The Experts below are selected from a list of 336 Experts worldwide ranked by ideXlab platform
Mingwu Ding - One of the best experts on this subject based on the ideXlab platform.
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one pot synthesis of 1h isochromenes and 1 2 dihydroisoquinolines by a sequential isocyanide based multicomponent wittig reaction
Organic and Biomolecular Chemistry, 2016Co-Authors: Zhirong Guan, Long Wang, Mingwu DingAbstract:A one-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 5, an acid, an amine (or without), and an isocyanide gave the 1H-isochromenes 7 or 1,2-dihydroisoquinolines 9 in good yields by a sequential Passerini or Ugi Condensation and an intramolecular Wittig reaction in the presence of K2CO3.
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One-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a sequential isocyanide-based multicomponent/Wittig reaction
Organic and Biomolecular Chemistry, 2016Co-Authors: Long Wang, Zhirong Guan, Mingwu DingAbstract:A one-pot synthesis of 1H-isochromenes and 1,2-dihydroisoquinolines by a I-MCR/Wittig sequence was developed. The reaction of phosphonium salt 5, an acid, an amine (or without), and an isocyanide gave the 1H-isochromenes 7 or 1,2-dihydroisoquinolines 9 in good yields by a sequential Passerini or Ugi Condensation and an intramolecular Wittig reaction in the presence of K2CO3.
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One-Pot Synthesis of Multisubstituted Benzimidazoles via Sequential Ugi and Catalytic Aza-Wittig Reaction Starting from 2-Aminobenzoyl Azides
The Journal of organic chemistry, 2016Co-Authors: Yan-mei Yan, Yong Rao, Mingwu DingAbstract:A simple and one-pot synthesis of multisubstituted benzimidazoles by a Ugi 4CC/catalytic aza-Wittig sequence was developed. The reaction of 2-aminobenzoyl azide 2, aldehyde 3, acid 4, and isocyanide 5 produced the benzimidazoles 8 in moderate to good yields via a sequential Ugi Condensation and catalytic aza-Wittig in the presence of a catalytic amount of phospholene oxide.
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One-Pot Synthesis of Multisubstituted Benzimidazoles via Sequential Ugi and Catalytic Aza-Wittig Reaction Starting from 2‑Aminobenzoyl Azides
2016Co-Authors: Yan-mei Yan, Yong Rao, Mingwu DingAbstract:A simple and one-pot synthesis of multisubstituted benzimidazoles by a Ugi 4CC/catalytic aza-Wittig sequence was developed. The reaction of 2-aminobenzoyl azide 2, aldehyde 3, acid 4, and isocyanide 5 produced the benzimidazoles 8 in moderate to good yields via a sequential Ugi Condensation and catalytic aza-Wittig in the presence of a catalytic amount of phospholene oxide
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One-Pot Synthesis of Isoquinolin-1(2H)-ones by a Sequential Ugi 4CC/Wittig Process
Synlett, 2015Co-Authors: Zhuan Duan, Yun Gao, Ding Yuan, Mingwu DingAbstract:A one-pot synthetic approach to isoquinolin-1(2 H )-ones through a Ugi/Wittig sequence has been developed. The reaction of phosphonium salt, aldehyde, secondary amine, and isocyanide produced isoquinolin-1(2 H )-ones in good yields through sequential Ugi Condensation and intramolecular Wittig reaction in the presence of K 2 CO 3 .
Alexandre V. Ivachtchenko - One of the best experts on this subject based on the ideXlab platform.
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A convenient synthesis of heterocyclic compounds containing 11-oxo-6,11,12,13-tetrahydrodibenzo[b,g][1,5]oxazonine fragment
Mendeleev Communications, 2009Co-Authors: Victor V. Potapov, Nataliya A. Fetisova, Alexandr V. Nikitina, Alexandre V. IvachtchenkoAbstract:A convenient synthesis of rare diaryl-fused nine-membered heterocyclic scaffold using a novel modification of four-component Ugi Condensation based on the usage of aromatic aldehyde-acid as bifunctional component is described.
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One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines.
The Journal of organic chemistry, 2006Co-Authors: Alexey P. Ilyn, Sergey E. Tkachenko, Dmitri V. Kravchenko, Marina V. Loseva, Vladimir Y. Vvedensky, Elena B. Putsykina, Alexandr V. Khvat, Mikhail Krasavin, Alexandre V. IvachtchenkoAbstract:We present a convenient synthesis of novel heteroaryl-fused 3-oxo-1,4-thiazepine-5-carboxamides and 5-oxo-1,4-thiazepine-3-carboxamides using a modification of four-component Ugi Condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved.
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One-step assembly of carbamoyl substituted annulated 1,4-oxazepines
Tetrahedron Letters, 2006Co-Authors: Alexey P. Ilyin, Sergey E. Tkachenko, Vladislav Z. Parchinski, Julia N. Peregudova, Andrey S. Trifilenkov, Elena B. Poutsykina, Dmitri V. Kravchenko, Alexandre V. IvachtchenkoAbstract:Abstract We present a convenient synthesis of heterocyclic scaffolds using a novel modification of four-component Ugi Condensation. Two complementary variants of this useful synthetic strategy provide an efficient one-step assembly of four novel pharmaceutically relevant (hetero)aryl-fused 1,4-oxazepines with different substituents’ profile.
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New four-component Ugi-type reaction. Synthesis of heterocyclic structures containing a pyrrolo[1,2-a][1,4]diazepine fragment.
The Journal of organic chemistry, 2005Co-Authors: Alexey P. Ilyn, Julia A. Kuzovkova, Andrey S. Trifilenkov, Sergey A. Kutepov, And Alexandre V. Nikitin, Alexandre V. IvachtchenkoAbstract:[reaction: see text] We present a convenient synthesis of novel heterocyclic structures containing pyrrolo[1,2-a][1,4]diazepine fragment using a novel modification of four-component Ugi Condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved.
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An efficient synthesis of novel heterocycle-fused derivatives of 1-oxo-1,2,3,4-tetrahydropyrazine using Ugi Condensation
Tetrahedron Letters, 2005Co-Authors: Alexey P. Ilyn, Julia A. Kuzovkova, Victor V. Potapov, Alexandre M. Shkirando, Denis I. Kovrigin, Sergey E. Tkachenko, Alexandre V. IvachtchenkoAbstract:We present a convenient synthesis of novel pyrrole- and indole-fused 1-oxo-1,2,3,4-tetrahydropyrazine heterocyclic structures using a novel modification of four-component Ugi Condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds, and discuss the scope and limitations of the chemistry involved.
Laura West - One of the best experts on this subject based on the ideXlab platform.
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a tandem petasis Ugi multi component Condensation reaction solution phase synthesis of six dimensional libraries
Tetrahedron Letters, 2003Co-Authors: David E. Portlock, Ryszard Ostaszewski, Dinabandhu Naskar, Laura WestAbstract:Abstract Amino acids with three points of diversity generated from the Petasis boronic acid–Mannich reaction can be used as one of the four components of the Ugi Condensation to prepare six dimensional libraries of dipeptide amides.
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A tandem Petasis–Ugi multi component Condensation reaction: solution phase synthesis of six dimensional libraries
Tetrahedron Letters, 2003Co-Authors: David E. Portlock, Ryszard Ostaszewski, Dinabandhu Naskar, Laura WestAbstract:Abstract Amino acids with three points of diversity generated from the Petasis boronic acid–Mannich reaction can be used as one of the four components of the Ugi Condensation to prepare six dimensional libraries of dipeptide amides.
David E. Portlock - One of the best experts on this subject based on the ideXlab platform.
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a tandem petasis Ugi multi component Condensation reaction solution phase synthesis of six dimensional libraries
Tetrahedron Letters, 2003Co-Authors: David E. Portlock, Ryszard Ostaszewski, Dinabandhu Naskar, Laura WestAbstract:Abstract Amino acids with three points of diversity generated from the Petasis boronic acid–Mannich reaction can be used as one of the four components of the Ugi Condensation to prepare six dimensional libraries of dipeptide amides.
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A tandem Petasis–Ugi multi component Condensation reaction: solution phase synthesis of six dimensional libraries
Tetrahedron Letters, 2003Co-Authors: David E. Portlock, Ryszard Ostaszewski, Dinabandhu Naskar, Laura WestAbstract:Abstract Amino acids with three points of diversity generated from the Petasis boronic acid–Mannich reaction can be used as one of the four components of the Ugi Condensation to prepare six dimensional libraries of dipeptide amides.
Christopher Hulme - One of the best experts on this subject based on the ideXlab platform.
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Expeditious Routes to Polycyclic Molecular Frameworks via One-Pot, Two-Step Ugi Ring-Closing Sequences
Synlett, 2013Co-Authors: Fabio De Moliner, Alexandra P. Cappelli, Muhammad Ayaz, Christopher HulmeAbstract:A very general and robust multicomponent-reaction protocol involving an Ugi Condensation between ethyl glyoxylate, isonitriles, N -Boc-α-amino acids, and mono - N -Boc-protected diamines followed by a series of acid-promoted cyclization steps in a one-pot fashion is reported. This process allows for the assembly of complex polycyclic structures by means of just two simple synthetic operations and a single chromatographic purification in high overall yields. Of note, the first scaffolds derived from a highly selective sequence of ring-closing events involving three internal amino nucleophiles is reported.
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MCC/SNAr methodology. Part 2: Novel three-step solution phase access to libraries of benzodiazepines
Tetrahedron Letters, 2003Co-Authors: Paul Tempest, Liping H. Pettus, Vijay Keshav Gore, Christopher HulmeAbstract:Abstract New developments in the search for novel pharmacological agents over the last decade have focused on the preparation of chemical libraries as sources for new leads for drug discovery. To aid this search a plethora of personal synthesizers and new automation technologies have emerged to help fuel the lead discovery engines of drug discovery organizations. In fact, multi-step solid-phase syntheses of diverse libraries in excess of 10,000 products are now feasible via split and mix techniques. At the same time, a multitude of more efficient, diversity or target oriented solution phase chemical methodologies have appeared in the chemical literature, which have enabled the relatively facile construction of successful lead generation libraries with low FTE input and little capital expenditure. This communication reveals a further application of N -BOC-α-aminoaldehydes in the Ugi Condensation reaction, followed by a secondary S N Ar cyclization, accessing arrays of biologically relevant benzodiazepines in good yield and overall purity.