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Katsumi Shibata - One of the best experts on this subject based on the ideXlab platform.
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Urinary Water-Soluble Vitamins as Potential Nutritional Biomarkers to Assess Their Intakes
Journal of Nutrition and Food Sciences, 2016Co-Authors: Tsutomu Fukuwatari, Katsumi ShibataAbstract:To determine micronutrient intake by dietary assessment is difficult because of high variations in habitual micronutrient intake. A nutritional biomarker can be an indicator of nutritional status with respect to intake or metabolism of dietary constituents. Recent validation studies have developed the urinary compounds as nutritional biomarkers to estimate nutrient intakes, and urinary nitrogen and sodium have been well established as nutritional biomarkers. Recent studies have conducted to establish urinary Water-Soluble Vitamins as nutritional biomarkers to assess their intakes, and made the following findings to contribute to the establishment and effective use of urinary Water-Soluble Vitamins as potential nutritional biomarkers. Only urinary vitamin B12 content reflects urine volume but not its intake. Eight of nine Water-Soluble vitamin levels in 24-hr urine increase in dose-dependent-manner, and are strongly correlated with vitamin intakes. Each urinary Water-Soluble vitamin level, except for vitamin B12, is positively correlated with the mean intake over the recent 2-4 days in free-living children, young and elderly. These findings suggest that urinary Water-Soluble Vitamins can be used as nutritional biomarkers to assess their mean intakes in groups. Based on previous findings, the reference values for urinary Water-Soluble Vitamins are proposed to show adequate nutritional status.
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Relationship Between Urinary Concentrations of Nine Water-Soluble Vitamins and their Vitamin Intakes in Japanese Adult Males.
Nutrition and metabolic insights, 2014Co-Authors: Katsumi Shibata, Junko Hirose, Tsutomu FukuwatariAbstract:Excess Water-Soluble Vitamins are thought to be eliminated in the urine. We have reported a strong relationship between Water-Soluble vitamin intake and urinary excretion in females. The relationship, however, is not well understood in males. In the present experiment, 10 Japanese male subjects were given a standard Japanese diet for the first week. The subjects remained on the same diet, and a synthesized Water-Soluble vitamin mixture containing one time the Dietary Reference Intakes (DRIs) for Japanese was given for the second week, three times the DRIs for the third week, and six times the DRIs for the fourth week. Twenty-four-hour urine samples were collected each week. Urinary excretion levels for seven of the nine Water-Soluble vitamin levels, excluding vitamin B12 and folate, increased linearly and sharply in a dose-dependent manner. These results suggest that measuring urinary Water-Soluble Vitamins can be good nutritional markers for assessing vitamin intakes in humans.
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Values for evaluating the nutritional status of Water-Soluble Vitamins in humans
Journal of Integrated OMICS, 2013Co-Authors: Katsumi ShibataAbstract:Previously, we clarified that the amount of urinary excretion of Water-Soluble Vitamins closely reflects the surplus amount of Water-Soluble Vitamins in the body stores of rats and humans. We tried to set a tentative amount of urinary excretion of eight Water-Soluble Vitamins of nine Water-Soluble Vitamins (except vitamin B 12 ) for maintaining health based on experiments in healthy young females administered a semi-chemically defined diet according to Japanese Dietary Reference Intakes and related data. We proposed a tentative value for the amount of urinary excretion of Water-Soluble Vitamins for maintaining health. The values were: 200–2000 nmol/d for vitamin B 1 ; 200–2000 nmol/d for vitamin B 2 ; 2–15 µ mol/d for 4-pyridoxic acid (a catabolite of vitamin B 6 ); 50–300 µ mol/d for the sum of the nicotinamide catabolites N 1 -methylnicotinamide, N 1 -methyl-2-pyridone-5-carboxamide, and N 1 -methyl-4-pyridone-3-carboxamide; 10–30 µ mol/d for pantothenic acid; 15–100 nmol/d for folate; 50–200 nmol/d for biotin; and 100–2000 µ mol/d for vitamin C. By using these values, we attempted to evaluate the nutritional status of Water-Soluble Vitamins for 709 young Japanese females. The percentage within the tentative value of urinary excretion of Water-Soluble vitamin for maintaining health was 73.6% for vitamin B 1 , 63.5% for vitamin B 2 , 90.0% for vitamin B 6 , 85.6% for niacin, 58.1% for folate, 85.6% for pantothenic acid, 70.2% for biotin, and 65.4% for vitamin C. The percentage beyond the lower limit of detection was 22.4% for vitamin B 1 , 31.3% for vitamin B 2 , 6.2% for vitamin B 6 , 14.0% for niacin, 40.9% for folate, 12.4% for pantothenic acid, 26.2% for biotin, and 33.0% for vitamin C. The percentage over the upper limit of detection was 4.1% for vitamin B 1 , 5.2% for vitamin B 2 , 3.8% for vitamin B 6 , 0.4% for niacin, 1.0% for folate, 2.0% for pantothenic acid, 3.6% for biotin, and 1.6% for vitamin C. Nutritional assessment using urinary excretion amounts of Water-Soluble Vitamins is persuasive, and leads to the transformation of habitual dietary intakes.
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Urinary excretion levels of Water-Soluble Vitamins in pregnant and lactating women in Japan.
Journal of nutritional science and vitaminology, 2013Co-Authors: Katsumi Shibata, Tsutomu Fukuwatari, Satoshi Sasaki, Mitsue Sano, Kahoru Suzuki, Chiaki Hiratsuka, Asami Aoki, Chiharu NagaiAbstract:Recent studies have shown that the urinary excretion levels of Water-Soluble Vitamins can be used as biomarkers for the nutritional status of these Vitamins. To determine changes in the urinary excretion levels of Water-Soluble Vitamins during pregnant and lactating stages, we surveyed and compared levels of nine Water-Soluble Vitamins in control (non-pregnant and non-lactating women), pregnant and lactating women. Control women (n=37), women in the 2nd (16-27 wk, n=24) and 3rd trimester of pregnancy (over 28 wk, n=32), and early- (0-5 mo, n=54) and late-stage lactating (6-11 mo, n=49) women took part in the survey. The mean age of subjects was ~30 y, and mean height was ~160 cm. A single 24-h urine sample was collected 1 d after the completion of a validated, self-administered comprehensive diet history questionnaire to measure Water-Soluble Vitamins or metabolites. The average intake of each Water-Soluble vitamin was ≍ the estimated average requirement value and adequate intake for the Japanese Dietary Reference Intakes in all life stages, except for vitamin B6 and folate intakes during pregnancy. No change was observed in the urinary excretion levels of vitamin B2, vitamin B6, vitamin B12, biotin or vitamin C among stages. Urine nicotinamide and folate levels were higher in pregnant women than in control women. Urine excretion level of vitamin B1 decreased during lactation and that of pantothenic acid decreased during pregnancy and lactation. These results provide valuable information for setting the Dietary Reference Intakes of Water-Soluble Vitamins for pregnant and lactating women.
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Effect of Fasting on the Urinary Excretion of Water-Soluble Vitamins in Humans and Rats
Journal of Nutritional Science and Vitaminology, 2010Co-Authors: Tsutomu Fukuwatari, Erina Yoshida, Kei Takahashi, Katsumi ShibataAbstract:Recent studies showed that the urinary excretion of the Water-Soluble Vitamins can be useful as a nutritional index. To determine how fasting affects urinary excretion of Water-Soluble Vitamins, a human study and an animal experiment were conducted. In the human study, the 24-h urinary excretion of Water-Soluble Vitamins in 12 healthy Japanese adults fasting for a day was measured. One-day fasting drastically decreased urinary thiamin content to 30%, and increased urinary riboflavin content by 3-fold. Other Water-Soluble vitamin contents did not show significant change by fasting. To further investigate the alterations of Water-Soluble vitamin status by starvation, rats were starved for 3 d, and Water-Soluble vitamin contents in the liver, blood and urine were measured during starvation. Urinary excretion of thiamin, riboflavin, vitamin B6 metabolite 4-pyridoxic acid, nicotinamide metabolites and folate decreased during starvation, but that of vitamin B12, pantothenic acid and biotin did not. As for blood vitamin levels, only blood vitamin B1, plasma PLP and plasma folate levels decreased with starvation. All Water-Soluble vitamin contents in the liver decreased during starvation, whereas vitamin concentrations in the liver did not decrease. Starvation decreased only concentrations of vitamin B12 and folate in the skeletal muscle. These results suggest that Water-Soluble Vitamins were released from the liver, and supplied to the peripheral tissues to maintain vitamin nutrition. Our human study also suggested that the effect of fasting should be taken into consideration for subjects showing low urinary thiamin and high urinary riboflavin.
Tsutomu Fukuwatari - One of the best experts on this subject based on the ideXlab platform.
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Urinary Water-Soluble Vitamins as Potential Nutritional Biomarkers to Assess Their Intakes
Journal of Nutrition and Food Sciences, 2016Co-Authors: Tsutomu Fukuwatari, Katsumi ShibataAbstract:To determine micronutrient intake by dietary assessment is difficult because of high variations in habitual micronutrient intake. A nutritional biomarker can be an indicator of nutritional status with respect to intake or metabolism of dietary constituents. Recent validation studies have developed the urinary compounds as nutritional biomarkers to estimate nutrient intakes, and urinary nitrogen and sodium have been well established as nutritional biomarkers. Recent studies have conducted to establish urinary Water-Soluble Vitamins as nutritional biomarkers to assess their intakes, and made the following findings to contribute to the establishment and effective use of urinary Water-Soluble Vitamins as potential nutritional biomarkers. Only urinary vitamin B12 content reflects urine volume but not its intake. Eight of nine Water-Soluble vitamin levels in 24-hr urine increase in dose-dependent-manner, and are strongly correlated with vitamin intakes. Each urinary Water-Soluble vitamin level, except for vitamin B12, is positively correlated with the mean intake over the recent 2-4 days in free-living children, young and elderly. These findings suggest that urinary Water-Soluble Vitamins can be used as nutritional biomarkers to assess their mean intakes in groups. Based on previous findings, the reference values for urinary Water-Soluble Vitamins are proposed to show adequate nutritional status.
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Relationship Between Urinary Concentrations of Nine Water-Soluble Vitamins and their Vitamin Intakes in Japanese Adult Males.
Nutrition and metabolic insights, 2014Co-Authors: Katsumi Shibata, Junko Hirose, Tsutomu FukuwatariAbstract:Excess Water-Soluble Vitamins are thought to be eliminated in the urine. We have reported a strong relationship between Water-Soluble vitamin intake and urinary excretion in females. The relationship, however, is not well understood in males. In the present experiment, 10 Japanese male subjects were given a standard Japanese diet for the first week. The subjects remained on the same diet, and a synthesized Water-Soluble vitamin mixture containing one time the Dietary Reference Intakes (DRIs) for Japanese was given for the second week, three times the DRIs for the third week, and six times the DRIs for the fourth week. Twenty-four-hour urine samples were collected each week. Urinary excretion levels for seven of the nine Water-Soluble vitamin levels, excluding vitamin B12 and folate, increased linearly and sharply in a dose-dependent manner. These results suggest that measuring urinary Water-Soluble Vitamins can be good nutritional markers for assessing vitamin intakes in humans.
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Urinary excretion levels of Water-Soluble Vitamins in pregnant and lactating women in Japan.
Journal of nutritional science and vitaminology, 2013Co-Authors: Katsumi Shibata, Tsutomu Fukuwatari, Satoshi Sasaki, Mitsue Sano, Kahoru Suzuki, Chiaki Hiratsuka, Asami Aoki, Chiharu NagaiAbstract:Recent studies have shown that the urinary excretion levels of Water-Soluble Vitamins can be used as biomarkers for the nutritional status of these Vitamins. To determine changes in the urinary excretion levels of Water-Soluble Vitamins during pregnant and lactating stages, we surveyed and compared levels of nine Water-Soluble Vitamins in control (non-pregnant and non-lactating women), pregnant and lactating women. Control women (n=37), women in the 2nd (16-27 wk, n=24) and 3rd trimester of pregnancy (over 28 wk, n=32), and early- (0-5 mo, n=54) and late-stage lactating (6-11 mo, n=49) women took part in the survey. The mean age of subjects was ~30 y, and mean height was ~160 cm. A single 24-h urine sample was collected 1 d after the completion of a validated, self-administered comprehensive diet history questionnaire to measure Water-Soluble Vitamins or metabolites. The average intake of each Water-Soluble vitamin was ≍ the estimated average requirement value and adequate intake for the Japanese Dietary Reference Intakes in all life stages, except for vitamin B6 and folate intakes during pregnancy. No change was observed in the urinary excretion levels of vitamin B2, vitamin B6, vitamin B12, biotin or vitamin C among stages. Urine nicotinamide and folate levels were higher in pregnant women than in control women. Urine excretion level of vitamin B1 decreased during lactation and that of pantothenic acid decreased during pregnancy and lactation. These results provide valuable information for setting the Dietary Reference Intakes of Water-Soluble Vitamins for pregnant and lactating women.
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Effect of Fasting on the Urinary Excretion of Water-Soluble Vitamins in Humans and Rats
Journal of Nutritional Science and Vitaminology, 2010Co-Authors: Tsutomu Fukuwatari, Erina Yoshida, Kei Takahashi, Katsumi ShibataAbstract:Recent studies showed that the urinary excretion of the Water-Soluble Vitamins can be useful as a nutritional index. To determine how fasting affects urinary excretion of Water-Soluble Vitamins, a human study and an animal experiment were conducted. In the human study, the 24-h urinary excretion of Water-Soluble Vitamins in 12 healthy Japanese adults fasting for a day was measured. One-day fasting drastically decreased urinary thiamin content to 30%, and increased urinary riboflavin content by 3-fold. Other Water-Soluble vitamin contents did not show significant change by fasting. To further investigate the alterations of Water-Soluble vitamin status by starvation, rats were starved for 3 d, and Water-Soluble vitamin contents in the liver, blood and urine were measured during starvation. Urinary excretion of thiamin, riboflavin, vitamin B6 metabolite 4-pyridoxic acid, nicotinamide metabolites and folate decreased during starvation, but that of vitamin B12, pantothenic acid and biotin did not. As for blood vitamin levels, only blood vitamin B1, plasma PLP and plasma folate levels decreased with starvation. All Water-Soluble vitamin contents in the liver decreased during starvation, whereas vitamin concentrations in the liver did not decrease. Starvation decreased only concentrations of vitamin B12 and folate in the skeletal muscle. These results suggest that Water-Soluble Vitamins were released from the liver, and supplied to the peripheral tissues to maintain vitamin nutrition. Our human study also suggested that the effect of fasting should be taken into consideration for subjects showing low urinary thiamin and high urinary riboflavin.
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Intra- and inter-individual variations of blood and urinary Water-Soluble Vitamins in Japanese young adults consuming a semi-purified diet for 7 days.
Journal of Nutritional Science and Vitaminology, 2009Co-Authors: Katsumi Shibata, Tsutomu Fukuwatari, Toshiaki Watanabe, Mamoru NishimutaAbstract:We have previously reported the levels of Water-Soluble Vitamins in the blood and urine of Japanese young adults. In the present paper, to assess the variations in these Water-Soluble vitamin markers during the above experiment, we comprehensively determined the intra- and inter-individual variations of blood and urinary Water-Soluble Vitamins to exactly the same amount of Water-Soluble vitamin intakes in the same experiment. The blood samples before breakfast and the 24-h urine samples were periodically collected from Japanese college male (n=10) and female (n=10) students consuming a semi-purified diet with Water-Soluble Vitamins based on Japanese Dietary Reference Intakes for 7 d, and the intra- and inter-individual variations of blood and urinary Water-Soluble Vitamins or their metabolites in blood and urine samples after adaptation were calculated. Although urinary excretion of vitamin B12 and vitamin C showed high intra-individual variations in both males and females, other urinary Vitamins and all blood Vitamins showed less than 20% of within-subject coefficients of variance in either male or female. Those showing more than 20% of between-subject coefficients of variances in both male and female were blood vitamin B6, vitamin B12 and folate levels, and urinary vitamin B1, vitamin B2, vitamin B12, nicotinamide metabolites, pantothenic acid, biotin and vitamin C. These results showed that oral administration of constant of Water-Soluble Vitamins generally decreased intra-individual variation, while individual differences in urinary vitamin excretion were observed.
Yogesh A. Kulkarni - One of the best experts on this subject based on the ideXlab platform.
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Water Soluble Vitamins and their Role in Diabetes and its Complications.
Current diabetes reviews, 2020Co-Authors: Shreeya V. Deshmukh, Bala Prabhakar, Yogesh A. KulkarniAbstract:Background Diabetes is a metabolic disorder associated with abnormally high levels of glucose in the blood due to inadequate production of insulin or inadequate sensitivity of cells to the action of insulin. Diabetes has become an increasing challenge in the world. The predicted diabetic population according to the World Health Organization is 8.7% between the age group 20-70 years. There are many complications linked to prolonged high blood glucose levels, such as microvascular complications and macrovascular complications. Vitamins play an important role in glucose metabolism and the potential utility of supplementation is relevant for the prevention and/or management of diabetes mellitus and its complications. Methods Literature search was performed using various dataset like PUBMED, EBSCO, ProQuest, Scopus and selected websites like the National Institute of Health and the World Health Organization. Result Water-Soluble Vitamins have been thoroughly studied for their activity in diabetes and diabetic complications. Conclusion Water-Soluble Vitamins like B1, B3, B6, B7, B9 and B12 have notable effects in diabetes mellitus and its related complications like nephropathy, neuropathy, retinopathy and cardiomyopathy.
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Water Soluble Vitamins and their Role in Diabetes and its Complications.
Current Diabetes Reviews, 2019Co-Authors: Shreeya V. Deshmukh, Bala Prabhakar, Yogesh A. KulkarniAbstract:BACKGROUND: Diabetes is a metabolic disorder associated with abnormally high levels of glucose in the blood due to inadequate production of insulin or inadequate sensitivity of cells to the action of insulin. Diabetes has become an increasing challenge in the world. The predicted diabetic population according to the World Health Organization is 8.7% between the age group 20-70 years. There are many complications linked to prolonged high glucose in the blood, such as microvascular complications and macrovascular complications. Vitamins play an important role in glucose metabolism and the potential utility of supplementation is relevant for the prevention and/or management of diabetes mellitus and its complications. METHODS: Literature search was performed using various dataset like PUBMED, EBSCO, ProQuest, Scopus and selected websites like the National Institutes of Health and the World Health Organization. RESULT: Water-Soluble Vitamins have been thoroughly studied for their activity in diabetes and diabetic complications. CONCLUSION: Water-Soluble Vitamins like B1, B3, B6, B7, B9 and B12 have notable effects in diabetes mellitus and its related complications like nephropathy, neuropathy, retinopathy and cardiomyopathy.
Shreeya V. Deshmukh - One of the best experts on this subject based on the ideXlab platform.
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Water Soluble Vitamins and their Role in Diabetes and its Complications.
Current diabetes reviews, 2020Co-Authors: Shreeya V. Deshmukh, Bala Prabhakar, Yogesh A. KulkarniAbstract:Background Diabetes is a metabolic disorder associated with abnormally high levels of glucose in the blood due to inadequate production of insulin or inadequate sensitivity of cells to the action of insulin. Diabetes has become an increasing challenge in the world. The predicted diabetic population according to the World Health Organization is 8.7% between the age group 20-70 years. There are many complications linked to prolonged high blood glucose levels, such as microvascular complications and macrovascular complications. Vitamins play an important role in glucose metabolism and the potential utility of supplementation is relevant for the prevention and/or management of diabetes mellitus and its complications. Methods Literature search was performed using various dataset like PUBMED, EBSCO, ProQuest, Scopus and selected websites like the National Institute of Health and the World Health Organization. Result Water-Soluble Vitamins have been thoroughly studied for their activity in diabetes and diabetic complications. Conclusion Water-Soluble Vitamins like B1, B3, B6, B7, B9 and B12 have notable effects in diabetes mellitus and its related complications like nephropathy, neuropathy, retinopathy and cardiomyopathy.
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Water Soluble Vitamins and their Role in Diabetes and its Complications.
Current Diabetes Reviews, 2019Co-Authors: Shreeya V. Deshmukh, Bala Prabhakar, Yogesh A. KulkarniAbstract:BACKGROUND: Diabetes is a metabolic disorder associated with abnormally high levels of glucose in the blood due to inadequate production of insulin or inadequate sensitivity of cells to the action of insulin. Diabetes has become an increasing challenge in the world. The predicted diabetic population according to the World Health Organization is 8.7% between the age group 20-70 years. There are many complications linked to prolonged high glucose in the blood, such as microvascular complications and macrovascular complications. Vitamins play an important role in glucose metabolism and the potential utility of supplementation is relevant for the prevention and/or management of diabetes mellitus and its complications. METHODS: Literature search was performed using various dataset like PUBMED, EBSCO, ProQuest, Scopus and selected websites like the National Institutes of Health and the World Health Organization. RESULT: Water-Soluble Vitamins have been thoroughly studied for their activity in diabetes and diabetic complications. CONCLUSION: Water-Soluble Vitamins like B1, B3, B6, B7, B9 and B12 have notable effects in diabetes mellitus and its related complications like nephropathy, neuropathy, retinopathy and cardiomyopathy.
Mirjana Medenica - One of the best experts on this subject based on the ideXlab platform.
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reversed phase ion pair hplc determination of some water soluble Vitamins in pharmaceuticals
Journal of Pharmaceutical and Biomedical Analysis, 1999Co-Authors: Darko Ivanovic, A Popovic, Dusanka Radulovic, Mirjana MedenicaAbstract:A reversed-phase ion-pair high-performance liquid chromatografic method (RP-IPC) was developed to assay some Water-Soluble Vitamins in solution dosage forms. Vitamins of the B-group B1, B2, B3, and B6, including vitamin C were determined in Oligovit® coated tablets. In Beviplex® coated tablets the Vitamins B1, B2, B3, B6 and p-aminobenzoic acid were analysed. Hexanesulphonic acid sodium salt and triethanolamine in water–methanol were used as mobile phase with adjusting pH to 2.8 with orthophosphoric acid. Phenol was used as an internal standard. For quantitative simultaneous analysis of Vitamins in pharmaceutical formulations, the method of internal standard was used. All parameters for the validation of the method are given.
