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Jeanmarie Bessiere - One of the best experts on this subject based on the ideXlab platform.
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aromatic plants of tropical central africa part xlix chemical composition of essential oils of the leaf and rhizome of Aframomum giganteum k schum from gabon
Flavour and Fragrance Journal, 2004Co-Authors: Huguette Agnaniet, Chantal Menut, Jeanmarie BessiereAbstract:The chemical composition of the essential oils obtained by hydrodistillation of the leaves and rhizomes of Aframomum giganteum K. Schum grown in Gabon were investigated by GC–FID and GC–MS. The major compounds in the leaf oil were found to be cis-pinocamphone (54%) and pinocarvone (10.1%), while the essential oil from the rhizomes is dominated by sesquiterpenes, namely β-caryophyllene (10.5%) and their oxygenated derivatives (40%). The antioxidant and the antiradical activity of both samples were evaluated. Copyright © 2004 John Wiley & Sons, Ltd.
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aromatic plants of tropical central africa xxxviii chemical composition of the essential oils from four Aframomum species collected in cameroon 1
Journal of Essential Oil Research, 2002Co-Authors: P Amvam H Zollo, R Abondo, L Biyiti, Chantal Menut, Jeanmarie BessiereAbstract:Abstract The essential oils isolated by hydrodistillation from the leaves or seeds of Aframomum citratum (Pereira) K. Schum., Aframomum hanburyi K. Schum., A. letestuanum Gagnepain and A. pruinosum Gagnepain (Zingiberaceae) grown in Cameroon were analyzed by GC and GC/MS. The leaf oils obtained from A. citratum and A. hanburyi were characterized by being rich in monoterpene hydrocarbons, dominated by pinenes. The major volatile components from seeds of the four species were oxygenated components belonging to the acyclic terpene class, such as geraniol (70.0%) in the case of A. citratum, (E,E)-farnesol (27.3%) and linalool (19.0%) for A. hanburyi, while A. letestuanum and A. pruinosum contained a main proportion of (E)-nerolidol (67.0% and 91.7%, respectively) in their seeds oils.
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aromatic plants of tropical central africa xii fruit essential oil of Aframomum pruinosum gagnepain a potential source of e r nerolidol
Journal of Essential Oil Research, 1994Co-Authors: Chantal Menut, P Amvam H Zollo, R Abondo, G Lamaty, Jeanmarie BessiereAbstract:ABSTRACT The essential oils obtained from seeds and leaves of Aframomum pruinosum Gagnepain from Cameroon have been analyzed by GC and GC/MS. Both samples are completely different; while the leaf oil contains almost similar percentages of mono- and sesquiterpenoids (β-pinene, 31.4%; β-caryophyllene, 25.8%), the fruit oil is characterized by more than 90% of (E)-(R)-nerolidol.
Jeanmaurille Ouamba - One of the best experts on this subject based on the ideXlab platform.
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Aframomum stipulatum gagnep k schum and Aframomum giganteum oliv hanb k schum as aroma tincto oleo crops resources essential oil fatty acids sterols tocopherols and tocotrienols composition of different fruit parts of congo varieties
Journal of the Science of Food and Agriculture, 2013Co-Authors: Adolphe Christian Ngakegnilimbili, Bachar Zebib, Muriel Cerny, Gouolally Tsiba, Arnold Murphy Elouma Ndinga, Zephirin Mouloungui, Isabelle Fourastier, Jeanmaurille OuambaAbstract:BACKGROUND: Today, few known plant species provide both an essential oil (EO) and a vegetable oil (VO). Seed and husk of two Aframomum species were investigated and compared in terms of EO, fatty acids, tocopherols, and tocotrienols. RESULTS: EO yield reaches 15.3 g kg−1 in the seeds and 3.2 g kg−1 in the husks, while VO yield is 180.0 g kg−1 in the seeds and 25.0 g kg−1 in the husks. β-Pinene, 1,8-cineol, α-selinene, terpine-4-ol, linalool, myrtenal and β-caryophyllene are the major compounds of seed and husk EO. Fatty acid analysis of two Aframomum species shows that oleic, linoleic, and palmitic acids were the major compounds of VO. Total sterol contents reached 4.3 g kg−1 in seed VO and 8.5 g kg−1 in husk VO. An appreciable amount of tocopherols (0.52 g kg−1) was found in seed VO. CONCLUSION: The seed and husk oil of A. stipulatum and A. giganteum fruits are rich sources of many bioactive constituents such as fatty acids, sterols, tocopherols and tocotrienols. These tropical wild fruits can be considered as new Aroma Tincto Oleo Crops (ATOC) resources that contain both EOs and VOs. Copyright © 2012 Society of Chemical Industry
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Aframomum stipulatum (Gagnep) K. Schum and Aframomum giganteum (Oliv. & Hanb) K. Schum as Aroma Tincto Oleo Crops resources: essential oil, fatty acids, sterols, tocopherols, and tocotrienols composition of different fruit parts of Congo varieties
Journal of the Science of Food and Agriculture, 2012Co-Authors: Adolphe Christian Ngakegni-limbili, Bachar Zebib, Muriel Cerny, Gouolally Tsiba, Arnold Murphy Elouma Ndinga, Zephirin Mouloungui, Isabelle Fourastier, Jeanmaurille OuambaAbstract:BACKGROUND: Today, few known plant species provide both an essential oil (EO) and a vegetable oil (VO). Seed and husk of two Aframomum species were investigated and compared in terms of EO, fatty acids, tocopherols, and tocotrienols. RESULTS: EO yield reaches 15.3 g kg−1 in the seeds and 3.2 g kg−1 in the husks, while VO yield is 180.0 g kg−1 in the seeds and 25.0 g kg−1 in the husks. β-Pinene, 1,8-cineol, α-selinene, terpine-4-ol, linalool, myrtenal and β-caryophyllene are the major compounds of seed and husk EO. Fatty acid analysis of two Aframomum species shows that oleic, linoleic, and palmitic acids were the major compounds of VO. Total sterol contents reached 4.3 g kg−1 in seed VO and 8.5 g kg−1 in husk VO. An appreciable amount of tocopherols (0.52 g kg−1) was found in seed VO. CONCLUSION: The seed and husk oil of A. stipulatum and A. giganteum fruits are rich sources of many bioactive constituents such as fatty acids, sterols, tocopherols and tocotrienols. These tropical wild fruits can be considered as new Aroma Tincto Oleo Crops (ATOC) resources that contain both EOs and VOs. Copyright © 2012 Society of Chemical Industry
C Menut - One of the best experts on this subject based on the ideXlab platform.
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chemical composition of essential oils from aerial parts of Aframomum exscapum sims hepper collected in guadeloupe french west indies
Flavour and Fragrance Journal, 2006Co-Authors: M Couppe A De K Martin, H Joseph, Sylvie Bercion, C MenutAbstract:Chemical composition of essential oils obtained by hydrodistillation of leaves, stems, pulp and seeds of fruits of Aframomum exscapum (Sims) Hepper grown in Guadeloupe was investigated by GC and GC–MS. Forty-four volatile compounds were identified, among which 1,8-cineole was the main constituent in all parts of the plant (47–86%). These analytical data confirm that the species from Guadeloupe is not Aframomum melegueta (Rosc.) K. Schum. as initially claimed by local botanists. Copyright © 2006 John Wiley & Sons, Ltd.
Solomon Umukoro - One of the best experts on this subject based on the ideXlab platform.
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Therapeutic Effects of Grains of Paradise (Aframomum melegueta) Seeds
Nuts and Seeds in Health and Disease Prevention, 2020Co-Authors: Solomon Umukoro, Aderemi Caleb AladeokinAbstract:Publisher Summary This chapter describes the cultivation, applications to health and disease prevention, and adverse effects of Aframomum melegueta seeds. Studies have revealed the potential of grains of paradise as a valuable medicinal agent for promoting good health and prevention of a variety of ailments. In ethno-medicine, the macerated seeds are often applied to swollen parts of the body to relieve inflammation and pain. Experimental studies showed that the crude extract of these seeds exhibited anti-inflammatory and analgesic activity in rats. The extract inhibited both acute and chronic inflammatory responses in rats, which provides the basis for its use in traditional medicine for acute and chronic inflammatory disorders. The anti-inflammatory effect of the seed might have resulted from inhibition of prostaglandin synthesis. In another study, an active compound obtained from the Aframomum melegueta seed was described as the most potent likely anti-inflammatory agent ever discovered. This compound has been licensed to biotechnology companies and might turn out to be a source of new drugs for the treatment of arthritis, heart disease, and other conditions that have inflammation as their root cause. As a potent anti-infective agent, GP may offer new medicines for the treatment of tropical diseases, which are one of the most common global health burdens. Grains of paradise may serve as a remedy for the treatment of male erectile dysfunction and premature ejaculation. Aframomum melegueta seed is generally recognized as safe, as no side effects have been reported from its consumption or usage over the years.
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psychopharmacological evaluation of antidepressant like activity of ethanol seed extract of grains of paradise Aframomum melegueta k schum in mice
Journal of Food Biochemistry, 2018Co-Authors: Oritoke Modupe Aluko, Solomon UmukoroAbstract:The antidepressant-like activity of ethanol seed extract of Aframomum melegueta (AM) in mice was evaluated in this study. The duration of immobility was measured 30 min after oral administration of AM (25–400 mg/kg) in forced swim test. In the unpredictable chronic mild stress (UCMS) paradigm, mice were treated with AM (25–100 mg/kg) 30 min before exposure to different stressors for 14 days. Thereafter, sucrose preference test, tail suspension test, and test for anxiety were done. The brain concentrations of malondialdehyde and glutathione were estimated spectrophotometrically. Brain histology and population of healthy neurons in cornu ammonis 3 of the hippocampus were also assessed. AM (25 and 50 mg/kg) significantly decreased the duration of immobility in forced swim test and prevented UCMS-induced anhedonia and anxiety-like behaviors, suggesting antidepressant potentials. The extract decreased malondialdehyde and increased glutathione concentrations in UCMS-induced mice. Therefore, AM extract offers protection against UCMS-induced damage to cornu ammonis 3 hippocampal neuronal cells indicating neuroprotection. Practical applications The seed of Grains of Paradise (Aframomum melegueta) is used in traditional medicine for fatigue and impotence, which are prominent symptoms of major depression. It is also widely chewed for its presumed central nervous system stimulant and endurance promoting effects. The results of this study revealed valuable evidence concerning the possible use of Grains of Paradise as an affordable natural, alternative, and/or complementary therapy with antioxidative and neuroprotective potentials. Consumption of these seeds in the right quantity might provide health benefits as Grains of Paradise exhibited antidepressant-like effect via inhibition of oxidative stress and neuroprotection.
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further pharmacological studies on aqueous seed extract of Aframomum melegueta in rats
Journal of Ethnopharmacology, 2008Co-Authors: Solomon Umukoro, Babatunde Rasaq AshorobiAbstract:This present study investigates the effect of an aqueous seed extract of Aframomum melegueta, on leukocytes migration and on phenylhydrazine-treated rat red blood cells (RBC). The effect of Aframomum melegueta on the number of white blood cells (WBC), in inflammatory exudates, was assessed by utilizing the granuloma air pouch model, for chronic inflammation in carrageenin-treated rats. The extract was tested for its anti-oxidant and membrane-stabilizing effects, in rat RBC exposed to phenylhydrazine. Aframomum melegueta was found to significantly reduce the number of WBC, in the fluid in a dose-related manner. The extract also produced significant inhibition of rat red blood cells lysis exposed to phenylhydrazine, which suggests a membrane-stabilizing effect. It further demonstrated a potent anti-oxidant activity, as it significantly reduced the levels of malonydialdehyde (MDA) formation in rat RBC exposed to phenylhydrazine. The results of this study, suggest that Aframomum melegueta possess membrane-stabilizing activity, along with anti-oxidant property and may also have a modifying effect, on the responses of WBC to tissue injury.
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further studies on the antinociceptive action of aqueous seed extract of Aframomum melegueta
Journal of Ethnopharmacology, 2007Co-Authors: Solomon Umukoro, Rasaq B AshorobiAbstract:Abstract This study presents the results of further investigations on the antinociceptive profiles of an aqueous seed extract of Aframomum melegueta in rodents. The antinociceptive activity of the intraperitonal doses of 25–100 mg/kg of Aframomum melegueta was assessed using the formalin-induced paw licking, Randall–Selitto paw pressure and hot plate models of pain. The extract was found to produce a significant dose-dependent inhibition of the inflammatory but not the neurogenic pains associated with the formalin test. In the Randall–Sellito paw pressure test, the extract significantly reduced the nociceptive responses elicited by compression of inflamed hind paw of rats in a dose-related manner. However, Aframomum melegueta did not alter the pain threshold in non-inflamed paw and also failed to prolong the reaction time of the animals to noxious heat in the hot plate test. Taken together, these findings suggest that the aqueous seed extract of Aframomum melegueta possess peripheral analgesic activity.
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Further Evaluation of the Anti–inflammatory Activity of Aframomum Melegueta Seed Extract and its Possible Mechanism of Action
Nigerian Journal of Health and Biomedical Sciences, 2005Co-Authors: Solomon Umukoro, Rasaq B AshorobiAbstract:The anti–inflammatory effect of aqueous seed extract of Aframomum melegueta (AM) was further evaluated in the study. Sub–chronic inflammatory conditions were induced by 2% formaldehyde and 6% nystatin respectively. Whilst the Selye granuloma pouch technique utilizing carrageenin–induced exudate formation was used as model of chronic inflammation. The membrane stabilizing activity of AM was assessed using rat erythrocyte exposed to hypotonic solution. The results revealed that AM (50–200 mg/kg, i.p.) significantly (P A. melegueta may contribute to its anti–inflammatory action. KEY WORDS: Aframomum melegueta, seed, membrane stabilization, inhibition, sub–chronic, inflam-matory responses. Nigerian Journal of Health and Biomedical Sciences Vol.4(1) 2005: 35-39
Pierre Tane - One of the best experts on this subject based on the ideXlab platform.
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Chemical composition and antimicrobial activity of essential oils from Aframomum citratum, Aframomum daniellii, Piper capense and Monodora myristica
Journal of Medicinal Plants Research, 2019Co-Authors: Sylvie Carolle Meffo Dongmo, Guy Sedar Singor Njateng, Jean-de-dieu Tamokou, Pierre Tane, Jules-roger KuiateAbstract:This study was initiated to evaluate the chemical composition and in vitro antimicrobial activity of essential oils from four Cameroonian spices and to determine the therapeutic effect of a cream based on essential oil from Aframomum citratum. Essential oils were extracted from seeds by hydrodistillation and analyzed by gas chromatography coupled with mass spectrometry (GC/MS). The broth microdilution method was used for the minimum inhibitory concentration (MIC) and minimum microbicidal concentration (MMC) determinations. The therapeutic effect of a cosmetic cream based on essential oil from A. citratum seed (1.25, 2.5 and 5% w/w) was evaluated against dermatosis induced with a Methicillin-Resistant Staphylococcus aureus (MRSA) in rats. The main identified compounds in the essential oils are geraniol for A. citratum; eucalyptol, α-terpineol and geraniol for Aframomum daniellii; β-pinene, germacrene D, trans-β-caryophyllene, α-pinene, naphthalene and sabinene for Piper capense; α-phellandrene, germacradienol and δ-cadinene for Monodora myristica. Essential oil of A. citratum (MIC = 8-4096 µg/ml) was the most active against bacteria and fungi, following in decreasing order by those of A. daniellii, P. capense and M. myristica. The antibacterial activity of the essential oil of A. citratum against MRSA and Escherichia coli S2(1) (MIC = 8 µg/ml) was higher than that of amoxicillin used as reference drug (MIC = 128- 256 µg/ml). The combination of essential oils of A. citratum and A. daniellii (1:1) displayed a synergistic effect. The cream based on essential oil of A. citratum (5%) and Baneocin (reference drug) eradicated the dermatosis induced with MRSA in rat after two weeks of treatment. These results indicate that the tested essential oils possess antimicrobial activities which could be a function of either the individual or the additive effects of the identified phytoconstituents. Key words: Spices, hydrodistillation, essential oils, gas chromatography/mass spectrometry (GC/MS), antibacterial, antifungal, synergistic effect.
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Essential Oils from Seeds of Aframomum citratum (C. Pereira) K. Schum, Aframomum daniellii (Hook. F.) K. Schum, Piper capense (Lin. F) and Monodora myristica (Gaertn.) Dunal NL and their Antioxidant Capacity in a Cosmetic Cream
Journal of Essential Oil Bearing Plants, 2019Co-Authors: Sylvie C.d. Meffo, Guy Sedar Singor Njateng, Jean-de-dieu Tamokou, Pierre Tane, Jules-roger KuiateAbstract:AbstractPreservative properties of essential oils from Aframomum citratum, Aframomum daniellii, Piper capense and Monodora myristica are well known in agri-food. In the current work, we study the p...
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antimicrobial principle from Aframomum longifolius
Planta Medica, 2006Co-Authors: Simplice Tatsimo, Pierre Tane, Brian M Schuster, Jacob Melissa, Beibam Luc Sondengam, Christopher O Okunji, Ikhlas A KhanAbstract:Antimicrobial activity-directed fractionation of the seeds of Aframomum longifolius (Zingiberaceae) afforded two new labdane-type diterpenoids, 15-hydroxy-15-methoxylabda-8(17), 12(E)-dien-16-al (aframolin A) (1) and 8β(17)-epoxy-15,15-dimethoxylabd-12(E)-en-16-al (aframolin B) (2), together with the known diterpenes labda-8(17),12(E)-diene-15,16-dial (3) and aframodial (4). Their structures were determined by spectroscopic methods. Compound 4 showed significant antimicrobial activity against Cryptococcus neoformans, Staphylococcus aureus and methicillin-resistant S. aureus (MRS) while 1, 2 and 3 were found to be inactive.
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trypanocidal diarylheptanoids from Aframomum letestuianum
Journal of Natural Products, 2003Co-Authors: Pierre Kamnaing, Pierre Tane, Apollinaire Tsopmo, Marguerite Tchuendem, Johnson F Ayafor, Olov Sterner, Eric A Tanifum, Donna Rattendi, Brian M Schuster, Cyrus J BacchiAbstract:Three new diarylheptanoids, (4Z,6E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-4,6-dien-3-one, letestuianin A (1), (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-4,6-dien-3-one, letestuianin B (2), and 1,7-bis(4-hydroxyphenyl)heptan-3,5-dione, letestuianin C (3), as well as the known (4Z,6E)-5-hydroxy-1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one (5) were isolated from Aframomum letestuianum. The known flavonoids 3-acetoxy-5,7,4'-trihydroxyflavanone, 3-acetoxy-7-methoxy-5,4'-dihydroxyflavanone, 7-methoxy-3,5,4'-trihydroxyflavone, and 3,3',4',5,7-pentahydroxyflavan were also obtained from this plant. Their structures were determined using a combination of 1D and 2D NMR techniques. The four diarylheptanoids were tested for growth inhibitory activity in vitro versus bloodstream forms of African trypanosomes. IC50 values in the range of 1-3 g/mL were found for compounds 3 and 5. (Less)
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three labdane diterpenoids from Aframomum sceptrum zingiberaceae
Phytochemistry, 2002Co-Authors: Christabel Tomla, Pierre Tane, Apollinaire Tsopmo, Godfred A Ayimele, Pierre Kamnaing, Eric A Tanifum, Johnson Foyere Ayafor, Joseph D ConnollyAbstract:Abstract Three labdane diterpenoids, 8β,17-epoxy-3β,7β-dihydroxy-12( E )-labden-16,15-olide ( 1 ), methyl 8β,17-epoxy-3β,7β,15-trihydroxy-12( E )-labden-16-oate ( 2 ) and 3β,7β,8β,12ζ,17-pentahydroxylabdan-16,15-olide ( 3 ) have been isolated from the seeds of Afromomum sceptrum K. Schum (Zingiberaceae) and their structures assigned on the basis of their spectroscopic properties. Nerolidol, and the known flavonoids 3-acetoxy-4′,5,7-trihydroxyflavanone, and 3,4′,5,7-tetrahydroxyflavanone were also obtained.
