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Jung-min Kim - One of the best experts on this subject based on the ideXlab platform.
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Changes in background electroencephalographic activity in Benign Childhood Epilepsy with centrotemporal spikes after oxcarbazepine treatment: a standardized low-resolution brain electromagnetic tomography (sLORETA) study.
BMC neurology, 2019Co-Authors: Ye-hwa Jun, Tae-hoon Eom, Young Hoon Kim, Seung-yun Chung, In-goo Lee, Jung-min KimAbstract:Several neuroimaging studies have reported neurophysiological alterations in patients with Benign Childhood Epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often. We investigated background EEG activity changes after six months of oxcarbazepine treatment to better understand the neurophysiological alterations and progression that occur in BCECTS. In 18 children with BCECTS, non-parametric statistical analyses using standardized low resolution brain electromagnetic tomography (sLORETA) were performed to compare the current density distribution of four frequency bands (delta, theta, alpha, and beta) between untreated and treated conditions. Background EEG activity for the delta frequency band was significantly decreased in the fronto-temporal and limbic regions of the left hemisphere after oxcarbazepine treatment (threshold log-F-ratio = ±2.729, P
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Changes in background electroencephalographic activity in Benign Childhood Epilepsy with centrotemporal spikes after oxcarbazepine treatment: a standardized low-resolution brain electromagnetic tomography (sLORETA) study
BMC, 2019Co-Authors: Ye-hwa Jun, Tae-hoon Eom, Young Hoon Kim, Seung-yun Chung, In-goo Lee, Jung-min KimAbstract:Abstract Background Several neuroimaging studies have reported neurophysiological alterations in patients with Benign Childhood Epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often. Methods We investigated background EEG activity changes after six months of oxcarbazepine treatment to better understand the neurophysiological alterations and progression that occur in BCECTS. In 18 children with BCECTS, non-parametric statistical analyses using standardized low resolution brain electromagnetic tomography (sLORETA) were performed to compare the current density distribution of four frequency bands (delta, theta, alpha, and beta) between untreated and treated conditions. Results Background EEG activity for the delta frequency band was significantly decreased in the fronto-temporal and limbic regions of the left hemisphere after oxcarbazepine treatment (threshold log-F-ratio = ±2.729, P
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Distributed source localization of interictal spikes in Benign Childhood Epilepsy with centrotemporal spikes: A standardized low-resolution brain electromagnetic tomography (sLORETA) study.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2017Co-Authors: Tae-hoon Eom, Jung-hyun Shin, Young Hoon Kim, Seung-yun Chung, In-goo Lee, Jung-min KimAbstract:Benign Childhood Epilepsy with centrotemporal spikes (BCECTS), also known as Rolandic Epilepsy, is the most common Benign Childhood Epilepsy. Centrotemporal spikes are characteristic findings on electroencephalography (EEG). Though the condition is considered Benign, many studies have reported some degree of neuropsychological impairment in individuals with BCECTS. There is also growing evidence from neuroimaging studies that BCECTS may affect a larger portion of the brain than originally thought. We performed distributed source localization analysis of interictal spikes in BCECTS. Current-source density (CSD) of the maximal negative peak of the interictal spikes averaged from each of 20 EEG epochs in 11 patients with BCECTS was measured using standardized low-resolution brain electromagnetic tomography (sLORETA). Rolandic area was included in the distribution of the CSD in all of the patients. The significant CSD and its maximal point were distributed in multiple cortical regions over the Rolandic area. It is suggested that the widespread cortical distribution of interictal spikes seen in this study may be associated with atypical presentation and a variety of comorbidities of BCECTS. Our results imply that BCECTS represents a deviation from normal development during a critical period of brain maturation and that children with BECTS might be more likely to need special medical attention.
Fabrice Wallois - One of the best experts on this subject based on the ideXlab platform.
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identifying neural drivers of Benign Childhood Epilepsy with centrotemporal spikes
NeuroImage: Clinical, 2018Co-Authors: Azeez Adebimpe, Emilie Bourelponchel, Fabrice WalloisAbstract:Epilepsy is a neurological disorder characterized by abnormal electrical discharges in a group of brain cells. Benign Childhood Epilepsy, which affect children under the age of 12 years, has been reported to contribute to the cognitive impairment of these children, even in the absence of structural abnormalities. Functional connectivity models have been applied to provide a deeper understanding of the processes that control and regulate interictal activity of Benign Childhood Epilepsy. These studies have shown regions of increased connectivity and activity, particularly at the epileptic zone, which is usually the central region around the sensorimotor cortex, and in the immediate regions surrounding the zone and reduced activity in distant regions, such as the frontal lobe and temporal regions. The present study was designed to identify the neural drivers involved in the initiation and propagation of epileptic activity and the causal relationships between brain regions with increased and decreased connectivity and functional activity. We used three different models to identify neural drivers and casual connectivity with dynamic causal modelling (DCM) of EEG data. All models showed that the central region, the source of the epileptic activity, is the major driver of the brain network during interictal discharges. Other regions include the temporoparietal junction and temporal pole. The central region also had influence on the frontal and contralateral hemisphere, which might explain the cognitive deficits observed in these patients.
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id 234 brain network analysis of eeg functional connectivity in patients with Benign Childhood Epilepsy with centro temporal spikes
Clinical Neurophysiology, 2016Co-Authors: Azeez Adebimpe, Ardalan Aarabi, Mahdi Mahmoudzadeh, E Bourel, Fabrice WalloisAbstract:Objectives There is increasing evidence that Epilepsy might alter the brain connectivities. We investigated the changes in the brain connectivity in children with Benign Childhood Epilepsy with centro-temporal spikes. Methods High density EEG data recorded from 8 patients and age-matched 9 controls with eyes closed. For controls five segments and for patients five with- and without-spike were randomly selected for further analysis. The phase locking value was calculated for all pairwise combination of channels within five frequency bands (™, , 〈, ®1 and ®2). We computed degree and small-world parameters- clustering coefficient (C) and path length (L). Results We observed higher degrees in the regions involved in the generation of spikes in all frequency bands. Patients showed reduced connectivity values at the occipital and right frontal region in 〈 band. The “small-world” features (high C and low L) were lost in patients. The epileptic brain network was more ordered (high C, high L) in lower frequency, but switched into a random mode (low C, low L) in higher frequencies. Conclusion These findings show that the epileptic brain network might be disrupted not only at the epileptic zone but also in other brain regions. The Benign epileptic brain networks also showed ordered and random topology in lower and higher frequencies respectively.
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functional brain dysfunction in patients with Benign Childhood Epilepsy as revealed by graph theory
PLOS ONE, 2015Co-Authors: Azeez Adebimpe, Emilie Bourelponchel, Ardalan Aarabi, Mahdi Mahmoudzadeh, Fabrice WalloisAbstract:There is growing evidence that brain networks are altered in epileptic subjects. In this study, we investigated the functional connectivity and brain network properties of Benign Childhood Epilepsy with centrotemporal spikes using graph theory. Benign Childhood Epilepsy with centrotemporal spikes is the most common form of idiopathic Epilepsy in young children under the age of 16 years. High-density EEG data were recorded from patients and controls in resting state with eyes closed. Data were preprocessed and spike and spike-free segments were selected for analysis. Phase locking value was calculated for all paired combinations of channels and for five frequency bands (δ, θ, α, β1 and β2). We computed the degree and small-world parameters--clustering coefficient (C) and path length (L)--and compared the two patient conditions to controls. A higher degree at epileptic zones during interictal epileptic spikes (IES) was observed in all frequency bands. Both patient conditions reduced connection at the occipital and right frontal regions close to the epileptic zone in the α band. The "small-world" features (high C and short L) were deviated in patients compared to controls. A changed from an ordered network in the δ band to a more randomly organized network in the α band was observed in patients compared to healthy controls. These findings show that the Benign epileptic brain network is disrupted not only at the epileptic zone, but also in other brain regions especially frontal regions.
Uri Kramer - One of the best experts on this subject based on the ideXlab platform.
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Does a Normalizing Electroencephalogram in Benign Childhood Epilepsy With Centrotemporal Spikes Abort Attention Deficit Hyperactivity Disorder
Pediatric neurology, 2012Co-Authors: Nira Schneebaum-sender, Hadassa Goldberg-stern, Aviva Fattal-valevski, Uri KramerAbstract:This retrospective study delineated the efficacy of antiepileptic drugs in preventing the need for methylphenidate in patients with Benign Childhood Epilepsy with centrotemporal spikes and attention deficit hyperactivity disorder. Seventeen patients were identified. A reduction of electroencephalogram pathologic activity by more than 50% was achieved in some patients with the antiepileptic drugs levetiracetam, sulthiame, lamotrigine, clobazam, and valproic acid. Complete normalization was achieved in two patients with sulthiame. Improvement in attention along with the reduction of pathologic electroencephalogram activity was observed in four patients, two with sulthiame, and one each with lamotrigine and levetiracetam (which was ceased because of suicidal tendencies). However, this improvement in attention was either temporary or not significant enough to discontinue methylphenidate. Methylphenidate was eventually prescribed to all patients.
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the prevalence of atypical presentations and comorbidities of Benign Childhood Epilepsy with centrotemporal spikes
Epilepsia, 2011Co-Authors: Eliel Tovia, Nathan Watemberg, Hadassa Goldbergstern, Bruria Ben Zeev, Eli Heyman, Aviva Fattalvalevski, Uri KramerAbstract:SUMMARY Purpose: Benign Childhood Epilepsy with centrotemporal spikes (BCECTS) isthe mostcommon epileptic syndrome in Childhood. The outcome is usually excellent, but there are some atypical forms of BCECTS with less favorable outcomes. The aim of this study was to delineate the frequency of these atypical features among patients with BCECTS. Methods: We conducted a retrospective chart study by retrieving the medical records of all consecutive patients with BCECTS who were evaluated in four pediatric neurology outpatient clinics in Israel between the years 1991 and 2008. Key Findings: A total of 196 patients with BCECTS were identified (78 female and 118 male; mean age at time of diagnosis 7.64 years, range 1.5‐14). The mean duration of follow-up was 4.43 years (range 2‐11). Nine patients (4.6%)developedelectricalstatusepilepticusinslowwaves sleep (ESES) during follow-up, four (2%) had Landau-Kleffner syndrome, three (1.5%) had BCECTS with frequent refractoryseizures,two(1%)hadBCECTSwithfallsatpresentation, one (0.5%) had a ‘‘classic’’ atypical variant, and one (0.5%) had oromotor dysfunction. None had rolandic status epilepticus. Sixty-one patients (31%) had attention deficithyperactivitydisorder(ADHD),43(21.9%) hadspecific cognitive deficits, and 23 (11.7%) had behavioral
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atypical presentations of Benign Childhood Epilepsy with centrotemporal spikes a review
Journal of Child Neurology, 2008Co-Authors: Uri KramerAbstract:Benign Childhood Epilepsy with centrotemporal spikes is the most common epileptic syndrome in Childhood. Atypical forms of Benign Childhood Epilepsy with centrotemporal spikes are common. The different atypical forms of the condition are believed to represent a continuum of the same underlying genetic mechanism. The atypical forms of Benign Childhood Epilepsy with centrotemporal spikes include electrical status epilepticus in slow waves sleep, Landau-Kleffner syndrome, status epilepticus of Benign Childhood Epilepsy with centrotemporal spikes, "classic" atypical form, and others. This review delineates the different forms with emphasis on the cognitive hazards of the more malignant types.
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Benign Childhood Epilepsy with centrotemporal spikes: clinical characteristics and identification of patients at risk for multiple seizures.
Journal of child neurology, 2002Co-Authors: Uri Kramer, Nathanel Zelnik, Tally Lerman-sagie, Eli ShaharAbstract:This study aimed to characterize patients diagnosed as having Benign Childhood Epilepsy with centrotemporal spikes and few seizures and compare them with patients with Benign Childhood Epilepsy with centrotemporal spikes with multiple seizures. The medical files of 87 consecutive patients with Benign Childhood Epilepsy with centrotemporal spikes were reviewed and data on gender, age at disease onset, duration of the disease, number of seizures, seizure semiology, and electroencephalographic and neuroimaging findings were analyzed. The mean age at disease onset was 8 years. The mean duration of the disease was 2 years. Eighteen percent of the patients had more than 20 seizures each, whereas 24% had 1 to 3 seizures each. The only predictor for a disease course with multiple seizures was an onset prior to 3 years of age.
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Carbamazepine versus sulthiame in treating Benign Childhood Epilepsy with centrotemporal spikes.
Journal of child neurology, 2002Co-Authors: Uri Kramer, Nathanel Zelnik, Tally Lerman-sagie, Eli Shahar, Nathan Watemberg, Yoram Nevo, Bruria Ben-zeevAbstract:We compared the therapeutic efficacy of carbamazepine versus sulthiame in patients with Benign Childhood Epilepsy with centrotemporal spikes. Drug efficacy was evaluated only in those patients who initiated treatment with any drug after at least three seizures. Thirty-eight patients who received carbamazepine and 18 patients who received sulthiame were included in the analysis. Cessation of seizures was observed in 73.6% of the former and in 66.7% of the latter (P = not significant). Five of eight patients who were switched to sulthiame after failing carbamazepine became seizure free, whereas none of the three patients who failed sulthiame became seizure free after being switched to carbamazepine. The rate of drug discontinuation owing to adverse reaction was 15% in carbamazepine and 14.3% in sulthiame. Normalization of interictal epileptiform activity on electroencephalography was seen more often following treatment with sulthiame (71%) than with carbamazepine (42%) (P = not significant). No significant differences between these two medications were found in the treatment of Benign Childhood Epilepsy with centrotemporal spikes in this small patient sample.
Ye-hwa Jun - One of the best experts on this subject based on the ideXlab platform.
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Changes in background electroencephalographic activity in Benign Childhood Epilepsy with centrotemporal spikes after oxcarbazepine treatment: a standardized low-resolution brain electromagnetic tomography (sLORETA) study.
BMC neurology, 2019Co-Authors: Ye-hwa Jun, Tae-hoon Eom, Young Hoon Kim, Seung-yun Chung, In-goo Lee, Jung-min KimAbstract:Several neuroimaging studies have reported neurophysiological alterations in patients with Benign Childhood Epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often. We investigated background EEG activity changes after six months of oxcarbazepine treatment to better understand the neurophysiological alterations and progression that occur in BCECTS. In 18 children with BCECTS, non-parametric statistical analyses using standardized low resolution brain electromagnetic tomography (sLORETA) were performed to compare the current density distribution of four frequency bands (delta, theta, alpha, and beta) between untreated and treated conditions. Background EEG activity for the delta frequency band was significantly decreased in the fronto-temporal and limbic regions of the left hemisphere after oxcarbazepine treatment (threshold log-F-ratio = ±2.729, P
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Changes in background electroencephalographic activity in Benign Childhood Epilepsy with centrotemporal spikes after oxcarbazepine treatment: a standardized low-resolution brain electromagnetic tomography (sLORETA) study
BMC, 2019Co-Authors: Ye-hwa Jun, Tae-hoon Eom, Young Hoon Kim, Seung-yun Chung, In-goo Lee, Jung-min KimAbstract:Abstract Background Several neuroimaging studies have reported neurophysiological alterations in patients with Benign Childhood Epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often. Methods We investigated background EEG activity changes after six months of oxcarbazepine treatment to better understand the neurophysiological alterations and progression that occur in BCECTS. In 18 children with BCECTS, non-parametric statistical analyses using standardized low resolution brain electromagnetic tomography (sLORETA) were performed to compare the current density distribution of four frequency bands (delta, theta, alpha, and beta) between untreated and treated conditions. Results Background EEG activity for the delta frequency band was significantly decreased in the fronto-temporal and limbic regions of the left hemisphere after oxcarbazepine treatment (threshold log-F-ratio = ±2.729, P
Tae-hoon Eom - One of the best experts on this subject based on the ideXlab platform.
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Changes in background electroencephalographic activity in Benign Childhood Epilepsy with centrotemporal spikes after oxcarbazepine treatment: a standardized low-resolution brain electromagnetic tomography (sLORETA) study.
BMC neurology, 2019Co-Authors: Ye-hwa Jun, Tae-hoon Eom, Young Hoon Kim, Seung-yun Chung, In-goo Lee, Jung-min KimAbstract:Several neuroimaging studies have reported neurophysiological alterations in patients with Benign Childhood Epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often. We investigated background EEG activity changes after six months of oxcarbazepine treatment to better understand the neurophysiological alterations and progression that occur in BCECTS. In 18 children with BCECTS, non-parametric statistical analyses using standardized low resolution brain electromagnetic tomography (sLORETA) were performed to compare the current density distribution of four frequency bands (delta, theta, alpha, and beta) between untreated and treated conditions. Background EEG activity for the delta frequency band was significantly decreased in the fronto-temporal and limbic regions of the left hemisphere after oxcarbazepine treatment (threshold log-F-ratio = ±2.729, P
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Changes in background electroencephalographic activity in Benign Childhood Epilepsy with centrotemporal spikes after oxcarbazepine treatment: a standardized low-resolution brain electromagnetic tomography (sLORETA) study
BMC, 2019Co-Authors: Ye-hwa Jun, Tae-hoon Eom, Young Hoon Kim, Seung-yun Chung, In-goo Lee, Jung-min KimAbstract:Abstract Background Several neuroimaging studies have reported neurophysiological alterations in patients with Benign Childhood Epilepsy with centrotemporal spikes (BCECTS). However, reported outcomes have been inconsistent, and the progression of these changes in the brain remains unresolved. Moreover, background electroencephalography (EEG) in cases of BCECTS has not been performed often. Methods We investigated background EEG activity changes after six months of oxcarbazepine treatment to better understand the neurophysiological alterations and progression that occur in BCECTS. In 18 children with BCECTS, non-parametric statistical analyses using standardized low resolution brain electromagnetic tomography (sLORETA) were performed to compare the current density distribution of four frequency bands (delta, theta, alpha, and beta) between untreated and treated conditions. Results Background EEG activity for the delta frequency band was significantly decreased in the fronto-temporal and limbic regions of the left hemisphere after oxcarbazepine treatment (threshold log-F-ratio = ±2.729, P
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Distributed source localization of interictal spikes in Benign Childhood Epilepsy with centrotemporal spikes: A standardized low-resolution brain electromagnetic tomography (sLORETA) study.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2017Co-Authors: Tae-hoon Eom, Jung-hyun Shin, Young Hoon Kim, Seung-yun Chung, In-goo Lee, Jung-min KimAbstract:Benign Childhood Epilepsy with centrotemporal spikes (BCECTS), also known as Rolandic Epilepsy, is the most common Benign Childhood Epilepsy. Centrotemporal spikes are characteristic findings on electroencephalography (EEG). Though the condition is considered Benign, many studies have reported some degree of neuropsychological impairment in individuals with BCECTS. There is also growing evidence from neuroimaging studies that BCECTS may affect a larger portion of the brain than originally thought. We performed distributed source localization analysis of interictal spikes in BCECTS. Current-source density (CSD) of the maximal negative peak of the interictal spikes averaged from each of 20 EEG epochs in 11 patients with BCECTS was measured using standardized low-resolution brain electromagnetic tomography (sLORETA). Rolandic area was included in the distribution of the CSD in all of the patients. The significant CSD and its maximal point were distributed in multiple cortical regions over the Rolandic area. It is suggested that the widespread cortical distribution of interictal spikes seen in this study may be associated with atypical presentation and a variety of comorbidities of BCECTS. Our results imply that BCECTS represents a deviation from normal development during a critical period of brain maturation and that children with BECTS might be more likely to need special medical attention.