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Donghyun Kim - One of the best experts on this subject based on the ideXlab platform.
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inhibitory effects of steroidal timosaponins isolated from the rhizomes of anemarrhena asphodeloides against passive cutaneous anaphylaxis reaction and pruritus
Immunopharmacology and Immunotoxicology, 2010Co-Authors: Bomi Lee, Hien Trung Trinh, Kangsik Jung, Sangjun Han, Donghyun KimAbstract:To investigate the Antiallergic effect of the rhizome of Anemarrhena asphodeloides (AA, family Liliaceae), which was found to inhibit the mouse passive cutaneous anaphylaxis (PCA) reaction induced by the antigen-immunoglobulin E (IgE) complex in preliminary experiments, main steroidal saponins, timosaponins AIII, BIII, and D, were isolated and their inhibitory effects against PCA reaction and scratching behaviors investigated in mice. Oral administration of three main steroidal sapogenins blocked the PCA reaction and scratching behaviors, timosaponin AIII was the most potent. However, intraperitoneal administration of timosaponin AIII showed weak inhibition. To understand its metabolism and Antiallergic mechanism, timosaponin AIII was anaerobically incubated with human intestinal microflora to afford a main metabolite, sarsasapogenin. Intraperitoneal administration of sarsasapogenin inhibited allergic reaction more potently than timosaponin AIII. In addition, sarsasapogenin more potently inhibited degranu...
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Antiallergic and antipsoriatic effects of korean red ginseng
Journal of Ginseng Research, 2005Co-Authors: Eunah Bae, Myung Joo Han, Yongwook Shin, Donghyun KimAbstract:Antiallergic and antipsoriatic effects of Korean Red Ginseng (KRG, steamed root of Panax ginseng CA Meyer, Family Araliaceae) were measured. Orally administered KRG water extract potently inhibited passive cutaneous anaphylaxis (PCA). KRG water extract also showed the potent inhibition in oxazolone-induced mouse dermatitis, and suppressed mouse ear swelling by 39% at 16 days at a dose of 0.1 %. KRG water extract reduced the levels of mRNA of cyclooxygenase (COX)-2, IL-1β, TNF-α and IFN-γ increased in oxazolone-applied mouse ears, however, did not inhibit that of IL-4. KRG water extract also inhibited iNOS and COX-2 mRNA expression level of RAW264.7 cell induced by lipopolysaccharide. Based on these findings, we suggest that KRG can improve atopic and contact dermatitis by the regulation of IL-1β and TNF-α produced by macrophage cells and interferon-γ produced by Th1 cells.
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Antiallergic activity of hesperidin is activated by intestinal microflora.
Pharmacology, 2004Co-Authors: Neung-kee Lee, Seung-hoon Choi, Sung-hwan Park, Eun-kyung Park, Donghyun KimAbstract:When hesperidin isolated from pericarpium of Citrus unshiu (family Rutaceae) was incubated with human intestinal microflora, its main metabolite was hesperetin, which was a main metabolite in urine of orally hesperidin-administered rats. The Antiallergic activity of hesperidin and its metabolite hesperetin were investigated. Hesperidin did not inhibit the histamine release from RBL-2H3 cells induced by IgE. However, its metabolite hesperetin potently inhibited the histamine release from RBL-2H3 cells induced by IgE and the PCA reaction. The inhibitory activity of hesperetin was found to be comparable with azelastine, a commercially available Antiallergic drug, and to potently inhibit prostaglandin E2 production in lipopolysaccharide-stimulated RAW 264.7 cells. Hesperetin weakly inhibits cyclooxygenase 2 enzyme activities. These results suggest that hesperidin may be a prodrug, which is metabolized to hesperetin by intestinal bacteria.
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ginsenoside rh1 possesses Antiallergic and anti inflammatory activities
International Archives of Allergy and Immunology, 2004Co-Authors: Eun-kyung Park, Minkyung Choo, Myung Joo Han, Donghyun KimAbstract:Background: Ginseng (the root of Panax ginseng C.A. Meyer, Araliaceae) has been reported to possess various biological activities, including anti-inflammatory and
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Antiallergic activity of ginsenoside rh2
Biological & Pharmaceutical Bulletin, 2003Co-Authors: Eun-kyung Park, Minkyung Choo, Myung Joo Han, Eunjin Kim, Donghyun KimAbstract:The Antiallergic activities of ginsenosides, which were isolated from acid-treated ginseng (Panax ginseng, Araliaceae), and their metabolites by human intestinal bacteria were measured. Ginsenoside Rh2, which is a main metabolite, had the most potent inhibitory activity on β-hexosaminidase release from RBL-2H3 cells and in the passive cutaneous anaphylaxis reaction. The inhibitory activity of ginsenoside Rh2 was more potent than that of disodium cromoglycate, a commercial Antiallergic drug. This compound showed membrane stabilizing action upon differential scanning calorimetry and inhibited nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide-stimulated RAW cells. However, this ginsenoside Rh2 did not inhibit the activation of hyaluronidase and did not scavenge active oxygen. These results suggest that ginsenoside Rh2 can exhibit Antiallergic activity originating from cell membrane-stabilizing activity and antiinflammatory activity by the inhibition of NO and PGE2 production.
Giorgio Ciprandi - One of the best experts on this subject based on the ideXlab platform.
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rupatadine improves nasal symptoms airflow and inflammation in patients with persistent allergic rhinitis a pilot study
Journal of Biological Regulators and Homeostatic Agents, 2010Co-Authors: Giorgio Ciprandi, I CirilloAbstract:Nasal obstruction is the main symptom in patients with allergic rhinitis and may be measured by rhinomanometry. Rupatadine is a new antihistamine with potential Antiallergic activities. The aim of this pilot study is to evaluate nasal symptoms, nasal airflow and nasal mediators in patients with persistent allergic rhinitis, before and after treatment with rupatadine. Twenty patients with persistent allergic rhinitis were evaluated, 15 males and 5 females (mean age 35 +/- 9.1 years), all of whom received rupatadine (10 mg/daily) for 3 weeks. Nasal and ocular symptoms (measured by VAS), rhinomanometry, and nasal mediators (ECP and tryptase) were assessed in all subjects before and after treatment. Rupatadine treatment induced significant symptom relief (both nasal and ocular, respectively p=0.005 and p=0.0004), including obstruction (p=0.0015) and significant increase of nasal airflow (p=0.0025). Moreover, there was a significant difference of nasal mediators. In conclusion, this pilot study demonstrates the effectiveness of rupatadine treatment in: i) improving nasal and ocular symptoms, ii) increasing nasal airflow, iii) exerting Antiallergic activity in patients with persistent allergic rhinitis. These positive results could explain the effectiveness of rupatadine in the treatment of persistent allergic rhinitis, as reported in a previous study Further controlled studies need to be conducted to confirm these preliminary findings.
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Lodoxamide Treatment of Allergic Conjunctivitis
International Archives of Allergy and Immunology, 1994Co-Authors: P. M. Cerqueti, Maria Angela Tosca, S. Buscaglia, Valdo Ricca, Giorgio CiprandiAbstract:Lodoxamide is an Antiallergic compound. The present study evaluated the efficacy on clinical and cytological parameters and safety of topical lodoxamide compared to placebo in the treatment of allergic conjunctivitis. The trial, designed as double-blind, randomized, placebo-controlled and parallel group treatment, was carried out in 30 patients, suffering from seasonal allergic conjunctivitis due to grass pollen, during the pollen season. Patients received lodoxamide tromethamine 0.1% eye drops or placebo eye drops, one drop in each eye t.i.d. for 4 weeks. The clinical and cytological evidence was investigated by clinicians on admission and after 4 weeks’ treatment. At the end of the trial, only the lodoxamide-treated group showed a significant clinical improvement, associated with a reduction of inflammatory cells. No serious side effects were observed. The results show the clinical efficacy of lodoxamide in the treatment of pollen-induced allergic conjunctivitis. In addition, lodoxamide exerts its Antiallergic activity by reducing inflammatory infiltrate (mainly eosinophils).
Sheng-chu Kuo - One of the best experts on this subject based on the ideXlab platform.
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Synthesis of 2-Alkoxy 1,4-Naphthoquinone Derivatives as Antiplatelet, Antiinflammatory, and Antiallergic Agents
Chemical & pharmaceutical bulletin, 2002Co-Authors: Jin-cherng Lien, Jihpyang Wang, Li-jiau Huang, Che-ming Teng, Sheng-chu KuoAbstract:In our continuing search for novel antiplatelet, Antiallergic, and antiinflammatory agents, 2-alkoxy derivatives of 1,4-naphthoquinone were prepared. Some of these compounds showed significant antiplatelet, Antiallergic, and antiinflammatory activities. Among them, 2-propoxy-1,4-naphthoquinone and 2-butoxy-1,4-naphthoquinone exhibited potent inhibitory effect on neutrophil superoxide anion formation. These two compounds are worthy of further exploration.
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three new flavonoids and Antiallergic anti inflammatory constituents from the heartwood of dalbergia odorifera
Planta Medica, 1998Co-Authors: Shiuh-chuan Chan, Yuan-shiun Chang, Jihpyang Wang, Shengchih Chen, Sheng-chu KuoAbstract:Abstract Three new flavonoids, (3R)-4'-methoxy-2',3,7-trihydroxyisoflavanone (11), 7-methoxy-3,3',4',6-tetrahydroxyflavone (18), and 2',7-dihydroxy-4',5'-dimethoxyisoflavone (22), were isolated from the heartwood of Dalbergia odorifera T. Chen. (Leguminosae), together with twenty-two known compounds, (S)-4-methoxydalbergione (1), cearoin (2), medicarpin (3), formononetin (4), sativanone (5), 3-hydroxy-9-methoxy-coumestan (6), meliotocarpan A (7), isoliquiritigenin (8), stevein (9), liquiritigenin (10), 3',4',7-trihydroxyflavanone (12), butein (13), 3'-hydroxymelanettin (14), koparin (15), bowdichione (16), fisetin (17), melanettin (19), sulfuretin (20), 3'-hydroxydaidzein (21), 3'-O-methylviolanone (23), xenognosin B (24), and dalbergin (25). These flavonoids were evaluated in Antiallergic and anti-inflammatory tests. The results showed that (S)-4-methoxydalbergione (1) and cearoin (2) exhibited Antiallergic activity while (S)-4-methoxydalbergione (1), cearoin (2), butein (13), koparin (15), bowdichione (16), 3'-O-methylviolanone (23), and xenognosin B (24) showed significant anti-inflammatory activity.
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synthesis and antiplatelet antiinflammatory and Antiallergic activities of 2 3 disubstituted 1 4 naphthoquinones
ChemInform, 1996Co-Authors: Jin-cherng Lien, Jihpyang Wang, Li-jiau Huang, Che-ming Teng, Kuohsiung Lee, Sheng-chu KuoAbstract:Modification of 2-acetamido-3-chloro-1,4-naphthoquinone, which has potent antiplatelet, Antiallergic and antiinflammatory activities, led to a series of 2,3-disubstituted 1,4-naphthoquinones. Some of these compounds showed significant antiplatelet, Antiallergic and antiinflammatory activities. Among them, 2-methoxy-3-chloro-1,4-naphthoquinone (15) and 2-ethoxy-3-chloro-1,4-naphthoquinone (17) exhibited potent inhibitory effects on neutrophil and mast cell degranulation. 2-Methoxy-1,4-naphthoquinone (20) and 2-ethoxy-1,4-naphthoquinone (21) exhibited potent inhibitory effect on neutrophil superoxide formation. These four compounds were thus selected for further evaluation.
Makio Kobayashi - One of the best experts on this subject based on the ideXlab platform.
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Immunological functions of soy sauce: hypoallergenicity and Antiallergic activity of soy sauce
Journal of bioscience and bioengineering, 2005Co-Authors: Makio KobayashiAbstract:Soy sauce is a traditional fermented seasoning of East Asian countries and is available throughout the world. In Japanese soy sauce (shoyu), soybeans and wheat are the two main raw materials, used in almost the same quantity. Proteins of the raw materials are completely degraded into peptides and amino acids by microbial proteolytic enzymes after fermentation, and no allergens of the raw materials are present in soy sauce. In contrast, polysaccharides originating from the cell wall of soybeans are resistant to enzymatic hydrolyses. These polysaccharides are present in soy sauce even after fermentation and termed shoyu polysaccharides (SPS). Soy sauce generally contains about 1% (w/v) SPS and SPS exhibit potent Antiallergic activities in vitro and in vivo. Furthermore, an oral supplementation of SPS is an effective intervention for patients with allergic rhinitis in two double-blind placebo-controlled clinical studies. In conclusion, soy sauce would be a potentially promising seasoning for the treatment of allergic diseases through food because of its hypoallergenicity and Antiallergic activity.
Masayuki Yoshikawa - One of the best experts on this subject based on the ideXlab platform.
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acetoxybenzhydrols as highly active and stable analogues of 1 s 1 acetoxychavicol a potent Antiallergic principal from alpinia galanga
ChemInform, 2009Co-Authors: Tomohisa Yasuhara, Masayuki Yoshikawa, Hisashi Matsuda, Yoshiaki Manse, Takayuki Morimoto, Wang Qilong, Osamu MuraokaAbstract:Abstract Through SAR studies on 1′S-1′-acetoxychavicol acetate (1) against Type I Antiallergic activity by indexing release of β-hexosaminidase, a marker of antigen-IgE-mediated degranulation in RBL-2H3 cells, more stable and potent analogue, 4-(methoxycarbonyloxyphenylmethyl)phenyl acetate (16), has been developed. The compound 16 also strongly inhibited the antigen-IgE-mediated TNF-α and IL-4 production.
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effects of phyllodulcin hydrangenol and their 8 o glucosides and thunberginols a and f from hydrangea macrophylla seringe var thunbergii makino on passive cutaneous anaphylaxis reaction in rats
Biological & Pharmaceutical Bulletin, 1999Co-Authors: Hisashi Matsuda, Hiroshi Shimoda, Johji Yamahara, Masayuki YoshikawaAbstract:We examined the Antiallergic effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F isolated from the processed leaves (Hydrangeae Dulcis Folium) and dried leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO using the passive cutaneous anaphylaxis (PCA) reaction. With the exception of phyllodulcin, these constituents were found to significantly inhibit the PCA reaction. Although thunberginol A showed the most potent inhibitory effect, hydrangenol was considered to be the principal Antiallergic component in the processed leaves, after taking into account their contents.
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immunomodulatory activity of thunberginol a and related compounds isolated from hydrangeae dulcis folium on splenocyte proliferation activated by mitogens
Bioorganic & Medicinal Chemistry Letters, 1998Co-Authors: Hisashi Matsuda, Hiroshi Shimoda, Johji Yamahara, Masayuki YoshikawaAbstract:We investigated the immunomodulatory effects of Antiallergic constituents from Hydrangeae Dulcis Folium, the processed leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO, on splenocyte proliferation in mice. Thunberginol A and hydrangenol significantly suppressed T lymphocyte proliferation induced by concanavalin A. Thunberginol A also suppressed B lymphocyte proliferation induced by lipopolysaccharide, but other constituents induced significant increases. These inhibitory effects of thunberginol A on splenocyte proliferation seemed to contribute to the suppressive effect on type IV allergy.