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Rik Gosselink - One of the best experts on this subject based on the ideXlab platform.
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the effects of elastic tubing based resistance training compared with conventional resistance training in patients with moderate chronic obstructive pulmonary disease a randomized clinical trial
Clinical Rehabilitation, 2014Co-Authors: Ercy Mara Cipulo Ramos, Alessandra Choqueta De Toledoarruda, Luciana Cristina Fosco, Rafaela Bonfim, Giovana Navarro Bertolini, Flavia Alessandra Guarnier, Rubens Cecchini, Carlos Marcelo Pastre, Daniel Langer, Rik GosselinkAbstract:Objective:To investigate the effects of elastic tubing training compared with conventional resistance training on the improvement of Functional Exercise capacity, muscle strength, fat-free mass, and systemic inflammation in patients with chronic obstructive pulmonary disease.Design:A prospective, randomized, eight-week clinical trial.Setting:The study was conducted in a university-based, outpatient, physical therapy clinic.Subjects:A total of 49 patients with moderate chronic obstructive pulmonary disease.Interventions:Participants were randomly assigned to perform elastic tubing training or conventional resistance training three times per week for eight weeks.Main measures:The primary outcome measure was Functional Exercise capacity. The secondary outcome measures were peripheral muscle strength, health-related quality of life assessed by the Chronic Respiratory Disease Questionnaire (CRDQ), fat-free mass, and cytokine profile.Results:After eight weeks, the mean distance covered during six minutes increa...
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early Exercise in critically ill patients enhances short term Functional recovery
Critical Care Medicine, 2009Co-Authors: Chris Burtin, Daniel Langer, Thierry Troosters, Marc Decramer, Beatrix Clerckx, Christophe Robbeets, Patrick Ferdinande, Greet Hermans, Rik GosselinkAbstract:Objectives: To investigate whether a daily Exercise session, using a bedside cycle ergometer, is a safe and effective intervention in preventing or attenuating the decrease in Functional Exercise capacity, Functional status, and quadriceps force that is associated with prolonged intensive care unit stay. A prolonged stay in the intensive care unit is associated with muscle dysfunction, which may contribute to an impaired Functional status up to 1 yr after hospital discharge. No evidence is available concerning the effectiveness of an early Exercise training intervention to prevent these detrimental complications. Design: Randomized controlled trial. Setting: Medical and surgical intensive care unit at University Hospital Gasthuisberg. Patients: Ninety critically ill patients were included as soon as their cardiorespiratory condition allowed bedside cycling Exercise (starting from day 5), given they still had an expected prolonged intensive care unit stay of at least 7 more days. Interventions: Both groups received respiratory physiotherapy and a daily standardized passive or active motion session of upper and lower limbs. In addition, the treatment group performed a passive or active Exercise training session for 20 mins/day, using a bedside ergometer. Measurements and Main Results: All outcome data are reflective for survivors. Quadriceps force and Functional status were assessed at intensive care unit discharge and hospital discharge. Six-minute walking distance was measured at hospital discharge. No adverse events were identified during and immediately after the Exercise training. At intensive care unit discharge, quadriceps force and Functional status were not different between groups. At hospital discharge, 6-min walking distance, isometric quadriceps force, and the subjective feeling of Functional well-being (as measured with “Physical Functioning” item of the Short Form 36 Health Survey questionnaire) were significantly higher in the treatment group (p < .05). Conclusions: Early Exercise training in critically ill intensive care unit survivors enhanced recovery of Functional Exercise capacity, self-perceived Functional status, and muscle force at hospital discharge. (Crit Care Med 2009; 37:000‐000)
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skeletal muscle force and Functional Exercise tolerance before and after lung transplantation a cohort study
American Journal of Transplantation, 2008Co-Authors: Gisele Maury, Daniel Langer, Rik Gosselink, Geert Verleden, Lieven Dupont, Marc Decramer, Thierry TroostersAbstract:We investigated the impact of lung transplantation and outpatient pulmonary rehabilitation after lung transplantation on skeletal muscle function and Exercise tolerance. Skeletal muscle force (Quadriceps force, QF), Exercise tolerance (six minute walking distance, 6MWD) and lung function were assessed in 36 patients before and after lung transplantation. Seventeen male and 19 female patients (age 57 +/- 4) showed skeletal muscle weakness before the transplantation. A further 32 +/- 21% reduction was seen 1.2 (interquartile range 0.9 to 2.0) months after LTX. The number of days on the intensive care unit was significantly related to the observed deterioration in muscle force after LTX. At this time point 6MWD was comparable to pre-LTX. Rehabilitation started 37 (IQR 29 to 61) days after LTX. 6MWD and QF improved significantly (140 +/- 91 m, and 35 +/- 48%, respectively; p < 0.05) with rehabilitation. QF remained below pre-LTX values. The evolution of the 6MWD with the transplantation and the subsequent rehabilitation was less in female compared to male subjects. We conclude that muscle strength deteriorates after lung transplantation, particularly in patients with long ICU stay. Outpatient pulmonary rehabilitation is feasible after lung transplantation and leads to recovery of skeletal muscle function. In female patients this recovery is significantly less compared to male recipients.
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characteristics of physical activities in daily life in chronic obstructive pulmonary disease
American Journal of Respiratory and Critical Care Medicine, 2005Co-Authors: Fabio Pitta, Thierry Troosters, Marc Decramer, Martijn A Spruit, Vanessa S Probst, Rik GosselinkAbstract:Quantification of physical activities in daily life in patients with chronic obstructive pulmonary disease has increasing clinical interest.However,detailedcomparisonwithhealthysubjectsisnotavailable.Furthermore,itisunknownwhethertimespentactivelyduring daily life is related to lung function, muscle force, or maximal and Functional Exercise capacity. We assessed physical activities and movement intensity with the DynaPort activity monitor in 50 patients (age 64 7 years; FEV1 43 18% predicted) and 25 healthy elderly individuals (age 66 5 years). Patients showed lower walking time (44 26 vs. 81 26 minutes/day), standing time (191 99 vs. 295 109 minutes/day), and movement intensity during walking (1.8 0.3 vs. 2.4 0.5 m/second 2 ;p 0.0001 for all), as well as higher sitting time (374 139 vs. 306 108 minutes/day; p 0.04) and lying time (87 97 vs. 29 33 minutes/day; p 0.004). Walking time was highly correlated with the 6-minute walking test (r 0.76, p 0.0001) and more modestly to maximal Exercise capacity, lung function, and muscle force (0.28 r 0.64, p 0.05). Patients with chronic obstructive pulmonary disease are
Ziyang Zhang - One of the best experts on this subject based on the ideXlab platform.
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hemi hamate autograft for reconstruction of the middle phalanx base
Chinese Journal of Hand Surgery, 2014Co-Authors: Dali Wang, Chengliang Deng, Ziyang ZhangAbstract:Objective To discuss the techniques and treatment outcomes of hemi-hamate autograft for reconstruction of the middle phalanx base.Methods Twelve cases of intra-articular comminuted fractures of middle phalanx base in 12 fingers were treated with transfer of hamate articular surface.Mini screws and external fixator were used to fix the pieces.Restricted Functional Exercise was carried out in the first 2 postoperative weeks.The external fixator was removed 4 to 6 weeks postoperatively dependent on fracture healing.Active joint movement was gradually increased.Results The patients were follow-up for 6 to 18 months.All the middle phalanx base fractures healed.Joint deformities were corrected.Proximal interphalangeal joint movement was satisfactory.The total range of motion of the finger was 180 °to 260 °.Based on the total active motion evaluation,the results were rated as excellent in 6 fingers,good in 3 fingers,fair in 2 fingers and poor in 1 finger.The excellent and good rate was 75％.Conclusion Hemi-hamate articular surface transfer is a good surgical procedure for treating intra-articular comminuted fractures of middle phalanx base.Early restricted Functional Exercise is beneficial to the recovery of joint function. Key words: Hamate; Phalanx; Fractures, bone; Fracture fixation
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hemi hamate autograft for reconstruction of the middle phalanx base
Chinese Journal of Hand Surgery, 2014Co-Authors: Dali Wang, Chengliang Deng, Ziyang ZhangAbstract:Objective To discuss the techniques and treatment outcomes of hemi-hamate autograft for reconstruction of the middle phalanx base.Methods Twelve cases of intra-articular comminuted fractures of middle phalanx base in 12 fingers were treated with transfer of hamate articular surface.Mini screws and external fixator were used to fix the pieces.Restricted Functional Exercise was carried out in the first 2 postoperative weeks.The external fixator was removed 4 to 6 weeks postoperatively dependent on fracture healing.Active joint movement was gradually increased.Results The patients were follow-up for 6 to 18 months.All the middle phalanx base fractures healed.Joint deformities were corrected.Proximal interphalangeal joint movement was satisfactory.The total range of motion of the finger was 180 °to 260 °.Based on the total active motion evaluation,the results were rated as excellent in 6 fingers,good in 3 fingers,fair in 2 fingers and poor in 1 finger.The excellent and good rate was 75％.Conclusion Hemi-hamate articular surface transfer is a good surgical procedure for treating intra-articular comminuted fractures of middle phalanx base.Early restricted Functional Exercise is beneficial to the recovery of joint function. Key words: Hamate; Phalanx; Fractures, bone; Fracture fixation
Ercy Mara Cipulo Ramos - One of the best experts on this subject based on the ideXlab platform.
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elastic resistance training produces benefits similar to conventional resistance training in people with chronic obstructive pulmonary disease systematic review and meta analysis
Physical Therapy, 2020Co-Authors: Fabiano Francisco De Lima, Vinicius Cavalheri, Bruna Spolador De Alencar Silva, Isis Grigoletto, Juliana Souza Uzeloto, Dionei Ramos, Carlos Augusto Camillo, Ercy Mara Cipulo RamosAbstract:OBJECTIVE The purpose of this study was to investigate the effectiveness of elastic resistance training on improving muscle strength, Functional Exercise capacity, health-related quality of life (HRQoL), and dyspnea in people with stable chronic obstructive pulmonary disease (COPD). METHODS For this systematic review, PubMed, The Cochrane Library, Embase (OVID), PEDro, SciELO, and CINAHL were searched from inception to November 2019. Included studies were randomized clinical trials in which people with stable COPD were allocated to (1) an experimental group that received lower-limb resistance training, upper-limb resistance training, or both using elastic resistance; or (2) a control group that received no or sham resistance training or conventional resistance training using weight machines. Data extraction was performed by 3 review authors. The methodological quality of the studies was assessed using the PEDro scale. Eight studies on 332 participants were included. RESULTS Knee extensor strength was higher in the experimental group (standardized mean difference = 0.52, 95% CI = 0.09-0.95) compared with the non-Exercise control group. Compared with the conventional Exercise control, the experimental group presented similar effects for muscle strength, Functional Exercise capacity, HRQoL, and dyspnea (95% CI overlapped the line of no effect for all). CONCLUSIONS Elastic resistance training improves muscle strength in people with COPD. The current review suggests elastic resistance as a potential alternative to conventional resistance training using weight machines, as they show similar effects on muscle strength, Functional Exercise capacity, HRQoL, and dyspnea. IMPACT Due to its beneficial effects, including reduced risk of exacerbation-related hospitalizations, Exercise training is viewed as the cornerstone of pulmonary rehabilitation in people with COPD. This study shows that elastic resistance training can be an effective, portable, practical, and low-cost alternative to conventional weight resistance training. LAY SUMMARY Training with elastic resistance tubes or bands-which are easy to carry, easy to use, and relatively low cost-can be an effective way to improve strength for people with COPD and promote similar benefits to those achieved with weight machines.
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the effects of elastic tubing based resistance training compared with conventional resistance training in patients with moderate chronic obstructive pulmonary disease a randomized clinical trial
Clinical Rehabilitation, 2014Co-Authors: Ercy Mara Cipulo Ramos, Alessandra Choqueta De Toledoarruda, Luciana Cristina Fosco, Rafaela Bonfim, Giovana Navarro Bertolini, Flavia Alessandra Guarnier, Rubens Cecchini, Carlos Marcelo Pastre, Daniel Langer, Rik GosselinkAbstract:Objective:To investigate the effects of elastic tubing training compared with conventional resistance training on the improvement of Functional Exercise capacity, muscle strength, fat-free mass, and systemic inflammation in patients with chronic obstructive pulmonary disease.Design:A prospective, randomized, eight-week clinical trial.Setting:The study was conducted in a university-based, outpatient, physical therapy clinic.Subjects:A total of 49 patients with moderate chronic obstructive pulmonary disease.Interventions:Participants were randomly assigned to perform elastic tubing training or conventional resistance training three times per week for eight weeks.Main measures:The primary outcome measure was Functional Exercise capacity. The secondary outcome measures were peripheral muscle strength, health-related quality of life assessed by the Chronic Respiratory Disease Questionnaire (CRDQ), fat-free mass, and cytokine profile.Results:After eight weeks, the mean distance covered during six minutes increa...
Hilary J Vernon - One of the best experts on this subject based on the ideXlab platform.
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Functional Exercise capacity strength balance and motion reaction time in barth syndrome
Orphanet Journal of Rare Diseases, 2019Co-Authors: Brittany Hornby, Rebecca Mcclellan, Hilary J Vernon, Lucy Buckley, Kimberley Carson, Tiffany GoodingAbstract:Barth syndrome (BTHS) is an X-linked disorder caused by defects in TAZ with key clinical features including cardiomyopathy, neutropenia and skeletal myopathy. In order to gain a better understanding of the range of clinical features, identify targets for monitoring, and increase knowledge of natural history of the disease, we conducted muscle strength testing, Functional Exercise capacity testing, physical activity assessment, balance assessment and motion reaction time testing in 33 affected individuals and 14 controls. We analyzed data points to provide a cross-sectional quantitative spectrum of disease characteristics. We also compared these data points to the matched data points collected two years prior to provide insight into effects of BTHS over time. In comparison to controls, pediatric subjects with BTHS present with significantly impaired balance and motion reaction time while adult subjects with BTHS present with significantly impaired motion reaction time. In comparison to controls, subjects with BTHS presented with decreased Functional Exercise capacity (assessed via 6 MWT), knee extensor strength (both assessed via handheld dynamometry and five times sit-to-stand (5 TSTS)), and self-reported physical activity. Comparison of Functional Exercise capacity, knee extensor strength and self-reported physical activity from identical cohorts in 2014 and 2016 BTHS showed that the deficits in 6 MWT do not change significantly over the 2 year time span. In this comprehensive assessment of musculoskeletal parameters in a cross-section of individuals with BTHS, we uncovered deficits in motion reaction time and balance, which were previously not known to be abnormal in in BTHS. We also confirmed results of our previous study showing that pediatric and adult subjects with BTHS have decreased Functional Exercise capacity, knee extensor strength, and physical activity in comparison to controls, r, verifying the importance of including these measures as part of the regular clinical assessment in individuals with BTHS, as well as introducing 5 TSTS as an additional testing parameter. Perhaps most importantly, we demonstrated that 6 MWT results do not significantly vary in pediatric and adult cohorts with BTHS over a 2-year period, supporting this as a reliable quantitative measure of therapeutic outcomes in clinical studies and for clinical monitoring.
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Functional Exercise capacity, strength, balance and motion reaction time in Barth syndrome
BMC, 2019Co-Authors: Brittany Hornby, Rebecca Mcclellan, Lucy Buckley, Kimberley Carson, Tiffany Gooding, Hilary J VernonAbstract:Abstract Background Barth syndrome (BTHS) is an X-linked disorder caused by defects in TAZ with key clinical features including cardiomyopathy, neutropenia and skeletal myopathy. In order to gain a better understanding of the range of clinical features, identify targets for monitoring, and increase knowledge of natural history of the disease, we conducted muscle strength testing, Functional Exercise capacity testing, physical activity assessment, balance assessment and motion reaction time testing in 33 affected individuals and 14 controls. We analyzed data points to provide a cross-sectional quantitative spectrum of disease characteristics. We also compared these data points to the matched data points collected two years prior to provide insight into effects of BTHS over time. Results In comparison to controls, pediatric subjects with BTHS present with significantly impaired balance and motion reaction time while adult subjects with BTHS present with significantly impaired motion reaction time. In comparison to controls, subjects with BTHS presented with decreased Functional Exercise capacity (assessed via 6 MWT), knee extensor strength (both assessed via handheld dynamometry and five times sit-to-stand (5 TSTS)), and self-reported physical activity. Comparison of Functional Exercise capacity, knee extensor strength and self-reported physical activity from identical cohorts in 2014 and 2016 BTHS showed that the deficits in 6 MWT do not change significantly over the 2 year time span. Conclusion In this comprehensive assessment of musculoskeletal parameters in a cross-section of individuals with BTHS, we uncovered deficits in motion reaction time and balance, which were previously not known to be abnormal in in BTHS. We also confirmed results of our previous study showing that pediatric and adult subjects with BTHS have decreased Functional Exercise capacity, knee extensor strength, and physical activity in comparison to controls, r, verifying the importance of including these measures as part of the regular clinical assessment in individuals with BTHS, as well as introducing 5 TSTS as an additional testing parameter. Perhaps most importantly, we demonstrated that 6 MWT results do not significantly vary in pediatric and adult cohorts with BTHS over a 2-year period, supporting this as a reliable quantitative measure of therapeutic outcomes in clinical studies and for clinical monitoring
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new targets for monitoring and therapy in barth syndrome
Genetics in Medicine, 2016Co-Authors: Reid W Thompson, Brittany Decroes, Rebecca Mcclellan, Jessica Rubens, Frederic M Vaz, Kara Kristaponis, Dimitrios Avramopoulos, Hilary J VernonAbstract:Barth syndrome (BTHS), an X-linked disorder caused by defects in TAZ, is the only known single-gene disorder of cardiolipin remodeling. We hypothesized that through analysis of affected individuals, we would gain a better understanding of the range of clinical features and identify targets for monitoring and therapy. We conducted a multidisciplinary investigation involving 42 patients with BTHS, including echocardiograms, muscle strength testing, Functional Exercise capacity testing, physical activity assessments, cardiolipin analysis, 3-methylglutaconic acid analysis, and review of genotype data. We analyzed data points to provide a quantitative spectrum of disease characteristics and to identify relationships among phenotype, genotype, and relevant metabolites. Echocardiography revealed considerable variability in cardiac features. By contrast, almost all patients had significantly reduced Functional Exercise capacity. Multivariate analysis revealed significant relationships between cardiolipin ratio and left ventricular mass and between cardiolipin ratio and Functional Exercise capacity. We additionally identified genotypes associated with a less severe metabolic and clinical profile. We defined previously unrecognized metabolite/phenotype/genotype relationships, established targets for therapeutic monitoring, and validated avenues for clinical assessment. In addition to providing insight into BTHS, these studies also provide insight into the myriad of multifactorial disorders that converge on the cardiolipin pathway. Genet Med 18 10, 1001–1010.
Jennifer A Alison - One of the best experts on this subject based on the ideXlab platform.
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Functional Exercise capacity and health related quality of life in people with asbestos related pleural disease an observational study
BMC Pulmonary Medicine, 2013Co-Authors: Marita T Dale, Zoe J Mckeough, Phillip A Munoz, Peter Corte, Peter T P Bye, Jennifer A AlisonAbstract:Functional Exercise capacity in people with asbestos related pleural disease (ARPD) is unknown and there are no data on health-related quality of life (HRQoL). The primary aims were to determine whether Functional Exercise capacity and HRQoL were reduced in people with ARPD. The secondary aim was to determine whether Functional Exercise capacity was related to peak Exercise capacity, HRQoL, physical activity or respiratory function. In participants with ARPD, Exercise capacity was measured by the six-minute walk test (6MWT) and incremental cycle test (ICT); HRQoL by the St George’s Respiratory Questionnaire and physical activity by an activity monitor worn for one week. Participants also underwent lung function testing. 25 males completed the study with a mean (SD) age of 71 (6) years, FVC 82 (19)% predicted, FEV1/FVC 66 (11)%, TLC 80 (19)% predicted and DLCO 59 (13)% predicted. Participants had reduced Exercise capacity demonstrated by six-minute walk distance (6MWD) of 76 (11)% predicted and peak work rate of 71 (21)% predicted. HRQoL was also reduced. The 6MWD correlated with peak work rate (r=0.58, p=0.002), St George’s Respiratory Questionnaire Total score (r=-0.57, p=0.003), metabolic equivalents from the activity monitor (r=0.45, p<0.05), and FVC % predicted (r=0.52, p<0.01). People with ARPD have reduced Exercise capacity and HRQoL. The 6MWT may be a useful surrogate measure of peak Exercise capacity and physical activity levels in the absence of cardiopulmonary Exercise testing and activity monitors. ANZCTR12608000147381
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ground walk training improves Functional Exercise capacity more than cycle training in people with chronic obstructive pulmonary disease copd a randomised trial
Journal of Physiotherapy, 2010Co-Authors: Regina Leung, Zoe J Mckeough, Jennifer A Alison, Matthew J PetersAbstract:Questions Does an eight-week program of walk training improve endurance walking capacity in people with COPD compared to cycle training? Does walk training improve peak walking capacity, cycle capacity, and quality of life compared to cycle training? Is the endurance shuttle walk test (ESWT) responsive to change in walking capacity elicited by Exercise training? Design Randomised trial with concealed allocation, assessor blinding, and intention-to-treat analysis. Participants 36 people with stable COPD recruited with four dropouts. Intervention Participants were randomised into either a walk or cycle training group. Both groups trained indoors for 30 to 45 minutes per session, three times weekly over eight weeks at Concord Hospital. Training intensities were based on baseline peak Exercise tests and progressed as able. Outcome measures The primary outcome was endurance walking capacity measured by the ESWT. Secondary outcomes included peak walking capacity, peak and endurance cycle capacity, and health-related quality of life. Measures were taken at baseline (Week 0) and following training (Week 8). Results The walk training group increased their endurance walking time by 279 seconds (95% CI 70 to 483) more than the cycle training group. No significant differences between the groups were found for any other outcome. Conclusion Ground walk training increased endurance walking capacity more than cycle training and was similar to cycle training in improving peak walking capacity, peak and endurance cycle capacity and quality of life. This study provides evidence for ground walking as a mode of Exercise training in pulmonary rehabilitation programs. Trial registration ACTRN12608000126314.
