The Experts below are selected from a list of 30480 Experts worldwide ranked by ideXlab platform
Jack J. Jiang - One of the best experts on this subject based on the ideXlab platform.
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Compensatory Movement of Contralateral Vocal Folds in Patients With Unilateral Vocal Fold Paralysis.
Journal of voice : official journal of the Voice Foundation, 2019Co-Authors: Peiyun Zhuang, Azure Wilson, Jack J. JiangAbstract:Summary Objectives Previous studies of subjects with unilateral Vocal fold paralysis (UVFP) as observed in a positron emission tomography-computed tomography (PET-CT) examination have demonstrated false positive results in the contralateral cricoarytenoid, in which the metabolism may be higher. This area may also be the site of contralateral compensatory movement in these patients. In this study, we compared the adduction speed of the contralateral Vocal Folds in patients with UVFP and in healthy subjects as measured by the stroboscopic laryngoscope frame rate. This study aimed to explore the contralateral compensatory movement of the Vocal Folds in subjects with UVFP. Methods (1) We collected visual data from 14 patients with UVFP and 14 healthy subjects through a stroboscopic laryngoscope. These subjects were divided into a Vocal fold paralysis group and a control group, and we analyzed the excessive adduction of the contralateral Vocal Folds in the Vocal fold paralysis group by examining Vocal fold movement speed (pixels/s) as featured in a stroboscopic laryngoscope video. (2) We analyzed the uptake of 18-FDG in the posterior Vocal fold from positron emission tomography-computed tomography imaging from four subjects with UVFP and 12 healthy subjects. An independent sample t test and a χ2 test were used to compare data. Results Four subjects with UVFP had a higher metabolic rate in the contralateral cricoarytenoid joints, with a significant difference between the two groups, P 0.05. Conclusion Subjects with UVFP exhibited faster adduction compensation in the contralateral Vocal Folds, and the contralateral cricoarytenoid joint's metabolism in subjects with UVFP was higher. These data may help clarify the diagnostic criteria for laryngeal nerve damage.
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quantitative measurement of the three dimensional structure of the Vocal Folds and its application in identifying the type of cricoarytenoid joint dislocation
Journal of Voice, 2019Co-Authors: Yong Wang, Jack J. Jiang, Jingan Wang, Jacob F Reiss, Li Zhou, Peiyun ZhuangAbstract:Summary Objective The objective of this study was to quantitatively measure the three-dimensional (3D) structure of the Vocal Folds in normal subjects and in patients with different types of cricoarytenoid dislocation. We will analyze differences in parameters between the groups and also determine if any morphologic parameters possess utility in distinguishing the type and the degree of cricoarytenoid dislocation. Study Design This retrospective study was conducted using university hospital data. Methods Subjects' larynges were scanned using dual-source computed tomography (CT). The normal subjects were divided into deep-inhalation and phonation groups, and patients with cricoarytenoid joint dislocation were divided into anterior-dislocation and posterior-dislocation groups. Membranous Vocal fold length and width were measured directly on the thin-section CT images. Vocal fold and airway 3D models were constructed using Mimics software and used in combination to measure Vocal fold thickness, subglottal convergence angle, and oblique angle of the Vocal Folds. Results The phonation group displayed a greater Vocal fold width, greater oblique angle, thinner Vocal Folds, and a smaller subglottal convergence angle than those of the deep-inhalation group (P Conclusions The 3D structure of the Vocal Folds during deep inhalation and phonation can be accurately measured using dual-source CT and laryngeal 3D reconstruction. As the anterior-dislocation group yielded negative values for the oblique angle and the posterior-dislocation group yielded positive values, the oblique angle of the Vocal Folds may possess utility for distinguishing the type and for quantitatively determining the degree of cricoarytenoid dislocation.
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topical application of 5 aminolevulinic acid is sufficient for photodynamic therapy on Vocal Folds
Laryngoscope, 2019Co-Authors: Chi Zhang, Jack J. Jiang, Ting Gong, Jiajia Wang, Adriana ChouAbstract:OBJECTIVES To evaluate the feasibility of topical photodynamic therapy (PDT) using 5-aminolevulinic acid (5-ALA) for Vocal fold leukoplakia. STUDY DESIGN Ex vivo and in vivo. METHODS 5-ALA was applied topically as a 20% solution to ex vivo canine Vocal Folds. The penetration depth and concentrations of 5-ALA in tissue were quantified using frozen sectioning and fluorescamine derivatization after 5-ALA contact incubation or topical spraying. Then, 5-ALA solution was sprayed on leporine Vocal Folds once, twice, or given systemically in vivo. Protoporphyrin IX (PPIX) location was visualized using fluorescence microscopy, and PPIX concentrations were measured using a fluorescent quantitative method. Hematoxylin and eosin (H&E) staining was performed to visualize the histological changes of Vocal Folds after PDT for each group. RESULTS Topical incubation of 15 minutes with 5-ALA achieved a penetration depth of over 2 mm and similar concentrations within the superficial 500 μm of epithelium, compared with longer incubation times. Topical spraying of 5-ALA produced sufficient concentrations in Vocal Folds, but the retention time is short. An in vivo leporine model showed that laryngeal spraying of 20% 5-ALA induced similar penetration depth and concentrations of PPIX compared to systemic administration of 5-ALA. Two sprays of 20% 5-ALA solution with an interval of 30 minutes are needed to produce complete exfoliation of Vocal fold epithelium. CONCLUSION Topical PDT with laryngeal spraying of 20% 5-ALA solution achieves sufficient therapeutic effects and is potentially applicable for the treatment of Vocal fold leukoplakia. LEVEL OF EVIDENCE NA Laryngoscope, 129:E80-E86, 2019.
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Quantitative Measurement of the Three-dimensional Structure of the Vocal Folds and Its Application in Identifying the Type of Cricoarytenoid Joint Dislocation
'Elsevier BV', 2019Co-Authors: Yong Wang, Jack J. Jiang, Jingan Wang, Jacob F Reiss, Li Zhou, Peiyun ZhuangAbstract:Summary(#br)Objective(#br)The objective of this study was to quantitatively measure the three-dimensional (3D) structure of the Vocal Folds in normal subjects and in patients with different types of cricoarytenoid dislocation. We will analyze differences in parameters between the groups and also determine if any morphologic parameters possess utility in distinguishing the type and the degree of cricoarytenoid dislocation.(#br)Study Design(#br)This retrospective study was conducted using university hospital data.(#br)Methods(#br)Subjects’ larynges were scanned using dual-source computed tomography (CT). The normal subjects were divided into deep-inhalation and phonation groups, and patients with cricoarytenoid joint dislocation were divided into anterior-dislocation and posterior-dislocation groups. Membranous Vocal fold length and width were measured directly on the thin-section CT images. Vocal fold and airway 3D models were constructed using Mimics software and used in combination to measure Vocal fold thickness, subglottal convergence angle, and oblique angle of the Vocal Folds.(#br)Results(#br)The phonation group displayed a greater Vocal fold width, greater oblique angle, thinner Vocal Folds, and a smaller subglottal convergence angle than those of the deep-inhalation group ( P < 0.05). The anterior-dislocation group displayed a smaller oblique angle and subglottal convergence angle than the posterior-dislocation group ( P < 0.05).(#br)Conclusions(#br)The 3D structure of the Vocal Folds during deep inhalation and phonation can be accurately measured using dual-source CT and laryngeal 3D reconstruction. As the anterior-dislocation group yielded negative values for the oblique angle and the posterior-dislocation group yielded positive values, the oblique angle of the Vocal Folds may possess utility for distinguishing the type and for quantitatively determining the degree of cricoarytenoid dislocation
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kymographic characterization of vibration in human Vocal Folds with nodules and polyps
Laryngoscope, 2012Co-Authors: Ann M Chodara, Christopher R Krausert, Jack J. JiangAbstract:Objectives/Hypothesis Digital kymography (DKG) can provide objective, quantitative data about Vocal fold vibration which may help distinguish normal from pathological Vocal Folds as well as nodules from polyps.
David A. Berry - One of the best experts on this subject based on the ideXlab platform.
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computation of the three dimensional medial surface dynamics of the Vocal Folds
Journal of Biomechanics, 2006Co-Authors: Michael Döllinger, David A. BerryAbstract:Abstract To increase our understanding of pathological and healthy voice production, quantitative measurement of the medial surface dynamics of the Vocal Folds is significant, albeit rarely performed because of the inaccessibility of the Vocal Folds. Using an excised hemilarynx methodology, a new calibration technique, herein referred to as the linear approximate (LA) method, was introduced to compute the three-dimensional coordinates of fleshpoints along the entire medial surface of the Vocal fold. The results were compared with results from the direct linear transform. An associated error estimation was presented, demonstrating the improved accuracy of the new method. A test on real data was reported including computation of quantitative measurements of Vocal fold dynamics.
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medial surface dynamics of the Vocal Folds in an in vivo canine model
Journal of the Acoustical Society of America, 2004Co-Authors: Michael Doellinger, Dinesh K Chhetri, Gerald S. Berke, David A. BerryAbstract:Quantitative measurement of the medial surface dynamics of the Vocal Folds is important for understanding how sound is generated in the larynx. However, such data are hard to gather because of the inaccessibility of the Vocal Folds. Recent studies have applied hemi‐larynx methodology to excised human larynges, to visualize these dynamics. The present study extends this methodology to obtain similar quantitative measurements using an in vivo canine hemi‐larynx setup, with varying levels of stimulation to the recurrent laryngeal nerve. Use of an in vivo model allows us to examine effects of intrinsic muscle contraction on the medial surface of the Vocal Folds, to provide greater insight into mechanisms of Vocal control. Data were collected using digital high‐speed imaging with a sampling frequency of up to 4000 Hz, and a spatial resolution of up to 1024×1024 pixels. Three‐dimensional motion will be extracted, computed, visualized, and contrasted as a function of the level of stimulation to the recurrent lar...
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quantitative measurements of the medial surface of the Vocal Folds in an in vivo canine model
2004Co-Authors: Michael Doellinger, Gerald S. Berke, David A. BerryAbstract:Medial surface dynamics of the Vocal Folds are important for an understanding of sound generation within the larynx. Such dynamics illustrate the propagation of the mucosal wave which makes voice production possible. Almost universally, in vivo investigations of Vocal fold dynamics are performed using endoscopic techniques which allow only a superior view of Vocal fold vibration. Hence, the view onto the medial margin is blocked which leads to an observation leak within the Vocal fold cycle. In this study, an excised hemi-larynx set-up, is adapted for use with an in vivo canine model. In vivo models allow us to examine effects of intrinsic muscle contraction on the medial surface dynamics of the Vocal Folds, and provide greater insight into mechanisms of Vocal control. Dynamics, of the Vocal Folds with varying levels of stimulation to the recurrent laryngeal nerve (RLN) will be shown. In particular, quantitative measurements such as fundamental frequency, Vocal intensity, and the dynamics of up to 15 different positions along the medial surface of the Vocal Folds will be presented as a function of RLN innervation. To capture the vibrations, the Vocal Folds were imaged with a sampling frequency of 2000 Hz, and a spatial resolution of 1024 x 1024 pixels
Stellan Hertegard - One of the best experts on this subject based on the ideXlab platform.
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injection of embryonic stem cells into scarred rabbit Vocal Folds enhances healing and improves viscoelasticity short term results
Laryngoscope, 2007Co-Authors: Jessica Cedervall, Bengt Svensson, Frans H J Maurer, Daniela Vidovska, Lars Ahrlundrichter, Kristina Forsgren, Stellan HertegardAbstract:Objectives: Scarring caused by trauma; postcancer treatment, or inflammation in the Vocal Folds is associated with stiffness of the lamina propria and results in severe voice problems. Currently th ...
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viscoelastic and histologic properties in scarred rabbit Vocal Folds after mesenchymal stem cell injection
Laryngoscope, 2006Co-Authors: Stellan Hertegard, Jessica Cedervall, Bengt Svensson, Kristina Forsberg, Frans H J Maurer, Daniela Vidovska, Petri Olivius, Lars Ahrlundrichter, Le K BlancAbstract:Viscoelastic and histological properties in scarred rabbit Vocal Folds after mesenchymal stem cell injection
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viscoelasticity of rabbit Vocal Folds after injection augmentation
Laryngoscope, 2004Co-Authors: Åke Dahlqvist, Assunta Borzacchiello, Ola Garskog, Claude Laurent, Stellan Hertegard, Luigi AmbrosioAbstract:Objectives/Hypothesis Vocal fold function is related to the viscoelasticity of the Vocal fold tissue. Augmentation substances used for injection treatment of voice insufficiency may alter the viscoelastic properties of Vocal Folds and their vibratory capacity. The objective was to compare the mechanical properties (viscoelasticity) of various injectable substances and the viscoelasticity of rabbit Vocal Folds, 6 months after injection with one of these substances. Study Design Animal model. Methods Cross-linked collagen (Zyplast), double cross-linked hyaluronan (hylan B gel), dextranomers in hyaluronan (DHIA), and polytetrafluoroethylene (Teflon) were injected into rabbit Vocal Folds. Six months after the injection, the animals were killed and the right- and left-side Vocal Folds were removed. Dynamic viscosity of the injected substances and the Vocal Folds was measured with a Bohlin parallel-plate rheometer during small-amplitude oscillation. Results All injected Vocal Folds showed a decreasing dynamic viscosity with increasing frequency. Hylan B gel and DiHA showed the lowest dynamic viscosity values, and Vocal Folds injected with these substances also showed the lowest dynamic viscosity (similar to noninjected control samples). Teflon (and Vocal Folds injected with Teflon) showed the highest dynamic viscosity values, followed by the collagen samples. Conclusion Substances with low viscoelasticity alter the mechanical properties of the Vocal fold to a lesser degree than substances with a high viscoelasticity. The data indicated that hylan B gel and DiHA render the most natural viscoelastic properties to the Vocal Folds. These substances seem to be appropriate for preserving or restoring the vibratory capacity of the Vocal Folds when glottal insufficiency is treated with augmentative injections.
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viscoelastic properties of rabbit Vocal Folds after augmentation
Otolaryngology-Head and Neck Surgery, 2003Co-Authors: Stellan Hertegard, Assunta Borzacchiello, Åke Dahlqvist, Claude Laurent, Luigi AmbrosioAbstract:Background: Vocal fold function is closely related to tissue viscoelasticity. Augmentation substances may alter the viscoelastic properties of Vocal fold tissues and hence their vibratory capacity.Objectives: We sought to investigate the viscoelastic properties of rabbit Vocal Folds in vitro after injections of various augmentation substances.Study Design and Setting: Polytetrafluoroethylene (Teflon), cross-linked collagen (Zyplast), and cross-linked hyaluronan, hylan b gel (Hylaform) were injected into the lamina propria and the thyroarytenoid muscle of rabbit Vocal Folds. Dynamic viscosity of the injected Vocal fold as a function of frequency was measured with a Bohlin parallel-plate rheometer during small-amplitude oscillation.Results: All injected Vocal Folds showed a decreasing dynamic viscosity with increasing frequency. Vocal fold samples injected with hylan b gel showed the lowest dynamic viscosity, quite close to noninjected control samples. Vocal Folds injected with polytetrafluoroethylene showed the highest dynamic viscosity followed by the collagen samples.Conclusions: The data indicated that hylan b gel in short-term renders the most natural viscoelastic properties to the Vocal fold among the substances tested. This is of importance to restore/preserve the vibratory capacity of the Vocal Folds when glottal insufficiency is treated with injections. (Otolaryngol Head Neck Surg 2003;128:401-6.)
Kazuya Takeda - One of the best experts on this subject based on the ideXlab platform.
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classification of speech under stress based on modeling of the Vocal Folds and Vocal tract
Eurasip Journal on Audio Speech and Music Processing, 2013Co-Authors: Xiao Yao, Takatoshi Jitsuhiro, Chiyomi Miyajima, Norihide Kitaoka, Kazuya TakedaAbstract:In this study, we focus on the classification of neutral and stressed speech based on a physical model. In order to represent the characteristics of the Vocal Folds and Vocal tract during the process of speech production and to explore the physical parameters involved, we propose a method using the two-mass model. As feature parameters, we focus on stiffness parameters of the Vocal Folds, Vocal tract length, and cross-sectional areas of the Vocal tract. The stiffness parameters and the area of the entrance to the Vocal tract are extracted from the two-mass model after we fit the model to real data using our proposed algorithm. These parameters are related to the velocity of glottal airflow and acoustic interaction between the Vocal Folds and the Vocal tract and can precisely represent features of speech under stress because they are affected by the speaker’s psychological state during speech production. In our experiments, the physical features generated using the proposed approach are compared with traditionally used features, and the results demonstrate a clear improvement of up to 10% to 15% in average stress classification performance, which shows that our proposed method is more effective than conventional methods.
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physical characteristics of Vocal Folds during speech under stress
International Conference on Acoustics Speech and Signal Processing, 2012Co-Authors: Xiao Yao, Takatoshi Jitsuhiro, Chiyomi Miyajima, Norihide Kitaoka, Kazuya TakedaAbstract:We focus on variations in the glottal source of speech production, which is essential for understanding the generation of speech under psychological stress. In this paper, a two-mass Vocal fold model is fitted to estimate the stiffness parameters of Vocal Folds during speech, and the stiffness parameters are then analyzed in order to classify recorded samples into neutral and stressed speech. Mechanisms of Vocal Folds under stress are derived from the experimental results. We propose using a Muscle Tension Ratio (MTR) to identify speech under stress. Our results show that MTR is more effective than a conventional method of stress measurement.
Assunta Borzacchiello - One of the best experts on this subject based on the ideXlab platform.
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Morphological and rheological findings of rabbit Vocal Folds injected with hyaluronans
Otolaryngology-Head and Neck Surgery, 2004Co-Authors: Ola Garskog Presenter, Lars Hallén, Laura Mayol, Assunta Borzacchiello, Åke DahlqvistAbstract:Abstract Problem: The viscoelasticity of the Vocal fold tissue is strongly related to the function of the Vocal Folds. The viscoelastic properties of Vocal Folds and hence their vibratory capacity may be changed by augmentation substances used for the injection treatment of voice insufficiency. The substances may also cause an inflammatory reaction that might be detrimental for the function of the Vocal Folds. The aim of this study was to examine the morphology and the viscoelasticity of rabbit Vocal Folds 6 months after the injection of either Restylane® or Deflux®, 2 hyaluronan derivatives. Methods: Stabilized hyaluronic acid (Restylane®) and dextranomeres in hyaluronan (Deflux®) were injected into rabbit Vocal Folds under anesthesia. The animals were euthanized 1 day, 3 months, and 6 months after the injection and the right and left Vocal Folds removed. The dynamic viscosity of the injected substances and the Vocal Folds was measured using a Bohlin parallel-plate rheometer during small-amplitude oscillation. Morphological examinations were performed by light microscopy. Results: The injected Vocal Folds showed a decreasing dynamic viscosity with increasing frequency. Samples injected with Restylane® showed the lowest dynamic viscosity, similar to non-injected Vocal Folds. Deflux® showed a slighter greater viscoelasticity compared with Restylane®. Three and 6 months after injection, significant amounts of the substances were found in the Vocal Folds. Microscopic examination showed some inflammatory cells 1 day after injection in all injected specimens but no inflammatory reaction was found after 6 months. Conclusion: Both Restylane® and Deflux®, when injected in rabbit Vocal Folds, showed viscoelastic properties quite close to noninjected Vocal Folds and to have a long-term (6 months) persistence in the tissue. Significance: The substances seem to be appropriate for preserving or restoring the vibratory capacity of the Vocal Folds when glottal insufficiency is treated with augmentative injection. Support: The study was supported by grants from the Faculty of Medicine, University of Umea.
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viscoelasticity of rabbit Vocal Folds after injection augmentation
Laryngoscope, 2004Co-Authors: Åke Dahlqvist, Assunta Borzacchiello, Ola Garskog, Claude Laurent, Stellan Hertegard, Luigi AmbrosioAbstract:Objectives/Hypothesis Vocal fold function is related to the viscoelasticity of the Vocal fold tissue. Augmentation substances used for injection treatment of voice insufficiency may alter the viscoelastic properties of Vocal Folds and their vibratory capacity. The objective was to compare the mechanical properties (viscoelasticity) of various injectable substances and the viscoelasticity of rabbit Vocal Folds, 6 months after injection with one of these substances. Study Design Animal model. Methods Cross-linked collagen (Zyplast), double cross-linked hyaluronan (hylan B gel), dextranomers in hyaluronan (DHIA), and polytetrafluoroethylene (Teflon) were injected into rabbit Vocal Folds. Six months after the injection, the animals were killed and the right- and left-side Vocal Folds were removed. Dynamic viscosity of the injected substances and the Vocal Folds was measured with a Bohlin parallel-plate rheometer during small-amplitude oscillation. Results All injected Vocal Folds showed a decreasing dynamic viscosity with increasing frequency. Hylan B gel and DiHA showed the lowest dynamic viscosity values, and Vocal Folds injected with these substances also showed the lowest dynamic viscosity (similar to noninjected control samples). Teflon (and Vocal Folds injected with Teflon) showed the highest dynamic viscosity values, followed by the collagen samples. Conclusion Substances with low viscoelasticity alter the mechanical properties of the Vocal fold to a lesser degree than substances with a high viscoelasticity. The data indicated that hylan B gel and DiHA render the most natural viscoelastic properties to the Vocal Folds. These substances seem to be appropriate for preserving or restoring the vibratory capacity of the Vocal Folds when glottal insufficiency is treated with augmentative injections.
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viscoelastic properties of rabbit Vocal Folds after augmentation
Otolaryngology-Head and Neck Surgery, 2003Co-Authors: Stellan Hertegard, Assunta Borzacchiello, Åke Dahlqvist, Claude Laurent, Luigi AmbrosioAbstract:Background: Vocal fold function is closely related to tissue viscoelasticity. Augmentation substances may alter the viscoelastic properties of Vocal fold tissues and hence their vibratory capacity.Objectives: We sought to investigate the viscoelastic properties of rabbit Vocal Folds in vitro after injections of various augmentation substances.Study Design and Setting: Polytetrafluoroethylene (Teflon), cross-linked collagen (Zyplast), and cross-linked hyaluronan, hylan b gel (Hylaform) were injected into the lamina propria and the thyroarytenoid muscle of rabbit Vocal Folds. Dynamic viscosity of the injected Vocal fold as a function of frequency was measured with a Bohlin parallel-plate rheometer during small-amplitude oscillation.Results: All injected Vocal Folds showed a decreasing dynamic viscosity with increasing frequency. Vocal fold samples injected with hylan b gel showed the lowest dynamic viscosity, quite close to noninjected control samples. Vocal Folds injected with polytetrafluoroethylene showed the highest dynamic viscosity followed by the collagen samples.Conclusions: The data indicated that hylan b gel in short-term renders the most natural viscoelastic properties to the Vocal fold among the substances tested. This is of importance to restore/preserve the vibratory capacity of the Vocal Folds when glottal insufficiency is treated with injections. (Otolaryngol Head Neck Surg 2003;128:401-6.)
