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Zenro Ikezawa - One of the best experts on this subject based on the ideXlab platform.
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correlation of Oral Allergy Syndrome due to plant derived foods with pollen sensitization in japan
Annals of Allergy Asthma & Immunology, 2010Co-Authors: Nobuko Maeda, Naoko Inomata, Akiko Morita, Mio Kirino, Zenro IkezawaAbstract:Background The clinical features of patients with Oral Allergy Syndrome (OAS) due to plant-derived foods related to pollen Allergy have been rarely reported in Japan. Objectives To evaluate the characteristics of OAS and to investigate whether pollen sensitizations are correlated with the prevalence of OAS in Japan. Methods We measured specific IgE antibodies against 5 pollens in 622 outpatients (277 males and 345 females; mean age, 37 years) with atopic dermatitis, urticaria, angioedema, and food Allergy during a 2-year period. Furthermore, OAS is diagnosed based on anamnesis and positive skin prick test reactions to suspected foods. Results Eighteen of the 436 patients (4.1%) sensitized to pollens were diagnosed as having OAS. Rates of specific IgE antibody–positive responses against Japanese cedar, ragweed, orchard grass, mugwort, and alder pollen were 69.8%, 35.3%, 29.1%, 24.1%, and 19.6%, respectively. The prevalence of OAS showed a significant positive correlation with sensitization to alder ( P P P P P P P Conclusion Sensitization to pollens from species in the Betulaceae family is most strongly implicated in causing OAS in Japan.
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Oral Allergy Syndrome due to plant derived foods a clinical review of 63 patients over a period of 6 years
Arerugī (Allergy), 2007Co-Authors: Naoko Inomata, Akiko Morita, Mio Kirino, Michiko Hirokado, Haruna Yamazaki, Jyunko Yamaguchi, Yumiko Yamane, Satoko Tatewaki, Megumi Kondo, Zenro IkezawaAbstract:BACKGROUND The clinical features of many patients with Oral Allergy Syndrome (OAS) due to plant-derived foods have rarely been reported in Japan. OBJECTIVES We aimed to determine the causative foods of OAS due to plant-derived foods based on clinical features and skin prick tests (SPTs). Furthermore, we aimed to elucidate the association between causative foods and sensitized pollens in patients with OAS due to plant-derived foods. METHODS SPTs and specific IgE measurements (CAP-FEIA: CAP) were performed in relation to foods and pollens in 118 patients with positive histories of OAS due to plant-derived foods. Patients with positive histories and with positive skin test responses were identified as having type I Allergy to the causative foods. RESULTS The mean age of 63 patients with positive histories and positive skin test responses was 29.2 years (range, 2-61 years), and there were twice as many females as male. The most frequent causative foods were found to be apple, peach, kiwi, and melon in 13, 12, 12, and 11 patients, respectively. CAP frequency was shown to be similar to that of SPT regarding apple, whereas it was less than that of SPT regarding melon, peach, and kiwi. A significant correlation between the frequencies of SPT and CAP was found regarding apple (r=0.39, p<0.05) but not peach, kiwi, and melon. Forty-one of 63 patients with OAS (66.1%) had pollinosis and/or allergic rhinitis. In patients with OAS due to apple, the positive ratio of CAP response against alder pollen was higher than that in patients with OAS due to melon. In patients with OAS due to melon, the positive ratio of CAP responses against ragweed pollen, grass pollen, and mugwort pollen was higher than that in patients with OAS due to apple. CONCLUSION In this study, positive ratios of SPT and CAP tended to differ according to the causative food, showing a smaller potential for reaction than might be suggested by patient history. Therefore, for the time being it would be more accurate to use a skin test for the diagnosis of OAS due to plant-derived foods.
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a case of occupational contact urticaria and Oral Allergy Syndrome due to seafood
Arerugī (Allergy), 2007Co-Authors: Junko Yamaguchi, Naoko Inomata, Michiko Hirokado, Kuniyoshi Shimakura, Kazuo Shiomi, Zenro IkezawaAbstract:A 20-year-old woman was referred for evaluation after about 2 years of recurrent episodes of localized urticaria during handling of several kinds of raw fish in a sushi shop, where she had worked part-time for 2 years. She had also experienced allergic symptoms such as itching and swelling of her lips, generalized urticaria, laryngeal tightness, stridor and dyspnea immediately after ingestion of raw and cooked seafood, including sole, horse mackerel, sea eel and shellfish, over the previous 1 year before referral. Skin prick tests and blood test for specific IgE antibodies were positive for many kinds of seafood, including sole, horse mackerel, sea eel, eel, crab, and abalone, which belonged to different taxonomic phyla, including Chordata, Arthropoda, and Mollusca. A challenge with a piece of broiled sole induced swelling of the lips, obstruction of the larynx, difficulty with deglutition, and abdominal pain. In addition, serum-specific IgE antibodies to two major fish allergens, parvalbumin and collagen, were detected by ELISA, suggesting that allergic symptoms could be induced by many kinds of seafood in the present patient. She was therefore diagnosed with occupational contact urticaria and Oral Allergy Syndrome due to seafood. At the time of this report, the present patient had been followed for one year and no reactions have occurred since she started to avoid the causative types of seafood.
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Oral Allergy Syndrome due to cashew nuts in the patient without pollinosis
Arerugī (Allergy), 2006Co-Authors: Naoko Inomata, Hiroyuki Osuna, Zenro IkezawaAbstract:A 26-year-old woman felt tingling on her tongue and itching both in the throat and on the face immediately after she put a cashew nut on her tongue. She had a history of atopic dermatitis and bronchial asthma, but not of pollinosis. CAP-FEIA and skin prick test (SPT) were positive for cashew nuts. The results showed negative for peanuts and other tree nuts than cashew nuts. Consequently, she was diagnosed with Oral Allergy Syndrome due to cashew nuts. In addition, the result of skin prick test with cashew nuts normalized one year after she began avoiding cashew nuts, indicating that cashew nuts Allergy would be due to sensitization by itself rather than to cross-reactivity between cashew nuts and pollens in this case.
Stefan Vieths - One of the best experts on this subject based on the ideXlab platform.
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predictive value of the sulfidoleukotriene release assay in Oral Allergy Syndrome to celery hazelnut and carrot
Journal of Investigational Allergology and Clinical Immunology, 2008Co-Authors: B K Ballmerweber, Stefan Vieths, J M Weber, B WuthrichAbstract:■ Abstract Background: Patients sensitized to birch pollen frequently suffer from a food Allergy to plant foods such as celery, carrots, or hazelnut. One of the main manifestations of birch pollen-related food Allergy is the Oral Allergy Syndrome. Skin tests and allergen-specifi c immunoglobulin (Ig) E determinations are poor predictors of such reactions when assessed by double-blind placebo-controlled food challenge (DBPCFC). Objective: To investigate whether a cellular test based on leukotriene release from basophils, the cellular antigen stimulation test in combination with enzyme-linked immunosorbent assay (CAST-ELISA), is predictive of pollen-related food Allergy. Methods: Birch pollen-sensitized patients with positive DBPCFC to celery (n = 21), hazelnut (n = 15), and carrot (n = 7) underwent skin tests along with determination of specifi c IgE and CAST-ELISA for the respective allergens. The results were compared with those of 24 birch pollen-sensitized patients with negative open food challenge to celery, hazelnut, and carrot. Results: While skin prick tests had a sensitivity of 85%, 80%, and 29% for commercial extracts of celery, hazelnut, and carrot, respectively, prick testing with self-prepared extracts yielded sensitivities of 100%, 80%, and 100%, respectively. For specifi c IgE determinations, sensitivities were 71%, 73%, and 57%, respectively, and the respective specifi cities were 67%, 73%, and 60%. For CAST-ELISA with various sources and doses of allergens, the sensitivity varied from 71% to 95% for celery, 73% to 80% for hazelnut, and 43% to 86% for carrot. The respective specifi cities were 67% to 92%, 75% to 88%, and 77% to 91%. Analysis of the predictive value of CAST-ELISA with receiver operating characteristic curves showed that the results of the tests were more predictive of pollen-related food Allergy than quantitative allergen-specifi c IgE determinations. Conclusions: CAST-ELISA is more specifi c than routine diagnostic tests for the diagnosis of pollen-related food Allergy to celery, hazelnut, and carrot.
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the Oral Allergy Syndrome improved diagnostic and treatment methods
Current Opinion in Allergy and Clinical Immunology, 2005Co-Authors: Adriano Mari, Barbara Ballmerweber, Stefan ViethsAbstract:PURPOSE OF REVIEW The aim of this article is to review recent clinical and molecular findings related to the Oral Allergy Syndrome in order to define its relevance in the field of food Allergy, describe current diagnostic approaches and discuss attempts to use specific immunotherapy for treatment. RECENT FINDINGS New allergenic sources causing the Oral Allergy Syndrome have been reported. Their allergenic molecules have been identified. In most of those studies Oral Allergy Syndrome is reported as a clinical manifestation among more severe ones. Some of the molecules generally considered not to be at risk for severe reactions have been demonstrated to pose a threat for inducing generalized reactions. Some studies tried to assess the usefulness of immunotherapy with birch pollen extract by either subcutaneous or sublingual routes for the treatment of associated food allergies. In most of the cases, a well defined study design and a molecular approach at different study levels are lacking and thus the value of the obtained results is limited. To date, no final conclusion can be drawn on the basis of reported results. SUMMARY The knowledge about the highly prevalent phenomenon of Oral Allergy Syndrome is still incomplete, in respect to both, epidemiology and foods inducing symptoms. It is very important to reach consensus on several aspects of this food-induced allergic disease. Further studies are required to highlight whether immunotherapy using co-recognized inhalant allergens is an effective way of curative treatment, or if co-treatment with purified pollen-related food allergens will be required to obtain a long-lasting effect.
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severe Oral Allergy Syndrome and anaphylactic reactions caused by a bet v 1 related pr 10 protein in soybean sam22
The Journal of Allergy and Clinical Immunology, 2002Co-Authors: Jorg Kleinetebbe, Andrea Wangorsch, Lothar Vogel, Dring N Crowell, U F Haustein, Stefan ViethsAbstract:Background: Anaphylactic reactions to soy products have been attributed to stable class 1 food allergens. Objective: IgE-mediated reactions to a soy-containing dietary food product in patients allergic to birch pollen were investigated. Methods: Detailed case histories were taken from 20 patients. Their sera were analyzed for IgE (UniCAP) specific for birch, grass, mugwort, the recombinant birch allergens rBet v 1 and rBet v2, and soy protein. Extracts from birch pollen, soy isolate, rBet v 1, and the recombinant PR-10 soy protein rSAM22 were coupled to paper disks or nitrocellulose for IgE measurements (enzyme allergosorbent test) or Western blot analysis. Enzyme allergosorbent testing, Western blot inhibition, and histamine release studies were performed with the same allergens. Results: Most patients (17/20) experienced facial, oropharyngeal, and/or systemic allergic symptoms within 20 minutes after ingesting the soy product for the first time. Birch pollen Allergy (16/20) was common, along with Oral Allergy Syndrome to apple (12/20) or hazelnut (11/20). IgE levels to birch and Bet v 1 but not to other inhalants were high in 18 of 20 patients. Significant IgE binding to rSAM22 occurred in 17 of 20 patients. Blot experiments with the soy isolate revealed IgEbinding bands at 17 kd (15/20), 22 kd (1/20), and 35 to 38 kd (2/20); the former was inhibited by preincubation of the sera with rBet v 1 or rSAM22. Birch extract and soy isolate, rBet v 1, and rSAM22 induced dose-dependent histamine release in the nanomolar range. Conclusion: Immediate-type allergic symptoms in patients with birch pollen Allergy after ingestion of soy protein‐containing food items can result from cross-reactivity of Bet v 1‐specific IgE to homologous pathogenesis-related proteins, particularly the PR-10 protein SAM22. (J Allergy Clin Immunol 2002;110: 797-804.)
Giorgio Walter Canonica - One of the best experts on this subject based on the ideXlab platform.
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409 Oral Allergy Syndrome and united airways disease is there a functional connection
World Allergy Organization Journal, 2012Co-Authors: Carlo Lombardi, Giovanni Passalacqua, Giorgio Walter CanonicaAbstract:Background The airways and the upper digestive tract have a common embrional origin, and in sensitized subjects they can respond to allergens with an immediate reaction (asthma, rhinitis or Oral Allergy Syndrome). We investigated the possible functional connection between respiratory tract and upper digestive tract by means of specific Oral allergen challenges.
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the functional connection between Oral Allergy Syndrome and united airways disease assessed by Oral challenge
Annals of Allergy Asthma & Immunology, 2012Co-Authors: Carlo Lombardi, Giovanni Passalacqua, Giorgio Walter CanonicaAbstract:Abstract Background The airways and the upper digestive tract have a common embryonic origin. In sensitized subjects they can respond to allergens with an immediate reaction (asthma, rhinitis, or Oral Allergy Syndrome [OAS]). Objective To investigate the possible functional connection between respiratory and upper digestive tract by means of specific Oral allergen challenges. Methods Patients sensitized to birch and apple were subdivided into group A ( n = 12; asthma + rhinitis caused by birch and OAS caused by apple); group B ( n = 10; OAS caused by apple without asthma/rhinitis); group C ( n = 8; asthma and rhinitis caused by birch without OAS). Healthy subjects represented the control group D ( n = 6). Oral provocation test with apple was performed out of the pollen season. Visual analog scale for eye, nose, and mouth symptoms, spirometry, nasal eosinophil count, and exhaled nitric oxide were assessed before and 6 hours after challenge. Results No change occurred in nasal and ocular symptoms before versus after challenge in all groups. On the contrary, in groups A and B the Oral scores significantly increased after challenge ( P Conclusion In the case of birch-apple Syndrome, eating apple does not functionally or clinically affect the respiratory tract.
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evaluation of food pollen cross reactivity by nose mouth cross challenge in pollinosis with Oral Allergy Syndrome
Allergy, 2005Co-Authors: Francesco Marcucci, Giorgio Walter Canonica, Franco Frati, L Sensi, Giuseppe Di Cara, Elio Novembre, R Bernardini, Giovanni PassalacquaAbstract:Background: Oral Allergy Syndrome (OAS) is often associated with pollen-induced rhinitis, and there are preferential associations between causative substances. If OAS and rhinitis are both immunoglobulin (Ig)E-mediated and there are cross-reacting proteins, it is expected that similar reactions can be elicited in the nose and mouth. In order to test this hypothesis we performed a series of ‘cross-challenges’ with foods and pollens in both the nose and the mouth. Methods: Nine patients with ascertained OAS due to vegetables and rhinitis due to pollens were studied. On the first day a nasal challenge with pollen extracts and an Oral challenge with fresh food was carried out. After a week, washout nasal challenge with food and an Oral challenge with pollens were performed. Immediate symptoms, mucosal tryptase and soluble eosinophil cationic protein (ECP) were assessed after each challenge. Results: The administration of pollen into the nose and food into the mouth elicited symptoms as expected, but the cross-challenge had no clinical effect. In parallel, tryptase and ECP increased after nasal challenge with pollens, whereas foods did not elicit a measurable response. Conclusion: The cross-reactivity between foods and pollens, when evaluated at the shock organ, was not clinically evident. This data can be explained with a low concentration of cross-reagent epitopes in pollen extracts and food homogenized because of degradation. The different behaviour upon challenge suggests that different immunological mechanisms may act in the nose and mouth.
Werner J Pichler - One of the best experts on this subject based on the ideXlab platform.
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continuous apple consumption induces Oral tolerance in birch pollen associated apple Allergy
Allergy, 2012Co-Authors: P Kopac, M Rudin, Thomas Gentinetta, R Gerber, Ch Pichler, Oliver Hausmann, B Schnyder, Werner J PichlerAbstract:Patients with birch pollen Allergy (major allergen: Bet v 1) have often an associated Oral Allergy Syndrome (OAS) to apple, which contains the cross-reactive allergen Mal d 1. As successful birch pollen immunotherapy does not consistently improve apple related OAS symptoms, we evaluated whether regular apple consumption has an effect on OAS and immune parameters of Mal d 1 or Bet v 1 Allergy.
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effect of tree pollen specific subcutaneous immunotherapy on the Oral Allergy Syndrome to apple and hazelnut
Allergy, 2004Co-Authors: X Bucher, Werner J Pichler, C A Dahinden, A HelblingAbstract:Background: The efficacy of specific immunotherapy (SIT) in pollen Allergy is well established. However, its effect on pollen associated food Allergy particularly the Oral Allergy Syndrome (OAS) is not definitely ascertained. Objective: The purpose of this controlled prospective study was to investigate whether SIT with tree pollen, mainly birch, has an effect on OAS induced by apple or hazelnut in birch pollen-allergic individuals. Methods: Twenty-seven birch pollen-allergic subjects with OAS induced by apple or hazelnut underwent open Oral provocation tests (OPT) with increasing doses (1 to 128 g) of fresh apple or ground hazelnut 1 year apart. Fifteen of 27 subjects were treated with SIT and 12 were not. Skin-prick test with birch pollen, apple and hazelnut, and specific serum IgE, IgG and IgG4 to rBet v 1, apple and hazelnut were determined. Results: Thirteen of 15 (87%) SIT-treated subjects could eat significantly (P < 0.001) more of apple or hazelnut without any symptoms/signs. The average tolerated quantity increased from 12.6 to 32.6 g apple after 1 year in this group. In contrast, only one of 12 (8%) individuals without SIT was able to consume a higher amount without symptoms. On evaluating laboratory parameters, only IgG4 antibodies to rBet v 1 were found to be significantly (P < 0.01) increased in the SIT-treated group after 1 year. Conclusions: The study shows that SIT with extracts containing birch pollen has a positive impact on OAS to apple or hazelnut in birch pollen-allergic individuals. In spite of this outcome, the amount of apple/hazelnut tolerated is still small. Thus, the effect of SIT on the patients’ management of OAS remains limited.
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boletus edulis a digestion resistant allergen may be relevant for food Allergy
Clinical & Experimental Allergy, 2002Co-Authors: A Helbling, Karl A. Brander, Nicolas Bonadies, Werner J PichlerAbstract:Summary Background Fungal components can cause allergic symptoms either through inhalation, ingestion or contact. Whereas respiratory Allergy is thought to be induced by spores, allergic reactions following ingestion are attributed to other parts of the mushroom. Reports of food-related allergic reactions due to the edible mushroom Boletus edulis have occasionally been reported. Objective The aim of the study was to investigate whether separate allergens may be detected in alimentary Allergy to Boletus edulis. Methods Sera of two subjects, one with recurrent anaphylaxis and the other with a predominantly Oral Allergy Syndrome following ingestion of Boletus edulis, have been analysed by a time-course digestion assay using simulated gastric fluid and by SDS-PAGE immunoblotting. Sera of four Boletus edulis skin prick test-negative subjects and all without clinical symptoms to ingested Boletus edulis served as controls. Results In lyophilized Boletus edulis extract, at least four water-soluble proteins were detected, the most reactive at 55 kDa and at 80 kDa. Following the time-course digestion assay, IgE binding was found to a 75-kDa protein, but only if the sera of the subject with recurrent anaphylaxis was used. Conclusion The data indicate that Boletus edulis can cause an IgE-mediated food Allergy due to a digestion-stabile protein at 75 kDa. No IgE immune response to this protein was detected in the serum of a subject with respiratory Allergy and Oral Allergy Syndrome to Boletus edulis nor in control sera.
C Zanussi - One of the best experts on this subject based on the ideXlab platform.
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allergenic cross reactivity among peach apricot plum and cherry in patients with Oral Allergy Syndrome an in vivo and in vitro study
The Journal of Allergy and Clinical Immunology, 1994Co-Authors: E A Pastorello, C Ortolani, Laura Farioli, Valerio Pravettoni, M Ispano, Ase Borga, Anders Bengtsson, Cristoforo Incorvaia, Candida Berti, C ZanussiAbstract:Abstract Background: Oral Allergy Syndrome in response to fruits and vegetables frequently occurs as clusters of hypersensitivity to members of the same botanical family, for which the immunologic basis lies in a number of common allergens, most of them still unidentified. Objective: This study was designed to assess the in vivo and in vitro cross-reactivity between fruits of the Prunoideae subfamily (i.e., peach, cherry, apricot, and plum) and to identify their major allergens and the cross-reactivity of the peach extract with grass and birch pollen. Methods: The in vivo study was conducted by skin prick tests and open food challenges with fresh fuits in 23 patients with Oral Allergy Syndrome for peach and positive skin prick test and RAST results for the other Prunoideae. In vitro sodium dodecylsulfate-polyacrylamide gel electrophoresis was followed by immunoblotting and immunoblotting inhibition. Results: A 13 kd component was identified as the only major allergen common to all the Prunoideae, the other major allergens were found at 14 kd in peach and at 30 kd in cherry. Immunoblotting inhibition showed wide cross-reactivity within the Prunoideae, whereas grass and birch pollen partially inhibited the peach blotting. Conclusions: Clinical cross-reactivity to Prunoideae is essentially due to a common 13 kd IgE-binding component, which seems to be the most important major allergen of this subfamily, not shared with grass and birch pollen.
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allergenic cross reactivity among peach apricot plum and cherry in patients with Oral Allergy Syndrome an in vivo and in vitro study
The Journal of Allergy and Clinical Immunology, 1994Co-Authors: E A Pastorello, C Ortolani, Laura Farioli, Valerio Pravettoni, M Ispano, Ase Borga, Anders Bengtsson, Cristoforo Incorvaia, Candida Berti, C ZanussiAbstract:Abstract Background: Oral Allergy Syndrome in response to fruits and vegetables frequently occurs as clusters of hypersensitivity to members of the same botanical family, for which the immunologic basis lies in a number of common allergens, most of them still unidentified. Objective: This study was designed to assess the in vivo and in vitro cross-reactivity between fruits of the Prunoideae subfamily (i.e., peach, cherry, apricot, and plum) and to identify their major allergens and the cross-reactivity of the peach extract with grass and birch pollen. Methods: The in vivo study was conducted by skin prick tests and open food challenges with fresh fuits in 23 patients with Oral Allergy Syndrome for peach and positive skin prick test and RAST results for the other Prunoideae. In vitro sodium dodecylsulfate-polyacrylamide gel electrophoresis was followed by immunoblotting and immunoblotting inhibition. Results: A 13 kd component was identified as the only major allergen common to all the Prunoideae, the other major allergens were found at 14 kd in peach and at 30 kd in cherry. Immunoblotting inhibition showed wide cross-reactivity within the Prunoideae, whereas grass and birch pollen partially inhibited the peach blotting. Conclusions: Clinical cross-reactivity to Prunoideae is essentially due to a common 13 kd IgE-binding component, which seems to be the most important major allergen of this subfamily, not shared with grass and birch pollen.