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Biosensing

The Experts below are selected from a list of 49977 Experts worldwide ranked by ideXlab platform

Martin Pumera – 1st expert on this subject based on the ideXlab platform

  • graphene in Biosensing
    Materials Today, 2011
    Co-Authors: Martin Pumera

    Abstract:

    Biosensing is paramount for improving the quality of human life. Biosensors and Biosensing protocols are able to detect a wide range of compounds, sensitively and selectively, with applications in security, health care for point-of-care analyses of diseases, and environmental safety. Here, we describe biosensors and Biosensing systems employing graphene. Graphene is a zero-gap semiconductor material, which is electroactive and transparent. Because of its interesting properties, graphene has found its way into a wide variety of Biosensing schemes. It has been used as a transducer in bio-field-effect transistors, electrochemical biosensors, impedance biosensors, electrochemiluminescence, and fluorescence biosensors, as well as biomolecular labels. In our review, we describe the application of graphene for enzymatic Biosensing, DNA sensing, and immunosensing. We compare different techniques and present our views on the future development of the field.

  • Graphene in Biosensing
    Materials Today, 2011
    Co-Authors: Martin Pumera

    Abstract:

    Biosensing is paramount for improving the quality of human life. Biosensors and Biosensing protocols are able to detect a wide range of compounds, sensitively and selectively, with applications in security, health care for point-of-care analyses of diseases, and environmental safety. Here, we describe biosensors and Biosensing systems employing graphene. Graphene is a zero-gap semiconductor material, which is electroactive and transparent. Because of its interesting properties, graphene has found its way into a wide variety of Biosensing schemes. It has been used as a transducer in bio-field-effect transistors, electrochemical biosensors, impedance biosensors, electrochemiluminescence, and fluorescence biosensors, as well as biomolecular labels. In our review, we describe the application of graphene for enzymatic Biosensing, DNA sensing, and immunosensing. We compare different techniques and present our views on the future development of the field. © 2011 Elsevier Ltd.

Yongkang Ye – 2nd expert on this subject based on the ideXlab platform

  • gold nanoparticle based signal amplification for Biosensing
    Analytical Biochemistry, 2011
    Co-Authors: Yongkang Ye

    Abstract:

    Colloidal gold nanoparticles (AuNPs), with unique properties such as highly resonant particle plasmons, direct visualization of single nanoclusters by scattering of light, catalytic size enhancement by silver deposition, conductivity, and electrochemical properties, are very attractive materials for several applications in biotechnology. Furthermore, as excellent biological tags, AuNPs can be easily conjugated with biomolecules and retain the biochemical activity of the tagged biomolecules, making AuNPs ideal transducers for several biorecognition applications. The goal of this article is to review recent advances of using AuNPs as labels for signal amplification in Biosensing applications. We focus on the signal amplification strategies of AuNPs in Biosensing/biorecognition, more specifically, on the main optical and electrochemical detection methods that involve AuNP-based Biosensing. Particular attention is given to recent advances and trends in sensing applications.

  • Gold nanoparticle-based signal amplification for Biosensing
    Analytical Biochemistry, 2011
    Co-Authors: Xiaodong Cao, Yongkang Ye, Songqin Liu

    Abstract:

    Colloidal gold nanoparticles (AuNPs), with unique properties such as highly resonant particle plasmons, direct visualization of single nanoclusters by scattering of light, catalytic size enhancement by silver deposition, conductivity, and electrochemical properties, are very attractive materials for several applications in biotechnology. Furthermore, as excellent biological tags, AuNPs can be easily conjugated with biomolecules and retain the biochemical activity of the tagged biomolecules, making AuNPs ideal transducers for several biorecognition applications. The goal of this article is to review recent advances of using AuNPs as labels for signal amplification in Biosensing applications. We focus on the signal amplification strategies of AuNPs in Biosensing/biorecognition, more specifically, on the main optical and electrochemical detection methods that involve AuNP-based Biosensing. Particular attention is given to recent advances and trends in sensing applications. © 2011 Elsevier Inc. All rights reserved.

Frank Vollmer – 3rd expert on this subject based on the ideXlab platform

  • Advances in Single Molecule Biosensing
    Sensors, 2015
    Co-Authors: Frank Vollmer

    Abstract:

    In this presentation, we will report on advancing chip-scale Biosensing capabilities with optical microresonators. His laboratory has developed a microcavity Biosensing platform that is capable of monitoring single DNA molecules and their interaction kinetics, hence achieving an unprecedented sensitivity for label-free detection with light. By thermal stabilization of the sensor it is furthermore possible to characterize the structural change of biopolymers in response to temperature. Stand-off biodetection capabilities are demonstrated with asymmetric microspheres. Article not available.

  • single molecule nucleic acid interactions monitored on a label free microcavity biosensor platform
    Nature Nanotechnology, 2014
    Co-Authors: Martin D Baaske, Matthew R Foreman, Frank Vollmer

    Abstract:

    Biosensing relies on the detection of molecules and their specific interactions. It is therefore highly desirable to develop transducers exhibiting ultimate detection limits. Microcavities are an exemplary candidate technology for demonstrating such a capability in the optical domain and in a label-free fashion. Additional sensitivity gains, achievable by exploiting plasmon resonances, promise Biosensing down to the single-molecule level. Here, we introduce a Biosensing platform using optical microcavity-based sensors that exhibits single-molecule sensitivity and is selective to specific single binding events. Whispering gallery modes in glass microspheres are used to leverage plasmonic enhancements in gold nanorods for the specific detection of nucleic acid hybridization, down to single 8-mer oligonucleotides. Detection of single intercalating small molecules confirms the observation of single-molecule hybridization. Matched and mismatched strands are discriminated by their interaction kinetics. Our platform allows us to monitor specific molecular interactions transiently, hence mitigating the need for high binding affinity and avoiding permanent binding of target molecules to the receptors. Sensor lifetime is therefore increased, allowing interaction kinetics to be statistically analysed.

  • Microcavity Biosensing
    Frontiers in Ultrafast Optics: Biomedical Scientific and Industrial Applications XI, 2011
    Co-Authors: Frank Vollmer

    Abstract:

    A microcavity biosensor monitors optical resonances in micro-and nanostrucrtures for label-free detection of molecules and their interactions. I will give an introduction to the field of microcavity Biosensing and present an overview on the current state-of-the art. I will emphasize recent applications of optical microcavities for nanoparticle detection, trapping and manipulation, and I will highlight different modalities for ultra-sensitve label-free Biosensing