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Ismael Jiménez-estrada - One of the best experts on this subject based on the ideXlab platform.
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The effect of chronic Undernourishment on the synaptic depression of cutaneous pathways in the rat spinal cord.
Brain research bulletin, 2012Co-Authors: Salvador Quiroz-gonzález, José Carlos Guadarrama Olmos, Bertha Segura-alegría, Ismael Jiménez-estradaAbstract:The aim of this study was to determine the effect of chronic Undernourishment on the amplitude depression of the first negative component in the cord dorsum potentials (N(1)-CDPs) caused by the conditioning stimulation of sensory cutaneous nerves in the rat spinal cord. Single electrical pulses (1Hz; 2 times threshold) applied to the sural (SU) nerve of control rats (n=14) produced CDPs with a first negative component (N(1)-CDPs) larger in amplitude (14.2±1.3%, p
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Effect of chronic Undernourishment on the cord dorsum potentials and the primary afferent depolarization evoked by cutaneous nerves in the rat spinal cord
Brain Research Bulletin, 2011Co-Authors: Salvador Quiróz González, Bertha Segura Alegría, José Carlos Guadarrama Olmos, Ismael Jiménez-estradaAbstract:The effect of chronic Undernourishment on the cord dorsum potentials (CDPs) and the dorsal root potential (DRP), closely related to primary afferent depolarization (PAD) and presynaptic inhibition in the spinal cord of the rat, was analyzed in this study. Single electrical pulses applied to the sural nerve (SU) of control (n = 14) and chronically undernourished (n = 16) Wistar rats produced CDPs, which are composed of four components: afferent volley (AV), two negative components (N1 and N2), and one positive component (P wave) and negative DRPs recorded in a small rootlet of the L6 segment of the rat. The CDPs of the control and undernourished rats with AV components of comparable amplitude (UAV/CAV = 0.96), showed N1 components of similar amplitude (UN1 /CN1 = 0.94), but smaller P wave (UPW/CPW = 0.23). A comparable reduction in the amplitude of the DRPs was obtained in the undernourished rats (UDRP/CDRP = 0.36). When normalized as a function of the body mass of the animals, the CDPs and DRPs produced in undernourished rats were of significantly smaller normalized amplitude than those evoked in the control. According to these results, it is suggested that chronic Undernourishment induce a depressive effect on the mechanisms generating the P wave component in the CDP and the DRPs either by decreasing the sensory input and/or the excitability of the dorsal horn neurones involved in the generation of PAD and presynaptic inhibition in the spinal cord of the rat.
Carsten Schulz - One of the best experts on this subject based on the ideXlab platform.
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feeding fish according to organic aquaculture guidelines ec 710 2009 influence of potato protein concentrates containing various glycoalkaloid levels on health status and growth performance of rainbow trout oncorhynchus mykiss
Aquaculture, 2011Co-Authors: K Tusche, Sven Wuertz, Andreas Susenbeth, Carsten SchulzAbstract:A feeding trial was conducted to evaluate the effect of potato protein concentrate (PPC) replacing fishmeal in nutrition of rainbow trout (Oncorhynchus mykiss) according to organic aquaculture guidelines. Eight diets were formulated by partial replacement of fishmeal (25, 50, 75 and 100) with PPC of two different qualities (LG-PPC with low glycoalkaloid content of 7.41 mg kg(-1) dry weight. HG-PPC with high glycoalkaloid content of 2150 mg kg(-1) dry weight) and one experimental diet without PPC served as control. Experimental diets were fed over a period of 84 days to triplicate experimental groups until apparent satiation. Best growth performance was observed in the control group. The inclusion of LG-PPC resulted in significantly reduced feed intake, feed utilization and growth with increasing replacement of 25 and higher. Increasing amount of dietary LG-PPC inclusion resulted in alterations in liver histology and in anterior intestine indicating an impact of glycoalkaloids on the different gastrointestinal tissues. The HG replacement revealed most prominently a decreased feed intake and growth parameters indicating massive Undernourishment. Congruently, hypotrophy of the liver with ceroid pigment accumulation, and villi degeneration in the intestine were observed in all HG groups. Blood parameters were equally affected by an inclusion of PPC (LG and HG) in the diets involving reduced plasma TG (HG75), glucose (HG100) as well as protein (HG100). As a conclusion PPC as alternative protein in fish nutrition is only feasible with LG contents as HG diets resulted in severe Undernourishment of fish, lowest growth performance and irreversible intestinal damages. (C) 2011 Elsevier B.V. All rights reserved.
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Feeding fish according to organic aquaculture guidelines EC 710/2009: Influence of potato protein concentrates containing various glycoalkaloid levels on health status and growth performance of rainbow trout (Oncorhynchus mykiss)
Aquaculture, 2011Co-Authors: K Tusche, Sven Wuertz, Andreas Susenbeth, Carsten SchulzAbstract:A feeding trial was conducted to evaluate the effect of potato protein concentrate (PPC) replacing fishmeal in nutrition of rainbow trout (Oncorhynchus mykiss) according to organic aquaculture guidelines. Eight diets were formulated by partial replacement of fishmeal (25, 50, 75 and 100) with PPC of two different qualities (LG-PPC with low glycoalkaloid content of 7.41 mg kg(-1) dry weight. HG-PPC with high glycoalkaloid content of 2150 mg kg(-1) dry weight) and one experimental diet without PPC served as control. Experimental diets were fed over a period of 84 days to triplicate experimental groups until apparent satiation. Best growth performance was observed in the control group. The inclusion of LG-PPC resulted in significantly reduced feed intake, feed utilization and growth with increasing replacement of 25 and higher. Increasing amount of dietary LG-PPC inclusion resulted in alterations in liver histology and in anterior intestine indicating an impact of glycoalkaloids on the different gastrointestinal tissues. The HG replacement revealed most prominently a decreased feed intake and growth parameters indicating massive Undernourishment. Congruently, hypotrophy of the liver with ceroid pigment accumulation, and villi degeneration in the intestine were observed in all HG groups. Blood parameters were equally affected by an inclusion of PPC (LG and HG) in the diets involving reduced plasma TG (HG75), glucose (HG100) as well as protein (HG100). As a conclusion PPC as alternative protein in fish nutrition is only feasible with LG contents as HG diets resulted in severe Undernourishment of fish, lowest growth performance and irreversible intestinal damages. (C) 2011 Elsevier B.V. All rights reserved.
Pasqualino Loi - One of the best experts on this subject based on the ideXlab platform.
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55 peri conceptional Undernourishment perturbs offspring sperm methylome
Reproduction Fertility and Development, 2019Co-Authors: Paola Toschi, E Capra, Debora Agata Anzalone, F Turri, F Pizzi, Barbara Lazzari, Alessandra Stella, Paolo Ajmonemarsan, Pasqualino LoiAbstract:Whereas an organism’s genotype is relatively static throughout life, the epigenome is highly dynamic and can adapt, or be altered, in response to the external environment such as diet. Intrauterine exposure to nutrient availability can alter the establishment of epigenetic marks, not only in the exposed individuals, but also in their offspring. Inheritance of such an environmentally acquired phenotype by the subsequent generation occurs through epigenetic modifications in the germline. Here, using a genome-wide approach, we evaluate how modification of the maternal diet pre- (14 days) and post- (28 days) conception can affect methylation status of the sperm of male offspring. Specifically, using a sheep model, we focused on the effect of maternal undernutrition on adult sperm methylation and its long-term consequences on sperm physiology and quality. Moreover, we investigated if supplementation of folic acid, to increase the availability of methyl donors, could prevent or ameliorate the adverse uterine environment caused by maternal undernutrition. Male lambs obtained from mothers subjected to different nutritional regimens (UND: undernutrition; FA: undernutrition and folic acid supplementation) appeared normal at birth, with a comparable body weight until Day 30 postpartum. Sperm DNA methylation, obtained by reduced representation bisulfite sequencing, differed in offspring that experienced in utero undernutrition (UND and FA) compared with the control group (CTR). In particular, the number of differentially methylated regions (DMR) was lower when UND and FA groups were compared, whereas a higher number of DMR was observed by comparison of CTR with both experimental groups. In addition, a high percentage of DMR were shared between UND and FA groups when compared with CTR, clearly indicating a influence of maternal nutrition on the offspring sperm DNA methylation rearrangement. Gene ontology (GO) analysis showed variation in functional categories related to sperm functionality such as chondroitin sulfate synthesis, potassium ion import, and others related to metabolism (biotin and glucagon). Furthermore, using computer-assisted semen analysis and flow cytometric measurement, we observed lower a sperm motility index and higher incidence of chromatin structure alterations in spermatozoa collected from UND and FA groups compared with CTR. Finally, to verify the effect of such reported abnormality on lamb fertility, we used the semen for in vitro embryo production. While we obtained good quality blastocysts from all 3 groups, a reduction in the percentage of embryo development, partially compensated in the FA group, was found using spermatozoa from UND rams. Taken together, our results confirm that a nutritional stress during early mammalian development can lead to epigenetic modification in the offspring. This damage can be partially ameliorated with folic acid supplementation; however, some alteration still persists in the germline and could be passed to the next generation, with as yet unknown consequences.
Jean-claude Desport - One of the best experts on this subject based on the ideXlab platform.
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Post-stroke Complications and Mortality in Burkinabè Hospitals: Relationships with Deglutition Disorders and Nutritional Status
Dysphagia, 2020Co-Authors: Jeoffray Diendéré, Athanase Millogo, Fayemendy Philippe, Jean Kaboré, Christian Napon, Anselme Dabilgou, Marie-paule Boncoeur-martel, Pierre-marie Preux, Jean-yves Salle, Jean-claude DesportAbstract:Stroke frequently causes deglutition disorders, leading to a decline in nutritional status and complications, and increasing mortality. Sub-Saharan data are scarce. The objectives of this study were to assess complications and mortality among hospitalized patients in Burkina Faso during the first two weeks after stroke, and to investigate associated factors. Patients with stroke were followed prospectively in Ouagadougou and Bobo-Dioulasso hospitals. Deglutition disorders and nutritional parameters were assessed at baseline (D0) and on Days 8 (D8) and 14 (D14). Complications and mortality were recorded up to D14. Factors associated with complications and mortality were investigated using multivariate analysis. Of the 222 patients included, 81.5% developed at least one complication, and mortality was 17.1%. At D0, D8, and D14, the rate of deglutition disorders was 37.4%, 28.4%, and 15.8%, respectively, and that of Undernourishment 25.2%, 29.4%, and 31.0%, respectively. In multivariate analysis, only the presence of deglutition disorders was a risk factor for developing at least one complication (OR = 5.47, 95% CI 1.81–16.51). Factors predicting death were the presence of deglutition disorders at D0 (OR = 7.19, 95% CI 3.10–16.66), and at least one seizure during follow-up (OR = 3.69, 95% CI 1.63–8.36). After stroke, the rates of complications, death, and Undernourishment were high compared to Western countries. Prevention and management of deglutition disorders, and specific follow-up of patients with seizures could reduce post-stroke mortality.
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Changes in nutritional state and dysphagia in stroke patients monitored during a 14-day period in a Burkina Faso hospital setting
Nutrition, 2018Co-Authors: Jeoffray Diendéré, Athanase Millogo, Pierre-marie Preux, Pierre Jésus, Jean-claude DesportAbstract:Introduction Dysphagia and Undernourishment are common in cerebrovascular accident (stroke) patients in developed countries. Despite the dietary transition, there is little information available in Africa on this topic. This study aims to assess the prevalence of Undernourishment and dysphagia in stroke patients in two Burkina Faso teaching hospitals at a starting point (D0), on the 8th day and on the 14th (D14) and to specify factors related to Undernourishment at day 14 Methodology The nutritional state of the patients was assessed using BMI, Triceps skinfold thickness (TSF) and the mid-upper arm circumference. Dysphagia was identified using the Practical Aspiration Screening Schema. Results 222 patients were included in the study. From D0 to D14, the prevalence of Undernourishment increased from 25.2% to 31.0% and the prevalence of dysphagia decreased from 37.4% to 15.8%. All nutritional criteria worsened. In a multivariate analysis, Undernourishment was more present at D14 for women (OR=7.01; 95% CI: 1.51–32.56, p=0.01), and was less present if weight (OR=0.69; 95% CI: 0.60–0.79, p=0.0001) or TSF (OR=0.85; 95% CI: 0.74–0.99, p=0.03) were high at D0. Conclusion The prevalence of Undernourishment was high at D0 and increased during the monitoring period. It would be advisable to monitor patients' weight and TSF, to optimise care for women and patients with low weight or TSF at D0, to monitor dysphagia, and to inform patients, families and relevant staff of nutritional concerns after a cerebrovascular accident.
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Changes in nutritional status and dysphagia in stroke patients monitored during a 14-day period in a Burkina Faso hospital setting
2017Co-Authors: Jeoffray Diendéré, Athanase Millogo, Pierre-marie Preux, Pierre Jésus, Jean-claude DesportAbstract:Introduction: Dysphagia and Undernourishment are common in stroke patients in developed countries. Despite the dietary transition, there is little information available in Africa on this topic. This study aims to assess the prevalence of Undernourishment and dysphagia in stroke patients in two Burkina Faso teaching hospitals at a starting point (D0), on the 8th day (D8) and on the 14th (D14) and to specify factors related to Undernourishment at day 14. Methodology: The nutritional status of the patients was assessed using body mass index (BMI), triceps skinfold thickness (TSF) and the mid-upper arm circumference. Dysphagia was identified using the Practical Aspiration Screening Schema (Zhou Z, Eur J Phys Rehabil Med 2011; 47:441–6). Results: Between November 2015 and August 2016, 558 patients with strokes were consecutively admitted, and 222 of them were included in the study. Sex-ratio was 1.2 and age mean 60.5 years (± 14.2). From D0 to D14, the prevalence of Undernourishment increased from 25.2% to 31.0% and the prevalence of dysphagia decreased from 37.4% to 15.8%. All nutritional criteria worsened. Undernourishment was more frequent in dysphagic patients than non dysphagic at D8 (40.3% vs 24.4%, p=0.02 ) and at D14 (42.6% vs 26.2%, p=0,03). In a multivariate analysis, Undernourishment was more present at D14 for women (OR=7.01; CR95: 1.51–32.56, p=0.01), and was less present if weight (OR=0.69; CR95: 0.60–0.79, p=0.0001) or TSF (OR=0.85 ; CR95: 0.74–0.99, p=0.03) were high at D0. Conclusion: The prevalence of Undernourishment was high at D0 and increased during the monitoring period. It would be advisable to monitor patients’ weight and TSF, to optimise care for women and patients with low weight or TSF at D0, to monitor dysphagia, and to inform patients, families and relevant staff of nutritional concerns after stroke.
K Tusche - One of the best experts on this subject based on the ideXlab platform.
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feeding fish according to organic aquaculture guidelines ec 710 2009 influence of potato protein concentrates containing various glycoalkaloid levels on health status and growth performance of rainbow trout oncorhynchus mykiss
Aquaculture, 2011Co-Authors: K Tusche, Sven Wuertz, Andreas Susenbeth, Carsten SchulzAbstract:A feeding trial was conducted to evaluate the effect of potato protein concentrate (PPC) replacing fishmeal in nutrition of rainbow trout (Oncorhynchus mykiss) according to organic aquaculture guidelines. Eight diets were formulated by partial replacement of fishmeal (25, 50, 75 and 100) with PPC of two different qualities (LG-PPC with low glycoalkaloid content of 7.41 mg kg(-1) dry weight. HG-PPC with high glycoalkaloid content of 2150 mg kg(-1) dry weight) and one experimental diet without PPC served as control. Experimental diets were fed over a period of 84 days to triplicate experimental groups until apparent satiation. Best growth performance was observed in the control group. The inclusion of LG-PPC resulted in significantly reduced feed intake, feed utilization and growth with increasing replacement of 25 and higher. Increasing amount of dietary LG-PPC inclusion resulted in alterations in liver histology and in anterior intestine indicating an impact of glycoalkaloids on the different gastrointestinal tissues. The HG replacement revealed most prominently a decreased feed intake and growth parameters indicating massive Undernourishment. Congruently, hypotrophy of the liver with ceroid pigment accumulation, and villi degeneration in the intestine were observed in all HG groups. Blood parameters were equally affected by an inclusion of PPC (LG and HG) in the diets involving reduced plasma TG (HG75), glucose (HG100) as well as protein (HG100). As a conclusion PPC as alternative protein in fish nutrition is only feasible with LG contents as HG diets resulted in severe Undernourishment of fish, lowest growth performance and irreversible intestinal damages. (C) 2011 Elsevier B.V. All rights reserved.
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Feeding fish according to organic aquaculture guidelines EC 710/2009: Influence of potato protein concentrates containing various glycoalkaloid levels on health status and growth performance of rainbow trout (Oncorhynchus mykiss)
Aquaculture, 2011Co-Authors: K Tusche, Sven Wuertz, Andreas Susenbeth, Carsten SchulzAbstract:A feeding trial was conducted to evaluate the effect of potato protein concentrate (PPC) replacing fishmeal in nutrition of rainbow trout (Oncorhynchus mykiss) according to organic aquaculture guidelines. Eight diets were formulated by partial replacement of fishmeal (25, 50, 75 and 100) with PPC of two different qualities (LG-PPC with low glycoalkaloid content of 7.41 mg kg(-1) dry weight. HG-PPC with high glycoalkaloid content of 2150 mg kg(-1) dry weight) and one experimental diet without PPC served as control. Experimental diets were fed over a period of 84 days to triplicate experimental groups until apparent satiation. Best growth performance was observed in the control group. The inclusion of LG-PPC resulted in significantly reduced feed intake, feed utilization and growth with increasing replacement of 25 and higher. Increasing amount of dietary LG-PPC inclusion resulted in alterations in liver histology and in anterior intestine indicating an impact of glycoalkaloids on the different gastrointestinal tissues. The HG replacement revealed most prominently a decreased feed intake and growth parameters indicating massive Undernourishment. Congruently, hypotrophy of the liver with ceroid pigment accumulation, and villi degeneration in the intestine were observed in all HG groups. Blood parameters were equally affected by an inclusion of PPC (LG and HG) in the diets involving reduced plasma TG (HG75), glucose (HG100) as well as protein (HG100). As a conclusion PPC as alternative protein in fish nutrition is only feasible with LG contents as HG diets resulted in severe Undernourishment of fish, lowest growth performance and irreversible intestinal damages. (C) 2011 Elsevier B.V. All rights reserved.
