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Black Tea Extract

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Wei Yang – 1st expert on this subject based on the ideXlab platform

  • mechanisms of nrf2 ho 1 pathway up regulation induced by pu erh Black Tea Extract supplementation for quinocetone treated sprague dawley rats
    Journal of Functional Foods, 2015
    Co-Authors: Miao Yu, Di Wang, Wei Yang, Mengjing Xu, Siyuan Xu

    Abstract:

    Abstract Pu-erh Tea is a special post-fermented Tea product that contains various compounds. Quinocetone (QCT) has been used as a veterinary drug in P.R. China. However, QCT has been proven to cause oxidative DNA damage, inflammation, and apoptosis. We have used Pu-erh Black Tea Extract (BTE) as an intervention for QCT-treated SD rats and analyzed its protective effect. Our data demonstrated that BTE improved QCT-induced functional and organic liver damage. This protective effect was accomplished by activating the Nrf2/HO-1 pathway expression and the potential mechanism consisted in the activation of the extracellular signal-regulated kinase (ERK) pathway by polyphenols contained in BTE. Moreover, some flavonoids and quinone (also contained in BTE) might effectively activate Nrf2/HO-1 pathway expression and protect SD rats from oxidative stress. Thus, the protective effect of BTE against QCT-induced oxidative damage demonstrated new insights into the antioxidative mechanisms of Pu-erh Tea.

  • Mechanisms of Nrf2/HO-1 pathway up-regulation induced by pu-erh Black Tea Extract supplementation for quinocetone-treated Sprague-Dawley rats
    Journal of Functional Foods, 2015
    Co-Authors: Miao Yu, Di Wang, Wei Yang, Mengjing Xu, Siyuan Xu

    Abstract:

    Abstract Pu-erh Tea is a special post-fermented Tea product that contains various compounds. Quinocetone (QCT) has been used as a veterinary drug in P.R. China. However, QCT has been proven to cause oxidative DNA damage, inflammation, and apoptosis. We have used Pu-erh Black Tea Extract (BTE) as an intervention for QCT-treated SD rats and analyzed its protective effect. Our data demonstrated that BTE improved QCT-induced functional and organic liver damage. This protective effect was accomplished by activating the Nrf2/HO-1 pathway expression and the potential mechanism consisted in the activation of the extracellular signal-regulated kinase (ERK) pathway by polyphenols contained in BTE. Moreover, some flavonoids and quinone (also contained in BTE) might effectively activate Nrf2/HO-1 pathway expression and protect SD rats from oxidative stress. Thus, the protective effect of BTE against QCT-induced oxidative damage demonstrated new insights into the antioxidative mechanisms of Pu-erh Tea.

  • pu erh Black Tea Extract supplementation attenuates the oxidative dna damage and oxidative stress in sprague dawley rats with renal dysfunction induced by subchronic 3 methyl 2 quinoxalin benzenevinylketo 1 4 dioxide exposure
    Food and Chemical Toxicology, 2012
    Co-Authors: Di Wang, Wei Yang, Mengjing Xu, Ying Zhong, Jie Meng

    Abstract:

    3-Methyl-2-quinoxalin benzenevinylketo-1,4-dioxide (Quinocetone, QCT), has been used to treat dysentery and promote growth in animal feeding. However, available data show that QCT has potential nephrotoxicity. The present study was designed to investigate the protective effects of Pu-erh Black Tea Extract (PBTE) which is a traditional remedy in China with antioxidant properties against oxidative DNA damage and oxidative stress in a rat model of QCT-induced renal dysfunction. Increased serum creatinine, blood urea nitrogen, pathological lesions, urinary 8-hydroxy 2-deoxyguanosine (8-OHdG) and renal DNA damage were observed in the QCT-fed rats. These were accompanied by intracellular reactive oxygen species accumulation, enhanced lipid peroxidation, and inhibited antioxidant system, i.e., glutathione glutathione S-transferase, glutathione peroxidase and glutathione reductase. Oral administration of PBTE effectively suppressed QCT-induced renal dysfunction, as evidenced by reduced serum creatinine, urinary 8-OHdG and DNA damage in isolated renal cells, amelioration of oxidative stress and modulation of antioxidative system. In conclusion, PBTE administration ameliorated QCT-induced nephrotoxicity by maintaining DNA’s double-helix architecture and mitigating oxidative stress.

Di Wang – 2nd expert on this subject based on the ideXlab platform

  • mechanisms of nrf2 ho 1 pathway up regulation induced by pu erh Black Tea Extract supplementation for quinocetone treated sprague dawley rats
    Journal of Functional Foods, 2015
    Co-Authors: Miao Yu, Di Wang, Wei Yang, Mengjing Xu, Siyuan Xu

    Abstract:

    Abstract Pu-erh Tea is a special post-fermented Tea product that contains various compounds. Quinocetone (QCT) has been used as a veterinary drug in P.R. China. However, QCT has been proven to cause oxidative DNA damage, inflammation, and apoptosis. We have used Pu-erh Black Tea Extract (BTE) as an intervention for QCT-treated SD rats and analyzed its protective effect. Our data demonstrated that BTE improved QCT-induced functional and organic liver damage. This protective effect was accomplished by activating the Nrf2/HO-1 pathway expression and the potential mechanism consisted in the activation of the extracellular signal-regulated kinase (ERK) pathway by polyphenols contained in BTE. Moreover, some flavonoids and quinone (also contained in BTE) might effectively activate Nrf2/HO-1 pathway expression and protect SD rats from oxidative stress. Thus, the protective effect of BTE against QCT-induced oxidative damage demonstrated new insights into the antioxidative mechanisms of Pu-erh Tea.

  • Mechanisms of Nrf2/HO-1 pathway up-regulation induced by pu-erh Black Tea Extract supplementation for quinocetone-treated Sprague-Dawley rats
    Journal of Functional Foods, 2015
    Co-Authors: Miao Yu, Di Wang, Wei Yang, Mengjing Xu, Siyuan Xu

    Abstract:

    Abstract Pu-erh Tea is a special post-fermented Tea product that contains various compounds. Quinocetone (QCT) has been used as a veterinary drug in P.R. China. However, QCT has been proven to cause oxidative DNA damage, inflammation, and apoptosis. We have used Pu-erh Black Tea Extract (BTE) as an intervention for QCT-treated SD rats and analyzed its protective effect. Our data demonstrated that BTE improved QCT-induced functional and organic liver damage. This protective effect was accomplished by activating the Nrf2/HO-1 pathway expression and the potential mechanism consisted in the activation of the extracellular signal-regulated kinase (ERK) pathway by polyphenols contained in BTE. Moreover, some flavonoids and quinone (also contained in BTE) might effectively activate Nrf2/HO-1 pathway expression and protect SD rats from oxidative stress. Thus, the protective effect of BTE against QCT-induced oxidative damage demonstrated new insights into the antioxidative mechanisms of Pu-erh Tea.

  • pu erh Black Tea Extract supplementation attenuates the oxidative dna damage and oxidative stress in sprague dawley rats with renal dysfunction induced by subchronic 3 methyl 2 quinoxalin benzenevinylketo 1 4 dioxide exposure
    Food and Chemical Toxicology, 2012
    Co-Authors: Di Wang, Wei Yang, Mengjing Xu, Ying Zhong, Jie Meng

    Abstract:

    3-Methyl-2-quinoxalin benzenevinylketo-1,4-dioxide (Quinocetone, QCT), has been used to treat dysentery and promote growth in animal feeding. However, available data show that QCT has potential nephrotoxicity. The present study was designed to investigate the protective effects of Pu-erh Black Tea Extract (PBTE) which is a traditional remedy in China with antioxidant properties against oxidative DNA damage and oxidative stress in a rat model of QCT-induced renal dysfunction. Increased serum creatinine, blood urea nitrogen, pathological lesions, urinary 8-hydroxy 2-deoxyguanosine (8-OHdG) and renal DNA damage were observed in the QCT-fed rats. These were accompanied by intracellular reactive oxygen species accumulation, enhanced lipid peroxidation, and inhibited antioxidant system, i.e., glutathione glutathione S-transferase, glutathione peroxidase and glutathione reductase. Oral administration of PBTE effectively suppressed QCT-induced renal dysfunction, as evidenced by reduced serum creatinine, urinary 8-OHdG and DNA damage in isolated renal cells, amelioration of oxidative stress and modulation of antioxidative system. In conclusion, PBTE administration ameliorated QCT-induced nephrotoxicity by maintaining DNA’s double-helix architecture and mitigating oxidative stress.

Rahul Gopalarishnan – 3rd expert on this subject based on the ideXlab platform

  • Antihyperglycemic Potential of Back Tea Extract Attenuates Tricarboxylic Acid Cycle Enzymes by Modulating Carbohydrate Metabolic Enzymes in Streptozotocin-Induced Diabetic Rats
    Indian Journal of Clinical Biochemistry, 2019
    Co-Authors: Sundaram Ramalingam, Sivakumar Mullaivanam Ramasamy, Ganesh Vasu, Rahul Gopalarishnan

    Abstract:

    The present study was aimed to investigate the effect of Black Tea Extract on blood glucose, plasma insulin, Hemoglobin, carbohydrate metabolic enzymes and tricarboxylic enzymes in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg b wt). Black Tea Extract was administered to diabetic rats at a dose of 25, 50 and 100 mg/kg body weight for 30 days. The effects of Black Tea Extract on glucose, insulin and HbA1c levels were analyzed to confirm the effective dose. Administration of Black Tea Extract to diabetic rats was significantly decreased the level of glucose, glycated hemoglobin and increased the levels of insulin in a dose dependent manner. The Black Tea Extracts at a dose of 100 mg/kg b wt showed a highly significant effect compared to other two doses (25 and 50 mg/kg b wt). The effect produced by Black Tea Extract (100 mg/kg b wt) was comparable to that of glibenclamide (5 mg/kg b wt) a reference anti diabetic drug. Therefore, 100 mg/kg b wt was fixed as an effective dose and used for further analyses. Black Tea Extract was administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. Black Tea Extract administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. The effect produced by Black Tea Extract of all the biochemical parameters were comparable with glibenclamide-used as a reference drug.

  • Antihyperglycemic Potential of Back Tea Extract Attenuates Tricarboxylic Acid Cycle Enzymes by Modulating Carbohydrate Metabolic Enzymes in Streptozotocin-Induced Diabetic Rats
    Indian Journal of Clinical Biochemistry, 2019
    Co-Authors: Sundaram Ramalingam, Sivakumar Mullaivanam Ramasamy, Ganesh Vasu, Rahul Gopalarishnan

    Abstract:

    The present study was aimed to investigate the effect of Black Tea Extract on blood glucose, plasma insulin, Hemoglobin, carbohydrate metabolic enzymes and tricarboxylic enzymes in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male albino Wistar rats by intraperitoneal administration of STZ (40 mg/kg b wt). Black Tea Extract was administered to diabetic rats at a dose of 25, 50 and 100 mg/kg body weight for 30 days. The effects of Black Tea Extract on glucose, insulin and HbA1c levels were analyzed to confirm the effective dose. Administration of Black Tea Extract to diabetic rats was significantly decreased the level of glucose, glycated hemoglobin and increased the levels of insulin in a dose dependent manner. The Black Tea Extracts at a dose of 100 mg/kg b wt showed a highly significant effect compared to other two doses (25 and 50 mg/kg b wt). The effect produced by Black Tea Extract (100 mg/kg b wt) was comparable to that of glibenclamide (5 mg/kg b wt) a reference anti diabetic drug. Therefore, 100 mg/kg b wt was fixed as an effective dose and used for further analyses. Black Tea Extract was administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. Black Tea Extract administered to diabetic rats at a dose of 100 mg/kg b wt for 30 days reinstated the altered levels of the plasma glucose, insulin, hemoglobin, glycosylated hemoglobin, carbohydrate metabolizing enzymes and tricarboxylic cycle enzymes in diabetic rats. The effect produced by Black Tea Extract of all the biochemical parameters were comparable with glibenclamide-used as a reference drug.