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Niels E Skakkebaek - One of the best experts on this subject based on the ideXlab platform.
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serum <B>InhiBinB> B and follicle stimulating hormone levels as tools in the evaluation of infertile men significance of adequate reference values from proven fertile men
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Annamaria Andersson, Jorgen Holm Petersen, Tina Kold Jensen, Niels Jorgensen, Niels E SkakkebaekAbstract:<B>InhiBinB> B and FSH levels in 289 idiopathic infertile men were compared with reference materials consisting of 303 proven fertile men (reference group 1) and 307 healthy men from the general population with unknown fertility status (reference group 2). The diagnostic power of these two serum markers of spermatogenesis was evaluated By the use of receiver operating characteristic plot analysis, and an example of how Both markers can Be used simultaneously in a Bivariate reference chart is presented. <B>InhiBinB> B levels were significantly lower and FSH levels were significantly higher in the infertile men, compared with either reference group, But with significant overlap, especially with reference group 2. Nevertheless, approximately 50% of the infertile men had an <B>InhiBinB> B or FSH, respectively, Below the 2.5 percentile or aBove the 97.5 percentile of reference group 1, whereas only approximately 25% of the infertile men had an <B>InhiBinB> B or FSH, respectively, Below the 2.5 percentile or aBove the 97.5 percentile of reference group 2. Fourteen and 11% of reference group 2 had an <B>InhiBinB> B or FSH, respectively, Below the 2.5 percentile or aBove the 97.5 percentile of reference group 1, suggesting that a significant numBer of individuals from the general population with unknown fertility But otherwise healthy may actually Be suBfertile. In conclusion, 1) proven fertile men constitute the most appropriate reference group in the evaluation of the FSH-<B>InhiBinB> B axis; the sensitivity of these markers to identify infertility increased By approximately 20% when fertile men rather than men from the general population were used as control group; 2) FSH alone had a slightly higher positive predictive value than <B>InhiBinB> B alone, But the positive predictive value were highest when Both markers of spermatogenesis were used in an <B>InhiBinB> B/FSH ratio; and 3) a Bivariate reference chart is a valuaBle oBjective tool in the simultaneous evaluation of FSH and <B>InhiBinB> B as two interrelated markers.
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serum <B>InhiBinB> B and follicle stimulating hormone levels as tools in the evaluation of infertile men significance of adequate reference values from proven fertile men
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Annamaria Andersson, Jorgen Holm Petersen, Tina Kold Jensen, Niels Jorgensen, Niels E SkakkebaekAbstract:<B>InhiBinB> B and FSH levels in 289 idiopathic infertile men were compared with reference materials consisting of 303 proven fertile men (reference group 1) and 307 healthy men from the general population with unknown fertility status (reference group 2). The diagnostic power of these two serum markers of spermatogenesis was evaluated By the use of receiver operating characteristic plot analysis, and an example of how Both markers can Be used simultaneously in a Bivariate reference chart is presented. <B>InhiBinB> B levels were significantly lower and FSH levels were significantly higher in the infertile men, compared with either reference group, But with significant overlap, especially with reference group 2. Nevertheless, approximately 50% of the infertile men had an <B>InhiBinB> B or FSH, respectively, Below the 2.5 percentile or aBove the 97.5 percentile of reference group 1, whereas only approximately 25% of the infertile men had an <B>InhiBinB> B or FSH, respectively, Below the 2.5 percentile or aBove the 97.5 percent...
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Longitudinal Studies of <B>InhiBinB> B Levels in Boys and Young Adults with Klinefelter Syndrome
The Journal of clinical endocrinology and metabolism, 2003Co-Authors: Peter Christiansen, Annamaria Andersson, Niels E SkakkebaekAbstract:The aim of the study was to investigate the longitudinal changes of <B>InhiBinB> B in a group of patients with Klinefelter syndrome (KS; karyotype 47,XXY) progressing through puBerty and to compare them to a group of age- and puBerty-matched controls. Seven Boys with nonmosaic KS (karyotype 47,XXY) and 11 controls were followed with longitudinal serum <B>InhiBinB> B measurements every 3-12 months as they approached and entered puBerty. None of the Boys had significant Bone age delay, and all entered puBerty at the normal time and progressed through it at the expected time. In addition, 15 young adults with KS, aged 16.7-29.5 yr, were studied. We found normal levels of <B>InhiBinB> B in prepuBertal Boys with KS and controls. In patients with KS as well as controls, <B>InhiBinB> B increased progressively Before clinical puBertal onset. However, during late puBerty <B>InhiBinB> B levels decreased gradually to the low/unmeasuraBle levels oBserved later in adult KS, while remaining unchanged in the controls.
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serum <B>InhiBinB> a and <B>InhiBinB> B in central precocious puBerty Before and during treatment with gnrh agonists
Hormone Research in Paediatrics, 2000Co-Authors: Astrid Sehested, Annamaria Andersson, Jorn Muller, Niels E SkakkebaekAbstract:Serum levels of the gonadal hormones <B>InhiBinB> A and <B>InhiBinB> B are undetectaBle or low in prepuBertal girls, and rise during puBerty. In girls with central precocious puBerty (CPP) the hypothalamic-pituitary-gonadal axis is prematurely activated, if the girl is thereafter treated with GnRH agonists Both gonadotropins and estradiol levels Become suppressed. We therefore investigated serum levels of <B>InhiBinB> A and <B>InhiBinB> B in girls with CPP at diagnosis and during treatment in order to test the hypothesis that <B>InhiBinB> secretion would increase and decrease in parallel with the activation and suppression of the hypothalamic-pituitary-gonadal axis. Serum levels of <B>InhiBinB> A and <B>InhiBinB> B were significantly (p
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diurnal rhythm in serum levels of <B>InhiBinB> B in normal men relation to testicular steroids and gonadotropins
The Journal of Clinical Endocrinology and Metabolism, 1999Co-Authors: Elisabeth Carlsen, Jorgen Holm Petersen, Annamaria Andersson, Claus Olsson, Niels E SkakkebaekAbstract:<B>InhiBinB> B is a testicular glycoprotein that is secreted from the Sertoli cells and Believed to play a role in FSH secretion. We characterized the diurnal profile of serum <B>InhiBinB> B and the relation to gonadotropins and testicular steroids. Serum <B>InhiBinB> B was measured in 13 healthy normal male volunteers (median age, 30 yr) By continuous Blood drawing, with sampling every 30 min for 24 h. Blood samples were also analyzed for FSH, LH, testosterone, estradiol, and sex hormone-Binding gloBulin. We found a significant diurnal variation in <B>InhiBinB> B, with peak values in the early morning and nadirs in the late afternoon, followed By gradual increasing nocturnal values. An average decline of 3%/h from 0900 until 1700 h was calculated. Significant cross-correlation was found Between <B>InhiBinB> B and testosterone as well as estradiol, whereas no cross-correlation was found Between <B>InhiBinB> B and FSH. Two-dimensional time-series analyses revealed a statistically significant influence of testosterone on <B>InhiBinB> B. In addition, estradiol and <B>InhiBinB> B had a significant influence on one another. In conclusion, we found a significant diurnal variation in <B>InhiBinB> B levels in normal men, with a pattern of higher values in the early morning hours and lower values in the late afternoon and evening. We did not find evidence for a role of FSH in this diurnal variation of <B>InhiBinB> B. However, covariation with serum levels of testosterone and estradiol suggested that these hormones might play a role in the diurnal rhythm of <B>InhiBinB> B, although some other common influence could not Be excluded.
Annamaria Andersson - One of the best experts on this subject based on the ideXlab platform.
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serum <B>InhiBinB> B in fertile men is strongly correlated with low But not high sperm counts a coordinated study of 1 797 european and us men
Fertility and Sterility, 2010Co-Authors: Niels Jorgensen, Annamaria Andersson, Tina Kold Jensen, Fan Liu, Matti Vierula, Stewart D Irvine, Jacques Auger, Charlene Brazil, Erma Z Drobnis, Pierre JouannetAbstract:OBjective To descriBe associations Between serum <B>InhiBinB>-B and sperm counts, adjusted for effect of time of Blood sampling, in larger cohorts than have Been previously reported. Design Cross-sectional studies of spermatogenesis markers. Setting Four European and four US centers. Patient(s) Fertile men (1,797) were included and examined from OctoBer 1996–FeBruary 2005. Intervention(s) The study was oBservational and therefore without any intervention. Main Outcome Measure(s) Associations Between <B>InhiBinB>-B and semen variaBles controlled for time of Blood sampling and other covariates. Result(s) <B>InhiBinB>-B decreased aBout 2.00% per hour from 8 am–12 pm and then aBout 3.25% per hour from 12 pm–4 pm. There was a strong positive association Between <B>InhiBinB>-B levels less than 150 pg/mL and Both sperm concentration and total sperm count (slopes of the regression lines were β = 0.011 and β = 0.013 for natural logarithm-transformed sperm concentration and total sperm count, respectively). For <B>InhiBinB>-B levels of 150–300 pg/mL the associations were not as steep (β = 0.002), But still significant. For <B>InhiBinB>-B levels more than 300 pg/mL there was little association to the sperm counts. Neither sperm motility nor morphology was significantly related to <B>InhiBinB>-B level in any group. Conclusion(s) Serum <B>InhiBinB>-B levels decrease nonlinearly during the daytime, and are positively correlated with sperm counts, But the predictive power is Best when <B>InhiBinB>-B is low.
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serum <B>InhiBinB> B and follicle stimulating hormone levels as tools in the evaluation of infertile men significance of adequate reference values from proven fertile men
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Annamaria Andersson, Jorgen Holm Petersen, Tina Kold Jensen, Niels Jorgensen, Niels E SkakkebaekAbstract:<B>InhiBinB> B and FSH levels in 289 idiopathic infertile men were compared with reference materials consisting of 303 proven fertile men (reference group 1) and 307 healthy men from the general population with unknown fertility status (reference group 2). The diagnostic power of these two serum markers of spermatogenesis was evaluated By the use of receiver operating characteristic plot analysis, and an example of how Both markers can Be used simultaneously in a Bivariate reference chart is presented. <B>InhiBinB> B levels were significantly lower and FSH levels were significantly higher in the infertile men, compared with either reference group, But with significant overlap, especially with reference group 2. Nevertheless, approximately 50% of the infertile men had an <B>InhiBinB> B or FSH, respectively, Below the 2.5 percentile or aBove the 97.5 percentile of reference group 1, whereas only approximately 25% of the infertile men had an <B>InhiBinB> B or FSH, respectively, Below the 2.5 percentile or aBove the 97.5 percentile of reference group 2. Fourteen and 11% of reference group 2 had an <B>InhiBinB> B or FSH, respectively, Below the 2.5 percentile or aBove the 97.5 percentile of reference group 1, suggesting that a significant numBer of individuals from the general population with unknown fertility But otherwise healthy may actually Be suBfertile. In conclusion, 1) proven fertile men constitute the most appropriate reference group in the evaluation of the FSH-<B>InhiBinB> B axis; the sensitivity of these markers to identify infertility increased By approximately 20% when fertile men rather than men from the general population were used as control group; 2) FSH alone had a slightly higher positive predictive value than <B>InhiBinB> B alone, But the positive predictive value were highest when Both markers of spermatogenesis were used in an <B>InhiBinB> B/FSH ratio; and 3) a Bivariate reference chart is a valuaBle oBjective tool in the simultaneous evaluation of FSH and <B>InhiBinB> B as two interrelated markers.
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serum <B>InhiBinB> B and follicle stimulating hormone levels as tools in the evaluation of infertile men significance of adequate reference values from proven fertile men
The Journal of Clinical Endocrinology and Metabolism, 2004Co-Authors: Annamaria Andersson, Jorgen Holm Petersen, Tina Kold Jensen, Niels Jorgensen, Niels E SkakkebaekAbstract:<B>InhiBinB> B and FSH levels in 289 idiopathic infertile men were compared with reference materials consisting of 303 proven fertile men (reference group 1) and 307 healthy men from the general population with unknown fertility status (reference group 2). The diagnostic power of these two serum markers of spermatogenesis was evaluated By the use of receiver operating characteristic plot analysis, and an example of how Both markers can Be used simultaneously in a Bivariate reference chart is presented. <B>InhiBinB> B levels were significantly lower and FSH levels were significantly higher in the infertile men, compared with either reference group, But with significant overlap, especially with reference group 2. Nevertheless, approximately 50% of the infertile men had an <B>InhiBinB> B or FSH, respectively, Below the 2.5 percentile or aBove the 97.5 percentile of reference group 1, whereas only approximately 25% of the infertile men had an <B>InhiBinB> B or FSH, respectively, Below the 2.5 percentile or aBove the 97.5 percent...
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Longitudinal Studies of <B>InhiBinB> B Levels in Boys and Young Adults with Klinefelter Syndrome
The Journal of clinical endocrinology and metabolism, 2003Co-Authors: Peter Christiansen, Annamaria Andersson, Niels E SkakkebaekAbstract:The aim of the study was to investigate the longitudinal changes of <B>InhiBinB> B in a group of patients with Klinefelter syndrome (KS; karyotype 47,XXY) progressing through puBerty and to compare them to a group of age- and puBerty-matched controls. Seven Boys with nonmosaic KS (karyotype 47,XXY) and 11 controls were followed with longitudinal serum <B>InhiBinB> B measurements every 3-12 months as they approached and entered puBerty. None of the Boys had significant Bone age delay, and all entered puBerty at the normal time and progressed through it at the expected time. In addition, 15 young adults with KS, aged 16.7-29.5 yr, were studied. We found normal levels of <B>InhiBinB> B in prepuBertal Boys with KS and controls. In patients with KS as well as controls, <B>InhiBinB> B increased progressively Before clinical puBertal onset. However, during late puBerty <B>InhiBinB> B levels decreased gradually to the low/unmeasuraBle levels oBserved later in adult KS, while remaining unchanged in the controls.
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serum <B>InhiBinB> a and <B>InhiBinB> B in central precocious puBerty Before and during treatment with gnrh agonists
Hormone Research in Paediatrics, 2000Co-Authors: Astrid Sehested, Annamaria Andersson, Jorn Muller, Niels E SkakkebaekAbstract:Serum levels of the gonadal hormones <B>InhiBinB> A and <B>InhiBinB> B are undetectaBle or low in prepuBertal girls, and rise during puBerty. In girls with central precocious puBerty (CPP) the hypothalamic-pituitary-gonadal axis is prematurely activated, if the girl is thereafter treated with GnRH agonists Both gonadotropins and estradiol levels Become suppressed. We therefore investigated serum levels of <B>InhiBinB> A and <B>InhiBinB> B in girls with CPP at diagnosis and during treatment in order to test the hypothesis that <B>InhiBinB> secretion would increase and decrease in parallel with the activation and suppression of the hypothalamic-pituitary-gonadal axis. Serum levels of <B>InhiBinB> A and <B>InhiBinB> B were significantly (p
Janet E Hall - One of the best experts on this subject based on the ideXlab platform.
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serum <B>InhiBinB> B in polycystic ovary syndrome regulation By insulin and luteinizing hormone
The Journal of Clinical Endocrinology and Metabolism, 2002Co-Authors: Corrine K Welt, Ann E Taylor, Kathryn A Martin, Janet E HallAbstract:<B>InhiBinB> B is a product of the granulosa cells of growing preantral and antral follicles. Despite the large ovarian volume and increased follicle numBer typically detected in women with polycystic ovary syndrome (PCOS), previous studies demonstrate that <B>InhiBinB> B is not elevated as would Be expected in PCOS, But is inversely correlated with Body mass index (BMI). We therefore hypothesized that <B>InhiBinB> B levels in women with PCOS are regulated By a factor related to BMI. Thus, LH, sex steroids, and metaBolic parameters were measured in 50 anovulatory PCOS suBjects in pools constituted from equal aliquots of serum drawn every 10 min for 4 h and were correlated with <B>InhiBinB> B. Based on the results of these correlative studies, <B>InhiBinB> B regulation By human chorionic gonadotropin (hCG) and insulin was tested directly. In PCOS suBjects, <B>InhiBinB> B correlated inversely with BMI (r = -0.413; P < 0.004) and fasting insulin (r = -0.409; P < 0.004). <B>InhiBinB> B also correlated directly with pool LH (r = 0.419; P < 0.003), LH pulse amplitude (r = 0.512; P < 0.0001), and SHBG (r = 0.429; P < 0.003). The relationships demonstrated for <B>InhiBinB> B were not demonstrated for <B>InhiBinB> A, nor were they evident in normal suBjects. To determine whether the correlations represent regulation of <B>InhiBinB> B, i.e. stimulation of <B>InhiBinB> B By LH or suppression By insulin, two interventional studies were performed. In the first study hCG (5000 U) was administered to PCOS suBjects (n = 15) to mimic the effects of LH. <B>InhiBinB> B was not increased, But was significantly reduced 24 h after hCG administration (223.8 +/- 21.3 vs. 152.4 +/- 15.9 pg/ml; P < 0.0005). In the second study, diazoxide (100 mg every 8 h) was administered for 3 d to PCOS suBjects (n = 9). <B>InhiBinB> B increased (85.4 +/- 12.4 to 136.6 +/- 18.8 pg/ml; P < 0.05) in association with a decrease in the insulin area under the curve (104 +/- 29 to 83 +/- 22 nmol/liter.min; P < 0.05) induced By diazoxide. In PCOS suBjects, <B>InhiBinB> B demonstrated significant relationships with BMI and factors related to BMI, including LH, insulin, and SHBG. Although LH was associated with <B>InhiBinB> B, hCG administration suppressed <B>InhiBinB> B secretion after 24 h, whereas short-term insulin suppression increased <B>InhiBinB> B. These findings suggest that Both increased LH and insulin may account for the relative suppression of <B>InhiBinB> B in patients with PCOS.
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Differential regulation of <B>InhiBinB> A and <B>InhiBinB> B By luteinizing hormone, follicle-stimulating hormone, and stage of follicle development.
The Journal of Clinical Endocrinology and Metabolism, 2001Co-Authors: Corrine K Welt, Zachary A. Smith, Donna K. Pauler, Janet E HallAbstract:<B>InhiBinB> B and <B>InhiBinB> A exhiBit unique patterns of secretion across the follicular phase of the menstrual cycle. To test the hypothesis that the distinct patterns of <B>InhiBinB> B and <B>InhiBinB> A secretion result from differential regulation By LH and FSH, a series of controlled experiments was designed to dissect the specific effects of LH and FSH at distinct stages of follicle development. After GnRH agonist desensitization, women with small antral follicles were treated with recomBinant human LH (rhLH), rhFSH, or rhFSH and estradiol (E(2)). rhLH or rhFSH was also administered when follicles reached the preovulatory stage in gonadotropin-stimulated or spontaneous cycles. At the small antral stage of development, rhFSH, But not rhLH, administration increased <B>InhiBinB> B (17.4 +/- 4.6 to 321.0 +/- 97.0 pg/mL; P < 0.05), <B>InhiBinB> A (0.6 +/- 0.1 to 2.6 +/- 0.6 IU/mL; P < 0.05), and E(2) [15.8 +/- 3.6 to 95.3 +/- 26.9 pg/mL (58.0 +/- 13.2 to 349.8 +/- 98.7 pmol/L); P < 0.05]. The <B>InhiBinB> B increase preceded <B>InhiBinB> A By 48 h. Addition of E(2) to FSH resulted in a greater increase in <B>InhiBinB> B (23.2 +/- 6.4 to 865.2 +/- 294.5 pg/mL; P < 0.05) than FSH alone (P < 0.05). At the preovulatory stage, rhLH administration increased <B>InhiBinB> A (15.9 +/- 10.3 to 21.5 +/- 13.7 IU/mL; P < 0.05) and E(2) [669.4 +/- 285.5 to 943.6 +/- 388.1 pg/mL (2457.4 +/- 1048.1 to 3464.0 +/- 1424.7 pmol/L); P < 0.05], But not <B>InhiBinB> B, as did rhFSH administration in spontaneous cycles [E(2): 226.4 +/- 102.7 to 264.7 +/- 121.0 pg/mL (831.1 +/- 377.0 to 971.7 +/- 444.2 pmol/L); P < 0.05; <B>InhiBinB> A: 2.6 +/- 1.3 to 3.7 +/- 1.9 IU/mL; P < 0.05; and <B>InhiBinB> B: 76.3 +/- 32.2 to 77.6 +/- 32.8 pg/mL; P = NS]. These findings suggest that increases in Both FSH and E(2) in the early follicular phase result in increased <B>InhiBinB> B secretion at early stages of follicle development, whereas the selective LH rise in the late follicular phase favors <B>InhiBinB> A secretion from more mature follicles. Thus, Both differential secretion of LH and FSH and the stage of follicle development determine the patterns of <B>InhiBinB> A and <B>InhiBinB> B secretion in the normal menstrual cycle.
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<B>InhiBinB> a and <B>InhiBinB> B reflect ovarian function in assisted reproduction But are less useful at predicting outcome
Human Reproduction, 1999Co-Authors: Janet E Hall, Corrine K Weltand, Daniel W CramerAbstract:To test the hypothesis that dimeric <B>InhiBinB> A and/or <B>InhiBinB> B concentrations represent improved markers of in-vitro fertilization (IVF) outcome over follicle stimulating hormone (FSH), 78 women who achieved pregnancy within three assisted reproduction treatment cycles were matched to 78 women who underwent at least three assisted reproductive treatment cycles and failed to achieve pregnancy. Baseline serum <B>InhiBinB> B and FSH were oBtained Between days 1 and 4 in a cycle prior to ovarian stimulation, and <B>InhiBinB> A and B were measured immediately Before the ovulatory stimulus and in follicular fluid from the lead follicle. Comparing pregnant and non-pregnant suBjects at Baseline, younger age (34.0 ± 0.5 versus 36.0 ± 0.5 years; P < 0.003) and a comBination of FSH lower than the median value (11.2 IU/l) and <B>InhiBinB> B higher than the median value (76.5 pg/ml) were associated with pregnancy (P < 0.03), But FSH (11.7 ± 0.5 versus 12.9 ± 0.9 IU/ml) and <B>InhiBinB> B (89.0 ± 10.2 versus 79.7 ± 7.7 pg/ml) were not independently associated. At the time of the ovulatory stimulus, serum <B>InhiBinB> A (52.8 ± 3.8 versus 40.0 ± 2.7 IU/ml; P < 0.004), <B>InhiBinB> B (1623.8 ± 165.1 versus 859.2 ± 94.8 pg/ml; P < 0.0009) and the numBer of oocytes retrieved (14.6 ± 0.8 versus 10.1 ± 0.6; P < 0.0001) were predictive of pregnancy when controlled for age. <B>InhiBinB> A was correlated with the numBer of emBryos (r = 0.4; P < 0.0001). However, neither <B>InhiBinB> A nor <B>InhiBinB> B provided additional information in predicting successful outcome over age and numBer of oocytes. We conclude that: (i) in patients undergoing assisted reproductive technology, age and numBer of oocytes retrieved are the strongest predictors of success; (ii) of the parameters availaBle prior to cycle initiation, a comBination of lower FSH and higher <B>InhiBinB> B was associated with a greater chance for a successful outcome But an aBsolute cut-off could not Be defined; and (iii) during ovarian stimulation, higher concentrations of <B>InhiBinB> A and <B>InhiBinB> B in serum are associated with successful IVF and mark ovarian reserve as a measure of oocyte numBer and quality.
William F Crowley - One of the best experts on this subject based on the ideXlab platform.
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relative roles of <B>InhiBinB> B and sex steroids in the negative feedBack regulation of follicle stimulating hormone in men across the full spectrum of seminiferous epithelium function
The Journal of Clinical Endocrinology and Metabolism, 2008Co-Authors: Paul A Boepple, Frances J Hayes, Andrew A Dwyer, Taneli Raivio, Hang Lee, William F Crowley, Nelly PitteloudAbstract:Context and OBjective: Our aim was to explore the relative roles of gonadal sex steroids and <B>InhiBinB> B in the regulation of FSH across a spectrum of seminiferous epithelium function. SuBjects: The study included three groups: group I, healthy men (n = 31); group II, men with idiopathic hypogonadotropic hypogonadism receiving pulsatile GnRH (n = 12) selected to represent a spectrum of seminiferous tuBular development, testicular size, and Baseline <B>InhiBinB> B levels; and group III, men with functional anorchia (n = 3) receiving testosterone replacement. Design: SuBjects were studied Before and after 3 d of acute sex steroid withdrawal. Setting: The study was conducted at the Mallinckrodt General Clinical Research Center of Massachusetts General Hospital. Interventions: Acute Biochemical castration was achieved using high-dose ketoconazole (groups I and II) or withdrawal of androgen therapy (group III). Main Outcome Measures: The relationship Between FSH and <B>InhiBinB> B in Both normal and castrate sex steroid milieu was measured. Results: In Both normal and castrate sex steroid milieus, there was a negative relationship Between <B>InhiBinB> B and FSH, Best descriBed By a logarithmic model. Acute Biochemical castration resulted in the most dramatic increases in FSH in men with the lowest Baseline <B>InhiBinB> B levels. Conclusions: We came to the following conclusions: 1) in the human male, <B>InhiBinB> B is the principal gonadal feedBack regulator of FSH secretion unless seminiferous tuBular function is severely compromised, and a logarithmic model Best descriBes this relationship; and 2) sex steroid inhiBition of FSH secretion is most apparent when serum <B>InhiBinB> B levels fall well Below the normal range.
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<B>InhiBinB> B in males with gonadotropin releasing hormone gnrh deficiency changes in serum concentration after shortterm physiologic gnrh replacement a clinical research center study
The Journal of Clinical Endocrinology and Metabolism, 1996Co-Authors: Stephanie B Seminara, Paul A Boepple, Lisa B Nachtigall, Francois P Pralong, R H Khoury, Patrick M Sluss, A E Lecain, William F CrowleyAbstract:To examine the role of <B>InhiBinB> B in the feedBack regulation of FSH secretion in the human male, we determined serial levels in 18 men with idiopathic hypogonadotropic hypogonadism (IHH) during their initial 8 weeks of GnRH replacement. Pulsatile GnRH was administered every 2 h, with the dose increased at 2-week intervals (5-50 ng/kg/Bolus). Every 2 weeks, sera were assayed for <B>InhiBinB> B, FSH, LH, and testosterone. Serial comparisons were performed within the IHH group as well as vs. normal men (n = 20). The Baseline <B>InhiBinB> B level in IHH patients averaged 68 +/- 11 pg/mL (mean +/- SEM), significantly less than that in normal men (239 +/- 14 pg/mL; P < 0.001). After 8 weeks of pulsatile GnRH, <B>InhiBinB> B levels in the IHH patients increased significantly to 118 +/- 14 pg/mL (P = 0.003). During GnRH replacement, FSH concentrations correlated negatively with <B>InhiBinB> B concentrations at all doses. Patients previously treated with testosterone Began with somewhat lower <B>InhiBinB> B levels But demonstrated a signif...
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<B>InhiBinB> B secretion in males with gonadotropin releasing hormone gnrh deficiency Before and during long term gnrh replacement relationship to spontaneous puBerty testicular volume and prior treatment a clinical research center study
The Journal of Clinical Endocrinology and Metabolism, 1996Co-Authors: Lisa B Nachtigall, Paul A Boepple, Stephanie B Seminara, R H Khoury, Patrick M Sluss, A E Lecain, William F CrowleyAbstract:To evaluate the physiology of <B>InhiBinB> B in the human male, we measured serum concentrations in normal adult men and men with isolated GnRH deficiency Before and during long-term replacement with pulsatile GnRH. At Baseline, <B>InhiBinB> B levels in the GnRH-deficient men (n = 31) were significantly lower than normal controls (85 +/- 10 pg/mL vs. 239 +/- 14 pg/mL; P or = 60 pg/mL). Increases in serum concentrations of <B>InhiBinB> B occurring during GnRH replacement demonstrate the gonadotropin regulation of gonadal <B>InhiBinB> B secretion. However, the variation in Baseline <B>InhiBinB> B levels Before GnRH administration suggests an additional gonadotropin-independent level of modulation. The negative correlation Between FSH and <B>InhiBinB> B secretion in GnRH-deficient men receiving long-term GnRH replacement is consistent with a putative role of <B>InhiBinB> B in the negative feedBack regulation of FSH, although direct confirmation of this role requires further investigation.
Juan A Vanrell - One of the best experts on this subject based on the ideXlab platform.
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day 3 serum <B>InhiBinB> B and fsh and age as predictors of assisted reproduction treatment outcome
Human Reproduction, 2000Co-Authors: Montserrat Creus, Francisco Fabregues, Juan A Vanrell, Joana Penarrubia, Ester Vidal, Francisco Carmona, Roser Casamitjana, Juan BalaschAbstract:Recent reports investigating the value of Basal <B>InhiBinB> B determination as a predictor of ovarian reserve and assisted reproduction treatment have led to discordant results. This study was undertaken to further assess the relative power of day 3 <B>InhiBinB> B and follicle stimulating hormone (FSH) (defined Before treatment) and the woman's age Both as single and comBined predictors of ovarian response and pregnancy in an in-vitro fertilization (IVF)/intracyto-plasmic sperm injection (ICSI) programme. A total of 120 women undergoing their first cycle of IVF or ICSI was included. Forty consecutive cycles cancelled Because of poor follicular response were initially selected. As a control group, the nearest completed IVF/ICSI cycles Before and after each cancelled cycle (i.e. the closest cycles in temporal relationship to the index cycle) were used. Mean age and Basal FSH concentrations were significantly higher in the cancelled than in the control group (P < 0.01 and P < 0.001 respectively), whereas Basal <B>InhiBinB> B was significantly higher in the latter (P < 0.05). The association of Basal FSH (with an accuracy or predictive value of ovarian response of 79%) with cancellation rate was significant, independent of, and stronger than the effects of age and <B>InhiBinB> B (P < 0.05). Any two or all three of these variaBles studied did not improve the predictive value of FSH alone. Woman's age was the only variaBle independently associated with pregnancy rate. It is concluded that the stronger predictors of success in patients undergoing their first IVF/ICSI treatment cycle are age and Basal FSH rather than <B>InhiBinB> B. Basal FSH concentration was a Better predictor of cancellation rate than age, But age was a stronger predictor of pregnancy rate.
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serum <B>InhiBinB> B determination is predictive of successful testicular sperm extraction in men with non oBstructive azoospermia
Human Reproduction, 2000Co-Authors: Jose Luis Ballesca, Juan Balasch, Josep M Calafell, Ricardo Alvarez, Francisco Fabregues, Ma Jesus Martinez De Osaba, Carlos Ascaso, Juan A VanrellAbstract:Recent work indicates that serum <B>InhiBinB> B is a useful marker of spermatogenesis and <B>InhiBinB> B production sufficient to maintain detectaBle serum concentrations in adults depends on spermatogenic activity. The purpose of the present study was to investigate the usefulness of serum <B>InhiBinB> B measurement to predict the success of testicular sperm extraction (TESE) in 17 men with nonoBstructive azoospermia to Be treated By intracytoplasmic sperm injection (ICSI) (group 1). Two additional groups were used as positive controls; group 2 comprised 22 infertile men having oBstructive azoospermia, and group 3, which included 29 semen donors having normal seminal parameters. Follicle stimulating hormone (FSH) was significantly higher (P 40 pg/ml (sensitivity 90%, specificity 100%). It is concluded that <B>InhiBinB> B measurement is a useful non-invasive predictor of spermatogenesis and thus, all azoospermic males should have serum <B>InhiBinB> B concentrations determined in addition to FSH measurement and karyotyping prior to undergoing TESE.
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day 5 <B>InhiBinB> B serum concentrations as predictors of assisted reproductive technology outcome in cycles stimulated with gonadotrophin releasing hormone agonist gonadotrophin treatment
Human Reproduction, 2000Co-Authors: Joana Penarrubia, Juan Balasch, Josep M Calafell, Francisco Fabregues, Francisco Carmona, Roser Casamitjana, Vicenta Moreno, Juan A VanrellAbstract:The present study investigates the usefulness of <B>InhiBinB> A, <B>InhiBinB> B and serum oestradiol concentrations oBtained in the fifth day of gonadotrophin therapy in predicting ovarian response and assisted reproductive treatment outcome in women undergoing ovarian stimulation under pituitary desensitization. A total of 80 women undergoing their first cycle of in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment were studied. Twenty consecutive cycles which were cancelled Because of a poor follicular response were initially selected. As a control group, 60 women were randomly selected from our assisted reproductive treatment programme matching By race, age, Body mass index, and indication for IVF/ICSI to those in the cancelled group. For each cancelled cycle, three IVF/ ICSI women who met the matching criteria were included. Basal follicle stimulating hormone (FSH) concentrations were significantly higher in the cancelled than in the control group, whereas Basal <B>InhiBinB> B was significantly higher in the latter. Basal oestradiol concentrations were similar in Both groups of patients. On day 5 of gonadotrophin therapy serum concentrations of oestradiol, <B>InhiBinB> A and <B>InhiBinB> B were significantly lower in the cancelled group as compared with controls. Logistic regression analysis showed that the association for day 5 <B>InhiBinB> B (with a predictive value of ovarian response of 91.03%) with cancellation rate was significant, independent of, and stronger than, the effects of any other hormone variaBle investigated. In addition, day 5 <B>InhiBinB> B concentrations were correlated directly with parameters of ovarian response, ovum retrieval and oocyte and fertilization outcome. However, day 5 <B>InhiBinB> B was not a Better predictor of pregnancy than the other hormone variaBles studied on this day. It is concluded that <B>InhiBinB> B concentrations oBtained early in the follicular phase during ovarian stimulation under pituitary suppression for assisted reproductive treatment are highly predictive of ovarian response.