The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Shunji Natori - One of the best experts on this subject based on the ideXlab platform.
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Molecules participating in Insect Immunity of Sarcophaga peregrina
Proceedings of the Japan Academy. Series B Physical and biological sciences, 2010Co-Authors: Shunji NatoriAbstract:Pricking the body wall of Sarcophaga peregrina (flesh fly) larvae with a needle activated the immune system of this Insect and induced various immune molecules, including antibacterial proteins, in the hemolymph. In this review, I summarize and discuss the functions of these immune molecules, with particular emphasis on the dual roles of some of these molecules in defense and development.(Communicated by Takao SEKIYA, M.J.A.)
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Molecules participating in Insect Immunity of Sarcophaga peregrina
Proceedings of the Japan Academy. Series B Physical and biological sciences, 2010Co-Authors: Shunji NatoriAbstract:Pricking the body wall of Sarcophaga peregrina (flesh fly) larvae with a needle activated the immune system of this Insect and induced various immune molecules, including antibacterial proteins, in the hemolymph. In this review, I summarize and discuss the functions of these immune molecules, with particular emphasis on the dual roles of some of these molecules in defense and development.(Communicated by Takao SEKIYA, M.J.A.)
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Molecules participating in Insect Immunity of Sarcophaga peregrina
Proceedings of the Japan Academy. Series B Physical and biological sciences, 2010Co-Authors: Shunji NatoriAbstract:Pricking the body wall of Sarcophaga peregrina (flesh fly) larvae with a needle activated the immune system of this Insect and induced various immune molecules, including antibacterial proteins, in the hemolymph. In this review, I summarize and discuss the functions of these immune molecules, with particular emphasis on the dual roles of some of these molecules in defense and development.
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a newly established in vitro culture using transgenic drosophila reveals functional coupling between the phospholipase a2 generated fatty acid cascade and lipopolysaccharide dependent activation of the immune deficiency imd pathway in Insect Immunity
Biochemical Journal, 2003Co-Authors: Masashi Yajima, Masatoshi Takada, Shunji Natori, Haruhisa Kikuchi, Nahoko Takahashi, Yoshiteru Oshima, Shoichiro KurataAbstract:Innate Immunity is the first line of defence against infectious micro-organisms, and the basic mechanisms of pathogen recognition and response activation are evolutionarily conserved. In mammals, the innate immune response in combination with antigen-specific recognition is required for the activation of adaptive Immunity. Therefore, innate Immunity is a pharmaceutical target for the development of immune regulators. Here, for the purpose of pharmaceutical screening, we established an in vitro culture based on the innate immune response of Drosophila. The in vitro system is capable of measuring lipopolysaccharide (LPS)-dependent activation of the immune deficiency (imd) pathway, which is similar to the tumour necrosis factor signalling pathway in mammals. Screening revealed that well-known inhibitors of phospholipase A(2) (PLA(2)), dexamethasone (Dex) and p-bromophenacyl bromide (BPB) inhibit LPS-dependent activation of the imd pathway. The inhibitory effects of Dex and BPB were suppressed by the addition of an excess of three (arachidonic acid, eicosapentaenoic acid and gamma-linolenic acid) of the fatty acids so far tested. Arachidonic acid, however, did not activate the imd pathway when used as the sole agonist. These findings indicate that PLA(2) participates in LPS-dependent activation of the imd pathway via the generation of arachidonic acid and other mediators, but requires additional signalling from LPS stimulation. Moreover, PLA(2) was activated in response to bacterial infection in Sarcophaga. These results suggest a functional link between the PLA(2)-generated fatty acid cascade and the LPS-stimulated imd pathway in Insect Immunity.
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Purification and Characterization of N-β-Alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine, a Novel Antibacterial Substance of Sarcophaga peregrina (Flesh Fly)
The Journal of biological chemistry, 1996Co-Authors: Jae Yoon Leem, Shoichiro Kurata, Chiaki Nishimura, Ichio Shimada, Ayako Kobayashi, Shunji NatoriAbstract:Abstract We purified a novel antibacterial substance from immunized adult Sarcophaga and determined its molecular structure to be N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S-GAD). We synthesized 5-S-GAD enzymatically from N-β-alanyl-3,4-dihydroxyphenylalanine (β-Ala-Dopa) and reduced glutathione (GSH). The antibacterial activity of 5-S-GAD was found to be due to its production of H2O2. This is a novel antibacterial mechanism as it differs from the mechanisms of known antibacterial peptides. Two possible roles of 5-S-GAD in Insect Immunity, suppression of bacterial growth and activation of a Rel family transcription factor, are proposed.
Bruno Lemaitre - One of the best experts on this subject based on the ideXlab platform.
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Insect Immunity from pattern recognition to symbiont mediated host defense
Cell Host & Microbe, 2009Co-Authors: David P Welchman, Frank Jiggins, Serap Aksoy, Bruno LemaitreAbstract:The Jacques Monod conference "Insect Immunity in Action: From Fundamental Mechanisms of Host Defense to Resistance Against Infections in Nature," organized by Ulrich Theopold (Stockholm University, Sweden) and Dominique Ferrandon (CNRS, France), was held in May 2009 in Aussois, France. Here, we review key topics and concepts that were presented and highlight emerging trends in the field of Insect Immunity.
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Insect Immunity the post genomic era
Immunity, 2006Co-Authors: Jenny Bangham, Frank Jiggins, Bruno LemaitreAbstract:Summary Insects have a complex and effective immune system, many components of which are conserved in mammals. But only in the last decade have the molecular mechanisms that regulate the Insect immune response—and their relevance to general biology and human immunology—become fully appreciated. A meeting supported by the Centre National de la Recherche Scientifique (France) was held to bring together the whole spectrum of researchers working on Insect Immunity. The meeting addressed diverse aspects of Insect Immunity and brought together geneticists working on Drosophila melanogaster with those working on other Insects.
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Insect Immunity: the post-genomic era.
Immunity, 2006Co-Authors: Jenny Bangham, Frank Jiggins, Bruno LemaitreAbstract:Insects have a complex and effective immune system, many components of which are conserved in mammals. But only in the last decade have the molecular mechanisms that regulate the Insect immune response--and their relevance to general biology and human immunology--become fully appreciated. A meeting supported by the Centre National de la R?erche Scientifique (France) was held to bring together the whole spectrum of researchers working on Insect Immunity. The meeting addressed diverse aspects of Insect Immunity and brought together geneticists working on Drosophila melanogaster with those working on other Insects.
Frank Jiggins - One of the best experts on this subject based on the ideXlab platform.
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Insect Immunity from pattern recognition to symbiont mediated host defense
Cell Host & Microbe, 2009Co-Authors: David P Welchman, Frank Jiggins, Serap Aksoy, Bruno LemaitreAbstract:The Jacques Monod conference "Insect Immunity in Action: From Fundamental Mechanisms of Host Defense to Resistance Against Infections in Nature," organized by Ulrich Theopold (Stockholm University, Sweden) and Dominique Ferrandon (CNRS, France), was held in May 2009 in Aussois, France. Here, we review key topics and concepts that were presented and highlight emerging trends in the field of Insect Immunity.
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Insect Immunity the post genomic era
Immunity, 2006Co-Authors: Jenny Bangham, Frank Jiggins, Bruno LemaitreAbstract:Summary Insects have a complex and effective immune system, many components of which are conserved in mammals. But only in the last decade have the molecular mechanisms that regulate the Insect immune response—and their relevance to general biology and human immunology—become fully appreciated. A meeting supported by the Centre National de la Recherche Scientifique (France) was held to bring together the whole spectrum of researchers working on Insect Immunity. The meeting addressed diverse aspects of Insect Immunity and brought together geneticists working on Drosophila melanogaster with those working on other Insects.
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Insect Immunity: the post-genomic era.
Immunity, 2006Co-Authors: Jenny Bangham, Frank Jiggins, Bruno LemaitreAbstract:Insects have a complex and effective immune system, many components of which are conserved in mammals. But only in the last decade have the molecular mechanisms that regulate the Insect immune response--and their relevance to general biology and human immunology--become fully appreciated. A meeting supported by the Centre National de la R?erche Scientifique (France) was held to bring together the whole spectrum of researchers working on Insect Immunity. The meeting addressed diverse aspects of Insect Immunity and brought together geneticists working on Drosophila melanogaster with those working on other Insects.
Jenny Bangham - One of the best experts on this subject based on the ideXlab platform.
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Insect Immunity the post genomic era
Immunity, 2006Co-Authors: Jenny Bangham, Frank Jiggins, Bruno LemaitreAbstract:Summary Insects have a complex and effective immune system, many components of which are conserved in mammals. But only in the last decade have the molecular mechanisms that regulate the Insect immune response—and their relevance to general biology and human immunology—become fully appreciated. A meeting supported by the Centre National de la Recherche Scientifique (France) was held to bring together the whole spectrum of researchers working on Insect Immunity. The meeting addressed diverse aspects of Insect Immunity and brought together geneticists working on Drosophila melanogaster with those working on other Insects.
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Insect Immunity: the post-genomic era.
Immunity, 2006Co-Authors: Jenny Bangham, Frank Jiggins, Bruno LemaitreAbstract:Insects have a complex and effective immune system, many components of which are conserved in mammals. But only in the last decade have the molecular mechanisms that regulate the Insect immune response--and their relevance to general biology and human immunology--become fully appreciated. A meeting supported by the Centre National de la R?erche Scientifique (France) was held to bring together the whole spectrum of researchers working on Insect Immunity. The meeting addressed diverse aspects of Insect Immunity and brought together geneticists working on Drosophila melanogaster with those working on other Insects.
Louis Lambrechts - One of the best experts on this subject based on the ideXlab platform.
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Taking Insect Immunity to the Single-Cell Level.
Trends in immunology, 2020Co-Authors: Sarah H. Merkling, Louis LambrechtsAbstract:For decades, Insect immunology has contributed groundbreaking discoveries on the intricacies of innate Immunity. These discoveries have profoundly impacted our understanding of innate immunology in mammalian systems and improved human therapeutic interventions, from the composition of vaccines to cell-based immune therapies. Current knowledge of Insect Immunity mainly encompasses detailed molecular mechanisms and systemic responses to pathogen infection. However, the organs and specific cell populations involved in immune responses remain elusive. Here, we highlight the need for a better understanding of Insect immune responses at the level of organs and cell populations. Not only will it improve our current understanding of tissue- or cell-specific immune processes across species, but it will also pave the way for spatial modeling of within-host infection dynamics.