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Kristian Borg - One of the best experts on this subject based on the ideXlab platform.

  • EFNS guideline on diagnosis and management of Post-Polio Syndrome
    2020
    Co-Authors: Elisabeth Farbu, Kristian Borg, Frans Nollet, A. Driessen, Robin S. Howard, J. Opara, E. Stalberg
    Abstract:

    Post-Polio Syndrome (PPS) is characterized by new or increased muscular weakness, atro- phy, muscle pain and fatigue several years after acute polio. The aim of the article is to prepare diagnostic criteria for PPS, and to evaluate the existing evidence for therapeutic interven- tions. The Medline, EMBASE and ISI databases were searched. Consensus in the group was reached after discus- sion by email.

  • Immunoglobulin treatment in Post-Polio Syndrome: Identification of responders and non-responders.
    Journal of Rehabilitation Medicine, 2015
    Co-Authors: Gunilla Östlund, Lisbet Broman, Lars Werhagen, Kristian Borg
    Abstract:

    To define and characterize responders and non-responders in a group of 124 patients with Post-Polio Syndrome who received a single treatment with intravenous immunoglobulin.Open trial, prospective follow-up study.Clinical examination and data from medical records. Short Form 36 (SF-36), Physical Activity Scale for the Elderly (PASE) and visual analogue scale (VAS) measured quality of life, physical activity and intensity of pain, respectively. Data were obtained before treatment and at 6-month follow-up.Two responder groups were identified with the outcome SF-36 Vitality and 3 with Bodily pain, respectively. Forty-five percent were positive-responders, identified before treatment by reduced physical function, muscle atrophy in the lower extremities, higher levels of fatigue and pain, and a VAS pain score above 20. Negative-responders were identified by good physical function and mental health, lesser muscle atrophy in the lower extremities, and low levels of fatigue and pain.Intravenous immunoglobulin is a biological intervention, and therefore it is important to be able to identify responders and non-responders. In order to maximize a positive outcome it is suggested that patients with a high level of fatigue and/or pain and reduced physical function are selected.

  • Elevated blood lipids are uncommon in patients with Post-Polio Syndrome – a cross sectional study
    BMC Neurology, 2015
    Co-Authors: Eva Melin, Thomas Kahan, Kristian Borg
    Abstract:

    Background The Post-Polio Syndrome occurs in people who previously have had poliomyelitis. After the initial recovery, new or increasing neurologic symptoms occur. Inflammation and dyslipidaemia may play an important role in the development of atherosclerotic complications, for example myocardial infarction and angina pectoris. Previous studies on cardiovascular risk factors in the Post-Polio Syndrome have found a higher prevalence of hypertension, ischemic heart disease, hyperlipidaemia, and stroke in these patients. The present study was undertaken in order to evaluate whether Post-Polio patients have elevated lipid values, and if blood lipid abnormalities could be correlated to signs of inflammation.

  • The Complexity of the Diagnosis of Post-Polio Syndrome
    journal of Clinical Case Reports, 2015
    Co-Authors: Lars Werhagen, Kristian Borg
    Abstract:

    The diagnosis of Post-Polio Syndrome (PPS) might be difficult as the diagnosis PPS mostly depends on the patient’s subjective description of the symptoms. Furthermore, the PPS patients have reached an age when concomitant diseases are common. However, an adequate diagnosis is important for treatment and prognosis. The aim of this case report is to describe the complexity of the PPS diagnosis.

  • Gait characteristics and influence of fatigue during the 6-minute walk test in patients with Post-Polio Syndrome.
    Journal of Rehabilitation Medicine, 2013
    Co-Authors: Katarina Skough Vreede, Kristian Borg, Jan Henriksson, Marketta Henriksson
    Abstract:

    OBJECTIVE: To evaluate gait in patients with Post-Polio Syndrome, using the 6-minute walk test (6MWT) combined with three-dimensional kinematic analysis. DESIGN: Descriptive study. SUBJECTS: Eighteen patients and 11 healthy controls. METHODS: Kinematic data were obtained during a 6MWT by a Vicon motion capture system. Distance, heart rate, leg tiredness, dyspnoea and exertion were also recorded. RESULTS: Patients with Post-Polio Syndrome showed larger increases in leg tiredness (p 

Christian A Vedeler - One of the best experts on this subject based on the ideXlab platform.

  • GM1 antibodies in Post-Polio Syndrome and previous paralytic polio.
    Journal of neuroimmunology, 2020
    Co-Authors: E Farbu, T Rekand, Olebjorn Tysnes, Johan A Aarli, N E Gilhus, Christian A Vedeler
    Abstract:

    We studied the relationship between Post-Polio Syndrome (PPS) and GM1 antibodies, since such antibodies have been associated with PPS and motor neuron disorders. Sera from 144 patients with previous poliomyelitis (105 paralytic, 22 nonparalytic and 17 PPS), 60 with previous Guillain-Barré Syndrome, 44 with amyotrophic lateral sclerosis (ALS) and 22 healthy blood donors were analyzed with ELISA for GM1 IgM, IgG and IgA antibodies. GM1 antibodies were present in 14% of the PPS patients, but the prevalence did not differ significantly from that of the other groups. Our study does not support the hypothesis that GM1 antibodies are involved in the pathogenesis of PPS.

  • gm1 antibodies in post polio Syndrome and previous paralytic polio
    Journal of Neuroimmunology, 2003
    Co-Authors: Elisabeth Farbu, T Rekand, Nils Erik Gilhus, Olebjorn Tysnes, Johan A Aarli, Christian A Vedeler
    Abstract:

    Abstract We studied the relationship between Post-Polio Syndrome (PPS) and GM1 antibodies, since such antibodies have been associated with PPS and motor neuron disorders. Sera from 144 patients with previous poliomyelitis (105 paralytic, 22 nonparalytic and 17 PPS), 60 with previous Guillain-Barre Syndrome, 44 with amyotrophic lateral sclerosis (ALS) and 22 healthy blood donors were analyzed with ELISA for GM1 IgM, IgG and IgA antibodies. GM1 antibodies were present in 14% of the PPS patients, but the prevalence did not differ significantly from that of the other groups. Our study does not support the hypothesis that GM1 antibodies are involved in the pathogenesis of PPS.

Elisabeth Farbu - One of the best experts on this subject based on the ideXlab platform.

  • Post-Polio Syndrome
    Encyclopedia of Neuroscience, 2020
    Co-Authors: Elisabeth Farbu
    Abstract:

    Post-Polio Syndrome (PPS) is characterized by new muscular weakness, atrophy, general and muscular fatigue, decreased endurance, pain, and loss of function several years after acute polio. Between 20 and 50% of polio survivors are affected. An ongoing, scattered loss of motor neurons, denervation of enlarged motor units, hypertrophic type I muscle fibers, and increased expression of inflammatory cytokines such as tumor necrosis factor-alpha and interferon-gamma in the cerebrospinal fluid are found. The disorder is slowly progressive with no generalized loss of motor neurons. No specific cure for PPS exists, and the cornerstone in management is supportive therapy after a careful diagnostic assessment. However, recent studies show that intravenous immunoglobulin may be a therapeutic option in some PPS patients.

  • EFNS guideline on diagnosis and management of Post-Polio Syndrome
    2020
    Co-Authors: Elisabeth Farbu, Kristian Borg, Frans Nollet, A. Driessen, Robin S. Howard, J. Opara, E. Stalberg
    Abstract:

    Post-Polio Syndrome (PPS) is characterized by new or increased muscular weakness, atro- phy, muscle pain and fatigue several years after acute polio. The aim of the article is to prepare diagnostic criteria for PPS, and to evaluate the existing evidence for therapeutic interven- tions. The Medline, EMBASE and ISI databases were searched. Consensus in the group was reached after discus- sion by email.

  • European Handbook of Neurological Management - Post‐Polio Syndrome
    Nederlands Tijdschrift voor Geneeskunde, 2010
    Co-Authors: Elisabeth Farbu, Kristian Borg, Frans Nollet, A. Driessen, Robin S. Howard, J. Opara, Nils Erik Gilhus, Michael P. Barnes, M. De Visser, E. Stalberg
    Abstract:

    Post-Polio Syndrome (PPS) is characterized by new muscular weakness, atrophy, general and muscular fatigue, decreased endurance, pain, and loss of function several years after acute polio. Between 20% and 50% of polio survivors are affected. An ongoing, scattered loss of motor neurons, denervation of enlarged motor units, hypertrophic type I muscle fibers, and increased expression of inflammatory cytokines such as tumor necrosis factor-alpha and interferon-gamma in the cerebrospinal fluid are found. The disorder is slowly progressive with no generalized loss of motor neurons. No specific cure for PPS exists, and the cornerstone in management is supportive therapy after a careful diagnostic assessment. For some selected patients, intravenous immunoglobulin may be a therapeutic option.

  • gm1 antibodies in post polio Syndrome and previous paralytic polio
    Journal of Neuroimmunology, 2003
    Co-Authors: Elisabeth Farbu, T Rekand, Nils Erik Gilhus, Olebjorn Tysnes, Johan A Aarli, Christian A Vedeler
    Abstract:

    Abstract We studied the relationship between Post-Polio Syndrome (PPS) and GM1 antibodies, since such antibodies have been associated with PPS and motor neuron disorders. Sera from 144 patients with previous poliomyelitis (105 paralytic, 22 nonparalytic and 17 PPS), 60 with previous Guillain-Barre Syndrome, 44 with amyotrophic lateral sclerosis (ALS) and 22 healthy blood donors were analyzed with ELISA for GM1 IgM, IgG and IgA antibodies. GM1 antibodies were present in 14% of the PPS patients, but the prevalence did not differ significantly from that of the other groups. Our study does not support the hypothesis that GM1 antibodies are involved in the pathogenesis of PPS.

Acary Souza Bulle Oliveira - One of the best experts on this subject based on the ideXlab platform.

  • Fatigue in Post-Polio Syndrome
    Brazilian Journal of Biological Sciences, 2019
    Co-Authors: Monalisa Pereira Motta, Abrahão Augusto Juveniano Quadros, Letícia Simões Ferreira, Acary Souza Bulle Oliveira
    Abstract:

    Post-Polio Syndrome (PPS) is characterized by the appearance of new muscular symptoms or worsening of previous residual symptoms, several years after the acute polio. The most common symptoms include a trial of fatigue, deterioration in muscle strength and pain. Fatigue is one of the most frequent complaints of PPS and the majority of patients identify fatigue as their most troubling symptom. The aetiology of the symptom arouses great interest, mainly due to its multifactorial character, and can be divided into two components: peripheral (muscular) fatigue and central (general) or simultaneously-occurring fatigue. Considering the importance of the symptom and the limitations that can cause in PPS patients, it is important to consider a series of variables, so that it can be better understood, thus providing a more effective and specific treatment.

  • Post-Polio Syndrome
    Brazilian Journal of Biological Sciences, 2018
    Co-Authors: Monalisa Pereira Motta, Abrahão Augusto Juveniano Quadros, Mônica De Souza Brito Conti, Acary Souza Bulle Oliveira
    Abstract:

    Among the late effects of poliomyelitis is the Post-Polio Syndrome (PPS), characterized by increased muscle strength loss, abnormal fatigue and pain after a period of stability of at least 15 years. The incidence and prevalence of PPS are unknown in the world and in Brazil, depending on the diagnostic criteria. The diagnosis of PPS is made by exclusion and there is no specific laboratory test, these only help to rule out other diseases. There is no curative treatment for PPS. Its etiology remains unknown. Strategies for their clinical management aim reducing muscle overusing and a balance active lifestyle is recommended to minimize the symptoms.

  • circadian variation of fatigue in both patients with paralytic poliomyelitis and post polio Syndrome
    Arquivos De Neuro-psiquiatria, 2013
    Co-Authors: Celiana Figueiredo Viana, Abrahão Augusto Juviniano Quadros, Luis Fabiano Marin, Marcia Pradellahallinan, Acary Souza Bulle Oliveira
    Abstract:

    ObjectiveIt was to evaluate the degree of fatigue in patients with paralytic poliomyelitis (PP) and with Post-Polio Syndrome (PPS), and correlate it with parameters of sleep and the circadian cycle.MethodsThirty patients, 17 female (56.7%), participated in the study: they answered the Revised Piper Fatigue Scale and performed a nocturnal polysomnographic study. Eleven had PP (mean age±standard deviation of 47.9±6.4 years), and 19 had PPS (mean age±standard deviation of 46.4±5.6 years).ResultsOur study showed that fatigue was worse in the afternoon in the PP Group and had a progressive increase throughout the day in the PPS Group. We also observed compromised quality of sleep in both groups, but no statically significant difference was found in the sleep parameters measured by polysomnography.ConclusionFatigue has a well-defined circadian variation, especially in PPS Group. Poor sleep quality is associated with fatigue and, therefore, sleep disturbances should be evaluated and treated in this group of PPS.

  • Restless legs Syndrome in Post-Polio Syndrome: A series of 10 patients with demographic, clinical and laboratorial findings
    Parkinsonism & Related Disorders, 2011
    Co-Authors: Luis Fabiano Marin, Acary Souza Bulle Oliveira, Luciane Bizari Coin De Carvalho, Lucila Bizari Fernandes Do Prado, Abrahão Augusto Juviniano Quadros, Gilmar Fernandes Do Prado
    Abstract:

    Abstract Background Few studies have described the occurrence of restless legs Syndrome in Post-Polio Syndrome. Methods We studied 10 consecutive patients with Post-Polio Syndrome and symptoms of restless legs Syndrome. We look at demographic, clinical and laboratorial data. Results A remarkable finding was the concomitant onset of symptoms of both diseases, suggesting a possible underlying mechanism. Severity of restless legs symptoms was moderate to very severe. Conclusion Epidemiological studies with larger samples are needed to better establish the relationship and the incidence of restless legs Syndrome in Post-Polio Syndrome.

  • Sleep disorders frequency in Post-Polio Syndrome patients caused by periodic limb movements
    Arquivos De Neuro-psiquiatria, 2010
    Co-Authors: Maria Auxiliadora De Paiva Araujo, Gustavo Antonio Moreira, Tatiana Mesquita E Silva, Sergio Tufik, Márcia Pradella-hallinan, Acary Souza Bulle Oliveira
    Abstract:

    Post-Polio Syndrome (PPS) in individuals with polio longer than 15 years is characterized by weakness and/or muscle fatigue, deficit of deglutition and breath and periodic limb movements (PLM) during sleep. We undertook a review of 99 patients with PPS, and assessed the frequency of PLM through polysomnographic recordings at our sleep disorders unit. The total number of PLM, total time of sleep (TTS), efficiency of sleep (EfS), awaking index (AI) and apnea-hypopnea index (AHI) were analyzed. Sixteen patients presented PLM in excess of 5 for the entire night. When comparing these with the group without PLM, a correlation was found (p=0.001). Significant difference was found for the correlation of the parameters: IAH, ID, TTS and EfS when compared the two groups. There is a close relationship between PPS and PLM.

T Rekand - One of the best experts on this subject based on the ideXlab platform.

  • GM1 antibodies in Post-Polio Syndrome and previous paralytic polio.
    Journal of neuroimmunology, 2020
    Co-Authors: E Farbu, T Rekand, Olebjorn Tysnes, Johan A Aarli, N E Gilhus, Christian A Vedeler
    Abstract:

    We studied the relationship between Post-Polio Syndrome (PPS) and GM1 antibodies, since such antibodies have been associated with PPS and motor neuron disorders. Sera from 144 patients with previous poliomyelitis (105 paralytic, 22 nonparalytic and 17 PPS), 60 with previous Guillain-Barré Syndrome, 44 with amyotrophic lateral sclerosis (ALS) and 22 healthy blood donors were analyzed with ELISA for GM1 IgM, IgG and IgA antibodies. GM1 antibodies were present in 14% of the PPS patients, but the prevalence did not differ significantly from that of the other groups. Our study does not support the hypothesis that GM1 antibodies are involved in the pathogenesis of PPS.

  • gm1 antibodies in post polio Syndrome and previous paralytic polio
    Journal of Neuroimmunology, 2003
    Co-Authors: Elisabeth Farbu, T Rekand, Nils Erik Gilhus, Olebjorn Tysnes, Johan A Aarli, Christian A Vedeler
    Abstract:

    Abstract We studied the relationship between Post-Polio Syndrome (PPS) and GM1 antibodies, since such antibodies have been associated with PPS and motor neuron disorders. Sera from 144 patients with previous poliomyelitis (105 paralytic, 22 nonparalytic and 17 PPS), 60 with previous Guillain-Barre Syndrome, 44 with amyotrophic lateral sclerosis (ALS) and 22 healthy blood donors were analyzed with ELISA for GM1 IgM, IgG and IgA antibodies. GM1 antibodies were present in 14% of the PPS patients, but the prevalence did not differ significantly from that of the other groups. Our study does not support the hypothesis that GM1 antibodies are involved in the pathogenesis of PPS.

  • short communication gm1 antibodies in post polio Syndrome and previous paralytic polio
    2003
    Co-Authors: E Farbu, T Rekand
    Abstract:

    We studied the relationship between Post-Polio Syndrome (PPS) and GM1 antibodies, since such antibodies have been associated with PPS and motor neuron disorders. Sera from 144 patients with previous poliomyelitis (105 paralytic, 22 nonparalytic and 17 PPS), 60 with