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Marc A. Benninga - One of the best experts on this subject based on the ideXlab platform.
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management of Functional Constipation in children and adults
Nature Reviews Gastroenterology & Hepatology, 2020Co-Authors: Mana H Vriesman, Carlo Di Lorenzo, Ilan J N Koppen, Michael Camilleri, Marc A. BenningaAbstract:Functional Constipation is common in children and adults worldwide. Functional Constipation shows similarities in children and adults, but important differences also exist regarding epidemiology, symptomatology, pathophysiology, diagnostic workup and therapeutic management. In children, the approach focuses on the behavioural nature of the disorder and the initial therapeutic steps involve toilet training and laxatives. In adults, management focuses on excluding an underlying cause and differentiating between different subtypes of Functional Constipation - normal transit, slow transit or an evacuation disorder - which has important therapeutic consequences. Treatment of adult Functional Constipation involves lifestyle interventions, pelvic floor interventions (in the presence of a rectal evacuation disorder) and pharmacological therapy. When conventional treatments fail, children and adults are considered to have intractable Functional Constipation, a troublesome and distressing condition. Intractable Constipation is managed with a stepwise approach and in rare cases requires surgical interventions such as antegrade continence enemas in children or colectomy procedures for adults. New drugs, including prokinetic and prosecretory agents, and surgical strategies, such as sacral nerve stimulation, have the potential to improve the management of children and adults with intractable Functional Constipation.
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quality of life in children with Functional Constipation a systematic review and meta analysis
The Journal of Pediatrics, 2019Co-Authors: Mana H Vriesman, Marieke Van Dijk, Merit M Tabbers, Ilan J N Koppen, Shaman Rajindrajith, Faridi S Van Etten Jamaludin, Niranga Manjuri Devanarayana, Marc A. BenningaAbstract:Objective To systematically review the literature on health-related quality of life (HRQoL) in children with Functional Constipation and to identify disease-related factors associated with HRQoL. Study design The Pubmed, Embase, and PsycINFO database were searched. Studies were included if they prospectively assessed HRQoL in children with Functional Constipation according to the Rome criteria. Articles were excluded if patients had organic causes of Constipation and if HRQoL was only assessed after successful therapeutic interventions. A meta-analysis was performed calculating sample size–weighted pooled mean and SD of HRQoL scores. The quality of the studies was also assessed. Results A total of 20 of 2658 studies were included, providing HRQoL data for 2344 children. Quality of evidence was considered to be poor in 9 of the 20 studies (45%); 13 of the 20 studies reported sufficient data to be included in the meta-analysis. Pooled total HRQoL scores of children with Functional Constipation were found to be lower compared with healthy reference samples (65.6 vs 86.1; P Conclusions HRQoL is compromised in children with Functional Constipation.
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controversies in the management of Functional Constipation in children
Current Gastroenterology Reports, 2019Co-Authors: M J Van Mill, Ilan J N Koppen, Marc A. BenningaAbstract:Functional Constipation (FC) in children is a common health problem with reported worldwide prevalence rates up to 32.2%. The majority of children with Constipation respond to oral laxative treatment. After 5 years of intensive treatment, however, approximately 50% of children remain symptomatic. To discuss the evidence for new treatments in these children, including pre- and probiotics, pelvic physiotherapy, prucalopride, sacral nerve stimulation, and surgery, and to highlight the controversies surrounding them. Pre- and probiotics and prucalopride are not effective in the treatment of childhood Constipation. Pelvic physiotherapy and sacral nerve stimulation are promising treatment options but larger trials are needed. Surgery for pediatric Constipation is the treatment of last resort. Large, well-designed placebo-controlled trials with proper outcome measures, as suggested by the Rome foundation pediatric subcommittee on clinical trials, are necessary to provide more insight regarding the efficacy of new treatments in childhood Constipation.
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adherence to polyethylene glycol treatment in children with Functional Constipation is associated with parental illness perceptions satisfaction with treatment and perceived treatment convenience
The Journal of Pediatrics, 2018Co-Authors: Ilan J N Koppen, Elsa A Van Wassenaer, Rinse W Barendsen, Paul L P Brand, Marc A. BenningaAbstract:Objectives To assess treatment adherence in children with Functional Constipation and to evaluate the association with parental beliefs about medication, illness perceptions, treatment satisfaction, and satisfaction with information about medication. Study design A cross-sectional survey was administered among parents of children with Functional Constipation treated with polyethylene glycol. Adherence was measured via the Medication Adherence Report Scale (MARS-5, score 5-25), with greater scores indicating better adherence (scores ≥23 were defined as adherent). Beliefs about medication, illness perceptions, satisfaction with treatment, and satisfaction with information about treatment were measured with the Beliefs about Medication Questionnaire, the Brief Illness Perception Questionnaire, the Treatment Satisfaction Questionnaire for Medication (TSQM), and the Satisfaction with Information about Medication Questionnaire. Associations between the questionnaire scores and adherence (MARS-5 score as a continuous variable) were analyzed with regression analyses. Results In total, 43 of 115 included children (37%) were adherent (MARS-5 ≥23). Spearman rank correlation test revealed a statistically significant correlation between TSQM-convenience, TSQM-satisfaction, Brief Illness Perception Questionnaire question 8 (emotions), and the MARS-5 score (rs 0.342, P = .000; rs 0.258, P = .006; rs –0.192, P = .044), which suggests that parental perceived treatment convenience, satisfaction with treatment, and illness perceptions may affect adherence in children with Functional Constipation. In the hierarchical multivariate regression model, 22% of the variability of the MARS-5 score could be explained by the selected predictors. The TSQM-convenience score contributed the most to the model (β: 0.384, P = .000). Conclusions Parents reported low adherence rates in their children with Functional Constipation. Treatment inconvenience, dissatisfaction with treatment, and the emotional impact of Functional Constipation may negatively influence treatment adherence.
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awareness and implementation of the 2014 espghan naspghan guideline for childhood Functional Constipation
Journal of Pediatric Gastroenterology and Nutrition, 2017Co-Authors: Ilan J N Koppen, Merit M Tabbers, Carlo Di Lorenzo, Mana H Vriesman, Marc A. BenningaAbstract:OBJECTIVE The aim of the study was to assess whether physicians approach children with Functional Constipation according to the 2014 European Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)/North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) guideline. METHODS We invited pediatricians and pediatric gastroenterologists in the Netherlands and the United States to participate in this anonymous survey using a self-developed questionnaire containing 19 multiple choice questions concerning evaluation and treatment of children with Constipation. RESULTS We included 328 physicians (67% from the United States, 34% from the Netherlands). The majority of US responders (53%) worked in primary care, whereas all Dutch responders worked in a hospital. In total, 31% of responders were not familiar with the guideline (38% US responders vs 16% Dutch responders, P < 0.001). Perianal inspection was frequently ("often" or "always" on a 5-point Likert scale) conducted by 78% of responders. Digital rectal examination was frequently done by 42%. Inquiry about sexual abuse was made by 18%. Commonly reported reasons for omitting these items were perceived patient or parental discomfort. Most frequently implemented initial nonpharmacological interventions included a toilet training program (89%), optimizing fluid and fiber intake (86% and 81%), a defecation diary (62%), and a reward system (60%). Polyethylene glycol was the most prescribed medication for disimpaction (68%) and maintenance treatment (57% for infants, 97% for children ≥1 year). CONCLUSIONS Many responders were not familiar with the ESPGHAN/NASPGHAN guideline for Functional Constipation. Nonetheless, therapeutic decisions correlated fairly well with recommendations from the guideline, especially for children 1 year of age or older. Guideline awareness and adherence remain to be improved. Future studies should focus on exploring strategies to improve guideline implementation through the development of digital learning tools.
Mami Itabashi - One of the best experts on this subject based on the ideXlab platform.
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dietary patterns associated with Functional Constipation among japanese women aged 18 to 20 years a cross sectional study
Journal of Nutritional Science and Vitaminology, 2007Co-Authors: Hitomi Okubo, Kentaro Murakami, Satoshi Sasaki, Yoko Hosoi, Mi Kyung Kim, Yoshiko Takahashi, Mami ItabashiAbstract:Although several nutrients and foods have been suggested to be preventive for Constipation, all previous studies have examined a single nutrient or food in each analysis. In contrast, analysis of dietary patterns may provide new insights into the influence of diet on Functional Constipation. We conducted a cross-sectional examination of the association between dietary pattern and Functional Constipation in 3,770 Japanese female dietetic course students aged 18-20 y from 53 institutions in Japan. Diet was assessed with a validated self-administered diet history questionnaire with 148 food items, from which 30 food groups were created and entered into a factor analysis. Functional Constipation was defined using the Rome I criteria, which has previously been used in several epidemiologic studies on Constipation. The prevalence of Functional Constipation was 26.0% (n=979). Four dietary patterns were identified: 1) “Healthy,” 2) “Japanese traditional,” 3) “Western,” and 4) “Coffee and dairy products.” After adjustment for several confounding factors, the “Japanese traditional” pattern, characterized by a high intake of rice, miso soup, and soy products and a low intake of bread and confectionaries, was associated with a significantly lower prevalence of Functional Constipation. In comparison with the lowest quintile, the multivariate adjusted odds ratio (95% confidence interval) was 0.52 (0.41-0.66) in the highest quintile (p for trend <0.0001). Other dietary patterns were not associated with Functional Constipation. The Japanese traditional dietary pattern, characterized by a high intake of rice and a low intake of bread and confectionaries, may be beneficial in preventing Functional Constipation in young Japanese women.
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association between dietary fiber water and magnesium intake and Functional Constipation among young japanese women
European Journal of Clinical Nutrition, 2007Co-Authors: Kentaro Murakami, Satoshi Sasaki, Hitomi Okubo, Y Takahashi, Yoko Hosoi, Mami ItabashiAbstract:Most research on Constipation has focused on dietary fiber intake. Here, we examined the intake of water and magnesium, nutrients possibly associated with Constipation, as well as that of dietary fiber in relation to Constipation. Cross-sectional study. A total of 3835 female Japanese dietetic students aged 18–20 years from 53 institutions in Japan. Dietary intake was estimated with a validated, self-administered diet history questionnaire. Functional Constipation was defined using the Rome I criteria. The prevalence of Functional Constipation was 26.2%. Neither dietary fiber intake (mean=6.4 g/4186 kJ) nor intakes of total water and water from fluids were associated with Constipation. Conversely, low intake of water from foods was associated with an increasing prevalence of Constipation. In comparison with women in the first (lowest) quintile, the multivariate adjusted odds ratio (OR) (95% confidence interval (CI)) for women in the second, third, fourth, and fifth quintiles were 0.72 (0.57, 0.90), 0.78 (0.62, 0.98), 0.71 (0.56, 0.89), and 0.77 (0.61, 0.97), respectively (P for trend=0.04). Additionally, low magnesium intake was associated with increasing prevalence of Constipation. Compared with women in the first quintile, the multivariate adjusted OR (95% CI) for women in the second, third, fourth and fifth quintiles were 0.70 (0.56, 0.88), 0.75 (0.60, 0.95), 0.73 (0.58, 0.92) and 0.79 (0.63, 0.996), respectively (P for trend=0.09). Low intakes of water from foods and magnesium are independently associated with an increasing prevalence of Functional Constipation among a population whose dietary fiber intake is relatively low.
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Association between dietary fiber, water and magnesium intake and Functional Constipation among young Japanese women.
European Journal of Clinical Nutrition, 2006Co-Authors: Kentaro Murakami, Satoshi Sasaki, Hitomi Okubo, Y Takahashi, Yoko Hosoi, Mami ItabashiAbstract:Association between dietary fiber, water and magnesium intake and Functional Constipation among young Japanese women
Kentaro Murakami - One of the best experts on this subject based on the ideXlab platform.
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dietary patterns associated with Functional Constipation among japanese women aged 18 to 20 years a cross sectional study
Journal of Nutritional Science and Vitaminology, 2007Co-Authors: Hitomi Okubo, Kentaro Murakami, Satoshi Sasaki, Yoko Hosoi, Mi Kyung Kim, Yoshiko Takahashi, Mami ItabashiAbstract:Although several nutrients and foods have been suggested to be preventive for Constipation, all previous studies have examined a single nutrient or food in each analysis. In contrast, analysis of dietary patterns may provide new insights into the influence of diet on Functional Constipation. We conducted a cross-sectional examination of the association between dietary pattern and Functional Constipation in 3,770 Japanese female dietetic course students aged 18-20 y from 53 institutions in Japan. Diet was assessed with a validated self-administered diet history questionnaire with 148 food items, from which 30 food groups were created and entered into a factor analysis. Functional Constipation was defined using the Rome I criteria, which has previously been used in several epidemiologic studies on Constipation. The prevalence of Functional Constipation was 26.0% (n=979). Four dietary patterns were identified: 1) “Healthy,” 2) “Japanese traditional,” 3) “Western,” and 4) “Coffee and dairy products.” After adjustment for several confounding factors, the “Japanese traditional” pattern, characterized by a high intake of rice, miso soup, and soy products and a low intake of bread and confectionaries, was associated with a significantly lower prevalence of Functional Constipation. In comparison with the lowest quintile, the multivariate adjusted odds ratio (95% confidence interval) was 0.52 (0.41-0.66) in the highest quintile (p for trend <0.0001). Other dietary patterns were not associated with Functional Constipation. The Japanese traditional dietary pattern, characterized by a high intake of rice and a low intake of bread and confectionaries, may be beneficial in preventing Functional Constipation in young Japanese women.
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association between dietary fiber water and magnesium intake and Functional Constipation among young japanese women
European Journal of Clinical Nutrition, 2007Co-Authors: Kentaro Murakami, Satoshi Sasaki, Hitomi Okubo, Y Takahashi, Yoko Hosoi, Mami ItabashiAbstract:Most research on Constipation has focused on dietary fiber intake. Here, we examined the intake of water and magnesium, nutrients possibly associated with Constipation, as well as that of dietary fiber in relation to Constipation. Cross-sectional study. A total of 3835 female Japanese dietetic students aged 18–20 years from 53 institutions in Japan. Dietary intake was estimated with a validated, self-administered diet history questionnaire. Functional Constipation was defined using the Rome I criteria. The prevalence of Functional Constipation was 26.2%. Neither dietary fiber intake (mean=6.4 g/4186 kJ) nor intakes of total water and water from fluids were associated with Constipation. Conversely, low intake of water from foods was associated with an increasing prevalence of Constipation. In comparison with women in the first (lowest) quintile, the multivariate adjusted odds ratio (OR) (95% confidence interval (CI)) for women in the second, third, fourth, and fifth quintiles were 0.72 (0.57, 0.90), 0.78 (0.62, 0.98), 0.71 (0.56, 0.89), and 0.77 (0.61, 0.97), respectively (P for trend=0.04). Additionally, low magnesium intake was associated with increasing prevalence of Constipation. Compared with women in the first quintile, the multivariate adjusted OR (95% CI) for women in the second, third, fourth and fifth quintiles were 0.70 (0.56, 0.88), 0.75 (0.60, 0.95), 0.73 (0.58, 0.92) and 0.79 (0.63, 0.996), respectively (P for trend=0.09). Low intakes of water from foods and magnesium are independently associated with an increasing prevalence of Functional Constipation among a population whose dietary fiber intake is relatively low.
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Association between dietary fiber, water and magnesium intake and Functional Constipation among young Japanese women.
European Journal of Clinical Nutrition, 2006Co-Authors: Kentaro Murakami, Satoshi Sasaki, Hitomi Okubo, Y Takahashi, Yoko Hosoi, Mami ItabashiAbstract:Association between dietary fiber, water and magnesium intake and Functional Constipation among young Japanese women
Yoko Hosoi - One of the best experts on this subject based on the ideXlab platform.
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dietary patterns associated with Functional Constipation among japanese women aged 18 to 20 years a cross sectional study
Journal of Nutritional Science and Vitaminology, 2007Co-Authors: Hitomi Okubo, Kentaro Murakami, Satoshi Sasaki, Yoko Hosoi, Mi Kyung Kim, Yoshiko Takahashi, Mami ItabashiAbstract:Although several nutrients and foods have been suggested to be preventive for Constipation, all previous studies have examined a single nutrient or food in each analysis. In contrast, analysis of dietary patterns may provide new insights into the influence of diet on Functional Constipation. We conducted a cross-sectional examination of the association between dietary pattern and Functional Constipation in 3,770 Japanese female dietetic course students aged 18-20 y from 53 institutions in Japan. Diet was assessed with a validated self-administered diet history questionnaire with 148 food items, from which 30 food groups were created and entered into a factor analysis. Functional Constipation was defined using the Rome I criteria, which has previously been used in several epidemiologic studies on Constipation. The prevalence of Functional Constipation was 26.0% (n=979). Four dietary patterns were identified: 1) “Healthy,” 2) “Japanese traditional,” 3) “Western,” and 4) “Coffee and dairy products.” After adjustment for several confounding factors, the “Japanese traditional” pattern, characterized by a high intake of rice, miso soup, and soy products and a low intake of bread and confectionaries, was associated with a significantly lower prevalence of Functional Constipation. In comparison with the lowest quintile, the multivariate adjusted odds ratio (95% confidence interval) was 0.52 (0.41-0.66) in the highest quintile (p for trend <0.0001). Other dietary patterns were not associated with Functional Constipation. The Japanese traditional dietary pattern, characterized by a high intake of rice and a low intake of bread and confectionaries, may be beneficial in preventing Functional Constipation in young Japanese women.
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association between dietary fiber water and magnesium intake and Functional Constipation among young japanese women
European Journal of Clinical Nutrition, 2007Co-Authors: Kentaro Murakami, Satoshi Sasaki, Hitomi Okubo, Y Takahashi, Yoko Hosoi, Mami ItabashiAbstract:Most research on Constipation has focused on dietary fiber intake. Here, we examined the intake of water and magnesium, nutrients possibly associated with Constipation, as well as that of dietary fiber in relation to Constipation. Cross-sectional study. A total of 3835 female Japanese dietetic students aged 18–20 years from 53 institutions in Japan. Dietary intake was estimated with a validated, self-administered diet history questionnaire. Functional Constipation was defined using the Rome I criteria. The prevalence of Functional Constipation was 26.2%. Neither dietary fiber intake (mean=6.4 g/4186 kJ) nor intakes of total water and water from fluids were associated with Constipation. Conversely, low intake of water from foods was associated with an increasing prevalence of Constipation. In comparison with women in the first (lowest) quintile, the multivariate adjusted odds ratio (OR) (95% confidence interval (CI)) for women in the second, third, fourth, and fifth quintiles were 0.72 (0.57, 0.90), 0.78 (0.62, 0.98), 0.71 (0.56, 0.89), and 0.77 (0.61, 0.97), respectively (P for trend=0.04). Additionally, low magnesium intake was associated with increasing prevalence of Constipation. Compared with women in the first quintile, the multivariate adjusted OR (95% CI) for women in the second, third, fourth and fifth quintiles were 0.70 (0.56, 0.88), 0.75 (0.60, 0.95), 0.73 (0.58, 0.92) and 0.79 (0.63, 0.996), respectively (P for trend=0.09). Low intakes of water from foods and magnesium are independently associated with an increasing prevalence of Functional Constipation among a population whose dietary fiber intake is relatively low.
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Association between dietary fiber, water and magnesium intake and Functional Constipation among young Japanese women.
European Journal of Clinical Nutrition, 2006Co-Authors: Kentaro Murakami, Satoshi Sasaki, Hitomi Okubo, Y Takahashi, Yoko Hosoi, Mami ItabashiAbstract:Association between dietary fiber, water and magnesium intake and Functional Constipation among young Japanese women
Satoshi Sasaki - One of the best experts on this subject based on the ideXlab platform.
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the relationship between Functional Constipation and dietary habits in school age japanese children
Journal of Nutritional Science and Vitaminology, 2019Co-Authors: Masayuki Okuda, Ichiro Kunitsugu, Norikazu Yoshitake, Satoshi SasakiAbstract:Functional Constipation negatively affects school-related quality of life for children and adolescents. We investigated the association between Functional Constipation, defined according to the Rome criteria version III, and dietary habits. The subjects of this cross-sectional study were 1,140 5th graders and 1,054 8th graders attending schools in Shunan City, Japan in 2012. Functional Constipation was defined as having two or more symptoms of Constipation. Dietary habits were assessed using a brief questionnaire. Self-reported biological, demographic and lifestyle information was obtained. Using multiple logistic models, dose-dependent associations among subgroups stratified with quintiles of nutrient and food intake were examined. The prevalence of Functional Constipation ranged from 3.7% to 8.3% across the grades. The most prevalent symptom was pain or hard stools. There was a link between higher rates of Functional Constipation and lower levels of dietary fiber intake, vegetables, and fruits (ptrend=0.010-0.030). Associations with vegetables and fruits attenuated when controlling for dietary fiber intake (ptrend=0.074-0.150). When 5th and 8th graders were separately analyzed, intake of dietary fiber, water from foods, and vegetables had beneficial effects on Functional Constipation in 8th graders (ptrend=0.005-0.038), and fruit intake had a beneficial effect in 5th graders (ptrend=0.012). Modification of dietary habits may have a positive effect in reducing Functional Constipation in school-age children. Diets rich in fiber, vegetables, and fruits, have the potential to improve Functional Constipation in Japanese children and adolescents.
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dietary patterns associated with Functional Constipation among japanese women aged 18 to 20 years a cross sectional study
Journal of Nutritional Science and Vitaminology, 2007Co-Authors: Hitomi Okubo, Kentaro Murakami, Satoshi Sasaki, Yoko Hosoi, Mi Kyung Kim, Yoshiko Takahashi, Mami ItabashiAbstract:Although several nutrients and foods have been suggested to be preventive for Constipation, all previous studies have examined a single nutrient or food in each analysis. In contrast, analysis of dietary patterns may provide new insights into the influence of diet on Functional Constipation. We conducted a cross-sectional examination of the association between dietary pattern and Functional Constipation in 3,770 Japanese female dietetic course students aged 18-20 y from 53 institutions in Japan. Diet was assessed with a validated self-administered diet history questionnaire with 148 food items, from which 30 food groups were created and entered into a factor analysis. Functional Constipation was defined using the Rome I criteria, which has previously been used in several epidemiologic studies on Constipation. The prevalence of Functional Constipation was 26.0% (n=979). Four dietary patterns were identified: 1) “Healthy,” 2) “Japanese traditional,” 3) “Western,” and 4) “Coffee and dairy products.” After adjustment for several confounding factors, the “Japanese traditional” pattern, characterized by a high intake of rice, miso soup, and soy products and a low intake of bread and confectionaries, was associated with a significantly lower prevalence of Functional Constipation. In comparison with the lowest quintile, the multivariate adjusted odds ratio (95% confidence interval) was 0.52 (0.41-0.66) in the highest quintile (p for trend <0.0001). Other dietary patterns were not associated with Functional Constipation. The Japanese traditional dietary pattern, characterized by a high intake of rice and a low intake of bread and confectionaries, may be beneficial in preventing Functional Constipation in young Japanese women.
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association between dietary fiber water and magnesium intake and Functional Constipation among young japanese women
European Journal of Clinical Nutrition, 2007Co-Authors: Kentaro Murakami, Satoshi Sasaki, Hitomi Okubo, Y Takahashi, Yoko Hosoi, Mami ItabashiAbstract:Most research on Constipation has focused on dietary fiber intake. Here, we examined the intake of water and magnesium, nutrients possibly associated with Constipation, as well as that of dietary fiber in relation to Constipation. Cross-sectional study. A total of 3835 female Japanese dietetic students aged 18–20 years from 53 institutions in Japan. Dietary intake was estimated with a validated, self-administered diet history questionnaire. Functional Constipation was defined using the Rome I criteria. The prevalence of Functional Constipation was 26.2%. Neither dietary fiber intake (mean=6.4 g/4186 kJ) nor intakes of total water and water from fluids were associated with Constipation. Conversely, low intake of water from foods was associated with an increasing prevalence of Constipation. In comparison with women in the first (lowest) quintile, the multivariate adjusted odds ratio (OR) (95% confidence interval (CI)) for women in the second, third, fourth, and fifth quintiles were 0.72 (0.57, 0.90), 0.78 (0.62, 0.98), 0.71 (0.56, 0.89), and 0.77 (0.61, 0.97), respectively (P for trend=0.04). Additionally, low magnesium intake was associated with increasing prevalence of Constipation. Compared with women in the first quintile, the multivariate adjusted OR (95% CI) for women in the second, third, fourth and fifth quintiles were 0.70 (0.56, 0.88), 0.75 (0.60, 0.95), 0.73 (0.58, 0.92) and 0.79 (0.63, 0.996), respectively (P for trend=0.09). Low intakes of water from foods and magnesium are independently associated with an increasing prevalence of Functional Constipation among a population whose dietary fiber intake is relatively low.
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Association between dietary fiber, water and magnesium intake and Functional Constipation among young Japanese women.
European Journal of Clinical Nutrition, 2006Co-Authors: Kentaro Murakami, Satoshi Sasaki, Hitomi Okubo, Y Takahashi, Yoko Hosoi, Mami ItabashiAbstract:Association between dietary fiber, water and magnesium intake and Functional Constipation among young Japanese women
