes cucumerina and thus scientifically supports the usage of this plant in various Ayurvedic preparations and traditional medicine for treatment of liver disorders.
