The Experts below are selected from a list of 63 Experts worldwide ranked by ideXlab platform
Hajime Hoshi - One of the best experts on this subject based on the ideXlab platform.
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ontogeny of the antigen reactive Lymph Follicle forming capacity of the popliteal Lymph node in neonatal mice
Histology and Histopathology, 2005Co-Authors: Masaki Hiramoto, Shin Aizawa, Kaeko Horie, Hidetsugu Nagata, Hajime HoshiAbstract:Summary. The ontogenetic development of the reactive Lymph Follicle-forming capacity of the popliteal Lymph node was investigated immunohistochemically in young mice which had received a single injection of hemocyanin (KLH) in a rear footpad at a predetermined age (between 1 and 21 days). The mice were sacrificed at various intervals after injection. In non-stimulated young mice, primary Lymph Follicles first appeared in the popliteal node at 11 days of age. When KLH was given to 7-day-old or older mice, each draining popliteal node showed a marked increase in B Lymphocytes in the extrafollicular zone 3 days after injection and produced a number of ‘new’ Lymph Follicles outside the pre-existing Follicles over the next few days. In mice injected at 2-4 days of age, these nodes showed an increase in B Lymphocytes in the outer cortex and had produced several Lymph Follicles by 8 days of age. The number of Lymph Follicles produced by each node tended to increase in line with age at injection. These results indicate that neonatal popliteal nodes become able to produce Lymph Follicles in response to exogenous antigens some time before ontogenetically developing Follicles appear. The formation of new Lymph Follicles observed in draining popliteal nodes after KLH injection at an early postnatal age is discussed in relation to the ontogenetic development of stromal cells (precursors of follicular dendritic cells) that are capable of interacting with B Lymphocytes and the extent of B Lymphocyte influx into the node induced by KLH stimulation.
Masaki Hiramoto - One of the best experts on this subject based on the ideXlab platform.
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ontogeny of the antigen reactive Lymph Follicle forming capacity of the popliteal Lymph node in neonatal mice
Histology and Histopathology, 2005Co-Authors: Masaki Hiramoto, Shin Aizawa, Kaeko Horie, Hidetsugu Nagata, Hajime HoshiAbstract:Summary. The ontogenetic development of the reactive Lymph Follicle-forming capacity of the popliteal Lymph node was investigated immunohistochemically in young mice which had received a single injection of hemocyanin (KLH) in a rear footpad at a predetermined age (between 1 and 21 days). The mice were sacrificed at various intervals after injection. In non-stimulated young mice, primary Lymph Follicles first appeared in the popliteal node at 11 days of age. When KLH was given to 7-day-old or older mice, each draining popliteal node showed a marked increase in B Lymphocytes in the extrafollicular zone 3 days after injection and produced a number of ‘new’ Lymph Follicles outside the pre-existing Follicles over the next few days. In mice injected at 2-4 days of age, these nodes showed an increase in B Lymphocytes in the outer cortex and had produced several Lymph Follicles by 8 days of age. The number of Lymph Follicles produced by each node tended to increase in line with age at injection. These results indicate that neonatal popliteal nodes become able to produce Lymph Follicles in response to exogenous antigens some time before ontogenetically developing Follicles appear. The formation of new Lymph Follicles observed in draining popliteal nodes after KLH injection at an early postnatal age is discussed in relation to the ontogenetic development of stromal cells (precursors of follicular dendritic cells) that are capable of interacting with B Lymphocytes and the extent of B Lymphocyte influx into the node induced by KLH stimulation.
Osamu Masamune - One of the best experts on this subject based on the ideXlab platform.
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Microbiology of the intestinal Lymph Follicle: a clue to elucidate causative microbial agent(s) in Crohn's disease
Medical hypotheses, 1998Co-Authors: M Chiba, Masafumi Komatsu, Masahiro Iizuka, Osamu Masamune, S. Hoshina, M. KongAbstract:It has been suggested that microbial agent(s) are involved in the onset of Crohn's disease. None of the candidates, however, has been unequivocally demonstrated to be a causative agent. The macroscopically earliest lesion takes place in the Lymph Follicle, irrespective of the initial attack or relapse in Crohn's disease. Human leucocyte antigen-DR (HLA-DR) antigens are expressed on the epithelium around the Lymph Follicle even in areas endoscopically uninvolved in Crohn's disease. These observations make the Lymph Follicle critical in the onset of Crohn's disease. The Lymph Follicle is a port of entry of a variety of microbial agent(s), leading to the speculation that microbial agent(s) exist in the Lymph Follicle. Polymerase chain reaction (PCR) using universal primers designed from conserved regions of bacterial ribosomal RNA or techniques such as representational difference analysis, may well identify microbial agent(s) in the Lymph Follicle that are specific to Crohn's disease. The existence of bacteria in the Lymph Follicle is here indicated by preliminary studies.
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IgG subclass-containing cells around the Lymph Follicle in the human intestine
Gastroenterologia Japonica, 1992Co-Authors: Masahiro Iizuka, Mitsuro Chiba, Nobuaki Ishii, Osamu MasamuneAbstract:The authors previously reported the ring-like distribution of IgG-containing cells around the Lymph Follicle in both the small and large intestine. In the present study, the distribution of IgG subclasscontaining cells around the Lymph Follicle was examined in both the small and large intestine, including Peyer’s patches, by the indirect immunoperoxidase staining method. A ring-like distribution of IgG subclass-containing cells was observed in 14 out of 21 Lymph Follicles including 4 Peyer’s patches (66.7%) in the terminal ileum, and 4 out of 7 (57.1%) in the large intestine. The percentages of IgG1-, IgG2-, IgG3-, and IgG4- containing cells around the Lymph Follicle in the terminal ileum were 27.6±11.6%, 51.9±15.4%, 16.5±10.2%, and 4.0±3.1%, respectively, and those in the large intestine were 22.9±15.4%, 47.4±14.9%, 11.2±4.1%, and 18.5±7.7%, respectively. Thus, among the IgG subclasses, IgG2-containing cells showed the most frequent ring-like distribution around the Lymph Follicle. The IgG2 predominance around the Lymph Follicle in the intestine was markedly different from reported IgGl predominance in the lamina propria in the large intestine. This difference in IgG subclass distribution may suggest different origins of the IgG subclass-containing cells in the lamina propria and in areas around the Lymph Follicle.
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Crohn's disease associated with diffuse Lymphoid hyperplasia of the large intestine: a possible role of the Lymph Follicle in HLA-DR antigen expression on epithelium.
Internal medicine (Tokyo Japan), 1992Co-Authors: Mitsuro Chiba, Masahiro Iizuka, Nobuaki Ishii, Osamu MasamuneAbstract:A 14-year-old girl diagnosed as Crohn's disease had Lymphoid hyperplasia throughout the large bowel. Biopsy specimens from the Lymphoid hyperplasia demonstrated non-caseous granulomas within the Lymph Follicles. An immuno-histochemical study of biopsy specimens showed that HLA-DR antigens were expressed on epithelium close to the Lymph Follicle, which was observed in all specimens containing the Lymph Follicle. This case provides evidence for the importance of the Lymph Follicle in the etiopathogenesis of Crohn's disease by demonstration of non-caseous granulomas within the Lymph Follicle and expression of HLA-DR antigens on epithelium close to the Lymph Follicle.(Internal Medicine 31 : 1271-1276, 1992)
Takashi Satoh - One of the best experts on this subject based on the ideXlab platform.
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expression of mucosal addressin cell adhesion molecule 1 on the reticular framework between white pulp and the marginal zone in the human spleen
Journal of Clinical and Experimental Hematopathology, 2019Co-Authors: Takashi Satoh, Hiroki Oikawa, Akiko Yashimaabo, Masao Nishiya, Tomoyuki MasudaAbstract:The antigenic heterogeneity of the reticular framework of the white pulp and marginal zone is well documented in the human adult spleen. Immunostaining of α-smooth muscle actin characterizes the heterogeneity of the reticular framework of the white pulp and marginal zone. In the human spleen, the blood cells flow in an open circulation. T and B Lymphocytes flow out from the arterial terminal, and migrate in the reticular framework. Homing of Lymphocytes to Lymphoid tissues is regulated by selective interactions between cell surface homing receptors and tissue vascular addressins at sites of Lymphocyte recruitment from the blood. In the present study, mucosal addressin cell adhesion molecule-1 was selectively expressed on α-smooth muscle actin-positive reticular framework. The reticular framework may function in Lymphocyte homing and segregation into the periarteriolar Lymphoid sheath, Lymph Follicle and marginal zone.
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Immunohistochemical observation of recovery of the periarteriolar Lymphoid sheath, Lymph Follicle and marginal zone in the 60Co-irradiated spleen of rats.
Acta pathologica japonica, 1991Co-Authors: Takashi SatohAbstract:After 60Co irradiation of rat spleen, the most severe damage was found initially in the Lymph Follicles (LFs); Lymphocytes were decreased in number in the periarteriolar Lymphoid sheath (PALS), and almost completely depleted in the marginal zone (MZ). Recovery was observed first in the PALS, followed by the LFs, and finally the MZ. From the results of immunohistochemistry, the process of recovery was assumed to involve migration of T and B Lymphocytes along the arterioles from the area surrounding the terminal arteriole at the end of the PALS into the central part of the PALS and into the LF. Peripheral blood lgM+, IgD− B Lymphocytes, known to be MZ precursor cells, flowed from the follicular artery to settle in the MZ. Furthermore, recovery of the PALS prior to the LFs was suggested to be essential for Lymphocyte migration to the LFs. Acta Pathol Jpn 41: 581-589, 1991.
Shin Aizawa - One of the best experts on this subject based on the ideXlab platform.
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ontogeny of the antigen reactive Lymph Follicle forming capacity of the popliteal Lymph node in neonatal mice
Histology and Histopathology, 2005Co-Authors: Masaki Hiramoto, Shin Aizawa, Kaeko Horie, Hidetsugu Nagata, Hajime HoshiAbstract:Summary. The ontogenetic development of the reactive Lymph Follicle-forming capacity of the popliteal Lymph node was investigated immunohistochemically in young mice which had received a single injection of hemocyanin (KLH) in a rear footpad at a predetermined age (between 1 and 21 days). The mice were sacrificed at various intervals after injection. In non-stimulated young mice, primary Lymph Follicles first appeared in the popliteal node at 11 days of age. When KLH was given to 7-day-old or older mice, each draining popliteal node showed a marked increase in B Lymphocytes in the extrafollicular zone 3 days after injection and produced a number of ‘new’ Lymph Follicles outside the pre-existing Follicles over the next few days. In mice injected at 2-4 days of age, these nodes showed an increase in B Lymphocytes in the outer cortex and had produced several Lymph Follicles by 8 days of age. The number of Lymph Follicles produced by each node tended to increase in line with age at injection. These results indicate that neonatal popliteal nodes become able to produce Lymph Follicles in response to exogenous antigens some time before ontogenetically developing Follicles appear. The formation of new Lymph Follicles observed in draining popliteal nodes after KLH injection at an early postnatal age is discussed in relation to the ontogenetic development of stromal cells (precursors of follicular dendritic cells) that are capable of interacting with B Lymphocytes and the extent of B Lymphocyte influx into the node induced by KLH stimulation.
