The Experts below are selected from a list of 15138 Experts worldwide ranked by ideXlab platform
Jingkui Tian - One of the best experts on this subject based on the ideXlab platform.
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Two new guaiane-type sesquiterpenoids from the fruits of Daucus carota L.
Fitoterapia, 2010Co-Authors: Lin Zhang, Yu-lin Feng, Jingkui TianAbstract:Two new guaiane-type sesquiterpenoids containing an interesting epoxy unit, Daucuside (1) and Daucusol (2) were isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation and they were also evaluated for the cytotoxic effects against two human gastric cancer cell lines BGC-823 and AGS.
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Guaiane type sesquiterpenes and other constituents from Daucus carota L.
Biochemical Systematics and Ecology, 2010Co-Authors: Lin Zhang, Yu-lin Feng, Jingkui TianAbstract:Abstract In a chemosystematic investigation of the fruits of Daucus carota L. we have isolated eleven compounds including four guaiane type sesquiterpenes ( 1 – 4 ), one eudesmane type sesquiterpene ( 5 ) and six other constituents ( 6 – 11 ). Among them, the five compounds 1 – 5 all are new for Daucus carota L. and all have been reported in Torilis japonica . The results show that Daucus carota L. is chemically similar with Torilis japonica providing chemical evidence for both species used as the same traditional Chinese medicine “nanheshi”.
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Two new guaiane-type sesquiterpene glycosides from the fruits of Daucus carota L.
Chemical & pharmaceutical bulletin, 2010Co-Authors: Ling Zhang, Run-ze Chen, Xin Wang, Jingkui TianAbstract:Two new guaiane-type sesquiterpene glycosides, 11-O-acetyl-torilolone 8-O-β-D-glucopyranoside (1) and 1β-hydroxytorilolone 11-O-β-D-glucopyranoside (2), were isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation.
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one new guaiane type sesquiterpene glycoside from the fruits of Daucus carota l
Die Pharmazie, 2010Co-Authors: Lin Zhang, Yu-lin Feng, Jingkui TianAbstract:A new guaiane-type sesquiterpene glycoside, torilolone 8-O-beta-D-glucopyranoside (1), together with a known analogue compound, torilolone 11-O-beta-D-glucopyranoside (2), was isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation. The cytotoxic activities of two isolated compounds were evaluated against two human gastric cancer cell lines BGC-823 and AGS using MTT assay.
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A New Sesquiterpene from the Fruits of Daucus carota L.
Molecules (Basel Switzerland), 2009Co-Authors: Lin Zhang, Jingkui TianAbstract:Phytochemical investigation of the fruits of Daucus carota L. resulted in the isolation of a new sesquiterpene named as daucucarotol (1). Its structure was elucidated on the basis of 1D and 2D NMR experiments, coupled with MS studies. To our knowledge, compound 1 is the first example for a natural eudesmane sesquiterpene with a hydroxymethyl group located at a methine carbon rather than a usual quaternary carbon in the two fused six-membered ring systems.
Adari Bhaskar Rao - One of the best experts on this subject based on the ideXlab platform.
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Asymmetric Reduction of Heteroaryl Methyl Ketones Using Daucus carota
Green and Sustainable Chemistry, 2011Co-Authors: Ch Sree Lakshmi, Goka Roopa Reddy, Adari Bhaskar RaoAbstract:Asymmetric reduction of the heteroaryl prochiral ketones to corresponding chiral alcohols by Daucus carota was studied. The study highlights selective bioreduction of different substituted heteroaryl ketones (1a - 1j) to their respective chiral alcohols (2a - 2j) using plant dehydrogenase enzymes present in Daucus carota in good yields (60% - 95%) and enantioselectivity (76% - 99%) with S-form configuration. The results obtained confirm that the membrane bound dehydrogenase enzyme has broad substrate specificity and selectivity in catalyzing both six and five membered heteroaryl methyl ketones. The present methodology demonstrates promising and alternative green route in the synthesis secondary chiral alcohols of biologically importance in a simple, inexpensive and eco-friendly process.
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Asymmetric Reduction of Heteroaryl Methyl Ketones Using <i>Daucus carota</i>
Green and Sustainable Chemistry, 2011Co-Authors: Ch Sree Lakshmi, Goka Roopa Reddy, Adari Bhaskar RaoAbstract:Asymmetric reduction of the heteroaryl prochiral ketones to corresponding chiral alcohols by Daucus carota was studied. The study highlights selective bioreduction of different substituted heteroaryl ketones (1a - 1j) to their respective chiral alcohols (2a - 2j) using plant dehydrogenase enzymes present in Daucus carota in good yields (60% - 95%) and enantioselectivity (76% - 99%) with S-form configuration. The results obtained confirm that the membrane bound dehydrogenase enzyme has broad substrate specificity and selectivity in catalyzing both six and five membered heteroaryl methyl ketones. The present methodology demonstrates promising and alternative green route in the synthesis secondary chiral alcohols of biologically importance in a simple, inexpensive and eco-friendly process
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Daucus carota and baker s yeast mediated bio reduction of prochiral ketones
Tetrahedron-asymmetry, 2007Co-Authors: J S Yadav, Gondi Sudershan Reddy, Gowravaram Sabitha, A. D. Krishna, Attaluri R. Prasad, Katta V. Rao, Adari Bhaskar RaoAbstract:Stereoselective reduction of prochiral ketones to the corresponding alcohols using biocatalysts has attracted much attention, from the viewpoint of green chemistry. Asymmetric reduction of indanone, tetralone and hydroxyl trimonoterpene ketones to the corresponding enantiomerically pure (S)-alcohols, using Daucus carota plant homogenate and fermented baker's yeast cells, is described. The present study illustrates the broad substrate selectivity of the dehydrogenase enzymes present in the D. carota in the synthesis of a wide range of chiral secondary alcohols of biological importance.
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Daucus carota and baker’s yeast mediated bio-reduction of prochiral ketones
Tetrahedron: Asymmetry, 2007Co-Authors: Jhillu S. Yadav, Gondi Sudershan Reddy, Gowravaram Sabitha, A. D. Krishna, Attaluri R. Prasad, Hafeez-u-r-rahaman, Katta V. Rao, Adari Bhaskar RaoAbstract:Stereoselective reduction of prochiral ketones to the corresponding alcohols using biocatalysts has attracted much attention, from the viewpoint of green chemistry. Asymmetric reduction of indanone, tetralone and hydroxyl trimonoterpene ketones to the corresponding enantiomerically pure (S)-alcohols, using Daucus carota plant homogenate and fermented baker's yeast cells, is described. The present study illustrates the broad substrate selectivity of the dehydrogenase enzymes present in the D. carota in the synthesis of a wide range of chiral secondary alcohols of biological importance.
Jhillu S. Yadav - One of the best experts on this subject based on the ideXlab platform.
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Enantioselective reduction of 2-substituted tetrahydropyran-4-ones using Daucus carota plant cells
Tetrahedron Letters, 2008Co-Authors: Jhillu S. Yadav, B. V. Subba Reddy, Ch. Sreelakshmi, G. G. K. S. Narayana Kumar, A. Bhaskar RaoAbstract:Enzymatic reduction of 2-substituted tetrahydropyran-4-ones with Daucus carota, plant cells as biocatalyst occurred in water under extremely mild and environmentally benign conditions giving a 1:1 mixture of diastereoselectively (2R,4S)- and (2S,4S)-2-aryl- or 2-alkyl-tetrahydropyranols in high yields.
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Daucus carota and baker’s yeast mediated bio-reduction of prochiral ketones
Tetrahedron: Asymmetry, 2007Co-Authors: Jhillu S. Yadav, Gondi Sudershan Reddy, Gowravaram Sabitha, A. D. Krishna, Attaluri R. Prasad, Hafeez-u-r-rahaman, Katta V. Rao, Adari Bhaskar RaoAbstract:Stereoselective reduction of prochiral ketones to the corresponding alcohols using biocatalysts has attracted much attention, from the viewpoint of green chemistry. Asymmetric reduction of indanone, tetralone and hydroxyl trimonoterpene ketones to the corresponding enantiomerically pure (S)-alcohols, using Daucus carota plant homogenate and fermented baker's yeast cells, is described. The present study illustrates the broad substrate selectivity of the dehydrogenase enzymes present in the D. carota in the synthesis of a wide range of chiral secondary alcohols of biological importance.
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Efficient enantioselective reduction of ketones with Daucus carota root.
The Journal of organic chemistry, 2002Co-Authors: Jhillu S. Yadav, Samik Nanda, P. Thirupathi Reddy, A. Bhaskar RaoAbstract:A novel and efficient reduction of various prochiral ketones such as acetopehones, α-azido aryl ketones, β-ketoesters, and aliphatic acyclic and cyclic ketones to the corresponding optically acive secondary alcohols with moderate to excellent chemical yield was achieved by using Daucus carota, root plant cells under extremely mild and environmentally benign conditions in aqueous medium, has been described. Many of these optically active alcohols are the potential chiral building blocks for the synthesis of pharmaceutically important molecules and asymmetric chiral ligands. Hence, this biocatalytic approach is found to be the most suitable for the preparation of a wide range of chiral alcohols and gave inspiration for the development of a new biotechnological process.
A. Bhaskar Rao - One of the best experts on this subject based on the ideXlab platform.
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Enantioselective reduction of 2-substituted tetrahydropyran-4-ones using Daucus carota plant cells
Tetrahedron Letters, 2008Co-Authors: Jhillu S. Yadav, B. V. Subba Reddy, Ch. Sreelakshmi, G. G. K. S. Narayana Kumar, A. Bhaskar RaoAbstract:Enzymatic reduction of 2-substituted tetrahydropyran-4-ones with Daucus carota, plant cells as biocatalyst occurred in water under extremely mild and environmentally benign conditions giving a 1:1 mixture of diastereoselectively (2R,4S)- and (2S,4S)-2-aryl- or 2-alkyl-tetrahydropyranols in high yields.
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Efficient enantioselective reduction of ketones with Daucus carota root.
The Journal of organic chemistry, 2002Co-Authors: Jhillu S. Yadav, Samik Nanda, P. Thirupathi Reddy, A. Bhaskar RaoAbstract:A novel and efficient reduction of various prochiral ketones such as acetopehones, α-azido aryl ketones, β-ketoesters, and aliphatic acyclic and cyclic ketones to the corresponding optically acive secondary alcohols with moderate to excellent chemical yield was achieved by using Daucus carota, root plant cells under extremely mild and environmentally benign conditions in aqueous medium, has been described. Many of these optically active alcohols are the potential chiral building blocks for the synthesis of pharmaceutically important molecules and asymmetric chiral ligands. Hence, this biocatalytic approach is found to be the most suitable for the preparation of a wide range of chiral alcohols and gave inspiration for the development of a new biotechnological process.
Lin Zhang - One of the best experts on this subject based on the ideXlab platform.
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Two new guaiane-type sesquiterpenoids from the fruits of Daucus carota L.
Fitoterapia, 2010Co-Authors: Lin Zhang, Yu-lin Feng, Jingkui TianAbstract:Two new guaiane-type sesquiterpenoids containing an interesting epoxy unit, Daucuside (1) and Daucusol (2) were isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation and they were also evaluated for the cytotoxic effects against two human gastric cancer cell lines BGC-823 and AGS.
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Guaiane type sesquiterpenes and other constituents from Daucus carota L.
Biochemical Systematics and Ecology, 2010Co-Authors: Lin Zhang, Yu-lin Feng, Jingkui TianAbstract:Abstract In a chemosystematic investigation of the fruits of Daucus carota L. we have isolated eleven compounds including four guaiane type sesquiterpenes ( 1 – 4 ), one eudesmane type sesquiterpene ( 5 ) and six other constituents ( 6 – 11 ). Among them, the five compounds 1 – 5 all are new for Daucus carota L. and all have been reported in Torilis japonica . The results show that Daucus carota L. is chemically similar with Torilis japonica providing chemical evidence for both species used as the same traditional Chinese medicine “nanheshi”.
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one new guaiane type sesquiterpene glycoside from the fruits of Daucus carota l
Die Pharmazie, 2010Co-Authors: Lin Zhang, Yu-lin Feng, Jingkui TianAbstract:A new guaiane-type sesquiterpene glycoside, torilolone 8-O-beta-D-glucopyranoside (1), together with a known analogue compound, torilolone 11-O-beta-D-glucopyranoside (2), was isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation. The cytotoxic activities of two isolated compounds were evaluated against two human gastric cancer cell lines BGC-823 and AGS using MTT assay.
-
A New Sesquiterpene from the Fruits of Daucus carota L.
Molecules (Basel Switzerland), 2009Co-Authors: Lin Zhang, Jingkui TianAbstract:Phytochemical investigation of the fruits of Daucus carota L. resulted in the isolation of a new sesquiterpene named as daucucarotol (1). Its structure was elucidated on the basis of 1D and 2D NMR experiments, coupled with MS studies. To our knowledge, compound 1 is the first example for a natural eudesmane sesquiterpene with a hydroxymethyl group located at a methine carbon rather than a usual quaternary carbon in the two fused six-membered ring systems.
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Two New Guaiane Sesquiterpenes from the Fruits of Daucus carota
Helvetica Chimica Acta, 2009Co-Authors: Lin Zhang, Shilin Yang, Jingkui TianAbstract:Two new sesquiterpenes, 11-(acetyloxy)torilolone (1) and 1β-hydroxytorilolone (2) were obtained from the fruits of Daucus carota. Their structures were elucidated on the basis of various spectroscopic analyses and chemical evidence.
