Baccharis

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Gustavo Heiden - One of the best experts on this subject based on the ideXlab platform.

  • a novel phylogenetic infrageneric classification of Baccharis asteraceae astereae a highly diversified american genus
    Taxon, 2019
    Co-Authors: Gustavo Heiden, Alexandre Antonelli, Jose Rubens Pirani
    Abstract:

    We present the hitherto most comprehensive phylogenetic hypothesis for Baccharis. Our results confirm that subtribe Baccharidinae is a monogeneric group and support a broad circumscription of Baccharis as monophyletic with the inclusion of all genera that have been previously segregated from it (Baccharidastrum, Baccharidiopsis, Heterothalamulopsis, Heterothalamus, Lanugothamnus). We provide comprehensive lists of accepted and synonymized infrageneric taxa. Seven main lineages are recognized, which we treat as subgenera. Subgenera Baccharis and Molina roughly match previous circumscriptions, while subgenera Pteronioides and Stephananthus are merged with Molina. In total, we propose that Baccharis comprises 440 species classified into 7 subgenera and 47 sections, while 22 sections are considered synonyms. The phylogeny provided constitutes the basis for further exploration of the evolutionary processes that have allowed the group to attain its wide geographic distribution, morphological variation, variable sexual reproductive strategies, and complex chemical contents.

  • chemical composition antioxidant and anti inflammatory activities of the essential oils from male and female specimens of Baccharis punctulata asteraceae
    Journal of Ethnopharmacology, 2019
    Co-Authors: Jociani Ascari, Murilo Silva De Oliveira, Domingos Savio Nunes, Daniel Granato, Dilamara Riva Scharf, Edesio Luiz Simionatto, Michel Fleith Otuki, Bruna Da Silva Soley, Gustavo Heiden
    Abstract:

    Abstract Ethnopharmacological relevance Baccharis punctulata (Asteraceae), popularly known as “Chillka saru saru” in Bolivia, has been used by rural communities in Bustillo Province of the Potosi Department for treatment of asthma, luxations and contusions. Aim of the study To analyze the chemical composition of the essential oils obtained from leaves of female (BPF) and male (BPM) specimens and evaluate their anti-inflammatory and antioxidant properties. Material and methods Chemical composition analyses of Baccharis punctulata essential oils isolated by hidrodistillation from leaves of male and female specimens were performed by GC-FID-MS. The in vivo anti-inflammatory activity was evaluated using the model of TPA (12-O-tetradecanoylphorbol-13-acetate) induced ear edema, and the polymorphonuclear cell migration was evaluated by mieloperoxidase (MPO) and analyzed histologically. To measure the reactive oxygen species (ROS) in the inflamed tissue, the DCFH-DA fluorescent probe was used. The chemical in vitro antioxidant activity of essential oils was determined using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) free radical assay. Results The chemical analysis showed high proportion of sesquiterpenes in the volatiles samples obtained from BPM, such as δ-elemene (14.29%), germacrene D (11.29%) and bicyclogermacrene (10.90%), and in the sample from BPF, bicyclogermacrene (42.44%), germacrene D (21.18%) and β-caryophyllene (14.06%). A statistical difference (p  Conclusions This study presents, for the first time, the chemical composition of the essential oils obtained from leaves of male and female specimens of Baccharis punctulata, and their anti-inflammatory and antioxidant activities. The results presented by the volatile samples in our biotests support traditional uses of this plant species.

  • foliar anatomy and microscopy of six brazilian species of Baccharis asteraceae
    Microscopy Research and Technique, 2018
    Co-Authors: Jane Manfron Budel, Gustavo Heiden, Vijayasankar Raman, Luciane Mendes Monteiro, Valter Paes De Almeida, Vanessa Barbosa Bobek, Ines Janete Mattoso Takeda, Ikhlas A Khan
    Abstract:

    We report for the first time the presence of cluster crystals of calcium oxalate within the glandular trichomes and oil bodies in the mesophyll for Baccharis species. Moreover, the comparative leaf anatomy and micro-morphology of six species of Baccharis, namely B. illinita, B. microdonta, B. pauciflosculosa, B. punctulata, B. reticularioides, and B. sphenophylla is investigated by light and scanning electron microscopy. The studied species exhibited differences in their leaf anatomical features such as the morphology of the cuticle, type and occurrence of the stomata, presence or absence of glandular trichomes, shape of the flagelliform trichomes, and the arrangement of the mesophyll tissues. These differences can be helpful in the species identification and classification and could represent informative characters for the reconstruction of the evolution of the genus.

  • novelties towards a phylogenetic infrageneric classification of Baccharis asteraceae astereae
    Phytotaxa, 2016
    Co-Authors: Gustavo Heiden, Jose Rubens Pirani
    Abstract:

    Names of new taxa, new combinations and names at new rank are proposed for subgenera and sections in Baccharis to move towards a phylogenetic infrageneric classification of this New World genus. Two earlier segregated genera and two previously recognised sections are moved to the subgeneric rank (as B. subgen. Coridifoliae , B. subgen. Heterothalamus , B. subgen. Heterothalamulopsis , and B. subgen. Oblongifoliae ). Three new combinations and/or names at new rank are proposed for the following sections: B. sect. Axillares (assigned to B. subgen. Baccharis ), B. sect. Heterothalamulopsis (assigned to B. subgen. Heterothalamulopsis ), and B. sect. Pluricephalae (assigned to B. subgen Coridifoliae ). Four new sections are described to accommodate taxa not corresponding to any previously described section: B. sect. Andina and B. sect. Illinitae (assigned to B. subgen. Baccharis ), B. sect. Bradeanae (assigned to B. subgen. Heterothalamus ), and B . sect. Polifoliae (assigned to B. subgen. Molina ). All taxa here recognized correspond to monophyletic groups based on highly supported clades in a recent molecular phylogenetic analysis.

Jairo Kenupp Bastos - One of the best experts on this subject based on the ideXlab platform.

  • incorporation of Baccharis dracunculifolia dc asteraceae leaf extract into phosphatidylcholine cholesterol liposomes improves its anti inflammatory effect in vivo
    Natural Product Research, 2019
    Co-Authors: Andrea S G Figueiredorinhel, Jairo Kenupp Bastos, Micassio Fernandes De Andrade, Ana Paula Landilibrandi, Ana Elisa Caleiro Seixas Azzolini, Luciana M Kabeya, Yara Maria Lucisanovalim
    Abstract:

    The aerial parts of Baccharis dracunculifolia (BdE) is used in the Brazilian folk medicine to treat inflammatory conditions. Here we examined the ability of free and liposomal BdE to modulate react...

  • hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue and p coumaric acid is a pivotal bioactive compound to this action
    Biofactors, 2019
    Co-Authors: Philipe Costa, Thaise Boeing, Lincon Bordignon Somensi, Benhur Judah Cury, Vanessa Lopes Espindola, Tauani Caroline Santos Franca, Marilia Oliveira De Almeida, Caroline Arruda, Jairo Kenupp Bastos, Luisa Mota Da Silva
    Abstract:

    Baccharis dracunculifolia is a medicinal plant native to southeastern Brazil and is the main botanical source used by bees (Apis mellifera) in the manufacture of green propolis and display similar gastroprotective action and chemical profile. This article reports the healing gastric ulcer activity of the hydroethanolic extract of B. dracunculifolia (HEBD) in an acetic acid-induced ulcer model. In addition to the extract, the isolated compounds ferulic acid, p-coumaric acid, caffeic acid, baccharin, and aromadendrin-4'-O-methyl ether were also assayed. HEBD at a dose of 300 mg/kg reduced the ulcerated area by 49.4% after treatment for 7 days, twice a day. Histological analyses revealed that the margins and base of the ulcer obtained significant regeneration, and periodic acid Schiff base staining showed a 78.2% increase in the mucin levels. The action on the enzymatic antioxidant system demonstrated an increased activity of superoxide dismutase and glutathione-S-transferase, in addition to raising glutathione reduced levels and myeloperoxidase activity. HEBD did not show cytotoxicity in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylterazole bromine test. In vitro, HEBD inhibited the H+ /K+ -ATPase enzyme and showed antioxidant activity in the 2,2 diphenyl-1-picryllydrazyl test. Regarding the isolated compounds, oral administration of p-coumaric acid (15 mg/kg) reduced the ulcerated area by 66.2%. The results suggest that HEBD recovers the gastric ulcerated tissue, raising mucus and antioxidant enzyme levels, and reducing the H+ /K+ -ATPase activity. In addition, the findings confirm that p-coumaric acid is a pivotal bioactive compound on the gastric healing effects elicited by HEBD. © 2019 BioFactors, 45(3):479-489, 2019.

  • comparative evaluation of antiproliferative effects of brazilian green propolis its main source Baccharis dracunculifolia and their major constituents artepillin c and baccharin
    Planta Medica, 2014
    Co-Authors: Pollyanna Francielli De Oliveira, Jairo Kenupp Bastos, Ildercilio Mota De Souza Lima, Carla Carolina Munari, Ademar A Da Silva Filho, Denise Crispim Tavares
    Abstract:

    This study evaluated the antiproliferative activity of the Brazilian green propolis and Baccharis dracunculifolia extracts and their major compounds artepillin C and baccharin in different tumor cell lines. The lowest IC50 values observed for Brazilian green propolis and B. dracunculifolia extracts were 41.0 ± 4.5 µg/mL for U343 and 44.9 ± 7.1 µg/mL for HepG2, respectively. Regarding artepillin C and baccharin, the lowest IC50 values were 20.1 ± 2.9 for U343 and 13.0 ± 1.5 µg/mL for B16F10, respectively. For the association of artepillin C plus baccharin, the lowest IC50 result was 35.2 ± 0.5 µg/mL for B16F10. Artepillin C and baccharin were more cytotoxic than both Brazilian green propolis and B. dracunculifolia extracts. No additive or synergistic effect was observed for the association of artepillin C plus baccharin.

  • baccharin prevents genotoxic effects induced by methyl methanesulfonate and hydrogen peroxide in v79 cells
    Journal of Food Science, 2012
    Co-Authors: Pollyanna Francielli De Oliveira, Jairo Kenupp Bastos, Ademar A Da Silva Filho, Luis Fernando Leandro, Giovana Montanheiro, Denise Crispim Tavares
    Abstract:

    Baccharin is one of the major chemical compounds isolated from the aerial parts of Baccharis dracunculifolia DC (Asteraceae), a native plant of South America and the most important botanical source of the Brazilian green propolis that has been used in alternative medicine to treat inflammation, liver disorders, and stomach ulcers. The present study was carried out in V79 cells to determine the possible genotoxic and antigenotoxic activities of baccharin utilizing comet and micronucleus assays, where 2 known mutagenic agents with different mechanisms of DNA damage were used as positive controls. The V79 cells were treated with concentrations of baccharin (0.25, 0.5, 1.0, and 2.0 μg/mL) and for to investigate the antigenotoxicity these concentrations were associated with methyl methanesulfonate (MMS; 200 μM-comet assay and 400 μM-micronucleus assay) or hydrogen peroxide (H(2)O(2;) 50 μM-comet assay and 100 μM-micronucleus assay). Statistically significant differences in the rate of DNA damage were observed in cultures treated with the highest concentration of baccharin when compared to the control group, but this difference was not found in the micronucleus assay. The results also showed that the frequencies of DNA damage and micronuclei induced by MMS and H(2)O(2) were significantly reduced after treatment with baccharin. The baccharin showed a chemoprevention effect and can be the chemical compound responsible for the antigenotoxicity also demonstrated by the B. dracunculifolia. The antioxidant potential of baccharin may be related to its chemoprevention activity induced against both genomic and chromosomal damages.

  • seasonality role on the phenolics from cultivated Baccharis dracunculifolia
    Evidence-based Complementary and Alternative Medicine, 2011
    Co-Authors: Joao Paulo Barreto De Sousa, Ademar A Da Silva Filho, Niege Aracari Jacometti Cardoso Furtado, Renata F Jorge, Mateus Freire Leite, D O Resende, Ademilson Espencer Egea Soares, Augusto Cesar Cropanese Spadaro, Pedro Melillo De Magalhaes, Jairo Kenupp Bastos
    Abstract:

    Baccharis dracunculifolia is the source of Brazilian green propolis (BGP). Considering the broad spectrum of biological activities attributed to green proplis, B. dracunculifolia has a great potential for the development of new cosmetic and pharmaceutical products. In this work, the cultivation of 10 different populations of native B. dracunculifolia had been undertaken aiming to determine the role of seasonality on its phenolic compounds. For this purpose, fruits of this plant were collected from populations of 10 different regions, and 100 individuals of each population were cultivated in an experimental area of 1800 m2. With respect to cultivation, the yields of dry plant, essential oil and crude extract were measured monthly resulting in mean values of 399 ± 80 g, 0.6 ± 0.1% and 20 ± 4%, respectively. The HPLC analysis allowed detecting seven phenolic compounds: caffeic acid, ferulic acid, aromadendrin-4′-methyl ether (AME), isosakuranetin, artepillin C, baccharin and 2-dimethyl-6-carboxyethenyl-2H-1-benzopyran acid, which were the major ones throughout the 1-year monthly analysis. Caffeic acid was detected in all cultivated populations with mean of 4.0%. AME displayed the wide variation in relation to other compounds showing means values of 0.65 ± 0.13% at last quarter. Isosakuranetin and artepillin C showed increasing concentrations with values between 0% and 1.4% and 0% and 1.09%, respectively. The obtained results allow suggesting that the best time for harvesting this plant, in order to obtain good qualitative and quantitative results for these phenolic compounds, is between December and April.

D. Wade Abbott - One of the best experts on this subject based on the ideXlab platform.

  • SACCHARIS: an automated pipeline to streamline discovery of carbohydrate active enzyme activities within polyspecific families and de novo sequence datasets
    Biotechnology for Biofuels, 2018
    Co-Authors: Darryl R. Jones, Dallas Thomas, Nicholas Alger, Ata Ghavidel, G. Douglas Inglis, D. Wade Abbott
    Abstract:

    Deposition of new genetic sequences in online databases is expanding at an unprecedented rate. As a result, sequence identification continues to outpace functional characterization of carbohydrate active enzymes (CAZymes). In this paradigm, the discovery of enzymes with novel functions is often hindered by high volumes of uncharacterized sequences particularly when the enzyme sequence belongs to a family that exhibits diverse functional specificities (i.e., polyspecificity). Therefore, to direct sequence-based discovery and characterization of new enzyme activities we have developed an automated in silico pipeline entitled: Sequence Analysis and Clustering of CarboHydrate Active enzymes for Rapid Informed prediction of Specificity (SACCHARIS). This pipeline streamlines the selection of uncharacterized sequences for discovery of new CAZyme or CBM specificity from families currently maintained on the CAZy website or within user-defined datasets. SACCHARIS was used to generate a phylogenetic tree of a GH43, a CAZyme family with defined subfamily designations. This analysis confirmed that large datasets can be organized into sequence clusters of manageable sizes that possess related functions. Seeding this tree with a GH43 sequence from Bacteroides dorei DSM 17855 (BdGH43b, revealed it partitioned as a single sequence within the tree. This pattern was consistent with it possessing a unique enzyme activity for GH43 as BdGH43b is the first described α-glucanase described for this family. The capacity of SACCHARIS to extract and cluster characterized carbohydrate binding module sequences was demonstrated using family 6 CBMs (i.e., CBM6s). This CBM family displays a polyspecific ligand binding profile and contains many structurally determined members. Using SACCHARIS to identify a cluster of divergent sequences, a CBM6 sequence from a unique clade was demonstrated to bind yeast mannan, which represents the first description of an α-mannan binding CBM. Additionally, we have performed a CAZome analysis of an in-house sequenced bacterial genome and a comparative analysis of B. thetaiotaomicron VPI-5482 and B. thetaiotaomicron 7330, to demonstrate that SACCHARIS can generate “CAZome fingerprints”, which differentiate between the saccharolytic potential of two related strains in silico. Establishing sequence-function and sequence-structure relationships in polyspecific CAZyme families are promising approaches for streamlining enzyme discovery. SACCHARIS facilitates this process by embedding CAZyme and CBM family trees generated from biochemically to structurally characterized sequences, with protein sequences that have unknown functions. In addition, these trees can be integrated with user-defined datasets (e.g., genomics, metagenomics, and transcriptomics) to inform experimental characterization of new CAZymes or CBMs not currently curated, and for researchers to compare differential sequence patterns between entire CAZomes. In this light, SACCHARIS provides an in silico tool that can be tailored for enzyme bioprospecting in datasets of increasing complexity and for diverse applications in glycobiotechnology.

  • SACCHARIS: an automated pipeline to streamline discovery of carbohydrate active enzyme activities within polyspecific families and de novo sequence datasets
    Biotechnology for Biofuels, 2018
    Co-Authors: Darryl R. Jones, Dallas Thomas, Nicholas Alger, Ata Ghavidel, G. Douglas Inglis, D. Wade Abbott
    Abstract:

    Background Deposition of new genetic sequences in online databases is expanding at an unprecedented rate. As a result, sequence identification continues to outpace functional characterization of carbohydrate active enzymes (CAZymes). In this paradigm, the discovery of enzymes with novel functions is often hindered by high volumes of uncharacterized sequences particularly when the enzyme sequence belongs to a family that exhibits diverse functional specificities (i.e., polyspecificity). Therefore, to direct sequence-based discovery and characterization of new enzyme activities we have developed an automated in silico pipeline entitled: Sequence Analysis and Clustering of CarboHydrate Active enzymes for Rapid Informed prediction of Specificity (SACCHARIS). This pipeline streamlines the selection of uncharacterized sequences for discovery of new CAZyme or CBM specificity from families currently maintained on the CAZy website or within user-defined datasets. Results SACCHARIS was used to generate a phylogenetic tree of a GH43, a CAZyme family with defined subfamily designations. This analysis confirmed that large datasets can be organized into sequence clusters of manageable sizes that possess related functions. Seeding this tree with a GH43 sequence from Bacteroides dorei DSM 17855 (BdGH43b, revealed it partitioned as a single sequence within the tree. This pattern was consistent with it possessing a unique enzyme activity for GH43 as BdGH43b is the first described α-glucanase described for this family. The capacity of SACCHARIS to extract and cluster characterized carbohydrate binding module sequences was demonstrated using family 6 CBMs (i.e., CBM6s). This CBM family displays a polyspecific ligand binding profile and contains many structurally determined members. Using SACCHARIS to identify a cluster of divergent sequences, a CBM6 sequence from a unique clade was demonstrated to bind yeast mannan, which represents the first description of an α-mannan binding CBM. Additionally, we have performed a CAZome analysis of an in-house sequenced bacterial genome and a comparative analysis of B. thetaiotaomicron VPI-5482 and B. thetaiotaomicron 7330, to demonstrate that SACCHARIS can generate “CAZome fingerprints”, which differentiate between the saccharolytic potential of two related strains in silico. Conclusions Establishing sequence-function and sequence-structure relationships in polyspecific CAZyme families are promising approaches for streamlining enzyme discovery. SACCHARIS facilitates this process by embedding CAZyme and CBM family trees generated from biochemically to structurally characterized sequences, with protein sequences that have unknown functions. In addition, these trees can be integrated with user-defined datasets (e.g., genomics, metagenomics, and transcriptomics) to inform experimental characterization of new CAZymes or CBMs not currently curated, and for researchers to compare differential sequence patterns between entire CAZomes. In this light, SACCHARIS provides an in silico tool that can be tailored for enzyme bioprospecting in datasets of increasing complexity and for diverse applications in glycobiotechnology.

Ademar A Da Silva Filho - One of the best experts on this subject based on the ideXlab platform.

  • comparative evaluation of antiproliferative effects of brazilian green propolis its main source Baccharis dracunculifolia and their major constituents artepillin c and baccharin
    Planta Medica, 2014
    Co-Authors: Pollyanna Francielli De Oliveira, Jairo Kenupp Bastos, Ildercilio Mota De Souza Lima, Carla Carolina Munari, Ademar A Da Silva Filho, Denise Crispim Tavares
    Abstract:

    This study evaluated the antiproliferative activity of the Brazilian green propolis and Baccharis dracunculifolia extracts and their major compounds artepillin C and baccharin in different tumor cell lines. The lowest IC50 values observed for Brazilian green propolis and B. dracunculifolia extracts were 41.0 ± 4.5 µg/mL for U343 and 44.9 ± 7.1 µg/mL for HepG2, respectively. Regarding artepillin C and baccharin, the lowest IC50 values were 20.1 ± 2.9 for U343 and 13.0 ± 1.5 µg/mL for B16F10, respectively. For the association of artepillin C plus baccharin, the lowest IC50 result was 35.2 ± 0.5 µg/mL for B16F10. Artepillin C and baccharin were more cytotoxic than both Brazilian green propolis and B. dracunculifolia extracts. No additive or synergistic effect was observed for the association of artepillin C plus baccharin.

  • baccharin prevents genotoxic effects induced by methyl methanesulfonate and hydrogen peroxide in v79 cells
    Journal of Food Science, 2012
    Co-Authors: Pollyanna Francielli De Oliveira, Jairo Kenupp Bastos, Ademar A Da Silva Filho, Luis Fernando Leandro, Giovana Montanheiro, Denise Crispim Tavares
    Abstract:

    Baccharin is one of the major chemical compounds isolated from the aerial parts of Baccharis dracunculifolia DC (Asteraceae), a native plant of South America and the most important botanical source of the Brazilian green propolis that has been used in alternative medicine to treat inflammation, liver disorders, and stomach ulcers. The present study was carried out in V79 cells to determine the possible genotoxic and antigenotoxic activities of baccharin utilizing comet and micronucleus assays, where 2 known mutagenic agents with different mechanisms of DNA damage were used as positive controls. The V79 cells were treated with concentrations of baccharin (0.25, 0.5, 1.0, and 2.0 μg/mL) and for to investigate the antigenotoxicity these concentrations were associated with methyl methanesulfonate (MMS; 200 μM-comet assay and 400 μM-micronucleus assay) or hydrogen peroxide (H(2)O(2;) 50 μM-comet assay and 100 μM-micronucleus assay). Statistically significant differences in the rate of DNA damage were observed in cultures treated with the highest concentration of baccharin when compared to the control group, but this difference was not found in the micronucleus assay. The results also showed that the frequencies of DNA damage and micronuclei induced by MMS and H(2)O(2) were significantly reduced after treatment with baccharin. The baccharin showed a chemoprevention effect and can be the chemical compound responsible for the antigenotoxicity also demonstrated by the B. dracunculifolia. The antioxidant potential of baccharin may be related to its chemoprevention activity induced against both genomic and chromosomal damages.

  • seasonality role on the phenolics from cultivated Baccharis dracunculifolia
    Evidence-based Complementary and Alternative Medicine, 2011
    Co-Authors: Joao Paulo Barreto De Sousa, Ademar A Da Silva Filho, Niege Aracari Jacometti Cardoso Furtado, Renata F Jorge, Mateus Freire Leite, D O Resende, Ademilson Espencer Egea Soares, Augusto Cesar Cropanese Spadaro, Pedro Melillo De Magalhaes, Jairo Kenupp Bastos
    Abstract:

    Baccharis dracunculifolia is the source of Brazilian green propolis (BGP). Considering the broad spectrum of biological activities attributed to green proplis, B. dracunculifolia has a great potential for the development of new cosmetic and pharmaceutical products. In this work, the cultivation of 10 different populations of native B. dracunculifolia had been undertaken aiming to determine the role of seasonality on its phenolic compounds. For this purpose, fruits of this plant were collected from populations of 10 different regions, and 100 individuals of each population were cultivated in an experimental area of 1800 m2. With respect to cultivation, the yields of dry plant, essential oil and crude extract were measured monthly resulting in mean values of 399 ± 80 g, 0.6 ± 0.1% and 20 ± 4%, respectively. The HPLC analysis allowed detecting seven phenolic compounds: caffeic acid, ferulic acid, aromadendrin-4′-methyl ether (AME), isosakuranetin, artepillin C, baccharin and 2-dimethyl-6-carboxyethenyl-2H-1-benzopyran acid, which were the major ones throughout the 1-year monthly analysis. Caffeic acid was detected in all cultivated populations with mean of 4.0%. AME displayed the wide variation in relation to other compounds showing means values of 0.65 ± 0.13% at last quarter. Isosakuranetin and artepillin C showed increasing concentrations with values between 0% and 1.4% and 0% and 1.09%, respectively. The obtained results allow suggesting that the best time for harvesting this plant, in order to obtain good qualitative and quantitative results for these phenolic compounds, is between December and April.

  • effect of Baccharis dracunculifolia d c asteraceae extracts and its isolated compounds on macrophage activation
    Journal of Pharmacy and Pharmacology, 2010
    Co-Authors: Fabiane Missima, Jairo Kenupp Bastos, Ademar A Da Silva Filho, Gladston A Nunes, Paula Carolina Pires Bueno, Joao Paulo Barreto De Sousa, Jose Mauricio Sforcin
    Abstract:

    Baccharis dracunculifolia D.C. (Asteraceae), a shrub which grows wild in Brazil, is the main botanical source of Brazilian green propolis. Since Brazilian propolis shows an immunomodulatory activity, the goal of this work was to evaluate the action of B. dracunculifolia extracts and some of its isolated compounds on reactive oxygen intermediate (H2O2) production by macrophages obtained from male BALB/c mice. The results showed that the leaf (Bd-L) (25, 50, and 100 μg mL−1), leaf rinse (Bd-LR) (25 μg mL−1), and the root (Bd-R) (25 μg mL−1) extracts enhanced H2O2 release by macrophages. A phytochemical study of the root and leaves of B. dracunculifolia was carried out. The chromatographic fractionation of Bd-R, using several techniques, afforded the isolation of Baccharis oxide (1), friedelanol (2), viscidone (11), 11-hydroxy-10,11-dihydro-euparin (12), and 6-hydroxy-tremetona (13), while Bd-LR gave the following isolated compounds: Baccharis oxide (1), friedelanol (2), isosakuranetin (3), aromadendrin-4′-methyl ether (4), dihydrocumaric acid (5), baccharin (6), hautriwaic acid lactone (7), hautriwaic acid acetate (8), drupanin (9), and cumaric acid (10). Among the isolated compounds, Baccharis oxide (1) and friedelanol (2) increased H2O2 production at a concentration of 100μM. This is the first time that the presence of compounds 7, 8, 12, and 13 in B. dracunculifolia has been reported. Based on these results it is suggested that the crude extracts and some isolated compounds from B. dracunculifolia display an immunomodulatory action.

  • anti inflammatory and antinociceptive effects of Baccharis dracunculifolia dc asteraceae in different experimental models
    Journal of Ethnopharmacology, 2010
    Co-Authors: Diogo Dos A Santos, Jairo Kenupp Bastos, Ademar A Da Silva Filho, Joao Paulo Barreto De Sousa, N Dhammika P Nanayakkara, Murilo De J Fukui, Shabana I Khan, Sergio Faloni De Andrade, Nara Lins Meira Quintao
    Abstract:

    Abstract Aim of the study The aerial parts of Baccharis dracunculifolia D.C., popularly known as “alecrim do campo”, are used in folk medicine as anti-inflammatory. The aim of the present study was to evaluate the anti-inflammatory and antinociceptive activities of the crude hydroalcoholic extract obtained from leaves of Baccharis dracunculifolia (BdE), which have not been reported. Materials and methods BdE was analyzed by HPLC and in vivo evaluated (doses ranging from 50 to 400 mg/kg, p.o.) by using the acetic acid-induced abdominal constrictions, paw oedema induced by carrageenan or histamine, overt nociception models using capsaicin, glutamate or phorbol myristate acetate (PMA), formalin-induced nociception and mechanical hypernociception induced by carrageenan or complete Freund adjuvant (CFA). As positive controls it was used paracetamol in both acetic acid and formalin tests; dipyrone in capsaicin, glutamate and PMA-induced nociception; indomethacin in CFA and carrageenan-induced hypernociception models. In addition, the in vitro effects of BdE on COX-2 activity and on the activation of NF-κB were also evaluated. Results BdE (50–400 mg/kg, p.o.) significantly diminished the abdominal constrictions induced by acetic acid, glutamate and CFA. Furthermore, BdE also inhibited the nociceptive responses in both phases of formalin-induced nociception. BdE, administered orally, also produced a long-lasting anti-hypernociceptive effect in the acute model of inflammatory pain induced by carrageenan. It was also observed the inhibition of COX-2 activity by BdE. Conclusion In summary, the data reported in this work confirmed the traditional anti-inflammatory indications of Baccharis dracunculifolia leaves and provided biological evidences that Baccharis dracunculifolia, like Brazilian green propolis, possess antinociceptive and anti-inflammatory activities.

F. L. F. De ,quadros - One of the best experts on this subject based on the ideXlab platform.

  • Floristic composition of a natural grassland in region of alto Camaquã, Rio Grande do Sul, Brazil
    'Facultad de Agronomia Instituto Nacional de Investigacion Agropecuaria', 2020
    Co-Authors: Casanova P. T., Boavista L., Moterle A. F., R. M. R. De ,carvalho, De Pereira L. P., Soares L. S. U., F. L. F. De ,quadros
    Abstract:

    Conhecer a composição florística, a diversidade e a modificação das espécies que compõe um bioma, contribui para o entendimento das relações ecológicas deste. Isto é útil na identificação do manejo adequado para um desempenho econômico e sustentável da pastagem. Em dezembro de 2011, foi realizado um levantamento botânico, pela metodología Botanal, no município de Pinheiro Machado na localidade do Alto Camaquã, integrante do bioma Pampa no Brasil. No levantamento foram encontradas 69 espécies vegetais, predominando as famílias de gramíneas, compostas e leguminosas sendo 33, 08 e 06 espécies, respectivamente para cada família, com predominâncias na composição da massa de Baccharis trimera, representando as compostas, Paspalum notatum , representando as gramíneas e Desmodium incanum, representando as leguminosas. As espécies Baccharis trimera e Eryngium horridum contribuíram com 49,78% da massa de forragem. O restante da massa foi composta por 67 diferentes espécies.Knowledge of floristic composition, diversity and modification of species that comprise a biome, contributes to the understanding of the ecological relationships of this. This is useful in the identifica tion of appropri ate management for a sustainable and ec onomic performance of pasture. In December 2011, we conducted a botanical survey, by the BOTANAL method in the city of Pinheiro Macha do in the region of Alto Cam aquã, part of Pampa biome in Brazil. In the survey 69 species were recorded, predominating speciesof grasses, Compositae and legumes families, being 33, 08 and 06 species respectively for each family, with predominance in the forage mass composition of Baccharis trimera, representing the Compositae, Paspalum notatum, representing grasses and Desmodium incanum, representing the legumes. The species Baccharis trimera and Eryngium horridum contributed with 49.78% of herbage mass. The remainder of the mass were consisted of 67 different species

  • Composição floristica de uma pastagem natural da região do alto Camaquã, Rio Grande do Sul, Brasil
    'Facultad de Agronomia Instituto Nacional de Investigacion Agropecuaria', 2020
    Co-Authors: Casanova P. T., Boavista L., Moterle A. F., R. M. R. De ,carvalho, De Pereira L. P., Soares L. S. U., F. L. F. De ,quadros
    Abstract:

    Knowledge of floristic composition, diversity and modification of species that comprise a biome, contributes to the understanding of the ecological relationships of this. This is useful in the identifica tion of appropri ate management for a sustainable and ec onomic performance of pasture. In December 2011, we conducted a botanical survey, by the BOTANAL method in the city of Pinheiro Macha do in the region of Alto Cam aquã, part of Pampa biome in Brazil. In the survey 69 species were recorded, predominating speciesof grasses, Compositae and legumes families, being 33, 08 and 06 species respectively for each family, with predominance in the forage mass composition of Baccharis trimera, representing the Compositae, Paspalum notatum, representing grasses and Desmodium incanum, representing the legumes. The species Baccharis trimera and Eryngium horridum contributed with 49.78% of herbage mass. The remainder of the mass were consisted of 67 different species.Conhecer a composição florística, a diversidade e a modificação das espécies que compõe um bioma, contribui para o entendimento das relações ecológicas deste. Isto é útil na identificação do manejo adequado para um desempenho econômico e sustentável da pastagem. Em dezembro de 2011, foi realizado um levantamento botânico, pela metodología Botanal, no município de Pinheiro Machado na localidade do Alto Camaquã, integrante do bioma Pampa no Brasil. No levantamento foram encontradas 69 espécies vegetais, predominando as famílias de gramíneas, compostas e leguminosas sendo 33, 08 e 06 espécies, respectivamente para cada família, com predominâncias na composição da massa de Baccharis trimera, representando as compostas, Paspalum notatum , representando as gramíneas e Desmodium incanum, representando as leguminosas. As espécies Baccharis trimera e Eryngium horridum contribuíram com 49,78% da massa de forragem. O restante da massa foi composta por 67 diferentes espécies

  • Composição floristica de uma pastagem natural da região do alto Camaquã, Rio Grande do Sul, Brasil
    'Universidad Nacional de La Pampa', 2020
    Co-Authors: P. T. Casanova, R. M. R. De ,carvalho, L. Boavista, A. F. Moterle, L. P. De Pereira, L. S. U. Soares, F. L. F. De ,quadros
    Abstract:

    Conhecer a composição florística, a diversidade e a modificação das espécies que compõe um bioma, contribui para o entendimento das relações ecológicas deste. Isto é útil na identificação do manejo adequado para um desempenho econômico e sustentável da pastagem. Em dezembro de 2011, foi realizado um levantamento botânico, pela metodología Botanal, no município de Pinheiro Machado na localidade do Alto Camaquã, integrante do bioma Pampa no Brasil. No levantamento foram encontradas 69 espécies vegetais, predominando as famílias de gramíneas, compostas e leguminosas sendo 33, 08 e 06 espécies, respectivamente para cada família, com predominâncias na composição da massa de Baccharis trimera, representando as compostas, Paspalum notatum , representando as gramíneas e Desmodium incanum, representando as leguminosas. As espécies Baccharis trimera e Eryngium horridum contribuíram com 49,78% da massa de forragem. O restante da massa foi composta por 67 diferentes espécies