The Experts below are selected from a list of 1773 Experts worldwide ranked by ideXlab platform
Brian G. R. Neville - One of the best experts on this subject based on the ideXlab platform.
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The surgical treatment of Landau‐Kleffner Syndrome
Epilepsia, 2009Co-Authors: J. Helen Cross, Brian G. R. NevilleAbstract:The medical management of Landau-Kleffner Syndrome is usually effective for seizure control and eventual seizure remission. However, the response for language and behavior is often poor. Surgery, in the form of multiple subpial transections (MSTs) to include Wernicke's area has been suggested as a way forward if electrophysiologic lateralization can be demonstrated. Surgical series in the literature are few and outcome from surgery variable.
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The surgical treatment of Landau-Kleffner Syndrome.
Epilepsia, 2009Co-Authors: J. Helen Cross, Brian G. R. NevilleAbstract:The medical management of Landau-Kleffner Syndrome is usually effective for seizure control and eventual seizure remission. However, the response for language and behavior is often poor. Surgery, in the form of multiple subpial transections (MSTs) to include Wernicke's area has been suggested as a way forward if electrophysiologic lateralization can be demonstrated. Surgical series in the literature are few and outcome from surgery variable.
Jutta Gärtner - One of the best experts on this subject based on the ideXlab platform.
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perisylvian polymicrogyria in Landau Kleffner Syndrome
Neurology, 2005Co-Authors: Peter Huppke, Kai Kallenberg, Jutta GärtnerAbstract:In 1957, Landau and Kleffner described six children with a Syndrome of acquired aphasia occurring between the second and eighth years of life.1 In the majority of cases, clinical seizures of various types occur. The EEG shows temporal or parieto-occipital multifocal spikes or spike waves with a potentiation during sleep. The epilepsy in Landau–Kleffner Syndrome (LKS) usually has a good prognosis; however, in a large subgroup, language disturbances remain.2 A now 7-year-old boy was born at term after an uneventful pregnancy. His parents are nonconsanguineous, and there is no family history of epilepsy, speech retardation, or hearing problems. His motor development was normal. He walked at 12 months and now, at age 7, has well developed fine motor skills. His speech development was normal until age 2½. He spoke his first words at 12 months and two-word sentences at age 2 years. At age 2½, dysarthria was first noted, but at that stage, …
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Perisylvian polymicrogyria in Landau–Kleffner Syndrome
Neurology, 2005Co-Authors: Peter Huppke, Kai Kallenberg, Jutta GärtnerAbstract:In 1957, Landau and Kleffner described six children with a Syndrome of acquired aphasia occurring between the second and eighth years of life.1 In the majority of cases, clinical seizures of various types occur. The EEG shows temporal or parieto-occipital multifocal spikes or spike waves with a potentiation during sleep. The epilepsy in Landau–Kleffner Syndrome (LKS) usually has a good prognosis; however, in a large subgroup, language disturbances remain.2 A now 7-year-old boy was born at term after an uneventful pregnancy. His parents are nonconsanguineous, and there is no family history of epilepsy, speech retardation, or hearing problems. His motor development was normal. He walked at 12 months and now, at age 7, has well developed fine motor skills. His speech development was normal until age 2½. He spoke his first words at 12 months and two-word sentences at age 2 years. At age 2½, dysarthria was first noted, but at that stage, …
J Gordon Millichap - One of the best experts on this subject based on the ideXlab platform.
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Prognosis of Landau-Kleffner Syndrome
Pediatric Neurology Briefs, 2009Co-Authors: J Gordon MillichapAbstract:The long-term follow-up of seven patients with Landau-Kleffner Syndrome (LKS) is reported from State University of Campinas, Brazil.
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Levetiracetam in Landau-Kleffner Syndrome
Pediatric Neurology Briefs, 2003Co-Authors: J Gordon MillichapAbstract:A 5-year-old girl with seizures and progressive language deterioration and a diagnosis of Landau-Kleffner Syndrome was benefited by treatment with levetiracetam at Johns Hopkins Hospital, Baltimore, MD.
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Subpial Resection for Landau-Kleffner Syndrome
Pediatric Neurology Briefs, 1999Co-Authors: J Gordon MillichapAbstract:Speech and language outcome of 14 children treated for Landau-Kleffner Syndrome by multiple subpial transection was evaluated at Rush-Prebyterian-St Luke’s Medical Center, Chicago.
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Landau-Kleffner Syndrome: IV g-Globulin Response
Pediatric Neurology Briefs, 1997Co-Authors: J Gordon MillichapAbstract:An 8-year-old girl with Landau-Kleffner Syndrome failed to respond to antiepileptic drugs and steroids but showed clinical and EEG improvement after intravenous g-globulin therapies at the American University of Beirut School of Medicine, Lebanon.
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SPECT and EEG in Landau-Kleffner Syndrome
Pediatric Neurology Briefs, 1996Co-Authors: J Gordon MillichapAbstract:Five right-handed children with Landau-Kleffner Syndrome (LKS) were studied with EEG and single-photon emission computed tomography (SPECT) before and after 6 months of corticosteroid therapy at the Universities of Estadual de Campinas and Sao Paulo, Brasil.
J. Helen Cross - One of the best experts on this subject based on the ideXlab platform.
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The surgical treatment of Landau‐Kleffner Syndrome
Epilepsia, 2009Co-Authors: J. Helen Cross, Brian G. R. NevilleAbstract:The medical management of Landau-Kleffner Syndrome is usually effective for seizure control and eventual seizure remission. However, the response for language and behavior is often poor. Surgery, in the form of multiple subpial transections (MSTs) to include Wernicke's area has been suggested as a way forward if electrophysiologic lateralization can be demonstrated. Surgical series in the literature are few and outcome from surgery variable.
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The surgical treatment of Landau-Kleffner Syndrome.
Epilepsia, 2009Co-Authors: J. Helen Cross, Brian G. R. NevilleAbstract:The medical management of Landau-Kleffner Syndrome is usually effective for seizure control and eventual seizure remission. However, the response for language and behavior is often poor. Surgery, in the form of multiple subpial transections (MSTs) to include Wernicke's area has been suggested as a way forward if electrophysiologic lateralization can be demonstrated. Surgical series in the literature are few and outcome from surgery variable.
Joann B Hoeppner - One of the best experts on this subject based on the ideXlab platform.
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language outcome following multiple subpial transection for Landau Kleffner Syndrome
Brain, 1999Co-Authors: Christopher L Grote, Patricia Van Slyke, Joann B HoeppnerAbstract:Landau-Kleffner Syndrome is an acquired epileptic aphasia occurring in normal children who lose previously acquired speech and language abilities. Although some children recover some of these abilities, many children with Landau-Kleffner Syndrome have significant language impairments that persist. Multiple subpial transection is a surgical technique that has been proposed as an appropriate treatment for Landau-Kleffner Syndrome in that it is designed to eliminate the capacity of cortical tissue to generate seizures or subclinical epileptiform activity, while preserving the cortical functions subserved by that tissue. We report on the speech and language outcome of 14 children who underwent multiple subpial transection for treatment of Landau-Kleffner Syndrome. Eleven children demonstrated significant postoperative improvement on measures of receptive or expressive vocabulary. Results indicate that early diagnosis and treatment optimize outcome, and that gains in language function are most likely to be seen years, rather than months, after surgery. Since an appropriate control group was not available, and that the best predictor of postoperative improvements in language function was that of length of time since surgery, these data might best be used as a benchmark against other Landau-Kleffner Syndrome outcome studies. We conclude that multiple subpial transection may be useful in allowing for a restoration of speech and language abilities in children diagnosed with Landau-Kleffner Syndrome.
