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Liang Zhang - One of the best experts on this subject based on the ideXlab platform.
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a reliable method for intracranial Electrode Implantation and chronic electrical stimulation in the mouse brain
BMC Neuroscience, 2013Co-Authors: Melanie Jeffrey, Min Lang, Jonathan Gane, Mcintyre W Burnham, Liang ZhangAbstract:Background Electrical stimulation of brain structures has been widely used in rodent models for kindling or modeling deep brain stimulation used clinically. This requires surgical Implantation of intracranial Electrodes and subsequent chronic stimulation in individual animals for several weeks. Anchoring screws and dental acrylic have long been used to secure implanted intracranial Electrodes in rats. However, such an approach is limited when carried out in mouse models as the thin mouse skull may not be strong enough to accommodate the anchoring screws. We describe here a screw-free, glue-based method for implanting bipolar stimulating Electrodes in the mouse brain and validate this method in a mouse model of hippocampal electrical kindling.
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A reliable method for intracranial Electrode Implantation and chronic electrical stimulation in the mouse brain
BMC Neuroscience, 2013Co-Authors: Melanie Jeffrey, Min Lang, Jonathan Gane, W Mcintyre Burnham, Liang ZhangAbstract:Background Electrical stimulation of brain structures has been widely used in rodent models for kindling or modeling deep brain stimulation used clinically. This requires surgical Implantation of intracranial Electrodes and subsequent chronic stimulation in individual animals for several weeks. Anchoring screws and dental acrylic have long been used to secure implanted intracranial Electrodes in rats. However, such an approach is limited when carried out in mouse models as the thin mouse skull may not be strong enough to accommodate the anchoring screws. We describe here a screw-free, glue-based method for implanting bipolar stimulating Electrodes in the mouse brain and validate this method in a mouse model of hippocampal electrical kindling. Methods Male C57 black mice (initial ages of 6–8 months) were used in the present experiments. Bipolar Electrodes were implanted bilaterally in the hippocampal CA3 area for electrical stimulation and electroencephalographic recordings. The Electrodes were secured onto the skull via glue and dental acrylic but without anchoring screws. A daily stimulation protocol was used to induce electrographic discharges and motor seizures. The locations of implanted Electrodes were verified by hippocampal electrographic activities and later histological assessments. Results Using the glue-based Implantation method, we implanted bilateral bipolar Electrodes in 25 mice. Electrographic discharges and motor seizures were successfully induced via hippocampal electrical kindling. Importantly, no animal encountered infection in the implanted area or a loss of implanted Electrodes after 4–6 months of repetitive stimulation/recording. Conclusion We suggest that the glue-based, screw-free method is reliable for chronic brain stimulation and high-quality electroencephalographic recordings in mice. The technical aspects described this study may help future studies in mouse models.
Jorge Gonzalezmartinez - One of the best experts on this subject based on the ideXlab platform.
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indications technique and safety profile of insular stereoelectroencephalography Electrode Implantation in medically intractable epilepsy
Journal of Neurosurgery, 2017Co-Authors: Soha Alomar, Jeffrey P Mullin, Saksith Smithason, Jorge GonzalezmartinezAbstract:OBJECTIVE Insular epilepsy is relatively rare; however, exploring the insular cortex when preoperative workup raises the suspicion of insular epilepsy is of paramount importance for accurate localization of the epileptogenic zone and achievement of seizure freedom. The authors review their clinical experience with stereoelectroencephalography (SEEG) Electrode Implantation in patients with medically intractable epilepsy and suspected insular involvement. METHODS A total of 198 consecutive cases in which patients underwent SEEG Implantation with a total of 1556 Electrodes between June 2009 and April 2013 were reviewed. The authors identified patients with suspected insular involvement based on seizure semiology, scalp EEG data, and preoperative imaging (MRI, PET, and SPECT or magnetoencephalography [MEG]). Patients with at least 1 insular Electrode based on the postoperative 3D reconstruction of CT fused with the preoperative MRI were included. RESULTS One hundred thirty-five patients with suspected insular epilepsy underwent insular Implantation of a total of 303 Electrodes (1-6 insular Electrodes per patient) with a total of 562 contacts. Two hundred sixty-eight Electrodes (88.5%) were implanted orthogonally through the frontoparietal or temporal operculum (420 contacts). Thirty-five Electrodes (11.5%) were implanted by means of an oblique trajectory either through a frontal or a parietal entry point (142 contacts). Nineteen patients (14.07%) had insular Electrodes placed bilaterally. Twenty-three patients (17.04% of the insular Implantation group and 11.6% of the whole SEEG cohort) were confirmed by SEEG to have ictal onset zones in the insula. None of the patients experienced any intracerebral hemorrhage related to the insular Electrodes. After insular resection, 5 patients (33.3%) had Engel Class I outcomes, 6 patients (40%) had Engel Class II, 3 patients (20%) had Engel Class III, and 1 patient (6.66%) had Engel Class IV. CONCLUSIONS Insula exploration with stereotactically placed depth Electrodes is a safe technique. Orthogonal Electrodes are implanted when the hypothesis suggests opercular involvement; however, oblique Electrodes allow a higher insular sampling rate.
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stereotactic placement of depth Electrodes in medically intractable epilepsy
Journal of Neurosurgery, 2014Co-Authors: Jorge Gonzalezmartinez, Juan Bulacio, Jeffrey P Mullin, Sumeet Vadera, Gwyneth Hughes, Stephen E Jones, Rei Enatsu, Imad NajmAbstract:Object Despite its long-reported successful record, with almost 60 years of clinical use, the technical complexity regarding the placement of stereoelectroencephalography (SEEG) depth Electrodes may have contributed to the limited widespread application of the technique in centers outside Europe. The authors report on a simplified and novel SEEG surgical technique in the extraoperative mapping of refractory focal epilepsy. Methods The proposed technique was applied in patients with medically refractory focal epilepsy. Data regarding general demographic information, method of Electrode Implantation, time of Implantation, number of implanted Electrodes, seizure outcome after SEEG-guided resections, and complications were prospectively collected. Results From March 2009 to April 2012, 122 patients underwent SEEG depth Electrode Implantation at the Cleveland Clinic Epilepsy Center in which the authors' technique was used. There were 65 male and 57 female patients whose mean age was 33 years (range 5–68 years)...
Jianguo Zhang - One of the best experts on this subject based on the ideXlab platform.
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anterior nucleus of thalamus stimulation inhibited abnormal mossy fiber sprouting in kainic acid induced epileptic rats
Brain Research, 2018Co-Authors: Guanyu Zhu, Dawei Meng, Yingchuan Chen, Yuye Liu, Defeng Liu, Lin Shi, Yin Jiang, Xin Zhang, Jianguo ZhangAbstract:Abstract Background Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) has demonstrated antiepileptic efficacy, especially for mesial temporal lobe epilepsy (MTLE). Mossy fiber sprouting (MFS) is involved in the pathogenesis of MTLE, and Sema-3A and GAP-43 are pivotal regulators of MFS. This study investigated the effects of ANT-DBS on MFS and expression levels of Sema-3A and GAP-43 as a possible mechanism for seizure suppression. Methods Adult male Sprague-Dawley rats were randomly divided into four groups: (1) control (saline injection), (2) KA (kainic acid injection), (3) KA + Sham-DBS (Electrode Implantation without stimulation), and (4) KA + DBS (Electrode Implantation with stimulation). Video electroencephalography (EEG) was used to ensure model establishment and monitor seizure frequency, latency, and severity (Racine stage). Chronic ANT stimulation was conducted for 35 days in the KA + DBS group, and MFS compared to the other groups by quantitative Timm staining. Sema-3A and GAP-43 expression levels in the hippocampal formation were evaluated in all groups with western blot. Results The latency period was significantly prolonged and spontaneous seizure frequency reduced in the KA + DBS group compared to KA and KA + Sham-DBS groups. Staining scores for MFS in CA3 and dentate gyrus (DG) were significantly lower in the KA + DBS group. The KA + DBS group also exhibited decreased GAP-43 expression and increased Sema-3A expression compared to KA and KA + Sham-DBS groups. Conclusion These results suggest that ANT-DBS extends the latent period following epileptogenic stimulation by impeding MFS through modulation of GAP-43 and Sema-3A expression.
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High-Frequency Stimulation of Nucleus Accumbens Changes in Dopaminergic Reward Circuit
2016Co-Authors: Na Yan, Jianguo Zhang, Ning Chen, Honghua Zhu, Moira Sim, Wei WangAbstract:Deep brain stimulation (DBS) of the nucleus accumbens (NAc) is a potential remedial therapy for drug craving and relapse, but the mechanism is poorly understood. We investigated changes in neurotransmitter levels during high frequency stimulation (HFS) of the unilateral NAc on morphine-induced rats. Sixty adult Wistar rats were randomized into five groups: the control group (administration of saline), the morphine-only group (systematic administration of morphine without Electrode Implantation), the morphine-sham-stimulation group (systematic administration of morphine with Electrode Implantation but not given stimulation), the morphine-stimulation group (systematic administration of morphine with Electrode Implantation and stimulation) and the saline-stimulation group (administration of saline with Electrode Implantation and stimulation). The stimulation Electrode was stereotaxically implanted into the core of unilateral NAc and microdialysis probes were unilaterally lowered into the ipsilateral ventral tegmental area (VTA), NAc, and ventral pallidum (VP). Samples from microdialysis probes in the ipsilateral VTA, NAc, and VP were analyzed for glutamate (Glu) and c-aminobutyric acid (GABA) by high-performance liquid chromatography (HPLC). The levels of Glu were increased in the ipsilateral NAc and VP of morphine-only group versus control group, whereas Glu levels were not significantly changed in the ipsilateral VTA. Furthermore, the levels of GABA decreased significantly in the ipsilateral NAc, VP, and VTA of morphine-only group when compared with control group. The profiles of increased Glu and reduced GABA in morphine-induced rat
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review on factors affecting targeting accuracy of deep brain stimulation Electrode Implantation between 2001 and 2015
Stereotactic and Functional Neurosurgery, 2016Co-Authors: Jianguo ZhangAbstract:Background: Accurate Implantation of a depth Electrode into the brain is of the greatest importance in deep brain stimulation (DBS), and various stereotactic syst
Melanie Jeffrey - One of the best experts on this subject based on the ideXlab platform.
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a reliable method for intracranial Electrode Implantation and chronic electrical stimulation in the mouse brain
BMC Neuroscience, 2013Co-Authors: Melanie Jeffrey, Min Lang, Jonathan Gane, Mcintyre W Burnham, Liang ZhangAbstract:Background Electrical stimulation of brain structures has been widely used in rodent models for kindling or modeling deep brain stimulation used clinically. This requires surgical Implantation of intracranial Electrodes and subsequent chronic stimulation in individual animals for several weeks. Anchoring screws and dental acrylic have long been used to secure implanted intracranial Electrodes in rats. However, such an approach is limited when carried out in mouse models as the thin mouse skull may not be strong enough to accommodate the anchoring screws. We describe here a screw-free, glue-based method for implanting bipolar stimulating Electrodes in the mouse brain and validate this method in a mouse model of hippocampal electrical kindling.
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A reliable method for intracranial Electrode Implantation and chronic electrical stimulation in the mouse brain
BMC Neuroscience, 2013Co-Authors: Melanie Jeffrey, Min Lang, Jonathan Gane, W Mcintyre Burnham, Liang ZhangAbstract:Background Electrical stimulation of brain structures has been widely used in rodent models for kindling or modeling deep brain stimulation used clinically. This requires surgical Implantation of intracranial Electrodes and subsequent chronic stimulation in individual animals for several weeks. Anchoring screws and dental acrylic have long been used to secure implanted intracranial Electrodes in rats. However, such an approach is limited when carried out in mouse models as the thin mouse skull may not be strong enough to accommodate the anchoring screws. We describe here a screw-free, glue-based method for implanting bipolar stimulating Electrodes in the mouse brain and validate this method in a mouse model of hippocampal electrical kindling. Methods Male C57 black mice (initial ages of 6–8 months) were used in the present experiments. Bipolar Electrodes were implanted bilaterally in the hippocampal CA3 area for electrical stimulation and electroencephalographic recordings. The Electrodes were secured onto the skull via glue and dental acrylic but without anchoring screws. A daily stimulation protocol was used to induce electrographic discharges and motor seizures. The locations of implanted Electrodes were verified by hippocampal electrographic activities and later histological assessments. Results Using the glue-based Implantation method, we implanted bilateral bipolar Electrodes in 25 mice. Electrographic discharges and motor seizures were successfully induced via hippocampal electrical kindling. Importantly, no animal encountered infection in the implanted area or a loss of implanted Electrodes after 4–6 months of repetitive stimulation/recording. Conclusion We suggest that the glue-based, screw-free method is reliable for chronic brain stimulation and high-quality electroencephalographic recordings in mice. The technical aspects described this study may help future studies in mouse models.
André Olivier - One of the best experts on this subject based on the ideXlab platform.
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Improving recorded volume in mesial temporal lobe by optimizing stereotactic intracranial Electrode Implantation planning.
International journal of computer assisted radiology and surgery, 2015Co-Authors: Rina Zelmann, André Olivier, Silvain Bériault, M. M. Marinho, Kelvin Mok, Jeffery A. Hall, Nicolas Guizard, Claire Haegelen, G. B. Pike, D. L. CollinsAbstract:Purpose Intracranial Electrodes are sometimes implanted in patients with refractory epilepsy to identify epileptic foci and propagation. Maximal recording of EEG activity from regions suspected of seizure generation is paramount. However, the location of individual contacts cannot be considered with current manual planning approaches. We propose and validate a procedure for optimizing intracranial Electrode Implantation planning that maximizes the recording volume, while constraining trajectories to safe paths.
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Morbidity in epilepsy surgery: an experience based on 2449 epilepsy surgery procedures from a single institution.
Journal of neurosurgery, 2009Co-Authors: Taner Tanriverdi, Abdulrazag Ajlan, Nicole Poulin, André OlivierAbstract:Object In this paper the authors aimed to provide information related to major and minor surgical and neurological complications encountered following stereoelectroencephalography and epilepsy surgery. Methods The authors performed a retrospective review of 491 and 1905 patients who underwent intracranial Electrode Implantation and epilepsy surgery, respectively, between 1976 and 2006 at the Montreal Neurological Institute. All intracranial Electrode Implantations and surgical procedures were performed by 1 surgeon (A.O.). Results A total of 6415 Electrode Implantations and 2449 surgical procedures were done. There were no deaths related to either procedure. There were no major complications after intracranial Electrode Implantation, and the risks of infection and intracranial hematoma were found to be 1.8 and 0.8%, respectively. The number of Electrodes per lobe (p = 0.05) and number of lobes covered (p = 0.04) were significant risk factors for hematoma and infection. Regarding epilepsy surgery, there we...
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Efficacy of and morbidity associated with stereoelectroencephalography using computerized tomography--or magnetic resonance imaging-guided Electrode Implantation.
Journal of neurosurgery, 2006Co-Authors: Antonio Nogueira De Almeida, André Olivier, Felipe Quesney, François Dubeau, Ghislaine Savard, Frederick AndermannAbstract:Object. The purpose of this paper was to define the general efficacy of and morbidity associated with stereoelectroencephalography using modern methods of imaging and to particularize the risks related to specific lobes of the brain. Methods. All patients admitted to the Montreal Neurological Institute who had undergone either computerized tomography‐ or magnetic resonance imaging‐guided Electrode Implantation by one surgeon (A.O.) were reviewed. The procedure was considered efficient if the obtained information was sufficient to make a decision either in support of or against surgery. Two hundred seventeen patients underwent 224 Implantations with 3022 Electrodes. Complications related to each lobe were as follows: temporal lobe, two abscesses (0.54%); frontal lobe, one abscess and three hematomas (1.4%); and occipital lobe, one hypointense lesion found 1 week after Electrode explantation (2.6%). Significant risk factors associated with hematomas were Implantation in the frontal lobe (p , 0.05) and the use of four or more implanted Electrodes (p , 0.025). General complications included the following: 26 patients, psychiatric symptoms during monitoring; one patient, meningitis; four patients, scalp cellulitis; and two patients, hemiparesis during angiography in the early 1980s. One of these latter patients maintained a mild hemiparesis and represents the only case of permanent neurological sequela in the entire series. Data obtained during recordings supported an indication for surgery in 178 patients (79.5%), excluded a surgical option in 37 patients (16.5%), and were unsatisfactory in nine patients (4%). Thus, the overall efficacy as defined previously was 96%. Conclusions. Stereoelectroencephalography is an efficient procedure with low associated morbidity. Bilateral exploration of the temporal lobes has a morbidity rate of approximately 1%. A higher risk of hematomas occurs with the Implantation of four or more Electrodes in the frontal lobes.