The Experts below are selected from a list of 231 Experts worldwide ranked by ideXlab platform
Luc Verschaeve - One of the best experts on this subject based on the ideXlab platform.
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genetic damage in subjects exposed to Radiofrequency Radiation
Mutation Research-reviews in Mutation Research, 2009Co-Authors: Luc VerschaeveAbstract:Despite many research efforts and public debate there is still great concern about the possible adverse effects of Radiofrequency (RF) Radiation on human health. This is especially due to the enormous increase of wireless mobile telephones and other telecommunication devices throughout the world. The possible genetic effects of mobile phone Radiation and other sources of radiofrequencies constitute one of the major points of concern. In the past several review papers were published on laboratory investigations that were devoted to in vitro and in vivo animal (cyto)genetic studies. However, it may be assumed that some of the most important observations are those obtained from studies with individuals that were exposed to relatively high levels of Radiofrequency Radiation, either as a result of their occupational activity or as frequent users of Radiofrequency emitting tools. In this paper the cytogenetic biomonitoring studies of RF-exposed humans are reviewed. A majority of these studies do show that RF-exposed individuals have increased frequencies of genetic damage (e.g., chromosomal aberrations) in their lymphocytes or exfoliated buccal cells. However, most of the studies, if not all, have a number of shortcomings that actually prevents any firm conclusion. Radiation dosimetry was lacking in all papers, but some of the investigations were flawed by much more severe imperfections. Large well-coordinated multidisciplinary investigations are needed in order to reach any robust conclusion.
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Cytogenetic investigation of subjects professionally exposed to Radiofrequency Radiation
Mutagenesis, 2006Co-Authors: Annemarie Maes, Urbain Van Gorp, Luc VerschaeveAbstract:Nowadays, virtually everybody is exposed to Radiofrequency Radiation (RFR) from mobile phone base station antennas or other sources. At least according to some scientists, this exposure can have detrimental health effects. We investigated cytogenetic effects in peripheral blood lymphocytes from subjects who were professionally exposed to mobile phone electromagnetic fields in an attempt to demonstrate possible RFR-induced genetic effects. These subjects can be considered well suited for this purpose as their RFR exposure is 'normal' though rather high, and definitely higher than that of the 'general population'. The alkaline comet assay, sister chromatid exchange (SCE) and chromosome aberration tests revealed no evidence of RFR-induced genetic effects. Blood cells were also exposed to the well known chemical mutagen mitomycin C in order to investigate possible combined effects of RFR and the chemical. No cooperative action was found between the electromagnetic field exposure and the mutagen using either the comet assay or SCE test.
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genetic effects of Radiofrequency Radiation rfr
Toxicology and Applied Pharmacology, 2005Co-Authors: Luc VerschaeveAbstract:Abstract The possible effects of Radiofrequency (RF) exposure on the genetic material of cells are considered very important since damage to the DNA of somatic cells can be linked to cancer development or cell death whereas damage to germ cells can lead to genetic damage in next and subsequent generations. This is why the scientific literature reports many investigations on the subject. According to a number of review papers, the conclusion so far is that there is little evidence that RFR is directly mutagenic and that adverse effects that were reported in some of the papers are predominantly the result of hyperthermia. Yet, some subtle indirect effects on DNA replication and/or transcription of genes under relatively restricted exposure conditions cannot be ruled out. Furthermore, the possibility of combined effects of RFR with environmental carcinogens/mutagens merits further attention. The present paper takes into account more recent investigations but the conclusion remains the same. A majority of studies report no increased (cyto)genetic damage but yet, a considerable number of investigations do. However, many studies were not sufficiently characterized, are therefore difficult to replicate and cannot be compared to others. Experimental protocols were very different from one study to another and investigations from a single laboratory were very often limited in the sample size or number of cells investigated, preventing a robust statistical analysis. Subtle, but significant differences between RFR-exposed and sham-exposed cells cannot be found in such conditions. For the above reasons, it was concluded at a workshop in Lowenstein (November 2002) that further investigations by individual laboratories most probably will not add much to the discussion of Radiofrequency Radiation (RFR) genotoxicity. Large, well coordinated, international collaborative studies involving participation of several experienced scientists are considered an alternative of uttermost importance. One such study is now being planned.
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Some Considerations on the Genotoxicity of Radiofrequency Radiation
Wireless Phones and Health, 2002Co-Authors: Luc VerschaeveAbstract:According to most scientific data, it may be anticipated that Radiofrequency Radiation is in itself not capable of breaking DNA or being genotoxic, especially when exposure is under so-called athermal conditions. Yet, occasionally, significant genetic changes (e.g., increased chromosome aberration frequencies) are found which may be ascribed to small differences in biological samples and/or in the exposure conditions. Experiments using well defined exposure conditions and materials should therefore be encouraged. Furthermore, up to now, little attention was paid to potential synergistic effects with chemical mutagens/carcinogens. Also, the choice of the investigated genetic endpoint is important. This is often not sufficiently taken into consideration when results are evaluated. Finally, experiments on biomonitoring should also consider the presence of possible hypersensitive subjects in the test population.
S J Allen - One of the best experts on this subject based on the ideXlab platform.
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The Radiofrequency Radiation Dosimetry Handbook: reminiscences.
Bioelectromagnetics, 1999Co-Authors: S J AllenAbstract:This paper traces the history of the development of the Radiofrequency Radiation Dosimetry Handbook and its subsequent impact on radio frequency Radiation exposure standards. The author's recollections are used to illustrate the behind the scenes efforts of the individuals involved in this project. The development of models at the University of Utah and confirmation of these results by various experimenters led to the publication of four editions of the Radiofrequency Radiation Dosimetry Handbook, i.e., "The RFR Experimenters Bible."
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The Radiofrequency Radiation Dosimetry Handbook: reminiscences.
Bioelectromagnetics, 1999Co-Authors: S J AllenAbstract:This paper traces the history of the development of the Radiofrequency Radiation Dosimetry Handbook and its subsequent impact on radio frequency Radiation exposure standards. The author's recollections are used to illustrate the behind the scenes efforts of the individuals involved in this project. The development of models at the University of Utah and confirmation of these results by various experimenters led to the publication of four editions of the Radiofrequency Radiation Dosimetry Handbook, i.e., “The RFR Experimenters Bible.” Bioelectromagnetics 20:9–11, 1999. © 1999 Wiley-Liss, Inc.
R. De Seze - One of the best experts on this subject based on the ideXlab platform.
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Biological effects of amplitude-modulated Radiofrequency Radiation
Scandinavian journal of work environment & health, 1998Co-Authors: Jukka Juutilainen, R. De SezeAbstract:Users of mobile telephones are exposed to Radiofrequency Radiation. One of the questions still open today is whether amplitude-modulated Radiofrequency signals from digital phones exert specific bioeffects different from those of continuous (unmodulated) Radiofrequency Radiation. This paper reviews recent literature on the bioeffects of amplitude-modulated Radiofrequency Radiation, from cells to humans. The consistency of the results is discussed, and exposure parameters are compared to identify possible biologically active forms of amplitude modulation. Several studies have reported findings consistent with effects on the nervous system and cancer-related biological processes. However, the methods and exposure parameters vary widely, and no independent replications of the positive findings have been reported. The results available today fail to support the existence of well-defined modulation-specific bioeffects from exposure to Radiofrequency Radiation. Additional systematic studies are needed to identify possible reproducible modulation-dependent effects and biologically active modulation parameters.
S.m.j. Mortazavi - One of the best experts on this subject based on the ideXlab platform.
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Short-term exposure to mobile jammer Radiofrequency Radiation adversely affects the human hearing
Biomedical Research-tokyo, 2017Co-Authors: Mohammad Mehdi Movahedi, B Javid-sharifi, A Tavakoli Golpaygani, S.m.j. MortazaviAbstract:Background: Several studies have been conducted to assess the effect of Radiofrequency Radiation on human health. Substantial evidence indicates that exposure to common sources of electromagnetic fields (EMFs) such as mobile phones, laptops or WiFi-connected laptops adversely affect human health. Over the past decades, the usage of mobile phone has spread widely and rapidly. Mobile jammers are devices which are used to block mobile phone signals in public places such as offices, places of worship and conference rooms, by emitting a series of EM pulses and distracting communication systems. This study was aimed at investigating the effect of short term exposure to mobile jammers on human hearing. Materials and Methods: A total of 70 young, healthy volunteer students were studied. These subjects were divided into two groups with an equal male to female ratio. None of the students had the history of hearing problems. Standard audiogram tests were performed for both groups after one hour of exposure/sham exposure. Data analysis was performed using SPSS software. Paired t-test and ANOVA were used for data analysis. Results: This is the first study to assess the effect of mobile jammer RF Radiation short term exposure on human hearing. Findings of this study showed that the quality of hearing in students who were exposed to jammer Radiofrequency Radiation for 1 h was significantly lower than that of the sham exposed group. There was a statistically significant difference between two groups, especially in 1000 and 2000 Hz frequencies. Conclusion: Exposure to mobile jammer Radiation for durations as low as 1 hour adversely affects the human hearing. Considering the health effects of mobile jammers, stricter regulations are needed for limiting the application of these devices.
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Oxidative mechanisms of biological activity of low-intensity Radiofrequency Radiation.
Electromagnetic biology and medicine, 2016Co-Authors: S.m.j. Mortazavi, S. A. R. MortazaviAbstract:We read with great interest an article by Yakymenko et al. entitled “Oxidative Mechanisms of Biological Activity of Low-Intensity Radiofrequency Radiation” that is published in the form of Early On...
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non linear adaptive phenomena which decrease the risk of infection after pre exposure to Radiofrequency Radiation
Dose-response, 2014Co-Authors: S.m.j. Mortazavi, Mohammad Taheri, Mohammad Motamedifar, G Namdari, A R Mortazavi, N ShokrpourAbstract:Substantial evidence indicates that adaptive response induced by low doses of ionizing Radiation can result in resistance to the damage caused by a subsequently high-dose Radiation or cause cross-resistance to other non-Radiation stressors. Adaptive response contradicts the linear-non-threshold (LNT) dose-response model for ionizing Radiation. We have previously reported that exposure of laboratory animals to Radiofrequency Radiation can induce a survival adaptive response. Furthermore, we have indicated that pre-exposure of mice to Radiofrequency Radiation emitted by a GSM mobile phone increased their resistance to a subsequent Escherichia coli infection. In this study, the survival rates in animals receiving both adapting (Radiofrequency) and challenge dose (bacteria) and the animals receiving only the challenge dose (bacteria) were 56% and 20%, respectively. In this light, our findings contribute to the assumption that Radiofrequency-induced adaptive response can be used as an efficient method for decr...
Maria Rosaria Scarfì - One of the best experts on this subject based on the ideXlab platform.
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Radiofrequency Radiation is capable of inducing adaptive response in human blood lymphocytes
2010Co-Authors: Anna Sannino, Olga Zeni, Maurizio Sarti, V. Vijayalaxmi, Stefania Romeo, Maria Rosaria ScarfìAbstract:In a previous study we demonstrated that 20 h exposure of human blood lymphocytes from five donors to 900 MHz Radiofrequency Radiation in GSM modulation (average SAR 1.25 W/kg) induced adaptive response when the cells were subsequently challenged with Mitomycin-C. In the present study we confirmed our previous results on a larger number of donors. The observed phenomenon suggests the possibility that Radiofrequency Radiation may be used to protect individuals from genotoxic treatments employed in clinical/diagnostic procedures.
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induction of adaptive response in human blood lymphocytes exposed to Radiofrequency Radiation
Radiation Research, 2009Co-Authors: Anna Sannino, Maurizio Sarti, Siddharth B Reddy, Thomas J Prihoda, Maria Rosaria ScarfìAbstract:Abstract Sannino, A., Sarti, M., Reddy, S. B., Prihoda, T. J., Vijayalaxmi and Scarfi, M. R. Induction of Adaptive Response in Human Blood Lymphocytes Exposed to Radiofrequency Radiation. Radiat. Res. 171, 735–742 (2009). The incidence of micronuclei was evaluated to assess the induction of an adaptive response to non-ionizing Radiofrequency (RF) Radiation in peripheral blood lymphocytes collected from five different human volunteers. After stimulation with phytohemagglutinin for 24 h, the cells were exposed to an adaptive dose of 900 MHz RF Radiation used for mobile communications (at a peak specific absorption rate of 10 W/kg) for 20 h and then challenged with a single genotoxic dose of mitomycin C (100 ng/ml) at 48 h. Lymphocytes were collected at 72 h to examine the frequency of micronuclei in cytokinesis-blocked binucleated cells. Cells collected from four donors exhibited the induction of adaptive response (i.e., responders). Lymphocytes that were pre-exposed to 900 MHz RF Radiation had a significan...
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Exposure to 900 MHz Radiofrequency Radiation induces caspase 3 activation in proliferating human lymphocytes.
Radiation research, 2008Co-Authors: Rosanna Palumbo, Anna Sannino, Maurizio Sarti, F. Brescia, Domenica Capasso, Miriam Capri, Emanuela Grassilli, Maria Rosaria ScarfìAbstract:Abstract Palumbo, R., Brescia, F., Capasso, D., Sannino, A., Sarti, M., Capri, M., Grassilli, E. and Scarfi, M. R. Exposure to 900 MHz Radiofrequency Radiation Induces Caspase 3 Activation in Proliferating Human Lymphocytes. Radiat. Res. 170, 327– 334 (2008). In this study, the induction of apoptosis after exposure to 900 MHz Radiofrequency Radiation (GSM signal) was investigated by assessing caspase 3 activation in exponentially growing Jurkat cells and in quiescent and proliferating human peripheral blood lymphocytes (PBLs). The exposure was carried out at an average specific absorption rate of 1.35 W/kg in a dual wire patch cell exposure system where the temperature of cell cultures was accurately controlled. After 1 h exposure to the Radiofrequency field, a slight but statistically significant increase in caspase 3 activity, measured 6 h after exposure, was observed in Jurkat cells (32.4%) and in proliferating human PBLs (22%). In contrast, no effect was detected in quiescent human PBLs. In the same e...
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Radiofrequency Radiation and Replication Studies
Chromosomal Alterations, 1Co-Authors: Maria Rosaria Scarfì, Ferdinando BersaniAbstract:The induction of genotoxic effects after exposure to Radiofrequency Radiation represents one of the important aspects in the risk assessment of human exposure because of a close correlation between DNA damage and carcinogenesis. Most of the papers on this topic, published in peer-reviewed scientific journals, refer to experiments conducted by independent investigations who employed different experimental conditions, such as exposure characteristics, biological material examined as well as laboratory techniques. In particular, genotoxicity has been evaluated using several cytogenetic techniques, such as chromosomal aberrations, sister-chromatid exchanges, micronuclei and single-cell gel electrophoresis/ comet assay. Just a few studies were “confirmatory,” carried out adopting exactly the same experimental conditions. In this chapter the studies reported in the literature on the genotoxic potential of in vivo and in vitro exposure to Radiofrequency Radiation where several authors employed similar experimental conditions are compared and discussed.