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Argye E Hillis - One of the best experts on this subject based on the ideXlab platform.
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characterizing subtypes and neural correlates of receptive aprosodia in acute Right Hemisphere Stroke
Cortex, 2021Co-Authors: Argye E Hillis, Shannon M Sheppard, Erin L Meier, Alexandra Zezinka Durfee, Alex Walker, Jennifer SheaAbstract:Abstract Introduction Speakers naturally produce prosodic variations depending on their emotional state. Receptive prosody has several processing stages. We aimed to conduct lesion-symptom mapping to determine whether damage (core infarct or hypoperfusion) to specific brain areas was associated with receptive aprosodia or with impairment at different processing stages in individuals with acute Right Hemisphere Stroke. We also aimed to determine whether different subtypes of receptive aprosodia exist that are characterized by distinctive behavioral performance patterns. Methods Twenty patients with receptive aprosodia following Right Hemisphere ischemic Stroke were enrolled within five days of Stroke; clinical imaging was acquired. Participants completed tests of receptive emotional prosody, and tests of each stage of prosodic processing (Stage 1: acoustic analysis; Stage 2: analyzing abstract representations of acoustic characteristics that convey emotion; Stage 3: semantic processing). Emotional facial recognition was also assessed. LASSO regression was used to identify predictors of performance on each behavioral task. Predictors entered into each model included 14 Right Hemisphere regions, hypoperfusion in four vascular territories as measured using FLAIR hyperintense vessel ratings, lesion volume, age, and education. A k-medoid cluster analysis was used to identify different subtypes of receptive aprosodia based on performance on the behavioral tasks. Results Impaired receptive emotional prosody and impaired emotional facial expression recognition were both predicted by greater percent damage to the caudate. The k-medoid cluster analysis identified three different subtypes of aprosodia. One group was primarily impaired on Stage 1 processing and primarily had frontotemporal lesions. The second group had a domain-general emotion recognition impairment and maximal lesion overlap in subcortical areas. Finally, the third group was characterized by a Stage 2 processing deficit and had lesion overlap in posterior regions. Conclusions Subcortical structures, particularly the caudate, play an important role in emotional prosody comprehension. Receptive aprosodia can result from impairments at different processing stages.
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abstract wp420 lesions associated with impaired expression of emotion Right Hemisphere Stroke
Stroke, 2018Co-Authors: Sona Patel, Kenichi Oishi, Amy Wright, Sadhvi Saxena, Argye E HillisAbstract:Introduction: Impaired expression of emotion through tone, loudness, rate, and rhythm of speech (affective prosody) is common after Right Hemisphere (RH) Stroke and impedes all social interactions....
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Selective Deficits in Prosody after Right Hemisphere Stroke (P6.325)
Neurology, 2017Co-Authors: Harry Sutherland-foggio, Amy Wright, Rajani Sebastian, Argye E HillisAbstract:Objective: To demonstrate that Right Hemisphere Stroke (RHS) can result in selective impairments to specific components of affective prosody (e.g. identifying prosodic features such as the pitch, rate, and volume of speech; accessing prosodic representations of which features convey specific emotions; retrieving the meanings of those emotions; and executing motor programs to produce prosody). Background: Impairments in both recognition and expression of affective prosody have been reported after RHS, but the acoustic and cognitive mechanisms underlying those deficits have not been identified. Design/Methods: 40 acute ischemic RHS patients and 40 healthy, age-matched controls were tested with a battery of tasks designed to evaluate each of the proposed mechanisms underlying prosody. Tasks included: (1) identifying prosodic features from auditory stimuli; (2) matching prosodic features to emotions; (3) identifying emotions from narrated sentences, assessing recognition of emotions from prosody; (4) matching emotions to situations and facial expressions; (5) reading sentences with specified emotions; and (6) repeating neutral-content sentences with the original speaker’s emotion. Deficits were defined by performance 2 standard deviations below the mean for controls on recognition tasks and by 2 SD below the mean coefficient of variation in fundamental frequency of speech on production tasks. Results: Patients with deficits in 1+ task had larger lesions than patients with normal performance on all tasks (25.9 versus 16.1 cc; p Conclusions: These selective deficits provide evidence for distinct, dissociable mechanisms underlying affective prosody recognition and production. Deficits to different mechanisms require different management strategies. Disclosure: Dr. Sutherland-Foggio has nothing to disclose. Dr. WRight has nothing to disclose. Dr. Sebastian has nothing to disclose. Dr. Hillis has received personal compensation in an editorial capacity for American Heart Association for serving as Associate Editor of Stroke and Elsevier for serving as Associate Editor of Practice Update Neurology.
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what makes Right Hemisphere Stroke patients sound emotionless p6 327
Neurology, 2017Co-Authors: Alexandra Basilakos, Amy Wright, Harry Sutherlandfoggio, Corey Demsky, Sadhvi Saxena, Donna C Tippett, Daniel Fogerty, Argye E HillisAbstract:Objective: Test the hypothesis that impairments of rhythm and pitch modulation are associated with listener perception of lack of emotion in speech of patients with Right Hemisphere Stroke (RHS). Background: Impaired expression of emotions through prosody (tone of voice, loudness, rate, and rhythm) has been reported after RHS, but acoustic features associated with listener perception of impaired prosody have not been identified. Design/Methods: We tested 49 patients with acute RHS on picture description and sentence repetition with the modeled emotion (sad, happy, surprised, or fearful). Twenty-one controls judged: (1) prosody of picture description on a 7-point scale, and (2) accuracy of patients’ reproducing the speaker’s emotion in repetition of neutral content sentences (as impaired, equivocal, or normal). Acoustic measurements included: coefficient of variation in fundamental frequency (CV Fo; pitch modulation), pitch and loudness range, and assessment of rhythm through Envelope Modulation Spectra (EMS). EMS measures included: energy in 5 frequency ranges; energy below 4 Hz; energy above 4 Hz; peak in the spectrum 1–8 Hz with greatest amplitude (peak frequency); amplitude of that peak divided by overall amplitude. We tested associations between listener ratings and acoustic variables. Results: CV Fo correlated with listener ratings of accuracy of reproducing emotions in sentence repetition (rho=0.31; p=0.028). Lowest quartile rating of accuracy was associated with the lowest quartile of CV Fo (chi squared=5.03; p=0.025). Lowest quartile of rating of prosody in picture description was associated with energy in the lowest band, adjusted for overall energy (energy in proband 1; chi squared = 5.63; p=0.018, and the peak frequency (chi squared=4.07; p=0.044). Using logistic regression, peak frequency, energy in proband 1, and CV Fo were all independently associated with lowest quartile of prosody rating (chi squared = 8.97; p = 0.029). Conclusions: Impaired pitch modulation and rhythm contribute to listener perception of lack of emotion in speech after RHS. Study Supported by: National Institutes of Health through awards R01 NS047691 and P50 DC014664. Disclosure: Dr. Basilakos has nothing to disclose. Dr. Sutherland-Foggio has nothing to disclose. Dr. Demsky has nothing to disclose. Dr. WRight has nothing to disclose. Dr. Saxena has nothing to disclose. Dr. Tippett has nothing to disclose. Dr. Fogerty has nothing to disclose. Dr. Hillis has received personal compensation in an editorial capacity for American Heart Association for serving as Associate Editor of Stroke and Elsevier for serving as Associate Editor of Practice Update Neurology.
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abstract wp431 acute Stroke in Right anterior insula and frontal operculum impair empathy
Stroke, 2016Co-Authors: Jui-hong Chien, Kumiko Oishi, Kenichi Oishi, Frederick Lenz, Argye E HillisAbstract:Introduction: Emotional empathy includes emotional contagion (sharing another’s feelings) and perspective-taking (inferring another’s feelings). Earlier studies show that Right Hemisphere Stroke (R...
Christoph Helmchen - One of the best experts on this subject based on the ideXlab platform.
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brain activations during optokinetic stimulation in acute Right Hemisphere Stroke patients and hemispatial neglect an fmri study
Neurorehabilitation and Neural Repair, 2019Co-Authors: Janina Von Der Gablentz, Inga Konemund, Andreas Sprenger, W Heide, Marcus Heldmann, Christoph Helmchen, Bjorn MachnerAbstract:Objective. Leftward optokinetic stimulation (OKS) is a promising therapeutic approach for Right-Hemisphere Stroke patients with left hemispatial neglect. We questioned whether the putative neural b...
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Randomized Controlled Trial on Hemifield Eye Patching and Optokinetic Stimulation in Acute Spatial Neglect
Stroke, 2014Co-Authors: B. Machner, Janina Von Der Gablentz, Inga Konemund, Andreas Sprenger, Christoph HelmchenAbstract:Background and Purpose—Right Hemisphere Stroke patients frequently experience spatial neglect, a severe lack of awareness for contralesional hemispace. Although neglect counts among the strongest predictors for poor functional outcome after Stroke, there is no established therapy, particularly not for the acute stage. Methods—In a randomized controlled trial, we compared the combined treatment of hemifield eye patching and repetitive optokinetic stimulation in acute Stroke patients with neglect to the spontaneous course. Outcome measures were a neuropsychological test battery for neglect as well as scales of functional independence and clinical impairment. Outcomes were assessed at baseline (day 1), post treatment (day 8), and at 1-month follow-up (day 30). Results—Final analysis included 21 acute Right Hemisphere Stroke patients with neglect (23 enrolled, 2 lost to follow-up) allocated either to the treatment (1 week hemifield eye patching and daily sessions of optokinetic stimulation, n=11) or the contr...
Maurizio Corbetta - One of the best experts on this subject based on the ideXlab platform.
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common and unique structural plasticity after left and Right Hemisphere Stroke
Journal of Cerebral Blood Flow and Metabolism, 2021Co-Authors: Yijun Chen, Yaya Jiang, Xiangyu Kong, Chenxi Zhao, Suyu Zhong, Liyuan Yang, Tao Feng, Shaoling Peng, Maurizio CorbettaAbstract:Strokes to the left and Right Hemisphere lead to distinctive behavioral profiles. Are left and Right Hemisphere Strokes (LHS and RHS) associated with distinct or common postStroke neuroplasticity p...
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differential white matter involvement associated with distinct visuospatial deficits after Right Hemisphere Stroke
Cortex, 2017Co-Authors: Alex R Carter, Jennifer Rengachary, Kristi Zinn, Joshua S Siegel, Nicholas V Metcalf, Gordon L Shulman, Mark P Mcavoy, Xin Hong, Serguei V Astafiev, Maurizio CorbettaAbstract:Abstract Visuospatial attention depends on the integration of multiple processes, and people with Right Hemisphere lesions after a Stroke may exhibit severe or no visuospatial deficits. The anatomy of core components of visuospatial attention is an area of intense interest. Here we examine the relationship between the disruption of core components of attention and lesion distribution in a heterogeneous group ( N = 70) of patients with Right Hemisphere Strokes regardless of the presence of clinical neglect. Deficits of lateralized spatial orienting, measured as the difference in reaction times for responding to visual targets in the contralesional or ipsilesional visual field, and deficits in re-orienting attention, as measured by the difference in reaction times for invalidly versus validly cued targets, were measured using a computerized spatial orienting task. Both measures were related through logistic regression and a novel ridge regression method to anatomical damage measured with magnetic resonance imaging. While many regions were common to both deficit maps, a deficit in lateralized spatial orienting was more associated with lesions in the white matter underlying the posterior parietal cortex, and middle and inferior frontal gyri. A deficit in re-orienting of attention toward unattended locations was associated with lesions in the white matter of the posterior parietal cortex, insular cortex and less so with white matter involvement of the anterior frontal lobe. An hodological analysis also supports this partial dissociation between the white matter tracts that are damaged in lateralized spatial biases versus impaired re-orienting. Our results underscore that the integrity of fronto-parietal white matter tracts is crucial for visuospatial attention and that different attention components are mediated by partially distinct neuronal substrates.
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dissociated functional connectivity profiles for motor and attention deficits in acute Right Hemisphere Stroke
Brain, 2016Co-Authors: Antonello Baldassarre, Abraham Z Snyder, Lenny Ramsey, Jennifer Rengachary, Kristi Zinn, Joshua S Siegel, Nicholas V Metcalf, Michael J Strube, Maurizio Corbetta, Gordon L ShulmanAbstract:Strokes often cause multiple behavioural deficits that are correlated at the population level. Here, we show that motor and attention deficits are selectively associated with abnormal patterns of resting state functional connectivity in the dorsal attention and motor networks. We measured attention and motor deficits in 44 Right Hemisphere-damaged patients with a first-time Stroke at 1–2 weeks post-onset. The motor battery included tests that evaluated deficits in both upper and lower extremities. The attention battery assessed both spatial and non-spatial attention deficits. Summary measures for motor and attention deficits were identified through principal component analyses on the raw behavioural scores. Functional connectivity in structurally normal cortex was estimated based on the temporal correlation of blood oxygenation level-dependent signals measured at rest with functional magnetic resonance imaging. Any correlation between motor and attention deficits and between functional connectivity in the dorsal attention network and motor networks that might spuriously affect the relationship between each deficit and functional connectivity was statistically removed. We report a double dissociation between abnormal functional connectivity patterns and attention and motor deficits, respectively. Attention deficits were significantly more correlated with abnormal interhemispheric functional connectivity within the dorsal attention network than motor networks, while motor deficits were significantly more correlated with abnormal interhemispheric functional connectivity patterns within the motor networks than dorsal attention network. These findings indicate that functional connectivity patterns in structurally normal cortex following a Stroke link abnormal physiology in brain networks to the corresponding behavioural deficits. * Abbreviations : DAN : dorsal attention network FC : functional connectivity L/RHD : left/Right Hemisphere damage
Janina Von Der Gablentz - One of the best experts on this subject based on the ideXlab platform.
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brain activations during optokinetic stimulation in acute Right Hemisphere Stroke patients and hemispatial neglect an fmri study
Neurorehabilitation and Neural Repair, 2019Co-Authors: Janina Von Der Gablentz, Inga Konemund, Andreas Sprenger, W Heide, Marcus Heldmann, Christoph Helmchen, Bjorn MachnerAbstract:Objective. Leftward optokinetic stimulation (OKS) is a promising therapeutic approach for Right-Hemisphere Stroke patients with left hemispatial neglect. We questioned whether the putative neural b...
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the ipsilesional attention bias in Right Hemisphere Stroke patients as revealed by a realistic visual search task neuroanatomical correlates and functional relevance
Neuropsychology (journal), 2018Co-Authors: Bjorn Machner, Janina Von Der Gablentz, Inga Konemund, Paul M Bays, Andreas SprengerAbstract:Objective Right-Hemisphere Stroke may cause an ipsilesional attention bias and left hemispatial neglect. Computerized time-limited tasks are more sensitive than conventional paper-pencil tests in detecting these spatial attention deficits. However, their frequency in the acute stage of Stroke, the neuroanatomical basis and functional relevance for patients' everyday life are unclear. Method A realistic visual search task is introduced, in which eye movements are recorded while the patient searches for paperclips among different everyday objects on a computer display. The "desk task" performance of 34 acute Right-Hemisphere Stroke patients was compared to established paper-pencil tests for neglect and the Posner reaction time task, and finally correlated to structural brain lesions. Results Most of the patients, even those without clinical neglect signs and with normal paper-pencil test performance, exhibited a clear ipsilesional attention bias in the desk task. This bias was highly correlated to the left-Right asymmetry in the Posner task and to neglect-related functional impairment scores. Lesion-symptom mapping revealed task-specific differences: deficits in the desk task were associated with lesions of the superior temporal gyrus, contralesional unawareness in the Posner task with ventral frontal cortex lesions and paper-pencil cancellation bias with damage to the inferior parietal lobe. Neglect behavior was further associated with distinct frontoparietal white matter tract disconnections (inferior longitudinal fasciculus, superior longitudinal fasciculus, arcuate). Conclusions Results from the novel desk task indicate a functional relevance of spatial attention deficits in Right-Hemisphere Stroke patients, even if they are "subclinical." This should be considered especially in patients without obvious clinical neglect signs. (PsycINFO Database Record (c) 2018 APA, all Rights reserved).
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Randomized Controlled Trial on Hemifield Eye Patching and Optokinetic Stimulation in Acute Spatial Neglect
Stroke, 2014Co-Authors: B. Machner, Janina Von Der Gablentz, Inga Konemund, Andreas Sprenger, Christoph HelmchenAbstract:Background and Purpose—Right Hemisphere Stroke patients frequently experience spatial neglect, a severe lack of awareness for contralesional hemispace. Although neglect counts among the strongest predictors for poor functional outcome after Stroke, there is no established therapy, particularly not for the acute stage. Methods—In a randomized controlled trial, we compared the combined treatment of hemifield eye patching and repetitive optokinetic stimulation in acute Stroke patients with neglect to the spontaneous course. Outcome measures were a neuropsychological test battery for neglect as well as scales of functional independence and clinical impairment. Outcomes were assessed at baseline (day 1), post treatment (day 8), and at 1-month follow-up (day 30). Results—Final analysis included 21 acute Right Hemisphere Stroke patients with neglect (23 enrolled, 2 lost to follow-up) allocated either to the treatment (1 week hemifield eye patching and daily sessions of optokinetic stimulation, n=11) or the contr...
Derick T Wade - One of the best experts on this subject based on the ideXlab platform.
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motor imagery in patients with a Right Hemisphere Stroke and unilateral neglect
Brain Injury, 2011Co-Authors: Anke Vromen, Jeanine A Verbunt, Sascha M C Rasquin, Derick T WadeAbstract:Introduction: In the last decade new treatments based on mental imagery have been developed for patients with Stroke. Whether this therapy works for patients with neglect is currently unclear.Objective: To investigate whether patients with a Right Hemisphere stoke complicated with unilateral neglect were less capable of performing motor imagery as compared to patients with a Right Hemisphere Stroke without unilateral neglect.Methods: In a patient-control study, 20 patients with a Right Hemisphere Stroke were included. Twelve patients were diagnosed on admission with neglect and eight without neglect. The ability to perform motor imagery was tested using mental rotation tasks, based on either a visual (CMIA ‘Hand Rotation’ test) or a verbal (Questionnaire d’Imagerie Mentale: Rotation des Mains) instruction. In both tasks subjects were instructed to generate a mental image of their hand.Results: Patients with neglect scored significantly less (p = 0.02) as compared to patients without neglect on the visual ...
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unilateral somatoparaphrenia after Right Hemisphere Stroke a case description
Cortex, 1995Co-Authors: Peter W Halligan, John C Marshall, Derick T WadeAbstract:We report a case of somatoparaphrenia in a 41 year-old man after Right temporo-parietal Stroke. An elaborate system of delusional beliefs was observed concerning the initially paralysed left leg, arm, and hand. The course of these beliefs is analysed as the patient progresses from a full-blown delusional state to having excellent insight into his condition. We outline the types of explantation that seem required to understand how somatoparaphrenic beliefs can arise.
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three arms a case study of supernumerary phantom limb after Right Hemisphere Stroke
Journal of Neurology Neurosurgery and Psychiatry, 1993Co-Authors: Peter W Halligan, John C Marshall, Derick T WadeAbstract:A case of supernumerary phantom limb is described after a haematoma within the Right basal ganglia. The phantom, which persisted for many months, occurred in the context of severe left hemiplegia, sensory loss, hemianopia, and neglect. The subjective reality of this "third arm" caused the patient considerable distress, which was not ameliorated by his attempts to rationalise its existence. Although deeply confused by the phantom, the patient was otherwise fully oriented, with a high verbal IQ, and normal cognition. Two distinct formal interpretations of the phenomenon are discussed.
