The Experts below are selected from a list of 618 Experts worldwide ranked by ideXlab platform
Ruey J. Sung - One of the best experts on this subject based on the ideXlab platform.
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Clinical efficacy of Propantheline Bromide in neurocardiogenic syncope: Pharmacodynamic implications
Cardiovascular Drugs and Therapy, 1997Co-Authors: Ruey J. SungAbstract:The pharmacological response with tilt-table testing predicts long-term efficacy in neurocardiogenic syncope. However, beta-blockers for neurocardiogenic syncope are often not tolerated or are ineffective. Since cholinergic tone is important in the efferent part of the neurocardiogenic reflex, we investigated the pharmacodynamics and efficacy of Propantheline Bromide in preventing neurocardiogenic syncope. We studied 16 patients (11 males) with a mean age of 48.8 (± 15.1) years with presyncope or syncope and who had positive baseline tilt-table studies at a mean of 15.8 (± 10.3) minutes into the upright 60° tilt. They were given Propantheline Bromide orally, an anticholinergic agent, at a dose of 64.3 (± 21.8) mg/day for 7 days, and tilt-table testing was repeated 1 hour after readministration of Propantheline Bromide, 30 mg orally. After Propantheline Bromide treatment, 13 of 16 patients (81%) had no inducible presyncope or syncope on repeat tilt-table testing. In this group of responders, the mean minimum heart rate during upright tilt-table testing increased from 43.2 (± 77.3) beats/min to 77.3 (± 17.2) beats/min after Propantheline Bromide (p
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clinical efficacy of Propantheline Bromide in neurocardiogenic syncope pharmacodynamic implications
Cardiovascular Drugs and Therapy, 1997Co-Authors: Ruey J. SungAbstract:The pharmacological response with tilt-table testing predicts long-term efficacy in neurocardiogenic syncope. However, beta-blockers for neurocardiogenic syncope are often not tolerated or are ineffective. Since cholinergic tone is important in the efferent part of the neurocardiogenic reflex, we investigated the pharmacodynamics and efficacy of Propantheline Bromide in preventing neurocardiogenic syncope. We studied 16 patients (11 males) with a mean age of 48.8 (± 15.1) years with presyncope or syncope and who had positive baseline tilt-table studies at a mean of 15.8 (± 10.3) minutes into the upright 60° tilt. They were given Propantheline Bromide orally, an anticholinergic agent, at a dose of 64.3 (± 21.8) mg/day for 7 days, and tilt-table testing was repeated 1 hour after readministration of Propantheline Bromide, 30 mg orally. After Propantheline Bromide treatment, 13 of 16 patients (81%) had no inducible presyncope or syncope on repeat tilt-table testing. In this group of responders, the mean minimum heart rate during upright tilt-table testing increased from 43.2 (± 77.3) beats/min to 77.3 (± 17.2) beats/min after Propantheline Bromide (p<0.005). More significantly, the minimum mean arterial blood pressure increased from 42.2 (± 25) mmHg to 81.3 (± 16.7) mmHg (p<0.0005) during upright tilt. At a follow-up of 15.2 (± 7.4) months, in the responder group (12 patients with long-term follow-up), the average dose of Propantheline Bromide was 32.5 (± 23.8) mg/day, which was significantly reduced from the initial dose (p<0.05). A clinical recurrence of symptoms occurred in only 4 out of 12 patients on Propantheline Bromide (33%), none of which were directly attributable to drug failure. It was concluded from this study that Propantheline Bromide is highly effective in preventing neurocardiogenic syncope. In addition, Propantheline Bromide's effectiveness is more than would be expected by prevention of cardioinhibition in neurocardiogenic syncope and would support a role for direct cholinergic control of vascular tone.
Richard H Stanford - One of the best experts on this subject based on the ideXlab platform.
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Propantheline Bromide in the Management of Hyperhidrosis Associated with Spinal Cord Injury
Annals of Pharmacotherapy, 1995Co-Authors: Bruce R. Canaday, Richard H StanfordAbstract:Objective:To report 2 cases in which oral Propantheline reduced the discomfort associated with sweating related to spinal cord injury (SCI), and to review the literature on the management of SCI-related sweating.Case Summaries:Case 1: A 27-year-old quadriplegic man with an American Spinal Injury Association (ASIA) Frankel class C injury to C5/C6 experienced profuse sweating and requested Propantheline. He stated that he had received the medication previously and reported that Propantheline 15 mg tid had controlled his sweating. Propantheline Bromide was reinstituted, and within 24 hours, the patient's episodes of profuse sweating had decreased markedly in number and frequency. Case 2: A 35-year-old quadriplegic woman had an ASIA class D lesion at C3. Since her injury, she had experienced profuse sweating that worsened when she became cold and at night. She stated that her sweating was under control as long as she took Propantheline. Propantheline therapy was continued and no further sweating episodes have...
P. G. Ramappa - One of the best experts on this subject based on the ideXlab platform.
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Thermoanalytical and spectral characterization of cadmium(II) complexes of Propantheline Bromide
1997Co-Authors: S. Shanmukhappa, P. G. RamappaAbstract:Synthesis, structure and properties of Cd(II) complexes of Propantheline Bromide (PPB) have been studied. The isolated complexes are characterised by various physico-chemical methods. Based on the data, tetrahedral structure has been suggested for the new metal complexes. Thermogravimetric studies of the complexes have Seen performed in order to establish the mode of their thermal stability. The thermal degradation process was found to proceed in two steps. Kinetic and thermodynamic parameters are evaluated on the basis of thermal degradation data. The values of activation energies are found to be in the range 8.5-33.5 kJ mol(-1).
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Synthesis, spectral, thermal studies and antimicrobial activity of cobalt(II) complexes of Propantheline Bromide
1996Co-Authors: S. Shanmukhappa, P. G. RamappaAbstract:The synthesis, spectral characterization, magnetic, susceptibility and molar conductance studies of new series of cobalt(II)complexes of Propantheline Bromide (PPB) with general stoichiometry [Co(PPB)(2)(H2O)(2)X(2)] are reported, where X = Cl-, Br-, ClO4- and CH3COO-. In all the complexes PPB behaves as a unidentate ligand. Thermal studies (TG/DTA) have been used to evaluate kinetic parameters such as order of the thermal reaction (n) and activation energy (E(a)). These new complexes were found to be more potent as antimicrobial agents than the free ligand.
H Y Wang - One of the best experts on this subject based on the ideXlab platform.
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determination of chlorphenamine and Propantheline Bromide in pukeling tablets by differential linear combination derivative spectrophotometry
Acta pharmaceutica Sinica, 1991Co-Authors: L M Lin, N J Zhang, H Y WangAbstract:This paper provides the basic principle and experimental technique of differential--linear combination equal value derivative spectrophotometry. Quantitative analysis of three or four component--mixture can be done without separation. This method was investigated to assay the contents of chlorphenamine and Propantheline Bromide in Pukeling tablets by using UV-210A spectrophotometer. The average recoveries of chlorphenamine and Propantheline Bromide were 100.2 +/- 1.49% (CV) and 99.89 +/- 1.03% (CV) respectively. The results showed that it not only can effectively remove disturbances from each other, but also give higher sensitivity and accuracy.
Bruce R. Canaday - One of the best experts on this subject based on the ideXlab platform.
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Propantheline Bromide in the Management of Hyperhidrosis Associated with Spinal Cord Injury
Annals of Pharmacotherapy, 1995Co-Authors: Bruce R. Canaday, Richard H StanfordAbstract:Objective:To report 2 cases in which oral Propantheline reduced the discomfort associated with sweating related to spinal cord injury (SCI), and to review the literature on the management of SCI-related sweating.Case Summaries:Case 1: A 27-year-old quadriplegic man with an American Spinal Injury Association (ASIA) Frankel class C injury to C5/C6 experienced profuse sweating and requested Propantheline. He stated that he had received the medication previously and reported that Propantheline 15 mg tid had controlled his sweating. Propantheline Bromide was reinstituted, and within 24 hours, the patient's episodes of profuse sweating had decreased markedly in number and frequency. Case 2: A 35-year-old quadriplegic woman had an ASIA class D lesion at C3. Since her injury, she had experienced profuse sweating that worsened when she became cold and at night. She stated that her sweating was under control as long as she took Propantheline. Propantheline therapy was continued and no further sweating episodes have...
