The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Jae Sue Choi - One of the best experts on this subject based on the ideXlab platform.
-
Recent advances in pharmacological research on Ecklonia species: a review
Archives of Pharmacal Research, 2017Co-Authors: Prashamsa Koirala, Hyun Ah Jung, Jae Sue ChoiAbstract:The genus Ecklonia (Lessoniaceae, Phaeophyceae), commonly called kelp (brown algae), is abundant on the coasts of Japan and Korea. During the past few decades, Ecklonia species have received tremendous attention for their wide range of therapeutic properties and multiple health benefits, such as great nutritional value and being rich in vitamins, minerals, dietary fiber, proteins, and polysaccharides. Several novel functional ingredients with diversified biological activities have been isolated and possess antimicrobial, antiviral, hepatoprotective, cardioprotective, anti-inflammatory, neuroprotective, anticarcinogenic, immunomodulatory, hypolipidemic, anti-diabetic, and antioxidant therapeutic properties. The present review discusses the phytochemical, pharmacological, therapeutic, nutritional, and health benefits of different species of genus Ecklonia , as well as their use in the prevention of disease and maintenance of good health.
-
Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes.
The Journal of pharmacy and pharmacology, 2014Co-Authors: Hyun Ah Jung, Jae-i Kim, Se-young Choung, Jae Sue ChoiAbstract:Objectives As part of our efforts to isolate anti-hepatotoxic agents from marine natural products, we screened the ability of 14 edible varieties of Korean seaweed to protect against doxorubicin-induced hepatotoxicity in primary rat hepatocytes. Methods Among the crude extracts of two Chlorophyta (Codium fragile and Capsosiphon fulvescens), seven Phaeophyta (Undaria pinnatifida, Sargassum thunbergii, Pelvetia siliquosa, Ishige okamurae, Ecklonia cava, Ecklonia stolonifera and Eisenia bicyclis), five Rhodophyta (Chondrus ocellatus, Gelidium amansii, Gracilaria verrucosa, Symphycladia latiuscula and Porphyra tenera), and the extracts of Ecklonia stolonifera, Ecklonia cava, Eisenia bicyclis and Pelvetia siliquosa exhibited significant protective effects on doxorubicin-induced hepatotoxicity, with half maximal effective concentration (EC50) values of 2.0, 2.5, 3.0 and 15.0 μg/ml, respectively. Key findings Since Ecklonia stolonifera exhibits a significant protective potential and is frequently used as foodstuff, we isolated six phlorotannins, including phloroglucinol (1), dioxinodehydroeckol (2), eckol (3), phlorofucofuroeckol A (4), dieckol (5) and triphloroethol-A (6). Phlorotannins 2 ∼ 6 exhibited potential protective effects on doxorubicin-induced hepatotoxicity, with corresponding EC50 values of 3.4, 8.3, 4.4, 5.5 and 11.5 μg/ml, respectively. Conclusion The results clearly demonstrated that the anti-hepatotoxic effects of Ecklonia stolonifera and its isolated phlorotannins are useful for further exploration and development of therapeutic modalities for treatment of hepatotoxicity.
-
Quantitative determination of major phlorotannins in Ecklonia stolonifera.
Archives of pharmacal research, 2010Co-Authors: Hyun Ryul Goo, Jae Sue ChoiAbstract:Ecklonia stolonifera is a rich source of phlorotannins, which are responsible for the potent pharmacological effects associated with this seaweed. The purpose of this study was to develop a reversed-phase high-performance liquid chromatography method for the simultaneous determination of three major phlorotannins, eckol, dieckol, and phlorofucofuroeckol-A, in the extracts of Ecklonia stolonifera. The optimal chromatographic conditions were achieved on a Thermo Hypersil Gold C-18 column (250 × 4.6 mm i.d., 5 μm) using linear gradient elution of acetonitrile and water containing 0.1% formic acid at UV 254 nm. The separated phlorotannins were identified by liquid chromatography-mass spectrometry. The high-performance liquid chromatography method showed good linearity (r2 > 0.998), precision (1.4–9.5%), and accuracy (93.9–108.7%). The limits of detection ranged from 0.06 to 0.30 μg/mL and the lower limits of quantitation ranged from 0.2 to 1.0 μg/mL. Among phlorotannins, dieckol was the most abundant in both ethanol and ethyl acetate extracts of Ecklonia stolonifera.
-
Inhibitory phlorotannins from the edible brown algaEcklonia stolonifera on total reactive oxygen species (ROS) generation
Archives of Pharmacal Research, 2004Co-Authors: Hye Sook Kang, Hyun Ah Jung, Hae Young Chung, Ji Young Kim, Byeng Wha Son, Jae Sue ChoiAbstract:Reactive oxygen species (ROS) play an important role in the pathogenesis of many human degenerative diseases such as cancer, aging, arteriosclerosis, and rheumatism. Much attention has been focused on the development of safe and effective antioxidants. To discover sources of antioxidative activity in marine algae, extracts from 17 kinds of seaweed were screened for their inhibitory effect on total ROS generation in kidney homogenate using 2′,7′-dichlorofluorescein diacetate (DCFH-DA). ROS inhibition was seen in three species: Ulva pertusa, Symphyocladia latiuscula , and Ecklonia stolonifera . At a final concentration of 25 μg/mL, U. pertusa inhibited 85.65±20.28% of total ROS generation, S. latiscula caused 50.63±0.09% inhibitory, and the Ecklonia species was 44.30±7.33% inhibition. E. stolonifera Okamura (Laminariaceae), which belongs to the brown algae, has been further investigated because it is commonly used as a foodstuff in Korea. Five compounds, phloroglucinol ( 1 ), eckstolonol ( 2 ), eckol ( 3 ), phlorofucofuroeckol A ( 4 ), and dieckol ( 5 ), isolated from the ethyl acetate soluble fraction of the methanolic extract of E. stolonifera inhibited total ROS generation.
-
A new phlorotannin from the brown alga Ecklonia stolonifera.
Chemical & pharmaceutical bulletin, 2003Co-Authors: Hye Sook Kang, Hae Young Chung, Byeng Wha Son, Jee H. Jung, Jae Sue ChoiAbstract:A new phlorotannin, named eckstolonol (1), was isolated from the EtOAc soluble fraction of the methanolic extract of the brown alga, Ecklonia stolonifera OKAMURA, along with three known phlorotannins, eckol (2), phlorofucofuroeckol A (3), and dieckol (4). The structure of eckstolonol was identified as 5,8,13,14-tetraoxa-pentaphene-1,3,6,9,11-pentaol on the basis of spectroscopic evidence. The new compound was found to be a radical scavenger on the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical.
Sung Hyun Yang - One of the best experts on this subject based on the ideXlab platform.
-
description of croceitalea gen nov in the family flavobacteriaceae with two species croceitalea Eckloniae sp nov and croceitalea dokdonensis sp nov isolated from the rhizosphere of the marine alga Ecklonia kurome
International Journal of Systematic and Evolutionary Microbiology, 2008Co-Authors: Kae Kyoung Kwon, Sung Hyun Yang, Chan Hong ParkAbstract:Two novel bacterial strains, designated DOKDO 025T and DOKDO 023T, were isolated on Dokdo Island, Korea, from the rhizosphere of the brown alga Ecklonia kurome. The strains were subjected to a polyphasic taxonomy study and were found to be Gram-negative, aerobic, rod-shaped, non-motile and orange-coloured. The isolates shared 96.3 % 16S rRNA gene sequence similarity. They showed 93.8–95.6 % 16S rRNA gene sequence similarity with respect to members of the genus Muricauda in the family Flavobacteriaceae, but formed a distinct phyletic line. Moreover, the cellular appendages reported for all Muricauda species were absent from strains DOKDO 025T and DOKDO 023T. The predominant cellular fatty acids of strain DOKDO 025T were iso-C15 : 0, iso-C15 : 1 and one with an equivalent chain-length of 13.565 and those of strain DOKDO 023T were iso-C15 : 0, iso-C15 : 1 and iso-C17 : 0 3-OH. The DNA G+C content of strains DOKDO 025T and DOKDO 023T were 59.5 and 66.5 mol%, respectively, higher than any values found in recognized members of the family Flavobacteriaceae. The major respiratory quinone was MK-6. On the basis of evidence from the polyphasic study, strains DOKDO 025T and DOKDO 023T represent two novel species in a new genus, Croceitalea gen. nov., for which the names Croceitalea Eckloniae sp. nov. (the type species) and Croceitalea dokdonensis sp. nov. are proposed. The type strain of Croceitalea Eckloniae sp. nov. is DOKDO 025T (=KCCM 42309T =JCM 13827T) and that of Croceitalea dokdonensis sp. nov. is DOKDO 023T (=KCCM 42308T =JCM 13826T).
-
flagellimonas Eckloniae gen nov sp nov a mesophilic marine bacterium of the family flavobacteriaceae isolated from the rhizosphere of Ecklonia kurome
International Journal of Systematic and Evolutionary Microbiology, 2007Co-Authors: Kae Kyoung Kwon, Sung Hyun YangAbstract:A marine bacterium, DOKDO 007T, was isolated from the rhizosphere of the marine alga Ecklonia kurome collected from Dokdo Island, Korea, in October 2004. The strain produced orange-coloured colonies on marine agar 2216. 16S rRNA gene sequence analysis indicated that the novel isolate belonged to the family Flavobacteriaceae and showed relatively high sequence similarities with members of the genus Muricauda (92.0–94.0 %). Phylogenetic analysis based on nearly complete 16S rRNA gene sequences revealed that the novel isolate shared a lineage with members of the genera Muricauda and Costertonia. Cells were aerobic, Gram-negative rods producing non-diffusible carotenoid pigments. In contrast to all other members of the family Flavobacteriaceae, cells of DOKDO 007T were motile by means of a polar flagellum. Optimal growth occurred in the presence of 3.5–4 % (w/v) sea salts (corresponding to 2.7–3.1 % NaCl), at pH 8 and at temperatures of 26–29 °C. The novel strain required Ca2+ ions in addition to NaCl for growth. The dominant fatty acids were iso-15 : 0, iso-15 : 1ω10c and 10-methyl-16 : 0. The major respiratory quinone was MK-6. The DNA G+C content was 56.3 mol%, an unusually high value for members of the family Flavobacteriaceae. On the basis of these polyphasic taxonomic data, strain DOKDO 007T should be classified as representing a new genus and novel species in the family Flavobacteriaceae, for which the name Flagellimonas Eckloniae gen. nov., sp. nov. is proposed. The type strain is DOKDO 007T (=KCCM 42307T=JCM 13831T).
-
Flagellimonas Eckloniae gen. nov., sp. nov., a mesophilic marine bacterium of the family Flavobacteriaceae, isolated from the rhizosphere of Ecklonia kurome.
International journal of systematic and evolutionary microbiology, 2007Co-Authors: Seung Seob Bae, Kae Kyoung Kwon, Sung Hyun Yang, Hee-soon Lee, Sang-jin Kim, Jung-hyun LeeAbstract:A marine bacterium, DOKDO 007(T), was isolated from the rhizosphere of the marine alga Ecklonia kurome collected from Dokdo Island, Korea, in October 2004. The strain produced orange-coloured colonies on marine agar 2216. 16S rRNA gene sequence analysis indicated that the novel isolate belonged to the family Flavobacteriaceae and showed relatively high sequence similarities with members of the genus Muricauda (92.0-94.0 %). Phylogenetic analysis based on nearly complete 16S rRNA gene sequences revealed that the novel isolate shared a lineage with members of the genera Muricauda and Costertonia. Cells were aerobic, Gram-negative rods producing non-diffusible carotenoid pigments. In contrast to all other members of the family Flavobacteriaceae, cells of DOKDO 007(T) were motile by means of a polar flagellum. Optimal growth occurred in the presence of 3.5-4 % (w/v) sea salts (corresponding to 2.7-3.1 % NaCl), at pH 8 and at temperatures of 26-29 degrees C. The novel strain required Ca(2+) ions in addition to NaCl for growth. The dominant fatty acids were iso-15 : 0, iso-15 : 1omega10c and 10-methyl-16 : 0. The major respiratory quinone was MK-6. The DNA G+C content was 56.3 mol%, an unusually high value for members of the family Flavobacteriaceae. On the basis of these polyphasic taxonomic data, strain DOKDO 007(T) should be classified as representing a new genus and novel species in the family Flavobacteriaceae, for which the name Flagellimonas Eckloniae gen. nov., sp. nov. is proposed. The type strain is DOKDO 007(T) (=KCCM 42307(T)=JCM 13831(T)).
Kae Kyoung Kwon - One of the best experts on this subject based on the ideXlab platform.
-
description of croceitalea gen nov in the family flavobacteriaceae with two species croceitalea Eckloniae sp nov and croceitalea dokdonensis sp nov isolated from the rhizosphere of the marine alga Ecklonia kurome
International Journal of Systematic and Evolutionary Microbiology, 2008Co-Authors: Kae Kyoung Kwon, Sung Hyun Yang, Chan Hong ParkAbstract:Two novel bacterial strains, designated DOKDO 025T and DOKDO 023T, were isolated on Dokdo Island, Korea, from the rhizosphere of the brown alga Ecklonia kurome. The strains were subjected to a polyphasic taxonomy study and were found to be Gram-negative, aerobic, rod-shaped, non-motile and orange-coloured. The isolates shared 96.3 % 16S rRNA gene sequence similarity. They showed 93.8–95.6 % 16S rRNA gene sequence similarity with respect to members of the genus Muricauda in the family Flavobacteriaceae, but formed a distinct phyletic line. Moreover, the cellular appendages reported for all Muricauda species were absent from strains DOKDO 025T and DOKDO 023T. The predominant cellular fatty acids of strain DOKDO 025T were iso-C15 : 0, iso-C15 : 1 and one with an equivalent chain-length of 13.565 and those of strain DOKDO 023T were iso-C15 : 0, iso-C15 : 1 and iso-C17 : 0 3-OH. The DNA G+C content of strains DOKDO 025T and DOKDO 023T were 59.5 and 66.5 mol%, respectively, higher than any values found in recognized members of the family Flavobacteriaceae. The major respiratory quinone was MK-6. On the basis of evidence from the polyphasic study, strains DOKDO 025T and DOKDO 023T represent two novel species in a new genus, Croceitalea gen. nov., for which the names Croceitalea Eckloniae sp. nov. (the type species) and Croceitalea dokdonensis sp. nov. are proposed. The type strain of Croceitalea Eckloniae sp. nov. is DOKDO 025T (=KCCM 42309T =JCM 13827T) and that of Croceitalea dokdonensis sp. nov. is DOKDO 023T (=KCCM 42308T =JCM 13826T).
-
flagellimonas Eckloniae gen nov sp nov a mesophilic marine bacterium of the family flavobacteriaceae isolated from the rhizosphere of Ecklonia kurome
International Journal of Systematic and Evolutionary Microbiology, 2007Co-Authors: Kae Kyoung Kwon, Sung Hyun YangAbstract:A marine bacterium, DOKDO 007T, was isolated from the rhizosphere of the marine alga Ecklonia kurome collected from Dokdo Island, Korea, in October 2004. The strain produced orange-coloured colonies on marine agar 2216. 16S rRNA gene sequence analysis indicated that the novel isolate belonged to the family Flavobacteriaceae and showed relatively high sequence similarities with members of the genus Muricauda (92.0–94.0 %). Phylogenetic analysis based on nearly complete 16S rRNA gene sequences revealed that the novel isolate shared a lineage with members of the genera Muricauda and Costertonia. Cells were aerobic, Gram-negative rods producing non-diffusible carotenoid pigments. In contrast to all other members of the family Flavobacteriaceae, cells of DOKDO 007T were motile by means of a polar flagellum. Optimal growth occurred in the presence of 3.5–4 % (w/v) sea salts (corresponding to 2.7–3.1 % NaCl), at pH 8 and at temperatures of 26–29 °C. The novel strain required Ca2+ ions in addition to NaCl for growth. The dominant fatty acids were iso-15 : 0, iso-15 : 1ω10c and 10-methyl-16 : 0. The major respiratory quinone was MK-6. The DNA G+C content was 56.3 mol%, an unusually high value for members of the family Flavobacteriaceae. On the basis of these polyphasic taxonomic data, strain DOKDO 007T should be classified as representing a new genus and novel species in the family Flavobacteriaceae, for which the name Flagellimonas Eckloniae gen. nov., sp. nov. is proposed. The type strain is DOKDO 007T (=KCCM 42307T=JCM 13831T).
-
Flagellimonas Eckloniae gen. nov., sp. nov., a mesophilic marine bacterium of the family Flavobacteriaceae, isolated from the rhizosphere of Ecklonia kurome.
International journal of systematic and evolutionary microbiology, 2007Co-Authors: Seung Seob Bae, Kae Kyoung Kwon, Sung Hyun Yang, Hee-soon Lee, Sang-jin Kim, Jung-hyun LeeAbstract:A marine bacterium, DOKDO 007(T), was isolated from the rhizosphere of the marine alga Ecklonia kurome collected from Dokdo Island, Korea, in October 2004. The strain produced orange-coloured colonies on marine agar 2216. 16S rRNA gene sequence analysis indicated that the novel isolate belonged to the family Flavobacteriaceae and showed relatively high sequence similarities with members of the genus Muricauda (92.0-94.0 %). Phylogenetic analysis based on nearly complete 16S rRNA gene sequences revealed that the novel isolate shared a lineage with members of the genera Muricauda and Costertonia. Cells were aerobic, Gram-negative rods producing non-diffusible carotenoid pigments. In contrast to all other members of the family Flavobacteriaceae, cells of DOKDO 007(T) were motile by means of a polar flagellum. Optimal growth occurred in the presence of 3.5-4 % (w/v) sea salts (corresponding to 2.7-3.1 % NaCl), at pH 8 and at temperatures of 26-29 degrees C. The novel strain required Ca(2+) ions in addition to NaCl for growth. The dominant fatty acids were iso-15 : 0, iso-15 : 1omega10c and 10-methyl-16 : 0. The major respiratory quinone was MK-6. The DNA G+C content was 56.3 mol%, an unusually high value for members of the family Flavobacteriaceae. On the basis of these polyphasic taxonomic data, strain DOKDO 007(T) should be classified as representing a new genus and novel species in the family Flavobacteriaceae, for which the name Flagellimonas Eckloniae gen. nov., sp. nov. is proposed. The type strain is DOKDO 007(T) (=KCCM 42307(T)=JCM 13831(T)).
Jong Moon Park - One of the best experts on this subject based on the ideXlab platform.
-
Column study on Cr(VI)-reduction using the brown seaweed Ecklonia biomass.
Journal of hazardous materials, 2006Co-Authors: Donghee Park, Yeoung-sang Yun, Dae Sung Lee, Seong-rin Lim, Jong Moon ParkAbstract:The potential use of the brown seaweed, Ecklonia, biomass as a bioreductant for reducing Cr(VI) was examined in a continuous packed-bed column. The effects of the operating parameters, such as influent Cr(VI) concentration, influent pH, biomass concentration, flow rate and temperature, on the Cr(VI) reduction were investigated. Increases in the influent Cr(VI) concentration and flow rate or a decrease in the biomass concentration inside the column led to a higher breakthrough of the Cr(VI) ions in the effluent. Particularly, the influent pH and temperature most significantly affected on the breakthrough curve of Cr(VI); a decrease in the influent pH or an increase in the temperature enhanced the Cr(VI) reduction in the column. For process application, a non-parametric model using neural network was used to predict the breakthrough curves of the column. Finally, the potential of the column packed with Ecklonia biomass for Cr(VI) detoxification was demonstrated.
-
Reduction of hexavalent chromium with the brown seaweed Ecklonia biomass.
Environmental science & technology, 2004Co-Authors: Donghee Park, Yeoung-sang Yun, Jong Moon ParkAbstract:A new type of biomass, protonated brown seaweed Ecklonia sp., was used for the removal of Cr(VI). When synthetic wastewater containing Cr(VI) was placed in contact with the biomass, the Cr(VI) was completely reduced to Cr(III). The converted Cr(III) appeared in the solution phase or was partly bound to the biomass. The Cr(VI) removal efficiency was always 100% in the pH range of this study (pH 1 to approximately 5). Furthermore, the Cr(VI) reduction was independent of the Cr(III) concentration, the reaction product, suggesting that the reaction was an irreversible process under our conditions. Proton ions were consumed in the ratio of 1.15 +/- 0.02 mol of protons/mol of Cr(VI), and the rate of Cr(VI) reduction increased with decreasing the pH. An optimum pH existed for the removal efficiency of total chromium (Cr(VI) plus Cr(III)), but this increased with contact time, eventually reaching approximately pH 4 when the reaction was complete. The electrons required for the Cr(VI) reduction also caused the oxidation of the organic compounds in the biomass. One gram of the biomass could reduce 4.49 +/- 0.12 mmol of Cr(VI). From a practical viewpoint, the abundant and inexpensive Ecklonia biomass could be used for the conversion of toxic Cr(VI) into less toxic or nontoxic Cr(III).
Johannes Van Staden - One of the best experts on this subject based on the ideXlab platform.
-
Bioactive molecules derived from smoke and seaweed Ecklonia maxima showing phytohormone-like activity in Spinacia oleracea L.
New biotechnology, 2018Co-Authors: Manoj G. Kulkarni, Kannan R.r. Rengasamy, S.c. Pendota, Jiří Grúz, Lenka Plačková, Ondřej Novák, Karel Doležal, Johannes Van StadenAbstract:Bioactive compounds such as karrikinolide (KAR1 from smoke) and eckol (from the seaweed Ecklonia maxima) show promising effects on several important crop plants. These plant growth-stimulating organic biomolecules, along with crude extracts (smoke-water and Kelpak® product prepared from Ecklonia maxima), were tested on spinach plants. Eckol sprayed at 10-6 M significantly increased all the growth and biochemical parameters examined compared to control spinach plants. All tested plant growth biostimulants significantly increased total chlorophyll, carotenoids and protein content of spinach leaves. The cytokinin profile of spinach plants was also determined. Cis-zeatin, dihydrozeatin and isopentenyladenine types of cytokinins were promoted by both smoke- and seaweed-based biostimulants. In comparison to the control plants, the level of free sinapic acid was greater in all spinach plants treated with these biostimulants. The application of these biostimulants can help spinach crop by improving growth, yield and nutritional quality; moreover, they are organic and cost-effective.
