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Wei Yang - One of the best experts on this subject based on the ideXlab platform.
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mechanisms of nrf2 ho 1 pathway up regulation induced by pu erh Black Tea Extract supplementation for quinocetone treated sprague dawley rats
Journal of Functional Foods, 2015Co-Authors: Miao Yu, Di Wang, Wei Yang, Mengjing Xu, Siyuan XuAbstract:Abstract Pu-erh Tea is a special post-fermented Tea product that contains various compounds. Quinocetone (QCT) has been used as a veterinary drug in P.R. China. However, QCT has been proven to cause oxidative DNA damage, inflammation, and apoptosis. We have used Pu-erh Black Tea Extract (BTE) as an intervention for QCT-treated SD rats and analyzed its protective effect. Our data demonstrated that BTE improved QCT-induced functional and organic liver damage. This protective effect was accomplished by activating the Nrf2/HO-1 pathway expression and the potential mechanism consisted in the activation of the extracellular signal-regulated kinase (ERK) pathway by polyphenols contained in BTE. Moreover, some flavonoids and quinone (also contained in BTE) might effectively activate Nrf2/HO-1 pathway expression and protect SD rats from oxidative stress. Thus, the protective effect of BTE against QCT-induced oxidative damage demonstrated new insights into the antioxidative mechanisms of Pu-erh Tea.
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Mechanisms of Nrf2/HO-1 pathway up-regulation induced by pu-erh Black Tea Extract supplementation for quinocetone-treated Sprague-Dawley rats
Journal of Functional Foods, 2015Co-Authors: Miao Yu, Di Wang, Wei Yang, Mengjing Xu, Siyuan XuAbstract:Abstract Pu-erh Tea is a special post-fermented Tea product that contains various compounds. Quinocetone (QCT) has been used as a veterinary drug in P.R. China. However, QCT has been proven to cause oxidative DNA damage, inflammation, and apoptosis. We have used Pu-erh Black Tea Extract (BTE) as an intervention for QCT-treated SD rats and analyzed its protective effect. Our data demonstrated that BTE improved QCT-induced functional and organic liver damage. This protective effect was accomplished by activating the Nrf2/HO-1 pathway expression and the potential mechanism consisted in the activation of the extracellular signal-regulated kinase (ERK) pathway by polyphenols contained in BTE. Moreover, some flavonoids and quinone (also contained in BTE) might effectively activate Nrf2/HO-1 pathway expression and protect SD rats from oxidative stress. Thus, the protective effect of BTE against QCT-induced oxidative damage demonstrated new insights into the antioxidative mechanisms of Pu-erh Tea.
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pu erh Black Tea Extract supplementation attenuates the oxidative dna damage and oxidative stress in sprague dawley rats with renal dysfunction induced by subchronic 3 methyl 2 quinoxalin benzenevinylketo 1 4 dioxide exposure
Food and Chemical Toxicology, 2012Co-Authors: Di Wang, Wei Yang, Mengjing Xu, Ying Zhong, Jie MengAbstract:3-Methyl-2-quinoxalin benzenevinylketo-1,4-dioxide (Quinocetone, QCT), has been used to treat dysentery and promote growth in animal feeding. However, available data show that QCT has potential nephrotoxicity. The present study was designed to investigate the protective effects of Pu-erh Black Tea Extract (PBTE) which is a traditional remedy in China with antioxidant properties against oxidative DNA damage and oxidative stress in a rat model of QCT-induced renal dysfunction. Increased serum creatinine, blood urea nitrogen, pathological lesions, urinary 8-hydroxy 2-deoxyguanosine (8-OHdG) and renal DNA damage were observed in the QCT-fed rats. These were accompanied by intracellular reactive oxygen species accumulation, enhanced lipid peroxidation, and inhibited antioxidant system, i.e., glutathione glutathione S-transferase, glutathione peroxidase and glutathione reductase. Oral administration of PBTE effectively suppressed QCT-induced renal dysfunction, as evidenced by reduced serum creatinine, urinary 8-OHdG and DNA damage in isolated renal cells, amelioration of oxidative stress and modulation of antioxidative system. In conclusion, PBTE administration ameliorated QCT-induced nephrotoxicity by maintaining DNA’s double-helix architecture and mitigating oxidative stress.
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Pu-erh Black Tea Extract supplementation attenuates the oxidative DNA damage and oxidative stress in Sprague–Dawley rats with renal dysfunction induced by subchronic 3-methyl-2-quinoxalin benzenevinylketo-1,4-dioxide exposure
Food and Chemical Toxicology, 2011Co-Authors: Di Wang, Wei Yang, Mengjing Xu, Ying Zhong, Jie MengAbstract:3-Methyl-2-quinoxalin benzenevinylketo-1,4-dioxide (Quinocetone, QCT), has been used to treat dysentery and promote growth in animal feeding. However, available data show that QCT has potential nephrotoxicity. The present study was designed to investigate the protective effects of Pu-erh Black Tea Extract (PBTE) which is a traditional remedy in China with antioxidant properties against oxidative DNA damage and oxidative stress in a rat model of QCT-induced renal dysfunction. Increased serum creatinine, blood urea nitrogen, pathological lesions, urinary 8-hydroxy 2-deoxyguanosine (8-OHdG) and renal DNA damage were observed in the QCT-fed rats. These were accompanied by intracellular reactive oxygen species accumulation, enhanced lipid peroxidation, and inhibited antioxidant system, i.e., glutathione glutathione S-transferase, glutathione peroxidase and glutathione reductase. Oral administration of PBTE effectively suppressed QCT-induced renal dysfunction, as evidenced by reduced serum creatinine, urinary 8-OHdG and DNA damage in isolated renal cells, amelioration of oxidative stress and modulation of antioxidative system. In conclusion, PBTE administration ameliorated QCT-induced nephrotoxicity by maintaining DNA’s double-helix architecture and mitigating oxidative stress.
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acute and subchronic oral toxicities of pu erh Black Tea Extract in sprague dawley rats
Journal of Ethnopharmacology, 2011Co-Authors: Di Wang, Ying Zhong, Kunlong Xu, Rong Xiao, Wei YangAbstract:ETHNOPHARMACOLOGICAL RELEVANCE: Pu-erh Black Tea, which is obtained by first parching crude green Tea leaves and then undergoes secondary fermentation with microorganisms, has been believed to be beneficial beverages for health for nearly 2000 years in China, Japan and Taiwan area. But its potential toxicity when administered at a high dose as concentrated Extracts has not been completely investigated. THE AIM OF THE STUDY: The present study was aimed at evaluating potential toxicity of Pu-erh Black Tea Extracts (BTE) from acute and sub-chronic administration to male and female Sprague-Dawley (SD) rats. MATERIALS AND METHODS: A single BTE dose of 10,000 mg/kg of body weight was administered by oral gavage for acute toxicity in SD rats. Four groups (10 males and 10 females per group) of dose levels of 1250, 2500, and 5,000 mg/kg/day of the test article, as well as controls (distilled water) were tested as the subchronic toxicity study. RESULTS: No deaths and signs of toxicity occurred during the 14 days of the study. There were no test article related mortalities, body weight gain, feed consumption, clinical observation, organ weight changes, gross finding, clinical or histopathological alterations during the 91-day administration. CONCLUSIONS: The LD(50) of BTE can be defined as more than 10,000 mg/kg, and a dose of 5,000 mg/kg/day was identified as the no-observed-adverse-effect-level (NOAEL) in this study.
Di Wang - One of the best experts on this subject based on the ideXlab platform.
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mechanisms of nrf2 ho 1 pathway up regulation induced by pu erh Black Tea Extract supplementation for quinocetone treated sprague dawley rats
Journal of Functional Foods, 2015Co-Authors: Miao Yu, Di Wang, Wei Yang, Mengjing Xu, Siyuan XuAbstract:Abstract Pu-erh Tea is a special post-fermented Tea product that contains various compounds. Quinocetone (QCT) has been used as a veterinary drug in P.R. China. However, QCT has been proven to cause oxidative DNA damage, inflammation, and apoptosis. We have used Pu-erh Black Tea Extract (BTE) as an intervention for QCT-treated SD rats and analyzed its protective effect. Our data demonstrated that BTE improved QCT-induced functional and organic liver damage. This protective effect was accomplished by activating the Nrf2/HO-1 pathway expression and the potential mechanism consisted in the activation of the extracellular signal-regulated kinase (ERK) pathway by polyphenols contained in BTE. Moreover, some flavonoids and quinone (also contained in BTE) might effectively activate Nrf2/HO-1 pathway expression and protect SD rats from oxidative stress. Thus, the protective effect of BTE against QCT-induced oxidative damage demonstrated new insights into the antioxidative mechanisms of Pu-erh Tea.
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Mechanisms of Nrf2/HO-1 pathway up-regulation induced by pu-erh Black Tea Extract supplementation for quinocetone-treated Sprague-Dawley rats
Journal of Functional Foods, 2015Co-Authors: Miao Yu, Di Wang, Wei Yang, Mengjing Xu, Siyuan XuAbstract:Abstract Pu-erh Tea is a special post-fermented Tea product that contains various compounds. Quinocetone (QCT) has been used as a veterinary drug in P.R. China. However, QCT has been proven to cause oxidative DNA damage, inflammation, and apoptosis. We have used Pu-erh Black Tea Extract (BTE) as an intervention for QCT-treated SD rats and analyzed its protective effect. Our data demonstrated that BTE improved QCT-induced functional and organic liver damage. This protective effect was accomplished by activating the Nrf2/HO-1 pathway expression and the potential mechanism consisted in the activation of the extracellular signal-regulated kinase (ERK) pathway by polyphenols contained in BTE. Moreover, some flavonoids and quinone (also contained in BTE) might effectively activate Nrf2/HO-1 pathway expression and protect SD rats from oxidative stress. Thus, the protective effect of BTE against QCT-induced oxidative damage demonstrated new insights into the antioxidative mechanisms of Pu-erh Tea.
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pu erh Black Tea Extract supplementation attenuates the oxidative dna damage and oxidative stress in sprague dawley rats with renal dysfunction induced by subchronic 3 methyl 2 quinoxalin benzenevinylketo 1 4 dioxide exposure
Food and Chemical Toxicology, 2012Co-Authors: Di Wang, Wei Yang, Mengjing Xu, Ying Zhong, Jie MengAbstract:3-Methyl-2-quinoxalin benzenevinylketo-1,4-dioxide (Quinocetone, QCT), has been used to treat dysentery and promote growth in animal feeding. However, available data show that QCT has potential nephrotoxicity. The present study was designed to investigate the protective effects of Pu-erh Black Tea Extract (PBTE) which is a traditional remedy in China with antioxidant properties against oxidative DNA damage and oxidative stress in a rat model of QCT-induced renal dysfunction. Increased serum creatinine, blood urea nitrogen, pathological lesions, urinary 8-hydroxy 2-deoxyguanosine (8-OHdG) and renal DNA damage were observed in the QCT-fed rats. These were accompanied by intracellular reactive oxygen species accumulation, enhanced lipid peroxidation, and inhibited antioxidant system, i.e., glutathione glutathione S-transferase, glutathione peroxidase and glutathione reductase. Oral administration of PBTE effectively suppressed QCT-induced renal dysfunction, as evidenced by reduced serum creatinine, urinary 8-OHdG and DNA damage in isolated renal cells, amelioration of oxidative stress and modulation of antioxidative system. In conclusion, PBTE administration ameliorated QCT-induced nephrotoxicity by maintaining DNA’s double-helix architecture and mitigating oxidative stress.
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Pu-erh Black Tea Extract supplementation attenuates the oxidative DNA damage and oxidative stress in Sprague–Dawley rats with renal dysfunction induced by subchronic 3-methyl-2-quinoxalin benzenevinylketo-1,4-dioxide exposure
Food and Chemical Toxicology, 2011Co-Authors: Di Wang, Wei Yang, Mengjing Xu, Ying Zhong, Jie MengAbstract:3-Methyl-2-quinoxalin benzenevinylketo-1,4-dioxide (Quinocetone, QCT), has been used to treat dysentery and promote growth in animal feeding. However, available data show that QCT has potential nephrotoxicity. The present study was designed to investigate the protective effects of Pu-erh Black Tea Extract (PBTE) which is a traditional remedy in China with antioxidant properties against oxidative DNA damage and oxidative stress in a rat model of QCT-induced renal dysfunction. Increased serum creatinine, blood urea nitrogen, pathological lesions, urinary 8-hydroxy 2-deoxyguanosine (8-OHdG) and renal DNA damage were observed in the QCT-fed rats. These were accompanied by intracellular reactive oxygen species accumulation, enhanced lipid peroxidation, and inhibited antioxidant system, i.e., glutathione glutathione S-transferase, glutathione peroxidase and glutathione reductase. Oral administration of PBTE effectively suppressed QCT-induced renal dysfunction, as evidenced by reduced serum creatinine, urinary 8-OHdG and DNA damage in isolated renal cells, amelioration of oxidative stress and modulation of antioxidative system. In conclusion, PBTE administration ameliorated QCT-induced nephrotoxicity by maintaining DNA’s double-helix architecture and mitigating oxidative stress.
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acute and subchronic oral toxicities of pu erh Black Tea Extract in sprague dawley rats
Journal of Ethnopharmacology, 2011Co-Authors: Di Wang, Ying Zhong, Kunlong Xu, Rong Xiao, Wei YangAbstract:ETHNOPHARMACOLOGICAL RELEVANCE: Pu-erh Black Tea, which is obtained by first parching crude green Tea leaves and then undergoes secondary fermentation with microorganisms, has been believed to be beneficial beverages for health for nearly 2000 years in China, Japan and Taiwan area. But its potential toxicity when administered at a high dose as concentrated Extracts has not been completely investigated. THE AIM OF THE STUDY: The present study was aimed at evaluating potential toxicity of Pu-erh Black Tea Extracts (BTE) from acute and sub-chronic administration to male and female Sprague-Dawley (SD) rats. MATERIALS AND METHODS: A single BTE dose of 10,000 mg/kg of body weight was administered by oral gavage for acute toxicity in SD rats. Four groups (10 males and 10 females per group) of dose levels of 1250, 2500, and 5,000 mg/kg/day of the test article, as well as controls (distilled water) were tested as the subchronic toxicity study. RESULTS: No deaths and signs of toxicity occurred during the 14 days of the study. There were no test article related mortalities, body weight gain, feed consumption, clinical observation, organ weight changes, gross finding, clinical or histopathological alterations during the 91-day administration. CONCLUSIONS: The LD(50) of BTE can be defined as more than 10,000 mg/kg, and a dose of 5,000 mg/kg/day was identified as the no-observed-adverse-effect-level (NOAEL) in this study.
Rahul Gopalarishnan - One of the best experts on this subject based on the ideXlab platform.
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Antihyperglycemic Potential of Back Tea Extract Attenuates Tricarboxylic Acid Cycle Enzymes by Modulating Carbohydrate Metabolic Enzymes in Streptozotocin-Induced Diabetic Rats
Indian Journal of Clinical Biochemistry, 2019Co-Authors: Sundaram Ramalingam, Sivakumar Mullaivanam Ramasamy, Ganesh Vasu, Rahul GopalarishnanAbstract:The present study was aimed to investigate the effect of Black Tea Extract on blood glucose, plasma insulin, Hemoglobin, carbohydrate metabolic enzymes and tricarboxylic enzymes in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg b wt). Black Tea Extract was administered to diabetic rats at a dose of 25, 50 and 100 mg/kg body weight for 30 days. The effects of Black Tea Extract on glucose, insulin and HbA1c levels were analyzed to confirm the effective dose. Administration of Black Tea Extract to diabetic rats was significantly decreased the level of glucose, glycated hemoglobin and increased the levels of insulin in a dose dependent manner. The Black Tea Extracts at a dose of 100 mg/kg b wt showed a highly significant effect compared to other two doses (25 and 50 mg/kg b wt). The effect produced by Black Tea Extract (100 mg/kg b wt) was comparable to that of glibenclamide (5 mg/kg b wt) a reference anti diabetic drug. Therefore, 100 mg/kg b wt was fixed as an effective dose and used for further analyses. Black Tea Extract was administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. Black Tea Extract administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. The effect produced by Black Tea Extract of all the biochemical parameters were comparable with glibenclamide-used as a reference drug.
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Antihyperglycemic Potential of Back Tea Extract Attenuates Tricarboxylic Acid Cycle Enzymes by Modulating Carbohydrate Metabolic Enzymes in Streptozotocin-Induced Diabetic Rats
Indian Journal of Clinical Biochemistry, 2019Co-Authors: Sundaram Ramalingam, Sivakumar Mullaivanam Ramasamy, Ganesh Vasu, Rahul GopalarishnanAbstract:The present study was aimed to investigate the effect of Black Tea Extract on blood glucose, plasma insulin, Hemoglobin, carbohydrate metabolic enzymes and tricarboxylic enzymes in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg b wt). Black Tea Extract was administered to diabetic rats at a dose of 25, 50 and 100 mg/kg body weight for 30 days. The effects of Black Tea Extract on glucose, insulin and HbA1c levels were analyzed to confirm the effective dose. Administration of Black Tea Extract to diabetic rats was significantly decreased the level of glucose, glycated hemoglobin and increased the levels of insulin in a dose dependent manner. The Black Tea Extracts at a dose of 100 mg/kg b wt showed a highly significant effect compared to other two doses (25 and 50 mg/kg b wt). The effect produced by Black Tea Extract (100 mg/kg b wt) was comparable to that of glibenclamide (5 mg/kg b wt) a reference anti diabetic drug. Therefore, 100 mg/kg b wt was fixed as an effective dose and used for further analyses. Black Tea Extract was administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. Black Tea Extract administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. The effect produced by Black Tea Extract of all the biochemical parameters were comparable with glibenclamide-used as a reference drug.
Sundaram Ramalingam - One of the best experts on this subject based on the ideXlab platform.
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Hypoglycemic effect of Black Tea Extract attenuates carbohydrate metabolic enzymes in streptozotocin-induced diabetic rats
International Journal of Green Pharmacy, 2019Co-Authors: Sundaram RamalingamAbstract:Aim: To evaluate the beneficial effects of Black Tea Extract (BTE) on key enzymes of carbohydrate metabolism in streptozotocin -induced diabetic rats. Materials and Methods: Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg b.wt). Results and Discussion: BTE was administered to diabetic rats at a dose of 100 mg/kg b.wt for 30 days significantly decreased the level of glucose, glycated hemoglobin and increased the levels of insulin. In addition, Black Tea administration reinstated the altered carbohydrate metabolizing enzymes to near normal levels. These findings suggest that the administration of Black Tea Extract was potentially ameliorated the carbohydrate metabolizing enzymes in addition to its antihyperglycemic effect. Conclusion: The effect produced by Black Tea Extract on various parameters was comparable to that of glibenclamide- an antidiabetic drug used as a reference drug.
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Antihyperglycemic Potential of Back Tea Extract Attenuates Tricarboxylic Acid Cycle Enzymes by Modulating Carbohydrate Metabolic Enzymes in Streptozotocin-Induced Diabetic Rats
Indian Journal of Clinical Biochemistry, 2019Co-Authors: Sundaram Ramalingam, Sivakumar Mullaivanam Ramasamy, Ganesh Vasu, Rahul GopalarishnanAbstract:The present study was aimed to investigate the effect of Black Tea Extract on blood glucose, plasma insulin, Hemoglobin, carbohydrate metabolic enzymes and tricarboxylic enzymes in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg b wt). Black Tea Extract was administered to diabetic rats at a dose of 25, 50 and 100 mg/kg body weight for 30 days. The effects of Black Tea Extract on glucose, insulin and HbA1c levels were analyzed to confirm the effective dose. Administration of Black Tea Extract to diabetic rats was significantly decreased the level of glucose, glycated hemoglobin and increased the levels of insulin in a dose dependent manner. The Black Tea Extracts at a dose of 100 mg/kg b wt showed a highly significant effect compared to other two doses (25 and 50 mg/kg b wt). The effect produced by Black Tea Extract (100 mg/kg b wt) was comparable to that of glibenclamide (5 mg/kg b wt) a reference anti diabetic drug. Therefore, 100 mg/kg b wt was fixed as an effective dose and used for further analyses. Black Tea Extract was administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. Black Tea Extract administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. The effect produced by Black Tea Extract of all the biochemical parameters were comparable with glibenclamide-used as a reference drug.
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Antihyperglycemic Potential of Back Tea Extract Attenuates Tricarboxylic Acid Cycle Enzymes by Modulating Carbohydrate Metabolic Enzymes in Streptozotocin-Induced Diabetic Rats
Indian Journal of Clinical Biochemistry, 2019Co-Authors: Sundaram Ramalingam, Sivakumar Mullaivanam Ramasamy, Ganesh Vasu, Rahul GopalarishnanAbstract:The present study was aimed to investigate the effect of Black Tea Extract on blood glucose, plasma insulin, Hemoglobin, carbohydrate metabolic enzymes and tricarboxylic enzymes in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg b wt). Black Tea Extract was administered to diabetic rats at a dose of 25, 50 and 100 mg/kg body weight for 30 days. The effects of Black Tea Extract on glucose, insulin and HbA1c levels were analyzed to confirm the effective dose. Administration of Black Tea Extract to diabetic rats was significantly decreased the level of glucose, glycated hemoglobin and increased the levels of insulin in a dose dependent manner. The Black Tea Extracts at a dose of 100 mg/kg b wt showed a highly significant effect compared to other two doses (25 and 50 mg/kg b wt). The effect produced by Black Tea Extract (100 mg/kg b wt) was comparable to that of glibenclamide (5 mg/kg b wt) a reference anti diabetic drug. Therefore, 100 mg/kg b wt was fixed as an effective dose and used for further analyses. Black Tea Extract was administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. Black Tea Extract administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. The effect produced by Black Tea Extract of all the biochemical parameters were comparable with glibenclamide-used as a reference drug.
Suham Amran - One of the best experts on this subject based on the ideXlab platform.
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Effects of Black Tea Extract on carbon tetrachloride-induced lipid peroxidation in liver, kidneys, and testes of rats.
Phytotherapy research : PTR, 2020Co-Authors: Zaineb Fadhel, Suham AmranAbstract:Previous studies have shown that green Tea and Black Tea have antioxidant effects and chemopreventive activity against chronic disease including some forms of cancer. We have, therefore, examined the effects of an aqueous Extract of Black Tea against carbon tetrachloride-induced lipid peroxidation as determined by the formation of thiobarbituric acid reactive substances in liver, kidneys and testes of rats. A 0.7% Black Tea Extract was used which contained 2 mg of Black Tea Extract solids per mL. Black Tea was administered as drinking water for 3, 6, 9 and 12 months before and during carbon tetrachloride (CCl(4)) treatment in female and male rats. Rats were treated with a single oral dose of CCl(4) 1.0 mL/kg. All rats were killed 24 h after CCl(4) treatment. All animals were dosed with CCl(4) at the end of the 3, 6, 9, and 12 month of treatment. Black Tea treatment for 75 days produced a decrease in CCl(4)-induced hepatic lipid peroxidation but significant decreases in thiobarbituric acid reactive substances occurred 3 months after treatment in both female and male rats. In liver and kidneys, Black Tea alone increased lipid peroxidation by 30%-50% in female and male rats. However, Black Tea decreased CCl(4)-induced lipid peroxidation in liver of female and male rats by approximately 49% and 37%, respectively. Black Tea decreased CCl(4)-induced lipid peroxidation in testes by approximately 37% at a dose of 1.0 mL CCl(4)/kg. These results suggest that the protective effects of Black Tea against CCl(4)-induced lipid peroxidation in liver, kidneys and testes is due at least partly to its antioxidant properties, scavenging CCl(4)-associated free radicals.
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effects of Black Tea Extract on carbon tetrachloride induced lipid peroxidation in liver kidneys and testes of rats
Phytotherapy Research, 2002Co-Authors: Zaineb Fadhel, Suham AmranAbstract:Previous studies have shown that green Tea and Black Tea have antioxidant effects and chemopreventive activity against chronic disease including some forms of cancer. We have, therefore, examined the effects of an aqueous Extract of Black Tea against carbon tetrachloride-induced lipid peroxidation as determined by the formation of thiobarbituric acid reactive substances in liver, kidneys and testes of rats. A 0.7% Black Tea Extract was used which contained 2 mg of Black Tea Extract solids per mL. Black Tea was administered as drinking water for 3, 6, 9 and 12 months before and during carbon tetrachloride (CCl4) treatment in female and male rats. Rats were treated with a single oral dose of CCl4 1.0 mL/kg. All rats were killed 24 h after CCl4 treatment. All animals were dosed with CCl4 at the end of the 3, 6, 9, and 12 month of treatment. Black Tea treatment for 75 days produced a decrease in CCl4-induced hepatic lipid peroxidation but significant decreases in thiobarbituric acid reactive substances occurred 3 months after treatment in both female and male rats. In liver and kidneys, Black Tea alone increased lipid peroxidation by 30%–50% in female and male rats. However, Black Tea decreased CCl4-induced lipid peroxidation in liver of female and male rats by approximately 49% and 37%, respectively. Black Tea decreased CCl4-induced lipid peroxidation in testes by approximately 37% at a dose of 1.0 mL CCl4/kg. These results suggest that the protective effects of Black Tea against CCl4-induced lipid peroxidation in liver, kidneys and testes is due at least partly to its antioxidant properties, scavenging CCl4-associated free radicals. Copyright © 2002 John Wiley & Sons, Ltd.
