The Experts below are selected from a list of 180 Experts worldwide ranked by ideXlab platform

Yuichi Utsumi - One of the best experts on this subject based on the ideXlab platform.

  • A Novel Micromixer with Three-Dimensionally Cross-Linked Capillary Array Structure Fabricated by Deep X-ray Lithography
    Ieej Transactions on Electronics Information and Systems, 2020
    Co-Authors: Saki Kondo, Yoshiaki Ukita, Kuniyo Fujiwara, Yuichi Utsumi
    Abstract:

    A novel micromixer is proposed, fabricated and verified. The new concept of the micromixere is to cross-link the many capillaries in three-dimensional structure. The characteristic flow behaviors are simulated by using computational Fluid dynamics(CFD) software “FLUENT”. The results of the CFD shows unique mixing behavior in three-dimensionally cross-linked capillaries. The mixing performance of the micromixer is strongly influenced by controlling the three-dimensional crossing condition. The micromixer is fabricated by means of deep X-ray lithography with multi step exposure. The cross-linked capillary structures are successfully fabricated with controlled cross-link conditions. The performance of micromixer is evaluated by using a kind of enzyme reaction. By comparing mixture, mixed with cross-linked Fluid Filter and Fluid Filter without cross-linked capillaries, we found out the speeding up of the reaction by using new micromixer.

  • A novel micromixer with three-dimensionally cross-linked capillary array structure fabricated by deep X-ray lithography
    Electrical Engineering in Japan, 2011
    Co-Authors: Saki Kondo, Yoshiaki Ukita, Kuniyo Fujiwara, Yuichi Utsumi
    Abstract:

    A novel micromixer was proposed, fabricated and verified. The new concept of the micromixer is to cross-link many capillaries in a three-dimensional structure. The characteristic flow behaviors were simulated by using the “FLUENT” computational Fluid dynamics (CFD) software. The results of the CFD showed unique mixing behavior in three-dimensionally cross-linked capillaries. The mixing performance of the micromixer is strongly influenced by controlling the three-dimensional crossing conditions. The micromixer was fabricated by deep X-ray lithography with multistep exposure. The cross-linked capillary structures were successfully fabricated while controlling the cross-link conditions. The performance of the micromixer was evaluated by using an enzyme reaction. By comparing the mixtures produced with a cross-linked Fluid Filter and with a Fluid Filter without cross-linked capillaries, we found that the reaction was accelerated by using the new micromixer. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 177(1): 26–31, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21157

  • High efficiency mixing by the use of cross-linked micro capillary Fluid Filter
    Microsystem Technologies-micro-and Nanosystems-information Storage and Processing Systems, 2008
    Co-Authors: Kuniyo Fujiwara, Yoshiaki Ukita, Masahiro Takeo, Seiji Negoro, Tomohiko Kanie, Makoto Katayama, Yuichi Utsumi
    Abstract:

    A novel type passive mixing device that causes the three-dimensional flow was proposed. This mixer consists of the integrated capillary bundle structure. And the capillaries ware cross-linked each other. So it is called cross-linked micro capillary Filter. The mixing effect of the cross-linked micro capillary Filter was calculated by the computational Fluid dynamics (CFD). The Fluid behaviour in the fine three-dimensional structure could be analysed by the use of CFD. In the result of CFD calculation, the cross-linked micro capillary Filter estimated high mixing effect. Moreover, the mixing efficiency was become higher by change the cross-linked form. The calculation result was decided the form of the cross-linked micro capillary Filter. And this Filter was fabricated by application of the Deep X-ray lithography. To form the cross-linked capillary, it was operated twice exposures. In these exposures, respectively the exposure stage was tilted to difference angle. The cross-linked capillary Filter fabricated in this way was applied to vertical Fluid flow operation. This cross-linked capillary Filter could hold and transmit the Fluid by the switchover of in impressed pressure. Herewith the cross-linked micro capillary Filter showed availability as high efficiency mixing device.

  • Polytetrafluoroethylene processing characteristics using high-energy X-ray
    Microsystem Technologies-micro-and Nanosystems-information Storage and Processing Systems, 2008
    Co-Authors: Yoshiaki Ukita, Kazuhiro Kanda, Shinji Matsui, Mitsuyoshi Kishihara, Yuichi Utsumi
    Abstract:

    Polytetrafluoroethylene (PTFE) microstructures’ processing characteristics using X-ray photo dcomposition and desorption are studied in the highest energy region (2 keV to >12 keV). While the exposed surface states are seen melting and boiling from the remaining bubble structure of the irradiated surface, basic photochemistry of PTFE is also same as previous reports and high-aspect ratio structures are successfully formed. We developed new Ni stencil electroformed stencil masks and successfully fabricated first and practical example of PTFE micro Fluidic parts. The characteristics of fabricated micro Fluidic parts, a PTFE Fluid Filter for vertical Fluid flow operation which works as passive valve, agreed with the calculated results. This suggests that the accuracy of patterning is adequate to apply this technique to fabricate microFluidic parts and other various microparts.

  • Application of vertical microreactor stack with polystylene microbeads to immunoassay
    Sensors and Actuators A-physical, 2008
    Co-Authors: Yoshiaki Ukita, Toshifumi Asano, Kuniyo Fujiwara, Masahiro Takeo, Seiji Negoro, Katsuhiro Matsui, Tomohiko Kanie, Makoto Katayama, Yuichi Utsumi
    Abstract:

    The advantages of vertical microreactor stack with three-dimensional (3D) structure for immunoassay are discussed. The vertical microreactor stack uses vertical Fluid flow operation with multifunctional Fluid Filters. The multifunction of Fluid Filter is very effective for micromixing and passive valve operation. The mechanism of micromixing is discussed by using computational Fluid dynamics (CFD), and the results suggest that the mixing mechanism based on two main effects. One is Coanda effect and the other is Taylor dispersion induced in enormously high aspect ratio capillary and liquid plug. We demonstrated enzyme reaction with unique repeat mixing operation, to evaluate the micromixing performance of Fluid Filter. As the results, we proved that the Fluid Filter has very effective mixing performance. The detection limit, which demonstrated by competition enzyme-linked immunosorvent assay (ELISA), is comparable with recommended detection limit, which suggested by Japanese ministry for the environment.

Yoshiaki Ukita - One of the best experts on this subject based on the ideXlab platform.

  • Calculation and Verification of the Behaviour of Vertical Fluid Flow Using the Multifunctional Fluid Filter
    Ieej Transactions on Electronics Information and Systems, 2020
    Co-Authors: Kuniyo Fujiwara, Yoshiaki Ukita, Toshifumi Asano, Masahiro Takeo, Seiji Negoro, Katsuhiro Matsui, Y. Utsumi
    Abstract:

    The vertical Fluid flow operation and multifunctional Fluid Filter for the operation were proposed. We calculated the flow behaviour by FLUENT of the CFD software. The CFD analysis estimated the threshold pressure of flow transmission and efficiency of mixing and the results indicated that the vertical liquid transportation is useful and the good multi function as channel , valve , mixer and micro reactor of the Filter we proposed. So we fabricated the Filter by SR lithography and performed the flow transmission experiment. As the result, the calculated threshold pressure configurate the measured pressure. We demonstrated ring-opening reaction of the Catechol by Catechol 2,3-dioxygenase as the catalyst to evaluate the performance of mixing. It shows that the Filter mixes the Fluid efficiently and is enough to mix at five times transportation.

  • A Novel Micromixer with Three-Dimensionally Cross-Linked Capillary Array Structure Fabricated by Deep X-ray Lithography
    Ieej Transactions on Electronics Information and Systems, 2020
    Co-Authors: Saki Kondo, Yoshiaki Ukita, Kuniyo Fujiwara, Yuichi Utsumi
    Abstract:

    A novel micromixer is proposed, fabricated and verified. The new concept of the micromixere is to cross-link the many capillaries in three-dimensional structure. The characteristic flow behaviors are simulated by using computational Fluid dynamics(CFD) software “FLUENT”. The results of the CFD shows unique mixing behavior in three-dimensionally cross-linked capillaries. The mixing performance of the micromixer is strongly influenced by controlling the three-dimensional crossing condition. The micromixer is fabricated by means of deep X-ray lithography with multi step exposure. The cross-linked capillary structures are successfully fabricated with controlled cross-link conditions. The performance of micromixer is evaluated by using a kind of enzyme reaction. By comparing mixture, mixed with cross-linked Fluid Filter and Fluid Filter without cross-linked capillaries, we found out the speeding up of the reaction by using new micromixer.

  • A novel micromixer with three-dimensionally cross-linked capillary array structure fabricated by deep X-ray lithography
    Electrical Engineering in Japan, 2011
    Co-Authors: Saki Kondo, Yoshiaki Ukita, Kuniyo Fujiwara, Yuichi Utsumi
    Abstract:

    A novel micromixer was proposed, fabricated and verified. The new concept of the micromixer is to cross-link many capillaries in a three-dimensional structure. The characteristic flow behaviors were simulated by using the “FLUENT” computational Fluid dynamics (CFD) software. The results of the CFD showed unique mixing behavior in three-dimensionally cross-linked capillaries. The mixing performance of the micromixer is strongly influenced by controlling the three-dimensional crossing conditions. The micromixer was fabricated by deep X-ray lithography with multistep exposure. The cross-linked capillary structures were successfully fabricated while controlling the cross-link conditions. The performance of the micromixer was evaluated by using an enzyme reaction. By comparing the mixtures produced with a cross-linked Fluid Filter and with a Fluid Filter without cross-linked capillaries, we found that the reaction was accelerated by using the new micromixer. © 2011 Wiley Periodicals, Inc. Electr Eng Jpn, 177(1): 26–31, 2011; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.21157

  • High efficiency mixing by the use of cross-linked micro capillary Fluid Filter
    Microsystem Technologies-micro-and Nanosystems-information Storage and Processing Systems, 2008
    Co-Authors: Kuniyo Fujiwara, Yoshiaki Ukita, Masahiro Takeo, Seiji Negoro, Tomohiko Kanie, Makoto Katayama, Yuichi Utsumi
    Abstract:

    A novel type passive mixing device that causes the three-dimensional flow was proposed. This mixer consists of the integrated capillary bundle structure. And the capillaries ware cross-linked each other. So it is called cross-linked micro capillary Filter. The mixing effect of the cross-linked micro capillary Filter was calculated by the computational Fluid dynamics (CFD). The Fluid behaviour in the fine three-dimensional structure could be analysed by the use of CFD. In the result of CFD calculation, the cross-linked micro capillary Filter estimated high mixing effect. Moreover, the mixing efficiency was become higher by change the cross-linked form. The calculation result was decided the form of the cross-linked micro capillary Filter. And this Filter was fabricated by application of the Deep X-ray lithography. To form the cross-linked capillary, it was operated twice exposures. In these exposures, respectively the exposure stage was tilted to difference angle. The cross-linked capillary Filter fabricated in this way was applied to vertical Fluid flow operation. This cross-linked capillary Filter could hold and transmit the Fluid by the switchover of in impressed pressure. Herewith the cross-linked micro capillary Filter showed availability as high efficiency mixing device.

  • Polytetrafluoroethylene processing characteristics using high-energy X-ray
    Microsystem Technologies-micro-and Nanosystems-information Storage and Processing Systems, 2008
    Co-Authors: Yoshiaki Ukita, Kazuhiro Kanda, Shinji Matsui, Mitsuyoshi Kishihara, Yuichi Utsumi
    Abstract:

    Polytetrafluoroethylene (PTFE) microstructures’ processing characteristics using X-ray photo dcomposition and desorption are studied in the highest energy region (2 keV to >12 keV). While the exposed surface states are seen melting and boiling from the remaining bubble structure of the irradiated surface, basic photochemistry of PTFE is also same as previous reports and high-aspect ratio structures are successfully formed. We developed new Ni stencil electroformed stencil masks and successfully fabricated first and practical example of PTFE micro Fluidic parts. The characteristics of fabricated micro Fluidic parts, a PTFE Fluid Filter for vertical Fluid flow operation which works as passive valve, agreed with the calculated results. This suggests that the accuracy of patterning is adequate to apply this technique to fabricate microFluidic parts and other various microparts.

Seiji Negoro - One of the best experts on this subject based on the ideXlab platform.

  • Calculation and Verification of the Behaviour of Vertical Fluid Flow Using the Multifunctional Fluid Filter
    Ieej Transactions on Electronics Information and Systems, 2020
    Co-Authors: Kuniyo Fujiwara, Yoshiaki Ukita, Toshifumi Asano, Masahiro Takeo, Seiji Negoro, Katsuhiro Matsui, Y. Utsumi
    Abstract:

    The vertical Fluid flow operation and multifunctional Fluid Filter for the operation were proposed. We calculated the flow behaviour by FLUENT of the CFD software. The CFD analysis estimated the threshold pressure of flow transmission and efficiency of mixing and the results indicated that the vertical liquid transportation is useful and the good multi function as channel , valve , mixer and micro reactor of the Filter we proposed. So we fabricated the Filter by SR lithography and performed the flow transmission experiment. As the result, the calculated threshold pressure configurate the measured pressure. We demonstrated ring-opening reaction of the Catechol by Catechol 2,3-dioxygenase as the catalyst to evaluate the performance of mixing. It shows that the Filter mixes the Fluid efficiently and is enough to mix at five times transportation.

  • High efficiency mixing by the use of cross-linked micro capillary Fluid Filter
    Microsystem Technologies-micro-and Nanosystems-information Storage and Processing Systems, 2008
    Co-Authors: Kuniyo Fujiwara, Yoshiaki Ukita, Masahiro Takeo, Seiji Negoro, Tomohiko Kanie, Makoto Katayama, Yuichi Utsumi
    Abstract:

    A novel type passive mixing device that causes the three-dimensional flow was proposed. This mixer consists of the integrated capillary bundle structure. And the capillaries ware cross-linked each other. So it is called cross-linked micro capillary Filter. The mixing effect of the cross-linked micro capillary Filter was calculated by the computational Fluid dynamics (CFD). The Fluid behaviour in the fine three-dimensional structure could be analysed by the use of CFD. In the result of CFD calculation, the cross-linked micro capillary Filter estimated high mixing effect. Moreover, the mixing efficiency was become higher by change the cross-linked form. The calculation result was decided the form of the cross-linked micro capillary Filter. And this Filter was fabricated by application of the Deep X-ray lithography. To form the cross-linked capillary, it was operated twice exposures. In these exposures, respectively the exposure stage was tilted to difference angle. The cross-linked capillary Filter fabricated in this way was applied to vertical Fluid flow operation. This cross-linked capillary Filter could hold and transmit the Fluid by the switchover of in impressed pressure. Herewith the cross-linked micro capillary Filter showed availability as high efficiency mixing device.

  • Application of vertical microreactor stack with polystylene microbeads to immunoassay
    Sensors and Actuators A-physical, 2008
    Co-Authors: Yoshiaki Ukita, Toshifumi Asano, Kuniyo Fujiwara, Masahiro Takeo, Seiji Negoro, Katsuhiro Matsui, Tomohiko Kanie, Makoto Katayama, Yuichi Utsumi
    Abstract:

    The advantages of vertical microreactor stack with three-dimensional (3D) structure for immunoassay are discussed. The vertical microreactor stack uses vertical Fluid flow operation with multifunctional Fluid Filters. The multifunction of Fluid Filter is very effective for micromixing and passive valve operation. The mechanism of micromixing is discussed by using computational Fluid dynamics (CFD), and the results suggest that the mixing mechanism based on two main effects. One is Coanda effect and the other is Taylor dispersion induced in enormously high aspect ratio capillary and liquid plug. We demonstrated enzyme reaction with unique repeat mixing operation, to evaluate the micromixing performance of Fluid Filter. As the results, we proved that the Fluid Filter has very effective mixing performance. The detection limit, which demonstrated by competition enzyme-linked immunosorvent assay (ELISA), is comparable with recommended detection limit, which suggested by Japanese ministry for the environment.

  • Enzyme-linked immunosorvent assay using vertical microreactor stack with microbeads
    Microsystem Technologies, 2008
    Co-Authors: Yoshiaki Ukita, Toshifumi Asano, Kuniyo Fujiwara, Masahiro Takeo, Seiji Negoro, Katsuhiro Matsui, Yuichi Utsumi
    Abstract:

    The advantages of vertical microreactor stack with three-dimensional (3D) structure for immunoassay are discussed. The vertical microreactor stack uses vertical Fluid flow operation with multifunctional Fluid Filters. The multi function of Fluid Filter is very effective for micromixing and passive valve operation. The mechanism of micromixing is discussed by using computational Fluid dynamics (CFD), and we know that the mixing mechanism based on Coanda effect. To evaluate the micromixing performance of Fluid Filter, we demonstrated enzyme reaction with unique repeat mixing operation. As the results, we proved that the Fluid Filter has very effective mixing performance. The detection limit, which demonstrated by competition enzyme-linked immunosorvent assay (ELISA), is comparable with recommended detection limit, which suggested by Japanese ministry for the environment.

  • Application of Vertical Micororeactor Stack with Polystylene Microbeads to Immuno Assay
    TRANSDUCERS 2007 - 2007 International Solid-State Sensors Actuators and Microsystems Conference, 2007
    Co-Authors: Yoshiaki Ukita, Seiji Negoro, Yuichi Utsumil
    Abstract:

    This paper proposes a vertical microreactor stack, a new concept of the microreactor, using vertical Fluid flow operation and multifunctional Fluid Filters and vertically stacked reservoirs. The vertical Fluid flow operation utilizes the surface tension of the liquid/ gas interface and pneumatic pressure to control the liquid behavior in vertical microreactor stack. The functions as microvalve, microcahnnel and micromixer of the Fluid Filter are estimated by computational Fluid dynamics (CFD) simulation and experiments. The enzyme linked immuno-solvent assay is demonstrated by using vertical microreactor stack and the calibration curve was successfully taken.

Todd Otanicar - One of the best experts on this subject based on the ideXlab platform.

  • Nanoparticle enhanced spectral filtration of insolation from trough concentrators
    Solar Energy Materials and Solar Cells, 2016
    Co-Authors: Drew Dejarnette, Nick Brekke, Ebrima Tunkara, Kenneth P. Roberts, Todd Otanicar, Aaron E. Saunders
    Abstract:

    Abstract A nanoparticle Fluid Filter consisting of gold nanoparticles and indium tin oxide nanocrystals was fabricated and the optical properties were assessed. Results were integrated against the AM 1.5 solar spectrum to determine solar weighted efficiency of the Filter for light energies transmitted above the bandgap to a photovoltaic cell for direct electrical generation while absorbing light below the bandgap that is converted to heat for thermal storage or processing. Temperature dependent bandgaps for both GaAs and cSi were used for optimization of the Filter design. GaAs is preferred based upon its higher IR reflectivity, lower temperature coefficient, and greater high-temperature efficiency. However, cSi is significantly cheaper than current and projected GaAs costs. It was found that the experimental Filter efficiency was 62% for GaAs and 56% for cSi which was within 6% of previous theoretical predictions.

  • Design and feasibility of high temperature nanoparticle Fluid Filter in hybrid thermal/photovoltaic concentrating solar power
    High and Low Concentrator Systems for Solar Energy Applications X, 2015
    Co-Authors: Drew Dejarnette, Nick Brekke, Ebrima Tunkara, Parameswar Hari, Kenneth P. Roberts, Todd Otanicar
    Abstract:

    A nanoparticle Fluid Filter used with concentrating hybrid solar/thermal collector design is presented. Nanoparticle Fluid Filters could be situated on any given concentrating system with appropriate customized engineering. This work shows the design in the context of a trough concentration system. Geometric design and physical placement in the optical path was modeled using SolTrace. It was found that a design can be made that blocks 0% of the traced rays. The nanoparticle Fluid Filter is tunable for different concentrating systems using various PV cells or operating at varying temperatures.

  • Selective spectral filtration with nanoparticles for concentrating solar collectors
    Journal of Photonics for Energy, 2015
    Co-Authors: Drew Dejarnette, Nick Brekke, Parameswar Hari, Todd Otanicar, Kenneth P. Roberts
    Abstract:

    University of Tulsa, 800 S. Tucker Drive, Tulsa, Oklahoma 74104, United StatesAbstract. A spectral Fluid Filter for potential use in hybrid photovoltaic/thermal concentratingsolar collectors has been developed, targeting maximum absorption above and transmissionbelow a desired wavelength. In this application, the temperature-dependent bandgap of thepotential solar cell is used in the optimization of the Filter. Dispersing a mix of colloidal nano-particles in a heat transfer Fluid is shown to absorb 86% of sub-bandgap insolation while absorb-ing only 18% above bandgap insolation. Transmission above bandgap light would be directlyabsorbed into the photovoltaic (PV) cell while absorbedphotons transfer energydirectly into theheat transfer Fluid ultimately reducing the number of heat transfer steps. Placement of a Filter infront of the PV cell is shown to decrease losses by converting an additional 2% of the total solarenergy into thermal energy since it allows recollection of light reflected off the receiver.

  • Photovoltaic/thermal system performance utilizing thin film and nanoparticle dispersion based optical Filters
    Journal of Renewable and Sustainable Energy, 2013
    Co-Authors: Todd Otanicar, Robert A. Taylor, Chinmay Telang
    Abstract:

    Hybrid photovoltaic/thermal (PV/T) collectors would benefit from the use of Fluid based optical Filters as a means to separate the useful irradiance for the PV cell from those wavelengths which are more suited to heat generation. Nanoparticle based dispersions within a working Fluid can be designed/tuned to serve as optical Filters for this purpose. The advantage of this concept is that the thermal part of the system is separated, allowing the photovoltaic and thermal components to operate at significantly different temperatures. Additionally, by using a Fluid Filter, it is relatively easy to remove heat from the thermal side. This paper theoretically investigates the performance of nanoparticle-based and conventional thin film-based optical Fluid Filters within a concentrating hybrid PV/T system. General results are presented to demonstrate the impact to overall efficiency when a realistic (i.e., non-ideal) Filter is used at a wide-range of operating conditions. The results demonstrate that nanoparticle ...

  • band gap tuned direct absorption for a hybrid concentrating solar photovoltaic thermal system
    Journal of Solar Energy Engineering-transactions of The Asme, 2011
    Co-Authors: Todd Otanicar, Ihtesham Chowdhury, Ravi Prasher, Patrick E Phelan
    Abstract:

    Two methods often proposed for harnessing renewable energy, photovoltaics and solar thermal, both utilize the power of the sun. Each of these systems independently presets unique engineering challenges but when coupled together the challenge intensifies due to competing operating requirements. Recent research has demonstrated these hybrid systems for low-temperature applications but there exists limited studies at higher concentration ratios, and thus higher temperatures. What these studies have shown is that keeping the photovoltaic (PV) cell temperature low keeps the overall system efficiency relatively high but results in low efficiencies from the thermal system. This study presents a unique design strategy for a hybrid PV/thermal system that only has mild thermal coupling which can lead to enhanced efficiency. By creating a Fluid Filter that absorbs energy directly in the Fluid below the band-gap and a PV cell with an active cooling strategy combined effrciencies greater than 38% can be achieved.

Toshifumi Asano - One of the best experts on this subject based on the ideXlab platform.

  • Calculation and Verification of the Behaviour of Vertical Fluid Flow Using the Multifunctional Fluid Filter
    Ieej Transactions on Electronics Information and Systems, 2020
    Co-Authors: Kuniyo Fujiwara, Yoshiaki Ukita, Toshifumi Asano, Masahiro Takeo, Seiji Negoro, Katsuhiro Matsui, Y. Utsumi
    Abstract:

    The vertical Fluid flow operation and multifunctional Fluid Filter for the operation were proposed. We calculated the flow behaviour by FLUENT of the CFD software. The CFD analysis estimated the threshold pressure of flow transmission and efficiency of mixing and the results indicated that the vertical liquid transportation is useful and the good multi function as channel , valve , mixer and micro reactor of the Filter we proposed. So we fabricated the Filter by SR lithography and performed the flow transmission experiment. As the result, the calculated threshold pressure configurate the measured pressure. We demonstrated ring-opening reaction of the Catechol by Catechol 2,3-dioxygenase as the catalyst to evaluate the performance of mixing. It shows that the Filter mixes the Fluid efficiently and is enough to mix at five times transportation.

  • Application of vertical microreactor stack with polystylene microbeads to immunoassay
    Sensors and Actuators A-physical, 2008
    Co-Authors: Yoshiaki Ukita, Toshifumi Asano, Kuniyo Fujiwara, Masahiro Takeo, Seiji Negoro, Katsuhiro Matsui, Tomohiko Kanie, Makoto Katayama, Yuichi Utsumi
    Abstract:

    The advantages of vertical microreactor stack with three-dimensional (3D) structure for immunoassay are discussed. The vertical microreactor stack uses vertical Fluid flow operation with multifunctional Fluid Filters. The multifunction of Fluid Filter is very effective for micromixing and passive valve operation. The mechanism of micromixing is discussed by using computational Fluid dynamics (CFD), and the results suggest that the mixing mechanism based on two main effects. One is Coanda effect and the other is Taylor dispersion induced in enormously high aspect ratio capillary and liquid plug. We demonstrated enzyme reaction with unique repeat mixing operation, to evaluate the micromixing performance of Fluid Filter. As the results, we proved that the Fluid Filter has very effective mixing performance. The detection limit, which demonstrated by competition enzyme-linked immunosorvent assay (ELISA), is comparable with recommended detection limit, which suggested by Japanese ministry for the environment.

  • Enzyme-linked immunosorvent assay using vertical microreactor stack with microbeads
    Microsystem Technologies, 2008
    Co-Authors: Yoshiaki Ukita, Toshifumi Asano, Kuniyo Fujiwara, Masahiro Takeo, Seiji Negoro, Katsuhiro Matsui, Yuichi Utsumi
    Abstract:

    The advantages of vertical microreactor stack with three-dimensional (3D) structure for immunoassay are discussed. The vertical microreactor stack uses vertical Fluid flow operation with multifunctional Fluid Filters. The multi function of Fluid Filter is very effective for micromixing and passive valve operation. The mechanism of micromixing is discussed by using computational Fluid dynamics (CFD), and we know that the mixing mechanism based on Coanda effect. To evaluate the micromixing performance of Fluid Filter, we demonstrated enzyme reaction with unique repeat mixing operation. As the results, we proved that the Fluid Filter has very effective mixing performance. The detection limit, which demonstrated by competition enzyme-linked immunosorvent assay (ELISA), is comparable with recommended detection limit, which suggested by Japanese ministry for the environment.

  • Fluid Filter fabricated by deep X-ray lithography for micro Fluidics
    Microsystem Technologies, 2007
    Co-Authors: Yoshiaki Ukita, Toshifumi Asano, Yuichi Utsumi
    Abstract:

    A new method and Fluid Filter with micro through capillary array for high-throughput micro Fluidics were proposed and fabricated. The method, utilizing liquid surface tension and directing Fluid flow in vertical direction, was achieved by using the Fluid Filter we originally proposed. The computational Fluid dynamics analysis was conducted to examine the feasibility of vertical Fluid flow operation using the Fluid Filter. And the results indicated that the vertical Fluid flow operation is useful and the good properties of the Fluid Filter. Fabrication of Fluid Filter was successfully conducted by using deep X-ray lithography. And vertical Fluid flow operation and its high throughput properties were successfully demonstrated.

  • Fabrication of a micro reactor for vertical unit operation using multifunctional Fluid Filter and its application to biochemical reaction
    Microsystem Technologies, 2007
    Co-Authors: Toshifumi Asano, Yoshiaki Ukita, Masahiro Takeo, Seiji Negoro, Katsuhiro Matsui, Yuichi Utsumi
    Abstract:

    We proposed and fabricated a vertical micro reactor stack with vertical Fluid flow operation for environment analysis, post-genome analysis, gene diagnosis, and screenings of useful materials for pharmaceutical. This reactor is characterized as the simple structure and new aspects of the vertical Fluid transportation evoked by the use of the Fluid Filter with micro through-bores. The lithographite, galvanoformung and abformung (LIGA) process using synchrotron radiation was applied for the fabrication of the Fluid Filters. The computational Fluid dynamics (CFD) simulation results suggested that the Fluid can be held by the Fluid Filter and easily transported by the pneumatic operation. It was also confirmed that the Fluid flow velocity through the Filter was controlled by varying the loaded pressure around several kPa. Furthermore, it was expected that the Fluid was stirred and mixed when passing through the Fluid Filter. It was demonstrated that the proposed chemical reactor result in a good performance of the vertical Fluid flow operation and biochemical reaction.