The Experts below are selected from a list of 129 Experts worldwide ranked by ideXlab platform
Igor J Koralnik - One of the best experts on this subject based on the ideXlab platform.
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a fatal case of jc Virus Meningitis presenting with hydrocephalus in an hiv seronegative patient
Annals of Neurology, 2014Co-Authors: Shruti P Agnihotri, Christian Wuthrich, Xin Dang, David Nauen, Reza Karimi, Raphael P Viscidi, Evelyn Bord, Stephanie Batson, Juan C Troncoso, Igor J KoralnikAbstract:JC Virus (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy, JCV granule cell neuronopathy and JCV encephalopathy. Whether JCV can also cause Meningitis, has not yet been demonstrated. We report a case of aseptic Meningitis resulting in symptomatic hydrocephalus in an HIV-seronegative patient. Brain imaging showed enlargement of ventricles but no parenchymal lesion. She had a very high JC viral load in the CSF and developed progressive cognitive dysfunction despite ventricular drainage. She was diagnosed with pancytopenia and passed away after 5 ½ months. Post-mortem exam revealed productive JCV infection of leptomeningeal and choroid plexus cells, and limited parenchymal involvement. Sequencing of JCV CSF strain showed an archetype-like regulatory region. Further studies of the role of JCV in aseptic Meningitis and in idiopathic hydrocephalus are warranted.
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a fatal case of jc Virus Meningitis presenting with hydrocephalus in a human immunodeficiency Virus seronegative patient
Annals of Neurology, 2014Co-Authors: Shruti P Agnihotri, Christian Wuthrich, Xin Dang, David Nauen, Reza Karimi, Raphael P Viscidi, Evelyn Bord, Stephanie Batson, Juan C Troncoso, Igor J KoralnikAbstract:JC Virus (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy, JCV granule cell neuronopathy, and JCV encephalopathy. Whether JCV can also cause Meningitis has not yet been demonstrated. We report a case of aseptic Meningitis resulting in symptomatic hydrocephalus in a human immunodeficiency Virus–seronegative patient. Brain imaging showed enlargement of ventricles but no parenchymal lesion. She had a very high JC viral load in the cerebrospinal fluid (CSF) and developed progressive cognitive dysfunction despite ventricular drainage. She was diagnosed with pancytopenia and passed away after 5.5 months. Postmortem examination revealed productive JCV infection of leptomeningeal and choroid plexus cells, and limited parenchymal involvement. Sequencing of JCV CSF strain showed an archetype-like regulatory region. Further studies of the role of JCV in aseptic Meningitis and in idiopathic hydrocephalus are warranted. Ann Neurol 2014;76:140–147
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a fatal case of jc Virus Meningitis presenting with hydrocephalus in a human immunodeficiency Virus seronegative patient
Annals of Neurology, 2014Co-Authors: Shruti P Agnihotri, Christian Wuthrich, Xin Dang, David Nauen, Reza Karimi, Raphael P Viscidi, Evelyn Bord, Stephanie Batson, Juan C Troncoso, Igor J KoralnikAbstract:JC Virus (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy, JCV granule cell neuronopathy, and JCV encephalopathy. Whether JCV can also cause Meningitis has not yet been demonstrated. We report a case of aseptic Meningitis resulting in symptomatic hydrocephalus in a human immunodeficiency Virus-seronegative patient. Brain imaging showed enlargement of ventricles but no parenchymal lesion. She had a very high JC viral load in the cerebrospinal fluid (CSF) and developed progressive cognitive dysfunction despite ventricular drainage. She was diagnosed with pancytopenia and passed away after 5.5 months. Postmortem examination revealed productive JCV infection of leptomeningeal and choroid plexus cells, and limited parenchymal involvement. Sequencing of JCV CSF strain showed an archetype-like regulatory region. Further studies of the role of JCV in aseptic Meningitis and in idiopathic hydrocephalus are warranted.
Shruti P Agnihotri - One of the best experts on this subject based on the ideXlab platform.
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a fatal case of jc Virus Meningitis presenting with hydrocephalus in an hiv seronegative patient
Annals of Neurology, 2014Co-Authors: Shruti P Agnihotri, Christian Wuthrich, Xin Dang, David Nauen, Reza Karimi, Raphael P Viscidi, Evelyn Bord, Stephanie Batson, Juan C Troncoso, Igor J KoralnikAbstract:JC Virus (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy, JCV granule cell neuronopathy and JCV encephalopathy. Whether JCV can also cause Meningitis, has not yet been demonstrated. We report a case of aseptic Meningitis resulting in symptomatic hydrocephalus in an HIV-seronegative patient. Brain imaging showed enlargement of ventricles but no parenchymal lesion. She had a very high JC viral load in the CSF and developed progressive cognitive dysfunction despite ventricular drainage. She was diagnosed with pancytopenia and passed away after 5 ½ months. Post-mortem exam revealed productive JCV infection of leptomeningeal and choroid plexus cells, and limited parenchymal involvement. Sequencing of JCV CSF strain showed an archetype-like regulatory region. Further studies of the role of JCV in aseptic Meningitis and in idiopathic hydrocephalus are warranted.
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a fatal case of jc Virus Meningitis presenting with hydrocephalus in a human immunodeficiency Virus seronegative patient
Annals of Neurology, 2014Co-Authors: Shruti P Agnihotri, Christian Wuthrich, Xin Dang, David Nauen, Reza Karimi, Raphael P Viscidi, Evelyn Bord, Stephanie Batson, Juan C Troncoso, Igor J KoralnikAbstract:JC Virus (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy, JCV granule cell neuronopathy, and JCV encephalopathy. Whether JCV can also cause Meningitis has not yet been demonstrated. We report a case of aseptic Meningitis resulting in symptomatic hydrocephalus in a human immunodeficiency Virus–seronegative patient. Brain imaging showed enlargement of ventricles but no parenchymal lesion. She had a very high JC viral load in the cerebrospinal fluid (CSF) and developed progressive cognitive dysfunction despite ventricular drainage. She was diagnosed with pancytopenia and passed away after 5.5 months. Postmortem examination revealed productive JCV infection of leptomeningeal and choroid plexus cells, and limited parenchymal involvement. Sequencing of JCV CSF strain showed an archetype-like regulatory region. Further studies of the role of JCV in aseptic Meningitis and in idiopathic hydrocephalus are warranted. Ann Neurol 2014;76:140–147
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a fatal case of jc Virus Meningitis presenting with hydrocephalus in a human immunodeficiency Virus seronegative patient
Annals of Neurology, 2014Co-Authors: Shruti P Agnihotri, Christian Wuthrich, Xin Dang, David Nauen, Reza Karimi, Raphael P Viscidi, Evelyn Bord, Stephanie Batson, Juan C Troncoso, Igor J KoralnikAbstract:JC Virus (JCV) is the etiologic agent of progressive multifocal leukoencephalopathy, JCV granule cell neuronopathy, and JCV encephalopathy. Whether JCV can also cause Meningitis has not yet been demonstrated. We report a case of aseptic Meningitis resulting in symptomatic hydrocephalus in a human immunodeficiency Virus-seronegative patient. Brain imaging showed enlargement of ventricles but no parenchymal lesion. She had a very high JC viral load in the cerebrospinal fluid (CSF) and developed progressive cognitive dysfunction despite ventricular drainage. She was diagnosed with pancytopenia and passed away after 5.5 months. Postmortem examination revealed productive JCV infection of leptomeningeal and choroid plexus cells, and limited parenchymal involvement. Sequencing of JCV CSF strain showed an archetype-like regulatory region. Further studies of the role of JCV in aseptic Meningitis and in idiopathic hydrocephalus are warranted.
Andreas F. Widmer - One of the best experts on this subject based on the ideXlab platform.
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lymphocytic chorioMeningitis Virus Meningitis after needlestick injury a case report
Antimicrobial Resistance and Infection Control, 2019Co-Authors: Sarah Drager, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas F. WidmerAbstract:Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel. In laboratories working with the lymphocytic chorioMeningitis Virus (LCMV), the Virus can be transmitted to humans through needlestick injury and lead to serious acute illness up to Meningitis. We report of a case of LCMV Meningitis in a laboratory worker who sustained a penetrating needlestick injury with a LCMV-contaminated hollow needle whilst disposing of a used syringe into the sharps waste bin. Four days after needlestick injury the laboratory worker developed a systemic disease: 11 days after exposure, she was diagnosed with Meningitis with clinical signs and symptoms of meningismus, photophobia, nausea and vomiting, requiring hospitalisation. The PCR was positive for LCMV from the blood sample. 18 days after exposure, seroconversion confirmed the diagnosis of LCMV-induced Meningitis with an increase in specific LCMV-IgM antibodies to 1:10′240 (day 42: 1:20′480). Ten weeks after exposure, a follow-up titre for IgM returned negative, whereas IgG titre increased to 1:20′480. This is the first case report of a PCR-documented LCMV Meningitis, coupled with seroconversion, following needlestick injury. It highlights the importance of infection prevention practices that comprise particularly well established safety precaution protocols in research laboratories handling this pathogenic Virus, because exposure to even a small amount of LCMV can lead to a severe, life-threatening infection.
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correction to lymphocytic chorioMeningitis Virus Meningitis after needlestick injury a case report
Antimicrobial Resistance and Infection Control, 2019Co-Authors: Sarah Drager, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas F. WidmerAbstract:The original article [1] contains several mentions of a potentially misleading assertion which the authors would like to clarify; each mention relating to LCMV needlestick injury and its potential capacity for injury.
Pascal Cherpillod - One of the best experts on this subject based on the ideXlab platform.
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lymphocytic chorioMeningitis Virus Meningitis after needlestick injury a case report
Antimicrobial Resistance and Infection Control, 2019Co-Authors: Sarah Drager, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas F. WidmerAbstract:Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel. In laboratories working with the lymphocytic chorioMeningitis Virus (LCMV), the Virus can be transmitted to humans through needlestick injury and lead to serious acute illness up to Meningitis. We report of a case of LCMV Meningitis in a laboratory worker who sustained a penetrating needlestick injury with a LCMV-contaminated hollow needle whilst disposing of a used syringe into the sharps waste bin. Four days after needlestick injury the laboratory worker developed a systemic disease: 11 days after exposure, she was diagnosed with Meningitis with clinical signs and symptoms of meningismus, photophobia, nausea and vomiting, requiring hospitalisation. The PCR was positive for LCMV from the blood sample. 18 days after exposure, seroconversion confirmed the diagnosis of LCMV-induced Meningitis with an increase in specific LCMV-IgM antibodies to 1:10′240 (day 42: 1:20′480). Ten weeks after exposure, a follow-up titre for IgM returned negative, whereas IgG titre increased to 1:20′480. This is the first case report of a PCR-documented LCMV Meningitis, coupled with seroconversion, following needlestick injury. It highlights the importance of infection prevention practices that comprise particularly well established safety precaution protocols in research laboratories handling this pathogenic Virus, because exposure to even a small amount of LCMV can lead to a severe, life-threatening infection.
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correction to lymphocytic chorioMeningitis Virus Meningitis after needlestick injury a case report
Antimicrobial Resistance and Infection Control, 2019Co-Authors: Sarah Drager, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas F. WidmerAbstract:The original article [1] contains several mentions of a potentially misleading assertion which the authors would like to clarify; each mention relating to LCMV needlestick injury and its potential capacity for injury.
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Additional file 1: of Lymphocytic chorioMeningitis Virus Meningitis after needlestick injury: a case report
2019Co-Authors: Sarah Dräger, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas WidmerAbstract:Figure S1: Thrombocytes, neutrophils and lymphocytes over the course of time after day of needlestick injury. (TIF 27480 kb
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toscana Virus Meningitis case in switzerland an example of the ezvir bioinformatics pipeline utility for the identification of emerging Viruses
Clinical Microbiology and Infection, 2015Co-Authors: Samuel Cordey, Tom J Petty, Mylene Docquier, L Sacco, Pascal Cherpillod, Martine Louissimonet, Lara Turin, Stéphane Emonet, Evgeny M ZdobnovAbstract:Toscana Virus (TOSV) represents a frequent cause of viral Meningitis in the Mediterranean Basin that remains neglected in neighbouring countries. We report a documented TOSV Meningitis case in a traveller returning from Tuscany to Switzerland. While routine serological and PCR assays could not discriminate between TOSV and Sandfly fever Naples Virus infection, a high-throughput sequencing performed directly on the cerebrospinal fluid specimen and analysed with the ezVIR pipeline provided an unequivocal viral diagnostic. TOSV could be unequivocally considered as the aetiological agent, proving the potential of ezVIR to improve standard diagnostics in cases of infection with uncommon or emerging Viruses.
A M Van Loon - One of the best experts on this subject based on the ideXlab platform.
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external quality assessment of enteroVirus detection and typing european union concerted action on Virus Meningitis and encephalitis
Bulletin of The World Health Organization, 1999Co-Authors: A M Van Loon, G C CleatorAbstract:Reported are the results of a study of an enteroVirus proficiency panel for use in isolation and serotyping and/or the polymerase chain reaction (PCR) carried out by 12 laboratories in nine European countries. Eleven laboratories reported results of Virus isolation and serotyping. In addition, four laboratories reported results of a PCR for enteroVirus detection. Correct Virus isolation results were obtained for 105 of 110 samples (95.5%, four false-negatives, one false-positive), and correct PCR results for 39 of 40 (97.5%, one false-negative). The highest isolation rate (87.5%) was observed in primary and tertiary monkey kidney cells; on monkey kidney cell lines, human diploid fibroblasts or human heteroploid cells the isolation rate varied between 64% and 71.4%. Serotyping results were less satisfactory. Only 63 of 106 (59.4%) isolated Viruses were typed correctly. Major problems were seen with samples containing mixtures of enteroViruses and with enteroVirus 71 or echoVirus 4, with 9%, 50%, and 55% correct results, respectively. These results underline the need for improvement of enteroVirus typing, especially in view of the poliomyelitis eradication initiative.
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the role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis a consensus report the eu concerted action on Virus Meningitis and encephalitis
Journal of Neurology Neurosurgery and Psychiatry, 1996Co-Authors: P Cinque, G M Cleator, Thomas Weber, P Monteyne, Christian Sindic, A M Van LoonAbstract:As effective therapies for the treatment of herpes simplex encephalitis (HSE) have become available, the virology laboratory has acquired a role of primary importance in the early diagnosis and clinical management of this condition. Several studies have shown that the polymerase chain reaction (PCR) of CSF for the detection of herpes simplex Virus type 1 (HSV-1) or type 2 (HSV-2) DNA provides a reliable method for determining an aetiological diagnosis of HSE. The use of PCR in combination with the detection of a specific intrathecal antibody response to HSV currently represents the most reliable strategy for the diagnosis and monitoring of the treatment of adult patients with HSE. The use of these techniques has also led to the identification of atypical presentations of HSV infections of the nervous system and permits the investigation of patients who develop a relapse of encephalitic illness after an initial episode of HSE. A strategy for the optimal use of the investigative laboratory in the diagnosis of HSE and subsequent management decisions is described.
