Eupenicillium

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Vebera Maslami - One of the best experts on this subject based on the ideXlab platform.

Gláucia Maria Falcão Aragão - One of the best experts on this subject based on the ideXlab platform.

  • Identificação e determinação da resistencia termica de fungos filamentosos termo-resistentes isolados de polpa de morango
    [s.n.], 2018
    Co-Authors: Gláucia Maria Falcão Aragão
    Abstract:

    Orientador: Pilar Rodriguez de MassaguerDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia de AlimentosResumo: Foram isoladas 58 culturas de fungos filamentosos termo-resistentes à partir de 15 amostras de polpa de morango que haviam sofrido um choque térmico de 2 horas a 70ºC. Após a identificação, quatro cepas de fungos perfeitos foram selecionadas para o teste de resistência térmica, utilizando suco de morango (15 brix; pH3.0) como meio de aquecimento para os esporos. As cepas selecionadas foram: Byssochylamys nívea, Neosartorya fischeri, Talaromces Flavus Var. flavus e Eupenicillium javanicum Var. javanicum....Observação: O resumo, na íntegra, poderá ser visualizado no texto completo da tese digital.Abstract: Fifty eight (58) cultures of heat-resistant molds were isolated from fifteen (15) samples of strawberry pulp after a heat shock of 2 hous at 70ºC. Followed identification, four cultures were selected to determine their heat resistance using strawberry juice. (15º Brix, Ph 3.0) as heating medium of the spores. Selected cultures were: Byssochlamys nivea, Neosartorya fischeri, Talaromces Flavus Var. flavus and Eupenicillium javanicum Var. javanicum....Note: The complete abstract is available with the full electronic document.MestradoMestre em Ciência de Alimento

  • Identificação e determinação da resistencia termica de fungos filamentosos termo-resistentes isolados de polpa de morango
    2017
    Co-Authors: Gláucia Maria Falcão Aragão
    Abstract:

    Resumo: Foram isoladas 58 culturas de fungos filamentosos termo-resistentes à partir de 15 amostras de polpa de morango que haviam sofrido um choque térmico de 2 horas a 70ºC. Após a identificação, quatro cepas de fungos perfeitos foram selecionadas para o teste de resistência térmica, utilizando suco de morango (15 brix; pH3.0) como meio de aquecimento para os esporos. As cepas selecionadas foram: Byssochylamys nívea, Neosartorya fischeri, Talaromces Flavus Var. flavus e Eupenicillium javanicum Var. javanicum....Observação: O resumo, na íntegra, poderá ser visualizado no texto completo da tese digital.Abstract:Fifty eight (58) cultures of heat-resistant molds were isolated from fifteen (15) samples of strawberry pulp after a heat shock of 2 hous at 70ºC. Followed identification, four cultures were selected to determine their heat resistance using strawberry juice. (15º Brix, Ph 3.0) as heating medium of the spores. Selected cultures were: Byssochlamys nivea, Neosartorya fischeri, Talaromces Flavus Var. flavus and Eupenicillium javanicum Var. javanicum....Note: The complete abstract is available with the full electronic document

Michael Spiteller - One of the best experts on this subject based on the ideXlab platform.

  • epigenetic modulation of endophytic Eupenicillium sp lg41 by a histone deacetylase inhibitor for production of decalin containing compounds
    Journal of Natural Products, 2017
    Co-Authors: Souvik Kusari, Christopher Golz, Hartmut Laatsch, Carsten Strohmann, Michael Spiteller
    Abstract:

    An endophytic fungus, Eupenicillium sp. LG41, isolated from the Chinese medicinal plant Xanthium sibiricum, was subjected to epigenetic modulation using an NAD+-dependent histone deacetylase (HDAC) inhibitor, nicotinamide. Epigenetic stimulation of the endophyte led to enhanced production of two new decalin-containing compounds, eupenicinicols C and D (3 and 4), along with two biosynthetically related known compounds, eujavanicol A (1) and eupenicinicol A (2). The structures and stereochemistry of the new compounds were elucidated by extensive spectroscopic analysis using LC-HRMS, NMR, optical rotation, and ECD calculations, as well as single-crystal X-ray diffraction. Compounds 3 and 4 exist in chemical equilibrium with two and three cis/trans isomers, respectively, as revealed by LC-MS analysis. Compound 4 was active against Staphylococcus aureus with an MIC of 0.1 μg/mL and demonstrated marked cytotoxicity against the human acute monocytic leukemia cell line (THP-1). We have shown that the HDAC inhibit...

  • Epigenetic Modulation of Endophytic Eupenicillium sp. LG41 by a Histone Deacetylase Inhibitor for Production of Decalin-Containing Compounds
    2017
    Co-Authors: Souvik Kusari, Christopher Golz, Hartmut Laatsch, Carsten Strohmann, Michael Spiteller
    Abstract:

    An endophytic fungus, Eupenicillium sp. LG41, isolated from the Chinese medicinal plant Xanthium sibiricum, was subjected to epigenetic modulation using an NAD+-dependent histone deacetylase (HDAC) inhibitor, nicotinamide. Epigenetic stimulation of the endophyte led to enhanced production of two new decalin-containing compounds, eupenicinicols C and D (3 and 4), along with two biosynthetically related known compounds, eujavanicol A (1) and eupenicinicol A (2). The structures and stereochemistry of the new compounds were elucidated by extensive spectroscopic analysis using LC-HRMS, NMR, optical rotation, and ECD calculations, as well as single-crystal X-ray diffraction. Compounds 3 and 4 exist in chemical equilibrium with two and three cis/trans isomers, respectively, as revealed by LC-MS analysis. Compound 4 was active against Staphylococcus aureus with an MIC of 0.1 μg/mL and demonstrated marked cytotoxicity against the human acute monocytic leukemia cell line (THP-1). We have shown that the HDAC inhibitor, nicotinamide, enhanced the production of compounds 3 and 4 by endophytic Eupenicillium sp. LG41, facilitating their isolation, structure elucidation, and evaluation of their biological activities

  • antibacterial secondary metabolites from an endophytic fungus Eupenicillium sp lg41
    Journal of Natural Products, 2014
    Co-Authors: Souvik Kusari, Hartmut Laatsch, Marc Lamshoft, Anja Schuffler, Michael Spiteller
    Abstract:

    Two new compounds containing the decalin moiety, eupenicinicols A and B (1 and 2), two new sirenin derivatives, eupenicisirenins A and B (3 and 4), and four known compounds, (2S)-butylitaconic acid (5), (2S)-hexylitaconic acid (6), xanthomegnin (7), and viridicatumtoxin (8), were isolated from an endophytic fungus, Eupenicillium sp. LG41, harbored in the roots of the Chinese medicinal plant Xanthium sibiricum. Their structures were confirmed through combined spectroscopic analysis (NMR and HRMSn), and their absolute configurations were deduced by ECD calculations or optical rotation data. Since the endophytic fungus was isolated from the roots, the antibacterial efficacies of the compounds 1–6 were investigated against Bacillus subtilis and Acinetobacter sp. BD4, which typically inhabit soil, as well as the clinically important Staphylococcus aureus and Escherichia coli. (2S)-Butylitaconic acid (5) and (2S)-hexylitaconic acid (6) exhibited pronounced efficacy against Acinetobacter sp., corroborating the n...

  • Antibacterial Secondary Metabolites from an Endophytic Fungus, Eupenicillium sp. LG41
    2014
    Co-Authors: Souvik Kusari, Hartmut Laatsch, Marc Lamshöft, Anja Schüffler, Michael Spiteller
    Abstract:

    Two new compounds containing the decalin moiety, eupenicinicols A and B (1 and 2), two new sirenin derivatives, eupenicisirenins A and B (3 and 4), and four known compounds, (2S)-butylitaconic acid (5), (2S)-hexylitaconic acid (6), xanthomegnin (7), and viridicatumtoxin (8), were isolated from an endophytic fungus, Eupenicillium sp. LG41, harbored in the roots of the Chinese medicinal plant Xanthium sibiricum. Their structures were confirmed through combined spectroscopic analysis (NMR and HRMSn), and their absolute configurations were deduced by ECD calculations or optical rotation data. Since the endophytic fungus was isolated from the roots, the antibacterial efficacies of the compounds 1–6 were investigated against Bacillus subtilis and Acinetobacter sp. BD4, which typically inhabit soil, as well as the clinically important Staphylococcus aureus and Escherichia coli. (2S)-Butylitaconic acid (5) and (2S)-hexylitaconic acid (6) exhibited pronounced efficacy against Acinetobacter sp., corroborating the notion that root-endophytes provide chemical defense to the host plants. Compound 2 was highly active against the clinically relevant S. aureus. By comparing 1 with 2, it was revealed that altering the substitution at C-11 could drastically increase the antibacterial efficacy of 1. Our study reveals plausible ecological roles of the endophyte and its potential pharmaceutical use as a source of antibacterial compounds

  • an endophytic fungus from azadirachta indica a juss that produces azadirachtin
    World Journal of Microbiology & Biotechnology, 2012
    Co-Authors: Souvik Kusari, Vijay C. Verma, Marc Lamshoeft, Michael Spiteller
    Abstract:

    Azadirachtin A and its structural analogues are a well-known class of natural insecticides having antifeedant and insect growth-regulating properties. These compounds are exclusive to the neem tree, Azadirachta indica A. Juss, from where they are currently sourced. Here we report for the first time, the isolation and characterization of a novel endophytic fungus from A. indica, which produces azadirachtin A and B in rich mycological medium (Sabouraud dextrose broth), under shake-flask fermentation conditions. The fungus was identified as Eupenicillium parvum by ITS analysis (ITS1 and ITS2 regions and the intervening 5.8S rDNA region). Azadirachtin A and B were identified and quantified by LC-HRMS and LC-HRMS2, and by comparison with the authentic reference standards. The biosynthesis of azadirachtin A and B by the cultured endophyte, which is also produced by the host neem plant, provides an exciting platform for further scientific exploration within both the ecological and biochemical contexts.

Jie Tang - One of the best experts on this subject based on the ideXlab platform.

  • azaphilone and isocoumarin derivatives from the sponge derived fungus Eupenicillium sp 6a 9
    Tetrahedron Letters, 2018
    Co-Authors: Jie Tang, Shu-ping Wang, Weihua Jiao, Fan Sun, Fan Yang, Houwen Lin
    Abstract:

    Abstract Three new azaphilones, eupenicilazaphilones A–C (1–3), and one new isocoumarin, eupenicillin A (4), as well as five known azaphilones were isolated from the sponge-derived fungus Eupenicillium sp. 6A-9. Their structures were elucidated by detailed spectroscopic analysis, comparison with literature data, and 13C NMR chemical shifts and TDDFT/ECD calculations. The antibacterial activity against Staphylococcus aureus ATCC25923, methicillin-resistant Staphylococcus aureus ATCC4330, and Acinetobacter baumanii ATCC19606 as well as the cytotoxic activity towards human cancer lines MCF-7 and A549 were examined.

  • 3,5‐Dimethylorsellinic Acid Derived Meroterpenoids from Eupenicillium sp. 6A‐9, a Fungus Isolated from the Marine Sponge Plakortis simplex
    European Journal of Organic Chemistry, 2018
    Co-Authors: Liyun Liu, Fan Yang, Shu-ping Wang, Fan Sun, Jie Tang, Ya‐jun Zeng, Hou-wen Lin
    Abstract:

    Two rare 6(D)/5(E) rings fused meroterpenoids, eupeniacetal A (1) and eupeniacetal B (2), and three new meroterpenoids, 1-oxymethyl-hydropreaustinoid A1 (3), hydroberkeleyone B (4), and 22-deoxy-10-ketominiolutelide B (5), as well as five known meroterpenoids, 22-deoxyminiolutelide B (6), preaustinoid A1 (7), berkeleyone C (8), berkeleyacetal A (9), and preaustinoid A3 (10), were LC-MS-guidedly isolated from the sponge-derived fungus Eupenicillium sp. 6A-9. The structures of these meroterpenoids were elucidated by detailed spectroscopic analysis, comparison with the literature data, and X-ray single-crystal diffraction. The absolute configurations were assigned by TDDFT/ECD and [α]D value calculations and X-ray analysis. These compounds showed inhibitory activity on TNF-α production in induced THP-1 cell line but inactive against normal tumor cell lines.

Guangying Chen - One of the best experts on this subject based on the ideXlab platform.

  • a new phenol derivative isolated from mangrove derived fungus Eupenicillium sp hj002
    Natural Product Research, 2020
    Co-Authors: Rongqing Mei, Caijuan Zheng, Guolei Huang, Youping Luo, Xuhua Nong, Bin Wang, Xueping Sun, Guangying Chen
    Abstract:

    A new phenol derivative, 3-chloro-5-hydroxy-4-methoxyphenylacetic acid methyl ester (1), along with five known compounds methyl 4-hydroxyphenylacetate (2), cytosporone B (3), (R)-striatisporolide A (4), (R)-butanedioic acid (5) and ergosterol (6) were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their structures were established by spectroscopic methods, GIAO based 13C NMR chemical shift calculations and comparison with the data of literature. Compounds 1-5 were isolated from Xylocarpus granatum Koening-derived fungus for the first time.

  • penicilindoles a c cytotoxic indole diterpenes from the mangrove derived fungus Eupenicillium sp hj002
    Journal of Natural Products, 2018
    Co-Authors: Caijuan Zheng, Meng Bai, Xueming Zhou, Guolei Huang, Taiming Shao, Youping Luo, Zhigang Niu, Yanyan Niu, Guangying Chen, Changri Han
    Abstract:

    Three new indole diterpenes, penicilindoles A–C (1–3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations were determined by interpretation of NMR spectroscopic data, HR-ESIMS, and X-ray diffraction analysis using Cu Kα radiation. The cytotoxic and antibacterial activities were evaluated in vitro; penicilindole A (1) showed cytotoxic activity against human A549 and HepG2 cell lines with IC50 values of 5.5 and 1.5 μM, respectively.

  • Penicilindoles A–C, Cytotoxic Indole Diterpenes from the Mangrove-Derived Fungus Eupenicillium sp. HJ002
    2018
    Co-Authors: Caijuan Zheng, Meng Bai, Xueming Zhou, Guolei Huang, Taiming Shao, Youping Luo, Zhigang Niu, Yanyan Niu, Guangying Chen, Changri Han
    Abstract:

    Three new indole diterpenes, penicilindoles A–C (1–3), were isolated from the mangrove-derived fungus Eupenicillium sp. HJ002. Their planar structures and absolute configurations were determined by interpretation of NMR spectroscopic data, HR-ESIMS, and X-ray diffraction analysis using Cu Kα radiation. The cytotoxic and antibacterial activities were evaluated in vitro; penicilindole A (1) showed cytotoxic activity against human A549 and HepG2 cell lines with IC50 values of 5.5 and 1.5 μM, respectively

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