The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform

Henry W. Lim - One of the best experts on this subject based on the ideXlab platform.

  • photoprotection according to skin phototype and dermatoses practical recommendations from an expert panel
    Journal of The European Academy of Dermatology and Venereology, 2021
    Co-Authors: Thierry Passeron, Henry W. Lim, C L Goh, H Y Kang, Akimichi Morita, Ocampo J Candiani, S Puig, Sergio Schalka, L Wei, Brigitte Dreno
    Abstract:

    Increasing evidence on the impact of the different wavelengths of sunlight on the skin demonstrates the need for tailored recommendations of sunscreen according to skin phototype and dermatoses, which is now possible due to advances in the filters and formulations of sunscreens. A selective literature search was performed by an international expert panel, focusing on the type of sunscreen to recommend for photoaging, skin cancers, photodermatoses, pigmentary disorders and skin inflammatory disorders. Protection against ultraviolet (UV)B is especially important for light skin as there is a high risk of sunburn, DNA damage and skin cancers. Darker skin may be naturally better protected against UVB but is more prone to hyperpigmentation induced by visible light (VL) and UVA. Protection against UVA, VL and infrared A can be helpful for all skin phototypes as they penetrate deeply and cause photoaging. Long-wave UVA1 plays a critical role in pigmentation, photoaging, skin cancer, DNA damage and photodermatoses. Adapting the formulation and texture of the sunscreen to the type of skin and dermatoses is also essential. Practical recommendations on the type of sunscreen to prescribe are provided to support the clinician in daily practice.

  • role of oral polypodium leucotomos extract in dermatologic diseases a review of the literature
    Journal of Drugs in Dermatology, 2014
    Co-Authors: Samreen Z Choudhry, Iltefat H Hamzavi, Neal Bhatia, Roger I Ceilley, Firas Hougeir, Robert Lieberman, Henry W. Lim
    Abstract:

    Polypodium leucotomos extract (PLE), derived from the tropical fern of Polypodiaceae family, has properties ranging from immunomodulatory and antioxidative to photoprotective. It is these multiple mechanisms of action, in combination with a favorable side effect profile, which makes PLE a promising adjunctive treatment for several dermatologic disorders. Studies are summarized on the use and potential applications of PLE in the treatment or management of photodermatoses, vitiligo, melasma, psoriasis, atopic dermatitis, and more recently, in minimizing infections in high-performance athletes. More data, however, with larger sample sizes are needed to confirm these benefits.

  • polymorphous light eruption presenting as pinhead papular eruption on the face
    Journal of Drugs in Dermatology, 2013
    Co-Authors: Prescilia Isedeh, Henry W. Lim
    Abstract:

    Polymorphic light eruption (PMLE) is the most common of the immunologically mediated photodermatoses. Onset is typically within the first three decades of life and affects females two to three times more than males. It occurs 30 minutes to 1-3 days after sun exposure and usually resolves in 7 to 10 days. Lesions present as non-scarring, erythematous and minimally pruritic papules, vesicles, papulovesicles, plaques or nodules. A pinpoint papular variant of PMLE has been reported in individuals with skin phototype IV-VI, characterized by the development of pinpoint papules, 1 to 2 mm, on sun-exposed areas after ultraviolet radiation. PMLE has a predilection for the arms, forearms, hands, head and neck region, usually with sparing of the face. We report two cases of African-American males who presented with the pinpoint papular variant of PMLE involving the face.

  • Polymorphous light eruption, chronic actinic dermatitis, solar urticaria and porphyria cutanea tarda
    Expert Review of Dermatology, 2006
    Co-Authors: Henry W. Lim
    Abstract:

    Photodermatoses can be divided into four general categories: immunologically mediated photodermatoses, drug- and chemical-induced photosensitivity, DNA repaired deficient photodermatoses and photoaggravated dermatoses. In this review, selected photodermomatoses will be discussed: polymorphous light eruption, chronic actinic dermatitis, solar urticaria and porphyria cutanea tarda. The frequency of photodermatoses has been reported from studies assessing patients in photodermatology referral centers in different parts of the world. All studies consistently showed that polymorphous light eruption is the most common primary Photodermatosis, ranging in frequency from 23 to 65% of the patients referred to those centers for evaluation. Other commonly seen primary photodermatoses include solar urticaria and chronic actinic dermatitis. In studies reported from Singapore and Melbourne, Australia, photoaggravation of skin diseases was also seen commonly, probably owing to the high level of sun exposure experienced b...

  • 011 polymorphous light eruption pmle in african americans presenting as pinpoint papules
    Photodermatology Photoimmunology and Photomedicine, 2002
    Co-Authors: Andrew P. Kontos, C. Cusack, Henry W. Lim
    Abstract:

    Polymorphous light eruption (PMLE) is the most common chronic idiopathic Photodermatosis with a prevalence estimated at 10-20% and a genetic predisposition from 5-45%. It tends to occur in the spring with gradual resolution as summer progresses. Papular eruptions are most commonly seen, however, several morphological variants exist among affected individuals, including vesicular, eczematous and papulovesicular lesions. Lesions are usually monomorphic in a given patient. We present nine African-American female patients in whom PMLE manifests as a pinpoint papular variant, which has not been commonly described previously. Of the four patients who were phototested, one had an abnormal UVA MED result of 12 J/cm2. Histopathologic findings revealed perivascular and focal lichenoid lymphohistiocytic infiltrate with papillary dermal hemorrhage in all biopsy specimens.

J.l.m. Hawk - One of the best experts on this subject based on the ideXlab platform.

  • an update and guidance on narrowband ultraviolet b phototherapy a british photodermatology group workshop report
    British Journal of Dermatology, 2004
    Co-Authors: S H Ibbotson, J Ferguson, B L Diffey, D Bilsland, Neil H Cox, R S Dawe, Christopher J Edwards, P M Farr, G Hart, J.l.m. Hawk
    Abstract:

    Summary These guidelines for use of narrowband (TL-01) ultraviolet B have been prepared for dermatologists by the British Photodermatology Group on behalf of the British Association of Dermatologists. They present evidence-based guidance for treatment of patients with a variety of dermatoses and photodermatoses, with identification of the strength of evidence available at the time of preparation of the guidelines, and a brief overview of background photobiology.

  • photoallergic contact dermatitis is uncommon
    British Journal of Dermatology, 2001
    Co-Authors: A Darvay, J.l.m. Hawk, Ian R White, R J G Rycroft, A B Jones, J P Mcfadden
    Abstract:

    Background Despite the enormous increase in sunscreen use, allergic contact (AC) and photoallergic (PA) reactions to ultraviolet (UV) filters are considered rare. Objectives To analyse the data from 2715 patients who underwent photopatch testing at St John's Institute of Dermatology during the period 1983–98. Methods A retrospective analysis of all positive photopatch test episodes was undertaken with the results retrieved from the environmental dermatology database and further verified with the original archived patch test documentation for each individual patient. Results In 111 patients with positive reactions (4·1%), there were 155 AC or PA reactions to allergens in the photopatch test series. Eighty PA reactions were observed in 62 (2·3%) patients (32 men and 30 women, age range 28–75 years), with UV filters accounting for 52 positive reactions (65%), drugs 16 (20%), musk ambrette 11 (14%) and the antiseptic trichlorocarbanilide one (1%). The most common UV filter photoallergen was benzophenone-3 with 14 positive results, followed by benzophenone-10 (n = 9), isopropyl dibenzoylmethane (n = 6), p-aminobenzoic acid (PABA) (n = 5), octyl dimethyl PABA (n = 5), butyl methoxydibenzoylmethane (n = 4), isoamyl methoxycinnamate (n = 2), ethyl methoxycinnamate (n = 2), octyl methoxycinnamate (n = 2), amyl dimethyl PABA (n = 2) and phenylbenzimidazole sulphonic acid (n = 1). A similar number of AC reactions to UV filters was detected in this study. Thus 49 patients (1·8%) had a total of 75 reactions: 51 due to UV filters and 24 as a result of exposure to fragrances and therapeutic agents. Benzophenone-10 accounted for 13 AC reactions and benzophenone-3 for eight reactions. Twenty-two patients had a PA reaction alone, whereas 19 patients had chronic actinic dermatitis and 15 patients polymorphic light eruption (PLE) in addition. Thus, 34 of the 62 patients (55%) had a preceding underlying Photodermatosis. Conclusions These results show a low yield of positive photopatch tests. Thus, despite the large increase in the use of UV filters over the last decade, the development of PA reactions remains rare. Furthermore, most of the common UV filter photoallergens identified in this study, including PABA, amyl dimethyl PABA and benzophenone-10, are now rarely used in sunscreen manufacture, while isopropyl dibenzoylmethane was voluntarily removed from the market in 1993. Currently, benzophenone-3 is the commonest contact photoallergen still in widespread use. In contrast, the UVB filter octyl methoxycinnamate, used in a number of sunscreens, produced only two positive PA reactions in 12 years of testing. Nevertheless, although these reactions are extremely rare, patients with photodermatoses such as PLE and chronic actinic dermatitis do represent a group of patients at increased risk of developing photoallergy. Further photopatch test series should be regularly reviewed and updated, as the relevance of individual photoallergens changes over time. Currently, there is no evidence that PA reactions represent a common clinical problem.

  • the red face chronic actinic dermatitis
    Clinics in Dermatology, 1993
    Co-Authors: Helene Du P Menage, J.l.m. Hawk
    Abstract:

    Abstract Chronic actinie dermatitis, a disabling Photodermatosis of middle-aged and elderly patients, particularly males, presents with an eczematous or pseudolymphomatous eruption of the face and other light-exposed sites.

Iltefat H Hamzavi - One of the best experts on this subject based on the ideXlab platform.

  • Photoprotection beyond ultraviolet radiation: A review of tinted sunscreens
    Journal of The American Academy of Dermatology, 2020
    Co-Authors: Alexis B. Lyons, Carles Trullas, Iltefat H Hamzavi
    Abstract:

    Ultraviolet radiation and visible light both have biologic effects on the skin. Visible light can induce erythema in light-skinned individuals and pigmentation in dark-skinned individuals. Broad-spectrum sunscreens protect against ultraviolet radiation but do not adequately protect against visible light. For a sunscreen to protect against visible light, it must be visible on the skin. Inorganic filters (also known as mineral filters), namely, zinc oxide and titanium dioxide, are used in the form of nanoparticles in sunscreens to minimize the chalky and white appearance on the skin; as such, they do not protect against visible light. Tinted sunscreens use different formulations and concentrations of iron oxides and pigmentary titanium dioxide to provide protection against visible light. Many shades of tinted sunscreens are available by combining different amounts of iron oxides and pigmentary titanium dioxide to cater to all skin phototypes. Therefore, tinted sunscreens are beneficial for patients with visible light–induced photodermatoses and those with hyperpigmentation disorders such as melasma and postinflammatory hyperpigmentation.

  • successful treatment of solar urticaria with uva1 hardening in three patients
    Photodermatology Photoimmunology and Photomedicine, 2019
    Co-Authors: Alexis B. Lyons, Anjelica Peacock, Raheel Zubair, Iltefat H Hamzavi
    Abstract:

    : Solar urticaria (SU) is an uncommon Photodermatosis that presents with sensitivity to ultraviolet (UV) or visible light which triggers urticarial lesions. Treatment of SU is a challenge and usually involves antihistamines and photoprotection as a first-line treatment. Phototherapy regimens are recommended if these first-line treatments fail to control the disease. Induction of tolerance by phototherapy (UV hardening) has been commonly described as a treatment modality. UVA1 has deeper penetration to the dermis than UVA or NB-UVB; its use in SU has not been previously reported. We present 3 patients with SU who were successfully treated with UVA1.

  • role of oral polypodium leucotomos extract in dermatologic diseases a review of the literature
    Journal of Drugs in Dermatology, 2014
    Co-Authors: Samreen Z Choudhry, Iltefat H Hamzavi, Neal Bhatia, Roger I Ceilley, Firas Hougeir, Robert Lieberman, Henry W. Lim
    Abstract:

    Polypodium leucotomos extract (PLE), derived from the tropical fern of Polypodiaceae family, has properties ranging from immunomodulatory and antioxidative to photoprotective. It is these multiple mechanisms of action, in combination with a favorable side effect profile, which makes PLE a promising adjunctive treatment for several dermatologic disorders. Studies are summarized on the use and potential applications of PLE in the treatment or management of photodermatoses, vitiligo, melasma, psoriasis, atopic dermatitis, and more recently, in minimizing infections in high-performance athletes. More data, however, with larger sample sizes are needed to confirm these benefits.

J Ferguson - One of the best experts on this subject based on the ideXlab platform.

Lim, Henry W - One of the best experts on this subject based on the ideXlab platform.

  • Dupilumab for the Treatment of Chronic Actinic Dermatitis
    Henry Ford Health System Scholarly Commons, 2020
    Co-Authors: Patel Nayha, Konda Sasank, Lim, Henry W
    Abstract:

    Chronic actinic dermatitis (CAD) is an immune-mediated Photodermatosis characterized by chronic, pruritic, eczematous, and often lichenified plaques distributed primarily upon sun-exposed skin.(1) The pathophysiology is believed to involve a delayed-type hypersensitivity reaction to an endogenous, photoinduced, cutaneous antigen, which has been speculated to be DNA.(1) First-line management options include strict photoprotection, topical corticosteroids (TCS), and topical calcineurin inhibitors (TCI). However, these are rarely sufficient on their own. Thus, many systemic therapies are often utilized with varying degrees of success

  • Polymorphic light eruption sine eruptione: A variant of polymorphous light eruption
    Henry Ford Health System Scholarly Commons, 2020
    Co-Authors: Vellaichamy Gautham, Chadha, Angad A, Hamzavi, Iltefat H, Lim, Henry W
    Abstract:

    Polymorphous light eruption (PMLE) is the most common immunologically-mediated Photodermatosis; it usually presents as a pruritic, papular eruption in sun-exposed regions of the skin hours to days after sun exposure. Several variants of PMLE have been described, manifesting with varying morphologies but with photosensitivity as a common etiology. Polymorphic light eruption sine eruptione (PLESE), a rare variant presenting as sun-induced pruritus without cutaneous eruption, has been reported in a single cohort of seven patients in 1988. We report a case of a 62-year-old white female who developed PLESE

  • Solar urticaria caused by visible light in a 33-year-old male refractory to treatment with omalizumab
    Henry Ford Health System Scholarly Commons, 2020
    Co-Authors: Wright Ellen, Kurland Elena, Lim, Henry W
    Abstract:

    Solar urticaria (SU) is a rare Photodermatosis characterized by development of urticarial papules and plaques within minutes of exposure to ultraviolet (UV)A, UVB, or visible light. It is an immunoglobulin (Ig)E‐mediated Photodermatosis likely caused by a photo allergen activated by a particular light spectrum. Solar urticaria has significant impact on patient\u27s quality of life and often poses a therapeutic challenge. We present the case of solar urticaria induced by visible light in a 33‐year‐old man that presented as an erythematous, urticarial plaque after 15‐minute exposure to fluorescent light while receiving omalizumab therapy

  • Phototherapy in the Evaluation and Management of Photodermatoses
    Henry Ford Health System Scholarly Commons, 2019
    Co-Authors: Jiang, Angela J, Lim, Henry W
    Abstract:

    Ultraviolet light (UV) and visible light are important components in the diagnosis of photodermatoses, and UV has the unique ability to also be used to manage photodermatoses. Phototesting, provocative light testing, and photopatch testing can provide important information in diagnosing patients with photodermatoses; phototesting can be used to determine the starting dose for phototherapy in these patients. Once photosensitivity is established, narrowband UVB and UVA1 therapy have helped to improve the quality of life of photosensitive patients, such as those with polymorphous light eruption, chronic actinic dermatitis, and solar urticarial