Santolina

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Shamsali Rezazadeh - One of the best experts on this subject based on the ideXlab platform.

  • Achillea Santolina reduces serum interlukin-6 level and hyperalgesia during complete Freund's adjuvant-induced inflammation in male Wistar rats.
    Journal of Chinese Integrative Medicine, 2010
    Co-Authors: Jalal Zaringhalam, Akhtar Akbari, Elaheh Tekieh, Homa Manaheji, Shamsali Rezazadeh
    Abstract:

    OBJECTIVE Immune system is involved in the etiology and pathophysiologic mechanisms of inflammation. Medicinal plants are an important source of substances which are claimed to induce non-specific immunomodulatory effects. In view of this and on account of the interleukin (IL)-6's role in inflammation and pain induction, this study investigated the effects of Achillea Santolina extracts on inflammation which was induced by complete Freund's adjuvant (CFA) in male Wistar rats. METHODS Both methanolic and defatted extracts prepared from aerial parts of the plant were examined. Inflammatory symptoms such as hyperalgesia and paw edema in CFA-injected rats' paw were measured by radiant heat and plethysmometer during different stages of study respectively. Serum IL-6 level was checked by rat standard enzyme-linked immunosorbent assay specific kit. RESULTS The results indicated dose-related effects of methanolic extract on paw edema, hyperalgesia and serum IL-6 level reduction in rats. Methanolic extract of A. Santolina exhibited significant antihyperalgesic and anti-inflammatory effects during pretreatment and short-term treatment at dose of 200 mg/kg and there was no significant difference between 200 and 400 mg/kg doses of this extract. Defatted extract did not show significant effect on CFA-induced inflammation during different stages of treatment (P>0.05). Short-term treatment with methanolic extract at dose of 200 mg/kg was more effective than indomethacin in edema, hyperalgesia and serum IL-6 level reduction (P

  • achillea Santolina reduces serum interlukin 6 level and hyperalgesia during complete freund s adjuvant induced inflammation in male wistar rats
    Journal of Chinese Integrative Medicine, 2010
    Co-Authors: Jalal Zaringhalam, Akhtar Akbari, Elaheh Tekieh, Homa Manaheji, Shamsali Rezazadeh
    Abstract:

    OBJECTIVE Immune system is involved in the etiology and pathophysiologic mechanisms of inflammation. Medicinal plants are an important source of substances which are claimed to induce non-specific immunomodulatory effects. In view of this and on account of the interleukin (IL)-6's role in inflammation and pain induction, this study investigated the effects of Achillea Santolina extracts on inflammation which was induced by complete Freund's adjuvant (CFA) in male Wistar rats. METHODS Both methanolic and defatted extracts prepared from aerial parts of the plant were examined. Inflammatory symptoms such as hyperalgesia and paw edema in CFA-injected rats' paw were measured by radiant heat and plethysmometer during different stages of study respectively. Serum IL-6 level was checked by rat standard enzyme-linked immunosorbent assay specific kit. RESULTS The results indicated dose-related effects of methanolic extract on paw edema, hyperalgesia and serum IL-6 level reduction in rats. Methanolic extract of A. Santolina exhibited significant antihyperalgesic and anti-inflammatory effects during pretreatment and short-term treatment at dose of 200 mg/kg and there was no significant difference between 200 and 400 mg/kg doses of this extract. Defatted extract did not show significant effect on CFA-induced inflammation during different stages of treatment (P>0.05). Short-term treatment with methanolic extract at dose of 200 mg/kg was more effective than indomethacin in edema, hyperalgesia and serum IL-6 level reduction (P<0.01, P<0.01 and P<0.05 respectively). CONCLUSION These results suggest that methanolic extract of A. Santolina possesses potent anti-inflammatory and immunomodulatory activities during pretreatment and short-term administration.

Alejandro F. Barrero - One of the best experts on this subject based on the ideXlab platform.

  • Longipinene derivatives from Santolina viscosa.
    Journal of Natural Products, 2000
    Co-Authors: Alejandro F. Barrero, Ramón Alvarez-manzaneda, M. M. Herrador, Miguel Quirós, And Armando Lara, José F. Quílez Del Moral
    Abstract:

    The neutral fraction of the hexane extract of the aerial parts of Santolina viscosa afforded eight new longipinene derivatives (1-8), oblongifolidiol (9), and several other known compounds. The structures of 1-8 were established by spectroscopic methods and chemical transformations. The vulgarone A-type structure previously reported for oblongifolidiol has been reassigned as the longipinene derivative 9 using 2D NMR, chemical correlations, and X-ray diffraction.

  • The first route toward oxygenated monocarbocyclic terpenoids: synthesis of elegansidiol, a new sesquiterpene from Santolina elegans
    Tetrahedron Letters, 1999
    Co-Authors: Alejandro F. Barrero, Enrique Alvarez-manzaneda, M. Mar Herrador, Ramón Alvarez-manzaneda, José F. Quílez, Rachid Chahboun, P. Linares, A. Rivas
    Abstract:

    This paper describes the isolation of elegansidiol (1), a new monocyclic sesquiterpenic alcohol, together with the known monocyclic triterpene achilleol A (2), both from Santolina elegans. The structure of 1 was confirmed by synthesis starting from 6,7-epoxygeranyl acetate (6), constituting the first route towards this type of compound.

  • Bioactive sesquiterpenes from Santolina rosmarinifolia subsp. Canescens. A conformational analysis of the germacrane ring.
    Phytochemistry, 1999
    Co-Authors: Alejandro F. Barrero, M. Mar Herrador, Ramón Alvarez-manzaneda, José F. Quílez, Dolores Portal, José A. Gavín, Dolores G. Gravalos, Monique S. J. Simmonds, Wally M. Blaney
    Abstract:

    The hexane extract of aerial parts of Santolina rosmarinifolia subsp. canescens afforded eight new sesquiterpenes in addition to known compounds. Their structures were determined by spectroscopic methods and chemical transformations. The conformational analysis of the germacrane constituents was carried out by spectroscopic methods, including NMR at varying temperature and by molecular mechanics calculations. The antifeedant, antibacterial and antitumoral activity of selected compounds has been tested.

  • Sesquiterpenes from Santolina chamaecyparissus subsp. squarrosa
    Phytochemistry, 1998
    Co-Authors: Alejandro F. Barrero, Ramón Alvarez-manzaneda, José F. Quílez, M. Mar Herrador
    Abstract:

    Abstract Four new sesquiterpenes, (E)-6β-acetoxy-7αH-germacra-4,10(14)diene-1α,2β-diol (1), (4E,9Z)-6β-acetoxy-7-αH- germacra-4,9-diene-1α,2β-diol (2), (E)-6β-acetoxy-7αH-germacra-1(10),4-diene-2β-ol (3) and 6β-acetoxy-5βH,7αH,10βMe-eudesm-4(15)-ene- 1α,2β-dol (4), were identified in the ether extract from the aerial parts of Santolina chamaecyparissus subsp. squarrosa. Their structures and preferred conformation in solution were determined by spectroscopic methods and molecular mechanics calculations.

Aixa O. Rivero-guerra - One of the best experts on this subject based on the ideXlab platform.

  • Phylogenetic analysis of the Santolina rosmarinifolia aggregate (Asteraceae: Anthemideae: Santolininae) based on morphological characteristics
    Nordic Journal of Botany, 2012
    Co-Authors: Aixa O. Rivero-guerra, Michel Laurin
    Abstract:

    The phylogenetic relationships between taxa of the Santolina rosmarinifolia aggregate were studied using TNT and PAUP parsimony analyses of a morphological data matrix that encompasses 2516 individuals. Two major clades can be distinguished: clade 1 comprises S. semidentata, S. melidensis, S. impressa, S. orocarpetana and S.×oblongifolia; clade 2 comprises S. ageratifolia, S. canescens and the subspecies arrabidensis, rosmarinifolia, castellana, pectinata and montiberica. No qualitative characteristics or groups of characteristics clearly differentiate these clades. Monophyly of the S. rosmarinifolia aggregate is supported. Most populations appear highly polyphyletic. Santolina impressa, S. melidensis, S. ageratifolia and the S. rosmarinifolia subspecies rosmarinifolia and arrabidensis form a monophyletic group whereas Santolina orocarpetana is polyphyletic and Santolina oblongifolia, S. canescens, S. semidentata and the subspecies castellana, pectinata and montiberica are all paraphyletic. The internal branches have an average length of 20.1 steps, with a standard deviation of 8.5 steps. The basal branch of several taxa shows a much higher number than average (20.1 steps) over the tree, which suggests that reasonably good clade support is present for these taxa. Santolina semidentata is the most variable taxon of this aggregate. The presence of a capitulum with three rows of involucral bracts is the ancestral condition in the aggregate. The results suggest that this aggregate arose from an ancient polyploid. A key to the taxa is provided.

  • Santolina orocarpetana sp. nov. (Asteraceae: Anthemideae), a new species from the Iberian Peninsula. Revision of the lectotype of S. oblongifolia Boiss.
    Adansonia, 2012
    Co-Authors: Aixa O. Rivero-guerra
    Abstract:

    ABSTRACT The lectotype of Santolina oblongifolia Boiss. is examined and discussed. Santolina heterophylla Willk. & Cut., S. oblongifolia Boiss. var. obtusifolia Willk., S. oblongifolia var. ceratophylla Willk., and S. lobata Jord. & Fourr. are lectotypified. Santolina oblongifolia Boiss. f. intermedia Pau is neotypified. The current status of these names is discussed. A new species from the Iberian Peninsula, S. orocarpetana sp. nov., is described.

  • Typification and synonymy of Santolina ageratifolia Barnades ex Asso (Asteraceae, Anthemideae), an endemic species of the Iberian Peninsula
    Adansonia, 2011
    Co-Authors: Aixa O. Rivero-guerra
    Abstract:

    ABSTRACT Patterns of speciation in the angiosperm genus Santolina (Asteraceae, Anthemideae) have recently been intensively studied, but progress is hampered by nomenclatural confusion. In this paper, the species S. ageratifolia Barnades ex Asso, S. pectinata Lag. var. paniculata Loscos & J.Pardo and S. longidentata Pau are lectotypified. An invalid name has been found: S. rosmarinifolia L. subvar. virens macrocephala Pau. The nomenclature of S. ageratifolia is provided.

  • Cytogenetics, biogeography and biology of Santolina ageratifolia Barnades ex Asso (Asteraceae: Anthemideae)
    Botanical Journal of the Linnean Society, 2008
    Co-Authors: Aixa O. Rivero-guerra
    Abstract:

    Santolina ageratifolia Barnades ex Asso is a natural autohexaploid (2n = 6x = 54, 54 + 1B), endemic to Teruel Province, Spain and inhabits a substrate derived from sandstone, red limolite and quartzite. Three chromosome formulae are found: 30m + 12sm + 12st, present in 52% of the descendants (52 metaphase), 24m + 5m-1sm + 18sm + 6st in 39% of the descendants (39 metaphase) and 24m + 5m-1sm + 18sm + 6st + 1B in 9% of the descendants (9 metaphase). Chiasmata are mostly interstitial rather than terminal, giving rise to the formation of cruciform structures. The predominance of bivalent configurations in the meiosis and the exclusively bivalent formation in four individuals indicate that this species has a strong tendency towards diploidization. Secondary association of bivalents is observed in the number of 2, 4–6 chromosomes associated, the average being 4.21 ± 1.20 chromosomes. The variation in the chromosomal characteristics suggests chromosome translocation and/or inversions. This species is partially sterile, with a mean pollen fertility of 40.56% and a mean fructification of 34.24%. The frequencies of multivalents and pollen fertility have a strongly significant effect on fructification percentage. Phenotypic variation in habits is not correlated with karyotype characteristics. The cytogeography of the polyploid taxa of the Santolina rosmarinifolia aggregate is discussed. © 2008 The Linnean Society of London, Botanical Journal of the Linnean Society, 2008, 157, 797–807.

Félix Tomi - One of the best experts on this subject based on the ideXlab platform.

  • biological activities and chemical composition of Santolina africana jord et fourr aerial part essential oil from algeria occurrence of polyacetylene derivatives
    Molecules, 2019
    Co-Authors: Charaf Eddine Watheq Malti, Félix Tomi, Clementine Baccati, Magali Mariani, Faical Hassani, Brahim Babali, Fewzia Atikbekkara, Mathieu Paoli, Jacques Maury, Chahrazed Bekhechi
    Abstract:

    The chemical composition of 18 oil samples of Santolina africana isolated from aerial parts at full flowering, collected in three locations in eastern Algeria was determined by GC(RI), GC/MS and 13C-NMR analysis. The major components were: germacrene D, myrcene, spathulenol, α-bisabolol, β-pinene, 1,8-cineole, cis-chrysanthenol, capillene, Santolina alcohol, camphor, terpinen-4-ol and lyratol. The chemical composition appeared homogeneous and characterized by the occurrence of four derivatives which exhibited a conjugated alkene dialkyne moiety. They were identified for the first time in an essential oil from S. africana. The collective oil sample exhibited moderate antimicrobial and antioxidant activities whereas the anti-inflammatory activity presented a real potential. IC50 value of Santolina africana essential oil (0.065 ± 0.004 mg/mL) is 5-fold higher than IC50 value of NDGA used as positive control.

  • Composition, irregular terpenoids, chemical variability and antibacterial activity of the essential oil from Santolina corsica Jordan et Fourr.
    Phytochemistry, 2007
    Co-Authors: Paul-georges Rossi, Bernard Ferrari, Liliane Berti, Joseph Casanova, Félix Tomi
    Abstract:

    A detailed analysis of Santolina corsica essential oil was carried out by combination of GC (RI), GC-MS and 13C NMR spectroscopy. After fractionation by column chromatography, 50 components were identified, accounting for 88.2% of the total amount of the oil. The chemical composition was dominated by monoterpene hydrocarbons, myrcene (34.6%), Santolina triene (13.5%) and beta-phellandrene (11.7%). Beside the main compounds, we noted the occurrence of irregular mono and sesquiterpenes belonging to five families: Santolinane, artemisane, chrysanthemane, lavandulane and sesquilavandulane. Three compounds, lyratyl butyrate, isolyratone and epi-isolyratol were isolated and their structure elucidated by 2D NMR. Antibacterial activity was tested against six bacteria strains. The essential oil was effective against Staphylococcus aureus and C. jejuni. Lyratol was identified as main responsive of the antibacterial activity. The content of lyratol was measured in 33 oil samples isolated from individual plants.

  • Two new irregular acyclic sesquiterpenes aldehydes from Santolina corsica essential oil.
    Magnetic Resonance in Chemistry, 2004
    Co-Authors: Bernard Ferrari, Félix Tomi, Pascal Richomme, Joseph Casanova
    Abstract:

    Two isomeric irregular sesquiterpene aldehydes, namely 3,9-dimethyl-6-isopropyl-2(E),7(E),9-decatrienal and 3,9-dimethyl-6-isopropyl-2(Z),7(E),9-decatrienal, were isolated from the essential oil of Santolina corsica and their structures were elucidated by 1D and 2D NMR spectroscopy.

Ivano Morelli - One of the best experts on this subject based on the ideXlab platform.

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