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Shao-ping Li - One of the best experts on this subject based on the ideXlab platform.

  • an evaluation system for characterization of polysaccharides from the fruiting body of hericium Erinaceus and identification of its commercial product
    Carbohydrate Polymers, 2015
    Co-Authors: Dingtao Wu, Qianxia Zhong, Yaojun Ju, Anton Bzhelyansky, Shao-ping Li, Wenzhi Li, Jun Chen, Jing Zhao
    Abstract:

    An evaluation system including colorimetric assay with iodine and potassium iodide, HPSEC–MALLS–RID analysis, GC–MS analysis, and saccharide mapping based on PACE analysis was proposed for the identification and discrimination of commercial product of Hericium Erinaceus based on the chemical characters of polysaccharides in H. Erinaceus fruiting body collected from different regions of China. The results showed that the molecular weights, the compositional monosaccharides and the glycosidic linkages of polysaccharides in H. Erinaceus collected from different regions of China were similar, respectively. However, polysaccharides in the widely consumed product of H. Erinaceus in China were significantly different from those of H. Erinaceus fruiting body. The implications from these results were found to be beneficial to improve the quality control of polysaccharides from the H. Erinaceus fruiting body, and suggest that the proposed evaluation system could be used as a routine approach for the quality control of polysaccharides in other edible and medicinal mushrooms.

Youngji Shiao - One of the best experts on this subject based on the ideXlab platform.

  • erinacine a enriched hericium Erinaceus mycelium ameliorates alzheimer s disease related pathologies in appswe ps1de9 transgenic mice
    Journal of Biomedical Science, 2016
    Co-Authors: Tzeng Tsaiteng, Chen Chinchu, Lee Liya, Chen Wanping, Lu Chungkuang, Shen Chienchang, Huang F Chiying, Chen Chienchih, Youngji Shiao
    Abstract:

    Background The fruiting body of Hericium Erinaceus has been demonstrated to possess anti-dementia activity in mouse model of Alzheimer’s disease and people with mild cognitive impairment. However, the therapeutic potential of Hericium Erinaceus mycelia on Alzheimer’s disease remains unclear. In this study, the effects of erinacine A-enriched Hericium Erinaceus mycelia (HE-My) on the pathological changes in APPswe/PS1dE9 transgenic mouse model of Alzheimer’s disease are studied.

  • erinacine s a rare sesterterpene from the mycelia of hericium Erinaceus
    Journal of Natural Products, 2016
    Co-Authors: Chien-chih Chen, Chin-chu Chen, Wan-ping Chen, Liya Lee, Youngji Shiao, Tsai-teng Tzeng, Chien-chang Shen
    Abstract:

    A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium Erinaceus. Their structures were elucidated by spectroscopic and X-ray analysis. A 30-day oral course of erinacines A and S attenuated Aβ plaque burden in the brains of 5-month-old female APP/PS1 transgenic mice. Moreover, erinacines A and S significantly increased the level of insulin-degrading enzyme in cerebral cortex.

  • Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium Erinaceus
    2016
    Co-Authors: Chien-chih Chen, Chin-chu Chen, Wan-ping Chen, Liya Lee, Youngji Shiao, Tsai-teng Tzeng, Chien-chang Shen
    Abstract:

    A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium Erinaceus. Their structures were elucidated by spectroscopic and X-ray analysis. A 30-day oral course of erinacines A and S attenuated Aβ plaque burden in the brains of 5-month-old female APP/PS1 transgenic mice. Moreover, erinacines A and S significantly increased the level of insulin-degrading enzyme in cerebral cortex

Hirokazu Kawagishi - One of the best experts on this subject based on the ideXlab platform.

  • Array of Metabolites in Italian Hericium Erinaceus Mycelium, Primordium, and Sporophore.
    Molecules (Basel Switzerland), 2019
    Co-Authors: Federica Corana, Hirokazu Kawagishi, Valentina Cesaroni, Elena Savino, Anna Maria Picco, Claudia Perini, Barbara Mannucci, Rebecca Michela Baiguera, Daniela Ratto, Carolina Girometta
    Abstract:

    Hericium Erinaceus is a medicinal mushroom that contains many molecules promising a plethora of therapeutic properties. In this study, the strain H.e.2 (MicUNIPV, University of Pavia, Italy) was isolated from a sporophore collected in Tuscany (Italy). Mycelium, primordium, and wild type and cultivated sporophores were analyzed by HPLC-UV-ESI/MS. Erinacine A in the mycelium and hericenones C and D in the sporophores were quantified by comparison with their standard molecules. For the first time, H. Erinaceus primordium was also investigated for the presence of these molecules. Comparing with the literature data, hericenes, molecules structurally similar to hericenones, were present in all our samples. The highest contents of hericenones C and D were detected in cultivated sporophores, compared to the wild type. The comparison of these data with those of another Italian H. Erinaceus strain (H.e.1 MicUNIPV) was discussed. The results led us to select H. Erinaceus strains more suitable for mycelium production or sporophore cultivation to obtain extracts with a higher content of bioactive compounds. This work provides a further step towards standardizing the procedures in the development of dietary supplements made from mushrooms.

  • erinacines j and k from the mycelia of hericium erinaceum
    ChemInform, 2007
    Co-Authors: Hirokazu Kawagishi, Shinji Tokuyama, Ayano Masui, Tomoyuki Nakamura
    Abstract:

    Two novel compounds, erinacines J (1) and K (3), were isolated from the cultured mycelia of Hericium erinaceum. Their structures were determined by spectral analyses. Erinacine K showed anti-MRSA activity.

  • erinacines a b and c strong stimulators of nerve growth factor ngf synthesis from the mycelia of hericium erinaceum
    Tetrahedron Letters, 1994
    Co-Authors: Hirokazu Kawagishi, Atsushi Shimada, Ryoko Shirai, Kenji Okamoto, Fumihiro Ojima, Hideki Sakamoto, Yukio Ishiguro, Shoei Furukawa
    Abstract:

    Abstract The structures of novel diterpenoids, erinacines A, B, and C, isolated from the cultured mycelia of Hericium erinaceum were determined by interpretation of the spectral data, and chemical and enzymatic reactions. These compounds showed potent stimulating activity of nerve growth factor (NGF)-synthesis.

  • antimicrobial chlorinated orcinol derivatives from mycelia of hericium erinaceum
    Phytochemistry, 1993
    Co-Authors: Kenji Okamoto, Atsushi Shimada, Ryoko Shirai, Fumihiro Ojima, Hideki Sakamoto, Yukio Ishiguro, Takuo Sakai, Satoshi Yoshida, Hirokazu Kawagishi
    Abstract:

    Abstract Two novel and a known chlorinated orcinol derivative were isolated from cultured mycelia of Hericium erinaceum . These three compounds exhibited antimicrobial activities.

Alfred S Traore - One of the best experts on this subject based on the ideXlab platform.

  • antioxidant and antibacterial activities of polyphenols from ethnomedicinal plants of burkina faso
    African Journal of Biotechnology, 2005
    Co-Authors: D S Karou, Mamoudou H Dicko, Jacques Simpore, Alfred S Traore
    Abstract:

    Polyphenols from four medicinal plants of Burkina Faso, Combretum micranthum, Khaya senegalensis, Pterocarpus Erinaceus and Sida acuta , were screened for their antioxidant and antimicrobial activities against pathogenic bacteria. The medicinal plants displayed different polyphenols contents and antioxidant activities. The bark of P. Erinaceus had the highest antioxidant activity. Some microorganisms were susceptible to polyphenol extracts with minimal bactericidal concentration values between 20 and 2000 mg/ml while other microorganisms appeared to be resistant to the extracts. Microbicide and microbiostatic activities of the extracts were dependent on the type of strains. Results suggest that these plants are not only interesting sources for antimicrobial activities but also potential sources of phenolic antioxidants. Key words : Antioxidants, polyphenols, antimicrobials, medicinal plants. African Journal of Biotechnology Vol. 4 (8), pp. 823-828

  • antimalarial activity of sida acuta burm f malvaceae and pterocarpus Erinaceus poir fabaceae
    Journal of Ethnopharmacology, 2003
    Co-Authors: D S Karou, Souleymane Sanon, Mamoudou H Dicko, Jacques Simpore, Alfred S Traore
    Abstract:

    Abstract Among strategies to combat malaria, the search for new antimalarial drugs appears to be a priority. Sheering for new antimalarial activities, four plants of the traditional medicine of Burkina Faso: Combretum micranthum, Khaya senegalensis, Pterocarpus Erinaceus and Sida acuta, were tested in vitro on fresh clinical isolates of Plasmodium falciparum. The screening showed that Sida acuta has a significant activity (IC50

Wenshih Huang - One of the best experts on this subject based on the ideXlab platform.

  • hericium Erinaceus mycelium and its isolated erinacine a protection from mptp induced neurotoxicity through the er stress triggering an apoptosis cascade
    Journal of Translational Medicine, 2016
    Co-Authors: Hsingchun Kuo, Chin-chu Chen, Chihchuan Teng, Chienheng Shen, Mengchiao Hsieh, Kochao Lee, Liya Lee, Wenshih Huang, Shuiyi Tung, Techuan Chen
    Abstract:

    Background Hericium Erinaceus is an edible mushroom; its various pharmacological effects which have been investigated. This study aimed to demonstrate whether efficacy of oral administration of H. Erinaceus mycelium (HEM) and its isolated diterpenoid derivative, erinacine A, can act as an anti-neuroinflammatory agent to bring about neuroprotection using an MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson’s disease, which results in motor disturbances, in addition to elucidating the mechanisms involved.

  • protective effects of hericium Erinaceus mycelium and its isolated erinacine a against ischemia injury induced neuronal cell death via the inhibition of inos p38 mapk and nitrotyrosine
    International Journal of Molecular Sciences, 2014
    Co-Authors: Kamfai Lee, Chin-chu Chen, Wan-ping Chen, Jiannhwa Chen, Chihchuan Teng, Chienheng Shen, Mengchiao Hsieh, Kochao Lee, Liya Lee, Wenshih Huang
    Abstract:

    Hericium Erinaceus, an edible mushroom, has been demonstrated to potentiate the effects of numerous biological activities. The aim of this study was to investigate whether H. Erinaceus mycelium could act as an anti-inflammatory agent to bring about neuroprotection using a model of global ischemic stroke and the mechanisms involved. Rats were treated with H. Erinaceus mycelium and its isolated diterpenoid derivative, erinacine A, after ischemia reperfusion brain injuries caused by the occlusion of the two common carotid arteries. The production of inflammatory cytokines in serum and the infracted volume of the brain were measured. The proteins from the stroke animal model (SAM) were evaluated to determine the effect of H. Erinaceus mycelium. H. Erinaceus mycelium reduced the total infarcted volumes by 22% and 44% at a concentration of 50 and 300 mg/kg, respectively, compared to the SAM group. The levels of acute inflammatory cytokines, including interleukin-1β, interleukin-6 and tumor necrosis factor a, were all reduced by erinacine A. Levels of nitrotyrosine-containing proteins, phosphorylation of p38 MAPK and CCAAT enhancer-binding protein (C/EBP) and homologous protein (CHOP) expression were attenuated by erinacine A. Moreover, the modulation of ischemia injury factors present in the SAM model by erinacine A seemed to result in the suppression of reactive nitrogen species and the downregulation of inducible NO synthase (iNOS), p38 MAPK and CHOP. These findings confirm the nerve-growth properties of Hericium Erinaceus mycelium, which include the prevention of ischemic injury to neurons; this protective effect seems to be involved in the in vivo activity of iNOS, p38 MAPK and CHOP.