The Experts below are selected from a list of 306 Experts worldwide ranked by ideXlab platform
Jan Stenlid - One of the best experts on this subject based on the ideXlab platform.
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Microsatellite markers for the Wood Decay Fungus Phlebiopsis gigantea
Conservation Genetics, 2009Co-Authors: Nicklas Samils, Brian P. Higgins, Campbell J Nairn, Bernard Slippers, Jan Stenlid, Sarah F. CovertAbstract:Nine polymorphic microsatellite markers were developed for the Wood-Decay basidiomycete Phlebiopsis gigantea, which is used commercially as a biocontrol agent for annosum root disease on conifers. Microsatellite sequences were isolated from repeat-enriched genomic libraries. Primers flanking these sequences were screened on P. gigantea isolates from Europe and North America. The number of alleles per locus ranged from 5 to 15, and gene diversity ranged from 0.72 to 0.90. These markers should be useful for studies of P. gigantea natural population structure and for making predictions about the impact of P. gigantea application in conifer forests.
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Population genetics of the Wood‐Decay Fungus Phlebia centrifuga P. Karst. in fragmented and continuous habitats
Molecular Ecology, 2007Co-Authors: Ina Franzén, Reijo Penttilä, Rimvydas Vasaitis, Jan StenlidAbstract:The basidiomycete Phlebia centrifuga is a Wood-Decay Fungus characteristic for unmanaged old-growth forests of spruce, a habitat that has become increasingly fragmented due to forest management. The aim of this study was to investigate the genetic population structures of P. centrifuga in both continuous and fragmented habitats, and estimate the potential impact of fragmentation on the genetic diversity of the Fungus. Three hundred fifteen single spore isolates (representing 47 spore families and 33 single isolates) from eight populations across northern Europe (Russia, Finland, and Sweden) were screened with seven microsatellite markers and arbitrary primed polymerase chain reaction with the M13 minisatellite. The two molecular methods generally gave the same pattern for the genetic population structure. There were no significant differences between the observed and the expected heterozygosities, and the inbreeding coefficient (FIS) did not indicate any inbreeding. The fixation index (FST) revealed a general pattern with little to moderate genetic differentiation for the majority of populations, while the southernmost Swedish population Norra Kvill was the only one showing high differentiation from about half of the other populations. Swedish population Fiby with the shortest distance to the continuous habitat was moderately differentiated from most of the others and to the largest extent differed from geographically closest population of Norra Kvill. The results indicate that the fragmentation of old-growth forest in Russia and Finland is more recent than the fragmentation in Sweden, and the genetic population structures of P. centrifuga in northern Europe might be related to differences in forest landscape dynamics between the two areas.
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population genetics of the Wood Decay Fungus phlebia centrifuga p karst in fragmented and continuous habitats
Molecular Ecology, 2007Co-Authors: Ina Franzén, Reijo Penttilä, Rimvydas Vasaitis, Jan StenlidAbstract:The basidiomycete Phlebia centrifuga is a Wood-Decay Fungus characteristic for unmanaged old-growth forests of spruce, a habitat that has become increasingly fragmented due to forest management. The aim of this study was to investigate the genetic population structures of P. centrifuga in both continuous and fragmented habitats, and estimate the potential impact of fragmentation on the genetic diversity of the Fungus. Three hundred fifteen single spore isolates (representing 47 spore families and 33 single isolates) from eight populations across northern Europe (Russia, Finland, and Sweden) were screened with seven microsatellite markers and arbitrary primed polymerase chain reaction with the M13 minisatellite. The two molecular methods generally gave the same pattern for the genetic population structure. There were no significant differences between the observed and the expected heterozygosities, and the inbreeding coefficient (FIS) did not indicate any inbreeding. The fixation index (FST) revealed a general pattern with little to moderate genetic differentiation for the majority of populations, while the southernmost Swedish population Norra Kvill was the only one showing high differentiation from about half of the other populations. Swedish population Fiby with the shortest distance to the continuous habitat was moderately differentiated from most of the others and to the largest extent differed from geographically closest population of Norra Kvill. The results indicate that the fragmentation of old-growth forest in Russia and Finland is more recent than the fragmentation in Sweden, and the genetic population structures of P. centrifuga in northern Europe might be related to differences in forest landscape dynamics between the two areas.
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Development of microsatellite markers for the red‐listed Wood‐Decay Fungus Phlebia centrifuga
Molecular Ecology Notes, 2006Co-Authors: Ina Franzén, Rimvydas Vasiliauskas, Bernard Slippers, Jan StenlidAbstract:Seven polymorphic microsatellite markers were developed for the Wood-Decay basidiomycete Phlebia centrifuga. The primers were identified using two techniques, based on intersimple sequence repeats (ISSR) and amplified fragment length polymorphism (AFLP), respectively. The markers were screened on 27 isolates from Europe and North America. Two markers varied only on a worldwide scale, but not within Europe. The other five showed variation on both scales. These markers will now be used to characterize populations of P. centrifuga, which is red-listed as near-threatened in its natural habitat due to human disturbance.
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development of microsatellite markers for the red listed Wood Decay Fungus phlebia centrifuga
Molecular Ecology Notes, 2006Co-Authors: Ina Franzén, Rimvydas Vasiliauskas, Bernard Slippers, Jan StenlidAbstract:Seven polymorphic microsatellite markers were developed for the Wood-Decay basidiomycete Phlebia centrifuga. The primers were identified using two techniques, based on intersimple sequence repeats (ISSR) and amplified fragment length polymorphism (AFLP), respectively. The markers were screened on 27 isolates from Europe and North America. Two markers varied only on a worldwide scale, but not within Europe. The other five showed variation on both scales. These markers will now be used to characterize populations of P. centrifuga, which is red-listed as near-threatened in its natural habitat due to human disturbance.
Mark Schubert - One of the best experts on this subject based on the ideXlab platform.
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Penetration capacity of the Wood-Decay Fungus Physisporinus vitreus
Complex Adaptive Systems Modeling, 2013Co-Authors: M. J. Fuhr, Mark Schubert, C. Stührk, Francis W. M. R. Schwarze, Hans Jürg HerrmannAbstract:Purpose: Bioincising is a biotechnological process for improving the permeability of refractory Wood such as Norway spruce heartWood using the Wood-Decay Fungus Physisporinus vitreus. The degradation of the bordered pit membranes by P. vitreus in its first stage of Wood colonization enhances the uptake of preservatives and Wood modification substances, whereas the strength of the material is not significantly reduced. Methods: We propose to study bioincising by means of a mathematical model, because many factors affect the growth and effects of P. vitreus in Norway spruce in such a complex way that an evaluation of the optimal incubation conditions (i.e. water activity, temperature or pH) is very expensive or even not possible solely using laboratory experiments. Results: Using a hyphal growth model we demonstrate here for the first time how to optimize bioincising by linking the microscopic growth behavior of P. vitreus with macroscopic system properties of the Wood. Moreover, we propose universal measures of Wood-Decay fungi, i.e., penetration velocity, penetration work and penetration capacity, which may figure as measures for the efficiency of Wood colonization. For example, our simulation shows that an increase of the hyphal growth rate (i.e. changing the incubation conditions) from 1 to 2 μm·d -1 results in an increase of the mycelium’s growth velocity from 0.8 to 1.75 μm·d -1 and an increase of the penetration capacity from 0.5 to 0.6 10 -3 ·mm 2 ·d -1 using a pit degradation rate of 2 μm·d -1 . Conclusions: Information about the penetration velocity, penetration work and penetration capacity is of significance for both its biotechnological use and the study of the colonization strategy of Wood-Decay fungi in general.
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penetration capacity of the Wood Decay Fungus physisporinus vitreus
Complex Adaptive Systems Modeling, 2013Co-Authors: M. J. Fuhr, Mark Schubert, C. Stührk, Francis W. M. R. Schwarze, Hans Jürg HerrmannAbstract:Bioincising is a biotechnological process for improving the permeability of refractory Wood such as Norway spruce heartWood using the Wood-Decay Fungus Physisporinus vitreus. The degradation of the bordered pit membranes by P. vitreus in its first stage of Wood colonization enhances the uptake of preservatives and Wood modification substances, whereas the strength of the material is not significantly reduced. We propose to study bioincising by means of a mathematical model, because many factors affect the growth and effects of P. vitreus in Norway spruce in such a complex way that an evaluation of the optimal incubation conditions (i.e. water activity, temperature or pH) is very expensive or even not possible solely using laboratory experiments. Using a hyphal growth model we demonstrate here for the first time how to optimize bioincising by linking the microscopic growth behavior of P. vitreus with macroscopic system properties of the Wood. Moreover, we propose universal measures of Wood-Decay fungi, i.e., penetration velocity, penetration work and penetration capacity, which may figure as measures for the efficiency of Wood colonization. For example, our simulation shows that an increase of the hyphal growth rate (i.e. changing the incubation conditions) from 1 to 2 μm·d-1 results in an increase of the mycelium’s growth velocity from 0.8 to 1.75 μm·d-1 and an increase of the penetration capacity from 0.5 to 0.6 10-3·mm2·d-1 using a pit degradation rate of 2 μm·d-1. Information about the penetration velocity, penetration work and penetration capacity is of significance for both its biotechnological use and the study of the colonization strategy of Wood-Decay fungi in general.
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Automated quantification of the impact of the Wood-Decay Fungus Physisporinus vitreus on the cell wall structure of Norway spruce by tomographic microscopy
Wood Science and Technology, 2011Co-Authors: M. J. Fuhr, C. Stührk, B. Münch, Francis W. M. R. Schwarze, Mark SchubertAbstract:The visualization and the quantification of microscopic Decay patterns are important for the study of the impact of Wood-Decay fungi in general, as well as for Wood-Decay fungi and microorganisms with possible applications in biotech- nology. In the present work, a method was developed for the automated localization and quantification of microscopic cell wall elements (CWE) of Norway spruce Wood such as bordered pits, intrinsic defects, hyphae or alterations induced by white-rot Fungus Physisporinus vitreus using high-resolution X-ray computed tomographic microscopy. In addition to classical destructive Wood anatomical methods such as light or laser scanning microscopy, this method allows for the first time to compute the properties (e.g., area, orientation and size distribution) of CWE of the tracheids in a sample. This is essential for modeling the influence of microscopic CWE on macroscopic properties such as Wood strength and permeability.
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Modelling the hyphal growth of the Wood-Decay Fungus Physisporinus vitreus
Fungal Biology, 2011Co-Authors: M. J. Fuhr, Mark Schubert, Francis W. M. R. Schwarze, Hans Jürg HerrmannAbstract:The white-rot Fungus, Physisporinus vitreus, degrades the membranes of bordered pits in tracheids and consequently increases the permeability of Wood, which is a process that can be used by the Wood industry to improve the uptake of Wood preservatives and environmentally benign Wood modification substances to enhance the use and sustainability of native conifer Wood species. To understand and apply this process requires an understanding of how a complex system (FunguseWood) interacts under defined conditions. We present a three-dimensional fungal growth model (FGM) of the hyphal growth of P. vitreus in the heartWood of Norway spruce. The model considers hyphae and nutrients as discrete structures and links the microscopic interactions between Fungus and Wood (e.g. degradation rate and degree of opening of pits) with macroscopic system properties, such penetration depth of the Fungus, biomass, and distribution of destroyed pits in early- and lateWood. Simulations were compared with experimental data. The growth of P. vitreus is characterized by a stepwise capture of the substrate and the effect of this on Wood according to different model parameters is discussed.
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Automated Quantification of the Impact of the Wood-Decay Fungus Physisporinus vitreus on the Cell Wall Structure of Norway spruce by Tomographic Microscopy
arXiv: Quantitative Methods, 2011Co-Authors: M. J. Fuhr, C. Stührk, B. Münch, Francis W. M. R. Schwarze, Mark SchubertAbstract:Wood-Decay fungi decompose their substrate by extracellular, degradative enzymes and play an important role in natural ecosystems by recycling carbon and minerals fixed in plants. Thereby, they cause significant damage to the Wood structure and limit the use of Wood as building material. Besides their role as biodeteriorators Wood-Decay fungi can be used for biotechnological purposes, e.g. the white-rot Fungus Physisporinus vitreus for improving the uptake of preservatives and Wood-modification substances of refractory Wood. Therefore, the visualization and the quantification of microscopic Decay patterns are important for the study of the impact of Wood-Decay fungi in general, as well as for Wood-Decay fungi and microorganisms with possible applications in biotechnology. In the present work, we developed a method for the automated localization and quantification of microscopic cell wall elements (CWE) of Norway spruce Wood such as bordered pits, intrinsic defects, hyphae or alterations induced by P. vitreus using high resolution X-ray computed tomographic microscopy. In addition to classical destructive Wood anatomical methods such as light or laser scanning microscopy, our method allows for the first time to compute the properties (e.g. area, orientation and size-distribution) of CWE of the tracheids in a sample. This is essential for modeling the influence of microscopic CWE to macroscopic properties such as Wood strength and permeability.
Trond Schumacher - One of the best experts on this subject based on the ideXlab platform.
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Regional and local population structure of the pioneer Wood-Decay Fungus Trichaptum abietinum.
Mycologia, 2003Co-Authors: Håvard Kauserud, Trond SchumacherAbstract:The population structure of 11 Fenno- scandian geographic populations of the pioneer Wood-Decay basidiomycete Trichaptum abietinum was assessed with PCR-RFLPs, intersequence simple re- peats (ISSRs) and mating studies. The three codom- inant PCR-RFLP markers (1) internal transcribed spacer 2 (nrDNA), (2) glyceraldehyde-3-phosphate dehydrogenase and (3) translation elongation factor lo1 showed that genotype distributions in most cases (94%) agreed with Hardy-Weinberg expectations and that random association of alleles occurred across loci. The molecular data suggest that T. abietinum is a highly outcrossing Fungus that regularly proliferates and spreads by sexual spores. Interstock mating re- actions suggest a high number of mating factors among individuals and that biological barriers to gene flow are nonexistent in the region. The three PCR-RFLP loci gave an overall FST = 0.03, indicating a low level of genetic differentiation and presumably high gene flow among the geographic populations. The ISSR markers revealed no systematic substruc- turing and the among-population variance compo- nent was low (6.1%) in AMOVA. However, all PCR- RFLP and most ISSR markers (7/12) showed signif- icant deviation from the null hypothesis of an even distribution of allele frequencies across the 11 geo- graphic populations. Allele frequencies varied in an apparently random manner, suggesting that genetic drift might be an important structuring factor in T abietinum. The spatial small-scale distribution of het- erokaryons on three selected substrate units (logs) showed that most isolates represented discrete indi- viduals and that a number of genets (19) may occupy a single log. The small-scale genotype distributions (within logs) were in agreement with panmictic Har-
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Genetic structure of Fennoscandian populations of the threatened Wood-Decay Fungus Fomitopsis rosea (Basidiomycota).
Fungal Biology, 2003Co-Authors: Håvard Kauserud, Trond SchumacherAbstract:The genetic structure of five Fennoscandian populations of the threatened Wood-Decay Fungus Fomitopsis rosea (Basidiomycota) was investigated using codominant PCR-RFLP, allele specific amplification (ASA) markers, inter simple sequence repeat (ISSR) markers and mating studies. Sequence analyses of a subset of single spore isolates revealed sequence variation in four target sequences; internal transcribed spacer (ITS) and intergenic spacer (IGS1) of the nuclear ribosomal DNA, the translation elongation factor 1 alpha ( efa ) gene and the super oxide dismutase ( sod ) gene. No sequence variation was found in amplified portions of the mitochondrial large and small rRNA genes. Genotype distributions were mostly (90%) in accordance with Hardy-Weinberg expectations, and the nrDNA markers (ITS/IGS1), efa and sod were in most cases (87%) in linkage equilibrium, indicating an outcrossing reproductive mode, panmictic conditions and large population sizes of the Fungus. Mating tests confirmed that F. rosea exhibits an outcrossing bipolar heterothallic mating system. Mating allele richness was high in two investigated populations. Phylogenetic analyses of ITS and IGS1 sequences from the five geographic populations revealed some geographic sub-structuring of the ITS sequences, but no sub-structuring of IGS1. The nrDNA (ITS/IGS1), efa and sod markers gave a low overall F ST (0.013). The ISSR markers gave no clustering of the populations in UPGMA, and the between-population variance component was very low in AMOVA (0.4%), indicating a high level of gene flow.
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Population structure of the endangered Wood Decay Fungus Phellinus nigrolimitatus (Basidiomycota)
Botany, 2002Co-Authors: Håvard Kauserud, Trond SchumacherAbstract:The population structure of five Fennoscandian geographic populations of the endangered Wood-Decay Fungus Phellinus nigrolimitatus (Romell) Bourdot et Galzin was examined by analyses of nuclear ribosomal DNA (nrDNA) spacer sequences (ITS and IGS1) and a partial sequence of the elongation factor 1α gene (efa). A high level of sequence variation was observed in ITS and IGS1, suggesting restrictions in nrDNA homogenization in this taxon. Six polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) markers, five located in nrDNA and one in efa, suggest that the geographic populations are genetically very similar, presumably owing to recent gene flow. However, linkage disequilibria were obtained in 50% of the cases in tests between the five nrDNA PCR-RFLP markers. The calculated FST values from the linked nrDNA markers and the unlinked efa marker were congruent, ranging from 0.006 to 0.042. In one geographic population, the efa locus showed significant deviation from Hardy- Weinberg expectations. Somatic incompatibility tests demonstrated that isolates derived from different basidiocarps and different logs belonged to different genets. In a microscale study including three logs, the independent assays of PCR- RFLP analysis and somatic incompatibility tests distinguished 10 genets. Life history traits and conservation status of P. nigrolimitatus are discussed in light of the results.
M. J. Fuhr - One of the best experts on this subject based on the ideXlab platform.
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Penetration capacity of the Wood-Decay Fungus Physisporinus vitreus
Complex Adaptive Systems Modeling, 2013Co-Authors: M. J. Fuhr, Mark Schubert, C. Stührk, Francis W. M. R. Schwarze, Hans Jürg HerrmannAbstract:Purpose: Bioincising is a biotechnological process for improving the permeability of refractory Wood such as Norway spruce heartWood using the Wood-Decay Fungus Physisporinus vitreus. The degradation of the bordered pit membranes by P. vitreus in its first stage of Wood colonization enhances the uptake of preservatives and Wood modification substances, whereas the strength of the material is not significantly reduced. Methods: We propose to study bioincising by means of a mathematical model, because many factors affect the growth and effects of P. vitreus in Norway spruce in such a complex way that an evaluation of the optimal incubation conditions (i.e. water activity, temperature or pH) is very expensive or even not possible solely using laboratory experiments. Results: Using a hyphal growth model we demonstrate here for the first time how to optimize bioincising by linking the microscopic growth behavior of P. vitreus with macroscopic system properties of the Wood. Moreover, we propose universal measures of Wood-Decay fungi, i.e., penetration velocity, penetration work and penetration capacity, which may figure as measures for the efficiency of Wood colonization. For example, our simulation shows that an increase of the hyphal growth rate (i.e. changing the incubation conditions) from 1 to 2 μm·d -1 results in an increase of the mycelium’s growth velocity from 0.8 to 1.75 μm·d -1 and an increase of the penetration capacity from 0.5 to 0.6 10 -3 ·mm 2 ·d -1 using a pit degradation rate of 2 μm·d -1 . Conclusions: Information about the penetration velocity, penetration work and penetration capacity is of significance for both its biotechnological use and the study of the colonization strategy of Wood-Decay fungi in general.
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penetration capacity of the Wood Decay Fungus physisporinus vitreus
Complex Adaptive Systems Modeling, 2013Co-Authors: M. J. Fuhr, Mark Schubert, C. Stührk, Francis W. M. R. Schwarze, Hans Jürg HerrmannAbstract:Bioincising is a biotechnological process for improving the permeability of refractory Wood such as Norway spruce heartWood using the Wood-Decay Fungus Physisporinus vitreus. The degradation of the bordered pit membranes by P. vitreus in its first stage of Wood colonization enhances the uptake of preservatives and Wood modification substances, whereas the strength of the material is not significantly reduced. We propose to study bioincising by means of a mathematical model, because many factors affect the growth and effects of P. vitreus in Norway spruce in such a complex way that an evaluation of the optimal incubation conditions (i.e. water activity, temperature or pH) is very expensive or even not possible solely using laboratory experiments. Using a hyphal growth model we demonstrate here for the first time how to optimize bioincising by linking the microscopic growth behavior of P. vitreus with macroscopic system properties of the Wood. Moreover, we propose universal measures of Wood-Decay fungi, i.e., penetration velocity, penetration work and penetration capacity, which may figure as measures for the efficiency of Wood colonization. For example, our simulation shows that an increase of the hyphal growth rate (i.e. changing the incubation conditions) from 1 to 2 μm·d-1 results in an increase of the mycelium’s growth velocity from 0.8 to 1.75 μm·d-1 and an increase of the penetration capacity from 0.5 to 0.6 10-3·mm2·d-1 using a pit degradation rate of 2 μm·d-1. Information about the penetration velocity, penetration work and penetration capacity is of significance for both its biotechnological use and the study of the colonization strategy of Wood-Decay fungi in general.
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Automated quantification of the impact of the Wood-Decay Fungus Physisporinus vitreus on the cell wall structure of Norway spruce by tomographic microscopy
Wood Science and Technology, 2011Co-Authors: M. J. Fuhr, C. Stührk, B. Münch, Francis W. M. R. Schwarze, Mark SchubertAbstract:The visualization and the quantification of microscopic Decay patterns are important for the study of the impact of Wood-Decay fungi in general, as well as for Wood-Decay fungi and microorganisms with possible applications in biotech- nology. In the present work, a method was developed for the automated localization and quantification of microscopic cell wall elements (CWE) of Norway spruce Wood such as bordered pits, intrinsic defects, hyphae or alterations induced by white-rot Fungus Physisporinus vitreus using high-resolution X-ray computed tomographic microscopy. In addition to classical destructive Wood anatomical methods such as light or laser scanning microscopy, this method allows for the first time to compute the properties (e.g., area, orientation and size distribution) of CWE of the tracheids in a sample. This is essential for modeling the influence of microscopic CWE on macroscopic properties such as Wood strength and permeability.
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Modelling the hyphal growth of the Wood-Decay Fungus Physisporinus vitreus
Fungal Biology, 2011Co-Authors: M. J. Fuhr, Mark Schubert, Francis W. M. R. Schwarze, Hans Jürg HerrmannAbstract:The white-rot Fungus, Physisporinus vitreus, degrades the membranes of bordered pits in tracheids and consequently increases the permeability of Wood, which is a process that can be used by the Wood industry to improve the uptake of Wood preservatives and environmentally benign Wood modification substances to enhance the use and sustainability of native conifer Wood species. To understand and apply this process requires an understanding of how a complex system (FunguseWood) interacts under defined conditions. We present a three-dimensional fungal growth model (FGM) of the hyphal growth of P. vitreus in the heartWood of Norway spruce. The model considers hyphae and nutrients as discrete structures and links the microscopic interactions between Fungus and Wood (e.g. degradation rate and degree of opening of pits) with macroscopic system properties, such penetration depth of the Fungus, biomass, and distribution of destroyed pits in early- and lateWood. Simulations were compared with experimental data. The growth of P. vitreus is characterized by a stepwise capture of the substrate and the effect of this on Wood according to different model parameters is discussed.
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Automated Quantification of the Impact of the Wood-Decay Fungus Physisporinus vitreus on the Cell Wall Structure of Norway spruce by Tomographic Microscopy
arXiv: Quantitative Methods, 2011Co-Authors: M. J. Fuhr, C. Stührk, B. Münch, Francis W. M. R. Schwarze, Mark SchubertAbstract:Wood-Decay fungi decompose their substrate by extracellular, degradative enzymes and play an important role in natural ecosystems by recycling carbon and minerals fixed in plants. Thereby, they cause significant damage to the Wood structure and limit the use of Wood as building material. Besides their role as biodeteriorators Wood-Decay fungi can be used for biotechnological purposes, e.g. the white-rot Fungus Physisporinus vitreus for improving the uptake of preservatives and Wood-modification substances of refractory Wood. Therefore, the visualization and the quantification of microscopic Decay patterns are important for the study of the impact of Wood-Decay fungi in general, as well as for Wood-Decay fungi and microorganisms with possible applications in biotechnology. In the present work, we developed a method for the automated localization and quantification of microscopic cell wall elements (CWE) of Norway spruce Wood such as bordered pits, intrinsic defects, hyphae or alterations induced by P. vitreus using high resolution X-ray computed tomographic microscopy. In addition to classical destructive Wood anatomical methods such as light or laser scanning microscopy, our method allows for the first time to compute the properties (e.g. area, orientation and size-distribution) of CWE of the tracheids in a sample. This is essential for modeling the influence of microscopic CWE to macroscopic properties such as Wood strength and permeability.
Anders Broberg - One of the best experts on this subject based on the ideXlab platform.
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Cytotoxic Illudalane Sesquiterpenes from the Wood-Decay Fungus Granulobasidium vellereum (Ellis & Cragin) Jülich
Molecules, 2014Co-Authors: Christina L. Nord, Audrius Menkis, Anders BrobergAbstract:Seven illudalane sesquiterpenes were obtained from the Wood decomposing Fungus Granulobasidium vellereum: granuloinden A, granuloinden B and dihydrogranuloinden, along with the previously known compounds radulactone, pterosin M, echinolactone A and D. Granuloinden B showed potent cytotoxic activity against the Huh7 and MT4 tumor cell lines (CC50 values of 6.7 and 0.15 µM, respectively), whereas granuloinden A and dihydrogranuloinden had no or moderate activity.
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cytotoxic illudalane sesquiterpenes from the Wood Decay Fungus granulobasidium vellereum ellis cragin julich
Molecules, 2014Co-Authors: Christina Nord, Audrius Menkis, Anders BrobergAbstract:Seven illudalane sesquiterpenes were obtained from the Wood decomposing Fungus Granulobasidium vellereum: granuloinden A, granuloinden B and dihydrogranuloinden, along with the previously known compounds radulactone, pterosin M, echinolactone A and D. Granuloinden B showed potent cytotoxic activity against the Huh7 and MT4 tumor cell lines (CC50 values of 6.7 and 0.15 µM, respectively), whereas granuloinden A and dihydrogranuloinden had no or moderate activity.
