The Experts below are selected from a list of 55260 Experts worldwide ranked by ideXlab platform
Jean Decety - One of the best experts on this subject based on the ideXlab platform.
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the speed of morality a high density electrical Neuroimaging Study
Journal of Neurophysiology, 2012Co-Authors: Jean Decety, Stephanie CacioppoAbstract:Neuroscience research indicates that moral reasoning is underpinned by distinct neural networks including the posterior superior temporal sulcus (pSTS), amygdala, and ventromedial prefrontal cortex...
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What you believe versus what you think they believe: a Neuroimaging Study of conceptual perspective-taking
The European journal of neuroscience, 2003Co-Authors: Perrine Ruby, Jean DecetyAbstract:Social communication requires shared representations as well as a cognitive flexibility for successful interactions between self and other. What neural mechanisms underlie the ability to distinguish between our own perspective vs. the perspective of others at a conceptual level? In this PET Study subjects who were medical students were asked according to the experimental conditions to respond to a list of health-related questions, taking either their own perspective or the perspective of a 'lay person'. Third-person perspective as compared to first-person perspective was associated with activation in the medial part of the superior frontal gyrus, in the left superior temporal sulcus, in the left temporal pole and in the right inferior parietal lobe. The reverse comparison revealed a specific activation in the postcentral gyrus for the first-person conceptual perspective. This Study provides congruent results at the conceptual level with previous studies investigating the neural correlates of self/other distinction at the motor level, and opens a new area of research in which conceptual cognition can be viewed in the continuity of motor cognition.
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does visual perception of object afford action evidence from a Neuroimaging Study
Neuropsychologia, 2002Co-Authors: Julie Grezes, Jean DecetyAbstract:Positron emission tomography (PET) was used to explore the neural correlates of a potential involvement of motor representation during the perception of visually presented objects with different tasks. The main result of this Study was that the perception of objects, irrespective of the task (judgement of the vertical orientation, motor imagery, and silent generation of the noun or of the corresponding action verb), versus perception of non-objects, was associated with rCBF increases in a common set of cortical regions. The occipito–temporal junction, the inferior parietal lobule, the SMA-proper, the pars triangularis in the inferior frontal gyrus, the dorsal and ventral precentral gyrus were engaged in the left hemisphere. The ipsilateral cerebellum was also involved. These activations are congruent with the idea of an involvement of motor representation already during the perception of object and thus provide neurophysiological evidence that the perception of objects automatically affords actions that can be made toward them. Besides this common set of cortical areas, each task engaged specific regions. © 2001 Elsevier Science Ltd. All rights reserved.
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does visual perception of object afford action evidence from a Neuroimaging Study
Neuropsychologia, 2002Co-Authors: Julie Grezes, Jean DecetyAbstract:Positron emission tomography (PET) was used to explore the neural correlates of a potential involvement of motor representation during the perception of visually presented objects with different tasks. The main result of this Study was that the perception of objects, irrespective of the task (judgement of the vertical orientation, motor imagery, and silent generation of the noun or of the corresponding action verb), versus perception of non-objects, was associated with rCBF increases in a common set of cortical regions. The occipito-temporal junction, the inferior parietal lobule, the SMA-proper, the pars triangularis in the inferior frontal gyrus, the dorsal and ventral precentral gyrus were engaged in the left hemisphere. The ipsilateral cerebellum was also involved. These activations are congruent with the idea of an involvement of motor representation already during the perception of object and thus provide neurophysiological evidence that the perception of objects automatically affords actions that can be made toward them. Besides this common set of cortical areas, each task engaged specific regions.
Henning Tiemeier - One of the best experts on this subject based on the ideXlab platform.
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fetal placental blood flow and neurodevelopment in childhood a population based Neuroimaging Study
Ultrasound in Obstetrics & Gynecology, 2020Co-Authors: Vincent W. V. Jaddoe, Henning Tiemeier, S Sammallahti, S Louwen, Eric A P Steegers, Manon H J Hillegers, Tonya WhiteAbstract:Objectives Antenatal Doppler measurements of fetal umbilical and cerebral circulations can predict perinatal complications, however, it is unclear if subtle variations in antenatal Doppler measures are associated with long-term neurodevelopmental outcomes. In this Study, we examined whether antenatal Doppler measurements of fetal-placental and fetal cerebral circulations are associated with cognitive and motor ability and brain morphology in childhood. Methods To evaluate the long-term sequelae of differences along a continuum of umbilical and cerebral artery circulation in the general population, we utilized a population-based longitudinal cohort Study approach. In 2,803 mothers from the Generation R Study, we measured 2nd - and 3rd -trimester umbilical artery pulsatility index. In a subsample (n=602), we additionally measured 3rd -trimester anterior and middle cerebral artery pulsatility indices to calculate cerebroplacental ratios (cerebral divided by umbilical artery pulsatility index). Children underwent non-verbal intelligence testing at 4-8 years; and fingertapping tests measuring fine-motor skills, balance beam measuring gross-motor skills, and brain magnetic resonance imaging at 8-12 years. We assessed the relationships between prenatal Doppler ultrasound measures and neurodevelopmental outcomes using linear regression. We adjusted for child age, sex, maternal age, education, parity, and smoking. Results Higher 3rd -trimester umbilical artery pulsatility index was associated with poorer fine-motor performance (0.41 fewer taps per one standard deviation higher umbilical artery pulsatility index, 95% Confidence Interval -0.70 to -0.11) and gross-motor performance (-0.64 steps, 95% Confidence Interval -1.08 to -0.20). Higher 3rd -trimester umbilical artery pulsatility index also associated with 0.65 points lower intelligence quotient (95% Confidence Interval -1.25 to -0.04): unlike associations with motor abilities, this finding did not survive correction for multiple testing. Higher 2nd -trimester umbilical artery pulsatility index was associated with smaller brain volume (-6.1 cm3 , 95% Confidence Interval -11.3 to -1.0), which did not survive correction for multiple testing. Conclusion Higher placental vascular resistance may have mild adverse effects on neurodevelopmental outcomes in school-age. While these effects are subtle at the population-level, we encourage future research into the role of early circulation in brain development. This could be used to develop targeted interventions. This article is protected by copyright. All rights reserved.
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neural profile of callous traits in children a population based Neuroimaging Study
Biological Psychiatry, 2019Co-Authors: Koen Bolhuis, Ryan L. Muetzel, Henning Tiemeier, Tonya White, Essi Viding, Hanan El Marroun, Desana Kocevska, Charlotte A M CecilAbstract:Abstract Background Callous traits during childhood, e.g., lack of remorse and shallow affect, are a key risk marker for antisocial behavior. Although callous traits have been found to be associated with structural and functional brain alterations, evidence to date has been almost exclusively limited to small, high-risk samples of boys. We characterized gray and white matter brain correlates of callous traits in over 2000 children from the general population. Methods Data on mother-reported callous traits and brain imaging were collected at age 10 years from participants of the Generation R Study. Structural magnetic resonance imaging was used to investigate brain morphology using volumetric indices and whole-brain analyses (n = 2146); diffusion tensor imaging was used to assess global and specific white matter microstructure (n = 2059). Results Callous traits were associated with lower global brain (e.g., total brain) volumes as well as decreased cortical surface area in frontal and temporal regions. Global mean diffusivity was negatively associated with callous traits, suggesting higher white matter microstructural integrity in children with elevated callous traits. Multiple individual tracts, including the uncinate and cingulum, contributed to this global association. Whereas no gender differences were observed for global volumetric indices, white matter associations were present only in girls. Conclusions This is the first Study to provide a systematic characterization of the structural neural profile of callous traits in the general pediatric population. These findings extend previous work based on selected samples by demonstrating that childhood callous traits in the general population are characterized by widespread macrostructural and microstructural differences across the brain.
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tracking brain development and dimensional psychiatric symptoms in children a longitudinal population based Neuroimaging Study
American Journal of Psychiatry, 2018Co-Authors: Ryan L. Muetzel, Vincent W. V. Jaddoe, Laura M E Blanken, Frank C Verhulst, Hanan El Marroun, Jan Van Der Ende, Philip Shaw, Gustavo G Sudre, Aad A Van Der Lugt, Henning TiemeierAbstract:Objective:Psychiatric symptomatology during childhood predicts persistent mental illness later in life. While Neuroimaging methodologies are routinely applied cross-sectionally to the Study of child and adolescent psychopathology, the nature of the relationship between childhood symptoms and the underlying neurodevelopmental processes remains unclear. The authors used a prospective population-based cohort to delineate the longitudinal relationship between childhood psychiatric problems and brain development.Method:A total of 845 children participated in the Study. Psychiatric symptoms were measured with the parent-rated Child Behavior Checklist at ages 6 and 10. MRI data were collected at ages 8 and 10. Cross-lagged panel models and linear mixed-effects models were used to determine the associations between psychiatric symptom ratings and quantitative anatomic and white matter microstructural measures over time.Results:Higher ratings for externalizing and internalizing symptoms at baseline predicted small...
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prenatal cannabis and tobacco exposure in relation to brain morphology a prospective Neuroimaging Study in young children
Biological Psychiatry, 2016Co-Authors: Hanan El Marroun, Aad Van Der Lugt, Vincent W. V. Jaddoe, Frank C Verhulst, Henning Tiemeier, Ingmar H A Franken, Benjamin B Lahey, Tonya WhiteAbstract:Abstract Background Cannabis use during pregnancy has been associated with negative behavioral outcomes and psychopathology in offspring. However, there has been little research evaluating alterations in brain structure as a result of maternal cannabis use. In this prospective Study, we investigated the association between prenatal cannabis exposure and brain morphology in young children. Methods We matched 96 children prenatally exposed to tobacco only (without cannabis) with 113 unexposed control subjects on the basis of age and gender and subsequently selected 54 children exposed to prenatal cannabis (mostly combined with tobacco exposure). These children (aged 6 to 8 years) were part of a population-based Study in the Netherlands, the Generation R Study, and were followed from pregnancy onward. We assessed brain volumetric measures and cortical thickness in magnetic resonance imaging scans using FreeSurfer. We performed vertexwise analyses in FreeSurfer and linear regression analyses adjusting for relevant covariates using Statistical Package for the Social Sciences. Results Prenatal cannabis exposure was not associated with global brain volumes, such as total brain volume, gray matter volume, or white matter volume. However, prenatal cannabis exposure was associated with differences in cortical thickness: compared with nonexposed control subjects, cannabis-exposed children had thicker frontal cortices. Prenatal tobacco exposure compared with nonexposed control subjects was associated with cortical thinning, primarily in the superior frontal and superior parietal cortices. Conclusions Our findings suggest an association between prenatal cannabis exposure and cortical thickness in children. Further research is needed to explore the causal nature of this association.
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White matter integrity and cognitive performance in school-age children: A population-based Neuroimaging Study.
NeuroImage, 2015Co-Authors: Ryan L. Muetzel, Sabine E. Mous, Jan Van Der Ende, Aad Van Der Lugt, Vincent W. V. Jaddoe, Laura M E Blanken, Frank C Verhulst, Henning Tiemeier, Tonya WhiteAbstract:Abstract Child and adolescent brain development are typically accompanied by marked improvements in a wide range of cognitive abilities. However, limited information is available surrounding the role of white matter in shaping cognitive abilities in children. The current Study examined associations between white matter microstructure and cognitive performance in a large sample (n = 778) of 6- to 10-year-old children. Results show white matter microstructure is related to non-verbal intelligence and to visuospatial ability, independent of age. Specificity was demonstrated, as white matter associations with visuospatial ability were independent of general intellectual ability. Associations between white matter integrity and cognition were similar in boys and girls. In summary, results demonstrate white matter structure–function associations are present in children, independent of age and broader cognitive abilities. The presence of such associations in the general population is informative for studies examining child psychopathology
Tonya White - One of the best experts on this subject based on the ideXlab platform.
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fetal placental blood flow and neurodevelopment in childhood a population based Neuroimaging Study
Ultrasound in Obstetrics & Gynecology, 2020Co-Authors: Vincent W. V. Jaddoe, Henning Tiemeier, S Sammallahti, S Louwen, Eric A P Steegers, Manon H J Hillegers, Tonya WhiteAbstract:Objectives Antenatal Doppler measurements of fetal umbilical and cerebral circulations can predict perinatal complications, however, it is unclear if subtle variations in antenatal Doppler measures are associated with long-term neurodevelopmental outcomes. In this Study, we examined whether antenatal Doppler measurements of fetal-placental and fetal cerebral circulations are associated with cognitive and motor ability and brain morphology in childhood. Methods To evaluate the long-term sequelae of differences along a continuum of umbilical and cerebral artery circulation in the general population, we utilized a population-based longitudinal cohort Study approach. In 2,803 mothers from the Generation R Study, we measured 2nd - and 3rd -trimester umbilical artery pulsatility index. In a subsample (n=602), we additionally measured 3rd -trimester anterior and middle cerebral artery pulsatility indices to calculate cerebroplacental ratios (cerebral divided by umbilical artery pulsatility index). Children underwent non-verbal intelligence testing at 4-8 years; and fingertapping tests measuring fine-motor skills, balance beam measuring gross-motor skills, and brain magnetic resonance imaging at 8-12 years. We assessed the relationships between prenatal Doppler ultrasound measures and neurodevelopmental outcomes using linear regression. We adjusted for child age, sex, maternal age, education, parity, and smoking. Results Higher 3rd -trimester umbilical artery pulsatility index was associated with poorer fine-motor performance (0.41 fewer taps per one standard deviation higher umbilical artery pulsatility index, 95% Confidence Interval -0.70 to -0.11) and gross-motor performance (-0.64 steps, 95% Confidence Interval -1.08 to -0.20). Higher 3rd -trimester umbilical artery pulsatility index also associated with 0.65 points lower intelligence quotient (95% Confidence Interval -1.25 to -0.04): unlike associations with motor abilities, this finding did not survive correction for multiple testing. Higher 2nd -trimester umbilical artery pulsatility index was associated with smaller brain volume (-6.1 cm3 , 95% Confidence Interval -11.3 to -1.0), which did not survive correction for multiple testing. Conclusion Higher placental vascular resistance may have mild adverse effects on neurodevelopmental outcomes in school-age. While these effects are subtle at the population-level, we encourage future research into the role of early circulation in brain development. This could be used to develop targeted interventions. This article is protected by copyright. All rights reserved.
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neural profile of callous traits in children a population based Neuroimaging Study
Biological Psychiatry, 2019Co-Authors: Koen Bolhuis, Ryan L. Muetzel, Henning Tiemeier, Tonya White, Essi Viding, Hanan El Marroun, Desana Kocevska, Charlotte A M CecilAbstract:Abstract Background Callous traits during childhood, e.g., lack of remorse and shallow affect, are a key risk marker for antisocial behavior. Although callous traits have been found to be associated with structural and functional brain alterations, evidence to date has been almost exclusively limited to small, high-risk samples of boys. We characterized gray and white matter brain correlates of callous traits in over 2000 children from the general population. Methods Data on mother-reported callous traits and brain imaging were collected at age 10 years from participants of the Generation R Study. Structural magnetic resonance imaging was used to investigate brain morphology using volumetric indices and whole-brain analyses (n = 2146); diffusion tensor imaging was used to assess global and specific white matter microstructure (n = 2059). Results Callous traits were associated with lower global brain (e.g., total brain) volumes as well as decreased cortical surface area in frontal and temporal regions. Global mean diffusivity was negatively associated with callous traits, suggesting higher white matter microstructural integrity in children with elevated callous traits. Multiple individual tracts, including the uncinate and cingulum, contributed to this global association. Whereas no gender differences were observed for global volumetric indices, white matter associations were present only in girls. Conclusions This is the first Study to provide a systematic characterization of the structural neural profile of callous traits in the general pediatric population. These findings extend previous work based on selected samples by demonstrating that childhood callous traits in the general population are characterized by widespread macrostructural and microstructural differences across the brain.
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prenatal cannabis and tobacco exposure in relation to brain morphology a prospective Neuroimaging Study in young children
Biological Psychiatry, 2016Co-Authors: Hanan El Marroun, Aad Van Der Lugt, Vincent W. V. Jaddoe, Frank C Verhulst, Henning Tiemeier, Ingmar H A Franken, Benjamin B Lahey, Tonya WhiteAbstract:Abstract Background Cannabis use during pregnancy has been associated with negative behavioral outcomes and psychopathology in offspring. However, there has been little research evaluating alterations in brain structure as a result of maternal cannabis use. In this prospective Study, we investigated the association between prenatal cannabis exposure and brain morphology in young children. Methods We matched 96 children prenatally exposed to tobacco only (without cannabis) with 113 unexposed control subjects on the basis of age and gender and subsequently selected 54 children exposed to prenatal cannabis (mostly combined with tobacco exposure). These children (aged 6 to 8 years) were part of a population-based Study in the Netherlands, the Generation R Study, and were followed from pregnancy onward. We assessed brain volumetric measures and cortical thickness in magnetic resonance imaging scans using FreeSurfer. We performed vertexwise analyses in FreeSurfer and linear regression analyses adjusting for relevant covariates using Statistical Package for the Social Sciences. Results Prenatal cannabis exposure was not associated with global brain volumes, such as total brain volume, gray matter volume, or white matter volume. However, prenatal cannabis exposure was associated with differences in cortical thickness: compared with nonexposed control subjects, cannabis-exposed children had thicker frontal cortices. Prenatal tobacco exposure compared with nonexposed control subjects was associated with cortical thinning, primarily in the superior frontal and superior parietal cortices. Conclusions Our findings suggest an association between prenatal cannabis exposure and cortical thickness in children. Further research is needed to explore the causal nature of this association.
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White matter integrity and cognitive performance in school-age children: A population-based Neuroimaging Study.
NeuroImage, 2015Co-Authors: Ryan L. Muetzel, Sabine E. Mous, Jan Van Der Ende, Aad Van Der Lugt, Vincent W. V. Jaddoe, Laura M E Blanken, Frank C Verhulst, Henning Tiemeier, Tonya WhiteAbstract:Abstract Child and adolescent brain development are typically accompanied by marked improvements in a wide range of cognitive abilities. However, limited information is available surrounding the role of white matter in shaping cognitive abilities in children. The current Study examined associations between white matter microstructure and cognitive performance in a large sample (n = 778) of 6- to 10-year-old children. Results show white matter microstructure is related to non-verbal intelligence and to visuospatial ability, independent of age. Specificity was demonstrated, as white matter associations with visuospatial ability were independent of general intellectual ability. Associations between white matter integrity and cognition were similar in boys and girls. In summary, results demonstrate white matter structure–function associations are present in children, independent of age and broader cognitive abilities. The presence of such associations in the general population is informative for studies examining child psychopathology
Jennifer Zuk - One of the best experts on this subject based on the ideXlab platform.
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multifactorial pathways facilitate resilience among kindergarteners at risk for dyslexia a longitudinal behavioral and Neuroimaging Study
Developmental Science, 2021Co-Authors: Jennifer Zuk, Jade Dunstan, Elizabeth S Norton, Ola Ozernovpalchik, Yingying Wang, Tiffany P Hogan, John D E Gabrieli, Nadine GaabAbstract:Recent efforts have focused on screening methods to identify children at risk for dyslexia as early as preschool/kindergarten. Unfortunately, while low sensitivity leads to under-identification of at-risk children, low specificity can lead to over-identification, resulting in inaccurate allocation of limited educational resources. The present Study focused on children identified as at-risk in kindergarten who do not subsequently develop poor reading skills to specify factors associated with better reading outcomes among at-risk children. Early screening was conducted in kindergarten and a subset of children was tracked longitudinally until second grade. Potential protective factors were evaluated at cognitive-linguistic, environmental, and neural levels. Relative to at-risk kindergarteners with subsequent poor reading, those with typical reading outcomes were characterized by significantly higher socioeconomic status (SES), speech production accuracy, and structural organization of the posterior right-hemispheric superior longitudinal fasciculus (SLF). A positive association between structural organization of the right SLF and subsequent decoding skills was found to be specific to at-risk children and not observed among typical controls. Among at-risk children, several kindergarten-age factors were found to significantly contribute to the prediction of subsequent decoding skills: white matter organization in the posterior right SLF, age, gender, SES, and phonological awareness. These findings suggest that putative compensatory mechanisms are already present by the start of kindergarten. The right SLF, in conjunction with the cognitive-linguistic and socioeconomic factors identified, may play an important role in facilitating reading development among at-risk children. This Study has important implications for approaches to early screening, and assessment strategies for at-risk children.
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multifactorial pathways facilitate resilience among kindergarteners at risk for dyslexia a longitudinal behavioral and Neuroimaging Study
bioRxiv, 2019Co-Authors: Jennifer Zuk, Jade Dunstan, Elizabeth S Norton, Ola Ozernovpalchik, Yingying Wang, Tiffany P Hogan, John D E Gabrieli, Nadine GaabAbstract:ABSTRACT Recent efforts have focused on screening methods to identify children at risk for dyslexia as early as preschool/kindergarten. Unfortunately, while low sensitivity leads to under-identification of at-risk children, low specificity can lead to over-identification, resulting in inaccurate allocation of limited educational resources. The present Study focused on children identified as at-risk in kindergarten who do not subsequently develop dyslexia to specify factors associated with better reading outcomes among at-risk children. Early screening was conducted in kindergarten and a subset of children was tracked longitudinally until second grade. Potential protective factors were evaluated at cognitive-linguistic, environmental, and neural levels. Relative to at-risk kindergarteners who subsequently developed dyslexia, those who did not were characterized by significantly higher socioeconomic status (SES), speech production accuracy, and microstructure of the posterior right-hemispheric superior longitudinal fasciculus (SLF). A positive association between microstructure of the right SLF and subsequent decoding skills was found to be specific to at-risk children and not observed among typical controls. Among at-risk children, several kindergarten-age factors were found to significantly contribute to the prediction of subsequent decoding skills: microstructure of the posterior right SLF, age, gender, SES, and phonological awareness. These findings suggest that putative compensatory mechanisms are already present by the start of kindergarten. The right SLF, in conjunction with the cognitive-linguistic and socioeconomic factors identified, may play an important role in facilitating reading development among at-risk children. This Study has important implications for approaches to early screening, and assessment strategies for at-risk children.
Chaogan Yan - One of the best experts on this subject based on the ideXlab platform.
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the subsystem mechanism of default mode network underlying rumination a reproducible Neuroimaging Study
NeuroImage, 2020Co-Authors: Xiao Chen, Ningxuan Chen, Yangqian Shen, Zhichen Zhu, Zhen Fan, Chaogan YanAbstract:Rumination is a repetitive self-referential thinking style that is often interpreted as an expression of abnormalities of the default mode network (DMN) observed during "resting-state" in major depressive disorder (MDD). Recent evidence has demonstrated that the DMN is not unitary but can be further divided into 3 functionally heterogenous subsystems, although the subsystem mechanistically underlying rumination remains unclear. Due to the unconstrained and indirect correlational nature of previous resting-state fMRI studies on rumination's network underpinnings, a paradigm allowing direct investigation of network interactions during active rumination is needed. Here, with a modified continuous state-like paradigm, we induced healthy participants to ruminate or imagine objective scenarios (distraction, as a control condition) on 3 different MRI scanners. We compared functional connectivities (FC) of the DMN and its 3 subsystems between rumination and distraction states. Results yielded a highly reproducible and dissociated pattern. During rumination, within-DMN FC was generally decreased as compared to the distraction state. At the subsystem level, we found increased FC between the core and medial temporal lobe (MTL) subsystem as well as decreased FC between the core and dorsal medial prefrontal cortex (DMPFC) subsystem and within the MTL subsystem. Finally, subjects' behavioral measures of rumination and brooding were negatively correlated with FC between the core and DMPFC subsystems. These results suggest active rumination involves enhanced constraint by the core subsystem on the MTL subsystem and decreased coupling between the core and DMPFC subsystem, allowing for more information exchange among those involved DMN components. Furthermore, the reproducibility of our findings provides a rigorous evaluation of their validity and significance.
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the subsystem mechanism of default mode network underlying rumination a reproducible Neuroimaging Study
bioRxiv, 2020Co-Authors: Xiao Chen, Ningxuan Chen, Yangqian Shen, Zhichen Zhu, Zhen Fan, Chaogan YanAbstract:Rumination is a repetitive self-referential thinking style and posited to be an expression of abnormalities in the default mode network (DMN) in major depressive disorder (MDD). Recent evidences indicate DMN is not a unitary network but can be further divided into 3 functionally heterogenous subsystems. However, the subsystem mechanism through which DMN underlie rumination remain unclear. Here, with a modified continuous state-like paradigm, we induced healthy participants to ruminate or imagine objective scenarios (as a distraction control condition) on 3 different MRI scanners. We compared functional connectivities (FC) and inter-subject correlations (ISC) of the DMN and its 3 subsystems between rumination and distraction states. Results yielded a highly reproducible and dissociated pattern. During rumination, within-DMN FC was generally decreased compared to the distraction state. At the subsystem level, we found increased FC between the core and medial temporal lobe (MTL) subsystem and decreased FC between the core and dorsal medial prefrontal cortex (DMPFC) subsystem and within the MTL subsystem. Furthermore, we found decreased ISC within the MTL subsystem. These results suggest a specific and less synchronous activity pattern of DMN during rumination and shed new light on the association between rumination and DMN substrates regarding MDD.