The Experts below are selected from a list of 297 Experts worldwide ranked by ideXlab platform

Avi Shupak - One of the best experts on this subject based on the ideXlab platform.

  • Vestibular evoked myogenic potentials and habituation to Seasickness.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2013
    Co-Authors: Dror Tal, Dov Hershkovitz, Gil Kaminski-graif, Guy Wiener, Orit Samuel, Avi Shupak
    Abstract:

    highlights abstract Objective: Seasickness may impose severe limitations on the performance of ships' crew. Cervical vestib- ular evoked myogenic potentials (cVEMP) assess the function of the saccule, the organ responsible for monitoring vertical linear acceleration, which has been found to be the most provocative motion stimu- lus in the evolution of motion sickness. We used the cVEMP test in a prospective evaluation of suscepti- bility and habituation to Seasickness. Methods: Forty-six naval recruits underwent the cVEMP test before exposure to sea conditions. After 6 months' sailing experience, participants completed a questionnaire evaluating their initial and current Seasickness severity. Based on their most recent experience, subjects were divided into three groups: non-vomiting non-habituating (NV-NH), vomiting (V), and non-vomiting habituating (NV-H). Results: Statistically significant lower thresholds for cVEMP were found in subjects who habituated to sea conditions (NV-H), compared with those remaining severely susceptible (V) (77.0 dB HL vs. 84.9 dB HL; p < 0.01). Conclusions: The ability to produce the cVEMP at lower thresholds represents a broader dynamic range, in which the reflex can respond to a wider array of stimuli amplitudes. Significance: The present study demonstrates the potential of the cVEMP test for predicting future habit- uation to Seasickness.

  • Postural dynamics and habituation to Seasickness.
    Neuroscience letters, 2010
    Co-Authors: Dror Tal, Ronen Bar, Zohar Nachum, Amnon Gil, Avi Shupak
    Abstract:

    The computerized dynamic posturography (CDP) test examines the response pattern to simultaneous, multimodal sensory stimulation. The purpose of this prospective, controlled study was to investigate whether postural dynamics evaluated by CDP are related to Seasickness severity and the process of habituation to sea conditions. Subjects included 74 naval personnel assigned to service aboard ship and 29 controls designated for shore-based positions. Study participants performed a baseline CDP test, and subsequent follow-up examinations 6 and 12 months after completion of their training. On those occasions they also completed a Seasickness severity questionnaire. Longitudinal changes in postural parameters were examined, as well as a possible correlation between baseline CDP results and final Seasickness severity scores. The results indicated longitudinal habituation to Seasickness. Reduced scores were found for sensory organization sub-tests 3 and 5 in the first follow-up examination, reflecting increased weighting of visual and somatosensory input in the maintenance of balance. Scores in the second follow-up examination were above baseline values, indicating increased reliance on vestibular cues. These significant bimodal changes were found only in study subjects having the highest degree of habituation to Seasickness. A significant decrease in motor response strength was found in parallel with increased habituation to Seasickness. Baseline CDP results and postural control dynamics were not correlated with subjects' final Seasickness severity score. These results suggest a potential role for CDP in monitoring the process of habituation to unusual motion conditions.

  • Ondansetron for the prevention of Seasickness in susceptible sailors: an evaluation at sea.
    Aviation space and environmental medicine, 2009
    Co-Authors: Dov Hershkovitz, Gil Kaminski, Ronen Bar, Avi Shupak, Noam Asna, Dror Tal
    Abstract:

    Background: Seasickness is a common problem, causing a significant decrement in performance among naval crew. In about 20―60% of crewmembers, symptoms appear with varying intensity depending on the sea state and the duration of the voyage. Recent studies have suggested antiemetic 5HT 3 blockers as a possible treatment for motion sickness, emphasizing their minor clinical and cognitive side effects. The purpose of the present study was to evaluate the 5HT 3 blocker ondansetron in the prevention of Seasickness. Methods: There were 16 volunteers with a normal otoneurologic examination and no previous medical history of inner ear disease or vertigo who took part in a double blind, randomized, crossover study. During an initial learning phase, the participants practiced on a battery of computerized performance tests until their results stabilized. Ondansetron 8 mg or placebo was administered 2 h before sailing aboard a 500-ton naval vessel in mild sea conditions. Participants did the performance tests and completed a questionnaire evaluating their Seasickness symptoms 4 h into the voyage. Results: No statistically significant reduction of Seasickness symptoms was demonstrated between ondansetron treatment and placebo (a Wiker score of 2.69 ± 1.78 and 2.81 ± 1.97, respectively). There was no statistically significant difference in side effects or the results of the performance tests. Conclusion: In this study, ondansetron was not found to be beneficial in the treatment of Seasickness. It could be speculated that the mechanism of nausea in Seasickness is different from that of toxin-induced nausea.

  • Seasickness pathogenesis and the otolithic organs: vestibular evoked myogenic potentials study--preliminary results.
    The Israel Medical Association journal : IMAJ, 2007
    Co-Authors: Dror Tal, Ronen Bar, Peter Gilbey, Avi Shupak
    Abstract:

    Background: Seasickness is thought to result from conflicting inputs from the vestibular, visual and somatosensory systems. The otolithic organs, which are responsible for the sensation of linear acceleration and tilt, are important in the pathogenesis of Seasickness. The vestibular evoked myogenic potentials test is an objective evaluation of saccular function. Objective: To examine whether saccular function is related to the pathogenesis of Seasickness. Methods: VEMP was performed in 10 subjects susceptible to Seasickness and in 14 non-susceptible subjects. Results: Bilateral VEMP responses were obtained in 7 (50%) of the non-susceptible subjects and 1 (10%) of the susceptible subjects. No differences were found between the groups in P13 and N23 wave latencies, amplitudes, N13-P23 inter-peak latencies, and peak-to-peak asymmetry ratios. More subjects in the susceptible group had asymmetry ratios > 35%. Conclusions: The attenuated saccular response might be explained in the context of the neural-mismatch theory and/or the subjective vertical theory, as reflecting an adaptation effort to sea conditions. A larger study is necessary to determine whether a statistically significant difference in VEMP responses exists between Seasickness-susceptible and non-susceptible subjects. IMAJ 2007;9:641–644

  • Scopolamine patch to prevent Seasickness: clinical response vs. plasma concentration in sailors.
    Aviation space and environmental medicine, 2005
    Co-Authors: Amnon Gil, Avi Shupak, Zohar Nachum, Shlomit Dachir, Shira Chapman, Aharon Levy, Yochai Adir, Dror Tal
    Abstract:

    Introduction: Scopolamine is highly effective for the treatment of Seasickness. Nevertheless, transdermal therapeutic system (TTS) scopolamine, despite high compliance on the part of persons treated by the drug, fails to provide protection against Seasickness in 26-38% of patients. To the best of our knowledge, the correlation between scopolamine levels in plasma and its therapeutic effect under sailing conditions in the open sea is investigated for the first time in the present study. Methods: Subjects were 61 crewmembers of naval vessels treated by TTS scopolamine. The therapeutic response at sea was documented by questionnaire. During a period ashore, a TTS scopolamine patch was applied in the same subjects. Blood samples were taken and an adverse effects questionnaire completed 8 h after scopolamine patch application. Scopolamine levels were determined using an established radioreceptor assay procedure. To verify the reproducibility of these measurements, blood samples were taken twice from most subjects, on separate days after different patch applications. Subjects were divided into "responders," who reported at least a moderate decrease in Seasickness severity compared with their previous experience at sea without TTS scopolamine therapy, and "non-responders," who had only slight symptomatic relief or no relief at all. Results: The mean scopolamine concentration in the plasma of the 37 responders (156.77 ′ 77.03 pg . ml - 1 ) was significantly higher than the mean level in the 24 non-responders (97.03 ′ 73.34 pg ml - 1 ; p = 0.005, simple t-test). Conclusions: Attempts to increase scopolamine levels in plasma by increasing the drug dosage or improving transdermal absorption should be considered for the treatment of "non-responders."

Li Min - One of the best experts on this subject based on the ideXlab platform.

  • Change of heme oxygenase-3 mRNA expression during Seasickness adaptation in rats
    China Occupational Medicine, 2008
    Co-Authors: Li Min
    Abstract:

    Objective To study the changes of heme oxygenase-3(HO-3)mRNA expression during Seasickness adaptation in rats.Methods Thirty pre-screened male SD rats were randomly divided into normal control group,Seasickness group and Seasickness adaptation group.Except the normal control group,the rats were stimulated with a stimulator 1 hour/day.The rats of Seasickness group and Seasickness adaptation group were killed immediately at the third and the 21st day after the excitation,respectively.HO-3 mRNA expression level in brain stem,hypothalamus and adrenal gland before and after adaptability formation were analyzed with semiquantitative RT-PCR.Results HO-3 mRNA expression in brain stem and hypothalamus of Seasickness and Seasickness adaptation groups were much higher than those of the control(P0.01).Conclusion HO-3 might play a role during Seasickness adaptability formation in rats.

  • The differential expression change of ferritin gene associated with Seasickness
    China Occupational Medicine, 2008
    Co-Authors: Li Min
    Abstract:

    Objective To study the expression change of ferritin gene associated with Seasickness.Methods Rats were stimulated with Seasickness stimulator for 3 days and 21 days respectively.Real-time PCR was used to analyze mRNA levels of ferritin in brain stem of the rats.Results mRNA level of ferritin did not change among the group of 3-day stimulation rats.mRNA levels of ferritin in 21-day stimulated susceptible rats were much lower than those of the controls,the Seasickness adaptive rats and the non-Seasickness rats(P0.05 or P0.01).mRNA levels of ferritin had no significant difference between the non-Seasickness and the controls.Conclusion The decrease of mRNA level of ferritin in brain stem of the rats could be associated with Seasickness.

  • EFFECT OF "KANG YUN WEI LI" MIXTURE ON MENTAL AND PHYSICAL PERFORMANCE IN ANIMALS WITH EXPERIMENTAL Seasickness
    Journal of Preventive Medicine of the Chinese People's Liberation Army, 2005
    Co-Authors: Li Min
    Abstract:

    Objective To explore the effect of "Kang Yun Wei Li" mixture on mental and physical performance in animal with experimental Seasickness and its possible mechanism. Methods Ninety mice were divided into six groups: normal control, distilled water control, antiSeasickness drug control,as well as low, middle, and high dose "Kang Yun Wei Li "mixture supplemented group. The learning and memory ability,and the swimming time of the mice were examined after simulated Seasickness stimulation. Thirty experimental Seasickness rats (antiSeasickness drug,distilled water control, mixture supplemented group) were used to analyze the content of glycogen, lactate and the activity of ATPase. Results "Kang Yun Wei Li" mixture could increase the mice learning and memory ability, and the swimming time. The memory ability, and swimming time were about 25%, and 27%～40% greater respectively in mixture supplemented groups than in distilled water control group (P0.05, P0.01); the learning and memory ability, and swimming time were about 20% and 23%～52% greater respectively in mixture supplemented groups than in control group treated with antiSeasickness drug (P0.05, P0.01). Moreover, the content of liver glycogen and activity of muscle ATPase of rats were increased while the level of cerebral lactate was decreased (P0.05, P0.01) in mixture supplemented group. Conclusion "Kang Yun Wei Li" mixture may improve experimental Seasickness animal's physical and mental performances. Its possible mechanism may be related to the increase in liver glycogen storage and improvement in muscular ability to utilize the energy, and in the aerobic metabolism of brain.

  • Identification of differentially expressed genes in brain stem of the Seasickness susceptible rats with suppression subtractive hybridization
    Chinese Occupational Medicine, 2005
    Co-Authors: Li Min
    Abstract:

    Objective In order to screen the differentially expressed genes in brain stem of the Seasickness susceptible rats. Methods Suppression subtractive hybridization(SSH) method was used for isolating the differentially expressed cDNA, the dot blot was used to screen the clones containing inserts. Results The subtracted library contained 442 clones with inserts, after being sequenced and analyzed, 16 clones were up-regulated, including 3 new genes; 25 clones were down-regulated, including 5 new genes. Conclusion SSH is an effective method for screening differentially expressed genes, the results of this study are helpful in exploring the mechanism of Seasickness susceptibility.

  • Change of contents of iron in the Seasickness rats
    Chinese Occupational Medicine, 2003
    Co-Authors: Li Min
    Abstract:

    Objective The study was conducted to quanti tively investigate the content of iron in various tissues and in urine in the rats with simulated Seasickness. Methods Twenty five SD rats w ere divided into the normal control and the Seasickness groups randomly, the con tent of iron in serum, urine and organs was determined with atomic absorption sp ectrophotometry. Results The contents of iron in serum, liver, cerebrum, cerebellum, adrenal gland in the Seasickness group were much higher th an those of the normal control. On the 1st day of rotation, the content of iron in urine of Seasickness rats was decreased remarkably, whereas increased on the 2nd and the 3rd day of rotation. Contrasting to the normal control, there was tend ency to increase of iron contents in heart, brain stem and hypothalamus in seas ickness rats. Conclusion Seasickness could influence the distr ibution of the iron in rat.

Dror Tal - One of the best experts on this subject based on the ideXlab platform.

  • Vestibular evoked myogenic potentials and habituation to Seasickness.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2013
    Co-Authors: Dror Tal, Dov Hershkovitz, Gil Kaminski-graif, Guy Wiener, Orit Samuel, Avi Shupak
    Abstract:

    highlights abstract Objective: Seasickness may impose severe limitations on the performance of ships' crew. Cervical vestib- ular evoked myogenic potentials (cVEMP) assess the function of the saccule, the organ responsible for monitoring vertical linear acceleration, which has been found to be the most provocative motion stimu- lus in the evolution of motion sickness. We used the cVEMP test in a prospective evaluation of suscepti- bility and habituation to Seasickness. Methods: Forty-six naval recruits underwent the cVEMP test before exposure to sea conditions. After 6 months' sailing experience, participants completed a questionnaire evaluating their initial and current Seasickness severity. Based on their most recent experience, subjects were divided into three groups: non-vomiting non-habituating (NV-NH), vomiting (V), and non-vomiting habituating (NV-H). Results: Statistically significant lower thresholds for cVEMP were found in subjects who habituated to sea conditions (NV-H), compared with those remaining severely susceptible (V) (77.0 dB HL vs. 84.9 dB HL; p < 0.01). Conclusions: The ability to produce the cVEMP at lower thresholds represents a broader dynamic range, in which the reflex can respond to a wider array of stimuli amplitudes. Significance: The present study demonstrates the potential of the cVEMP test for predicting future habit- uation to Seasickness.

  • Postural dynamics and habituation to Seasickness.
    Neuroscience letters, 2010
    Co-Authors: Dror Tal, Ronen Bar, Zohar Nachum, Amnon Gil, Avi Shupak
    Abstract:

    The computerized dynamic posturography (CDP) test examines the response pattern to simultaneous, multimodal sensory stimulation. The purpose of this prospective, controlled study was to investigate whether postural dynamics evaluated by CDP are related to Seasickness severity and the process of habituation to sea conditions. Subjects included 74 naval personnel assigned to service aboard ship and 29 controls designated for shore-based positions. Study participants performed a baseline CDP test, and subsequent follow-up examinations 6 and 12 months after completion of their training. On those occasions they also completed a Seasickness severity questionnaire. Longitudinal changes in postural parameters were examined, as well as a possible correlation between baseline CDP results and final Seasickness severity scores. The results indicated longitudinal habituation to Seasickness. Reduced scores were found for sensory organization sub-tests 3 and 5 in the first follow-up examination, reflecting increased weighting of visual and somatosensory input in the maintenance of balance. Scores in the second follow-up examination were above baseline values, indicating increased reliance on vestibular cues. These significant bimodal changes were found only in study subjects having the highest degree of habituation to Seasickness. A significant decrease in motor response strength was found in parallel with increased habituation to Seasickness. Baseline CDP results and postural control dynamics were not correlated with subjects' final Seasickness severity score. These results suggest a potential role for CDP in monitoring the process of habituation to unusual motion conditions.

  • Ondansetron for the prevention of Seasickness in susceptible sailors: an evaluation at sea.
    Aviation space and environmental medicine, 2009
    Co-Authors: Dov Hershkovitz, Gil Kaminski, Ronen Bar, Avi Shupak, Noam Asna, Dror Tal
    Abstract:

    Background: Seasickness is a common problem, causing a significant decrement in performance among naval crew. In about 20―60% of crewmembers, symptoms appear with varying intensity depending on the sea state and the duration of the voyage. Recent studies have suggested antiemetic 5HT 3 blockers as a possible treatment for motion sickness, emphasizing their minor clinical and cognitive side effects. The purpose of the present study was to evaluate the 5HT 3 blocker ondansetron in the prevention of Seasickness. Methods: There were 16 volunteers with a normal otoneurologic examination and no previous medical history of inner ear disease or vertigo who took part in a double blind, randomized, crossover study. During an initial learning phase, the participants practiced on a battery of computerized performance tests until their results stabilized. Ondansetron 8 mg or placebo was administered 2 h before sailing aboard a 500-ton naval vessel in mild sea conditions. Participants did the performance tests and completed a questionnaire evaluating their Seasickness symptoms 4 h into the voyage. Results: No statistically significant reduction of Seasickness symptoms was demonstrated between ondansetron treatment and placebo (a Wiker score of 2.69 ± 1.78 and 2.81 ± 1.97, respectively). There was no statistically significant difference in side effects or the results of the performance tests. Conclusion: In this study, ondansetron was not found to be beneficial in the treatment of Seasickness. It could be speculated that the mechanism of nausea in Seasickness is different from that of toxin-induced nausea.

  • Seasickness pathogenesis and the otolithic organs: vestibular evoked myogenic potentials study--preliminary results.
    The Israel Medical Association journal : IMAJ, 2007
    Co-Authors: Dror Tal, Ronen Bar, Peter Gilbey, Avi Shupak
    Abstract:

    Background: Seasickness is thought to result from conflicting inputs from the vestibular, visual and somatosensory systems. The otolithic organs, which are responsible for the sensation of linear acceleration and tilt, are important in the pathogenesis of Seasickness. The vestibular evoked myogenic potentials test is an objective evaluation of saccular function. Objective: To examine whether saccular function is related to the pathogenesis of Seasickness. Methods: VEMP was performed in 10 subjects susceptible to Seasickness and in 14 non-susceptible subjects. Results: Bilateral VEMP responses were obtained in 7 (50%) of the non-susceptible subjects and 1 (10%) of the susceptible subjects. No differences were found between the groups in P13 and N23 wave latencies, amplitudes, N13-P23 inter-peak latencies, and peak-to-peak asymmetry ratios. More subjects in the susceptible group had asymmetry ratios > 35%. Conclusions: The attenuated saccular response might be explained in the context of the neural-mismatch theory and/or the subjective vertical theory, as reflecting an adaptation effort to sea conditions. A larger study is necessary to determine whether a statistically significant difference in VEMP responses exists between Seasickness-susceptible and non-susceptible subjects. IMAJ 2007;9:641–644

  • Vestibular evoked myogenic potential threshold and Seasickness susceptibility.
    Journal of vestibular research : equilibrium & orientation, 2006
    Co-Authors: Dror Tal, Gil Kaminski, Dov Hershkovitz, Ronen Bar
    Abstract:

    Numerous attempts have been made to find physiological parameters that might predict susceptibility to Seasickness. However, to date, no physiological index has been found that can serve as a diagnostic tool for individual susceptibility to motion sickness at the personnel selection stage. A number of studies have demonstrated that linear acceleration in the vertical plane is the most provocative stimulus of motion sickness. The main physiological sensory modality responsible for monitoring vertical acceleration is the saccule. Over the last decade, vestibular evoked myogenic potentials (VEMP) have come to be recognized as a reliable procedure for the evaluation of saccular function. We used the VEMP test to assess otolith responses in 15 Seasickness-susceptible (SS) and 15 non-Seasickness-susceptible (NSS) healthy male crew members. The SS group exhibited a significantly higher VEMP threshold and a significantly lower peak-to-peak p13-n23 amplitude interval compared with the NSS group. Further analysis by logistic regression found threshold to be the dominant factor associated with Seasickness susceptibility. The study demonstrated differences in the VEMP reflex of the SS and NSS groups. The threshold difference may represent an intrinsic mechanistic difference between the vestibular systems of the two groups. Theoretically, increased susceptibility to Seasickness may be due to a discrepancy between the various neural systems as a result of reduced otolith responses.

Guo Jun-sheng - One of the best experts on this subject based on the ideXlab platform.

  • Measurement of total antioxidative capacity,superoxde dismutase and reactive oxygen species activity of brain stem from Seasickness susceptible rats
    Journal of Navy Medicine, 2009
    Co-Authors: Guo Jun-sheng
    Abstract:

    Objective:To study the activity changes of total antioxidative capacity(T-AOC),superoxde dismutase(SOD) and reactive oxygen species(ROS) of brain stem from Seasickness susceptible rats,and explore the function of oxidative stress in Seasickness susceptibility.Methods: According to kaolin intakes after Seasickness motivation,rats were divided into Seasickness susceptible group,Seasickness group,non-Seasickness group and control group.T-AOC,SOD and ROS were measured by colorimetry,xanthine and fenton methods respectively.Results: T-AOC and SOD in Seasickness susceptible group decreased dramatically than those of non-Seasickness group and control group(P0.01).T-AO and SOD of Seasickness group were slightly higher than Seasickness susceptible group but lower than those of control group and non-Seasickness group(P0.05).T-AOC and SOD of non-Seasickness group were lower than those of the control group but without statistic significance(P0.05).ROS changed the opposite way of T-AOC and SOD.Conclusion: The anti-oxidative capability of rat brain stem decreases during the procedure of Seasickness susceptibility while reactive oxidative species increases,which suggests that oxidative stress plays an important role in the development of Seasickness susceptibility.

  • Screen of Seasickness behavior indices of simulated Seasickness in rats and observation of adaptability rules
    Academic Journal of Second Military Medical University, 2009
    Co-Authors: Guo Jun-sheng
    Abstract:

    Objective:To screen for Seasickness behavior parameters in rats with simulated Seasickness,so as to investigate the rule of Seasickness adaptation in rats.Methods:SD rats were stimulated daily by Crampton model.Urine volume (UV) and amount of fecal particle (FP) were observed during stimulation,and the spontaneous activity (SA) was also determined immediately after stimulation.Interventional experiments were performed using anti-motion sickness drugs to examine the specificity of the indices.Results:On the first day of stimulation,the FP of stimulating group increased significantly compared with the normal control group (P0.05),while SA decreased significantly (P0.01).FP and SA of stimulating group gradually recovered with the increase of stimulation period; there was a significant correlation between FP,SA with stimulation times (P0.01).FP and SA recovered to the normal levels on the 9th,7th day,respectively.The experimental group received gastric perfusion of scopolamine(0.5,1 mg/kg)and was then subjected to rotation stimulation.The indices had no significant difference between the experimental group and the normal control group.Conclusion:It is indicated that FP during stimulation and SA after stimulation can be used for effective judgment of Seasickness in rats.The rats become adapted to Seasickness after 9 days' continuous stimulation.

  • Two-dimensional electrophoresis in proteomic comparison and identification of brain stem proteins in Seasickness adaptive and non-adaptive rats
    Academic Journal of Second Military Medical University, 2006
    Co-Authors: Zhang Jian-peng, Feng Wei-hua, Du Peng, Guo Jun-sheng
    Abstract:

    Objective:To establish a two-dimensional eletrophoresis system for total brain stem proteins of Seasickness adaptive and non-adaptive rats and to identify the differentially expressed proteins for investigation of the possible mechanism of Seasickness adaptation.Methods: According to the kaolin intakes after Seasickness stimulation,30 rats were divided into non-Seasickness group(n=10),Seasickness adaptive group(n=12) and Seasickness non-adaptive group(n=8).Another 10 normal rats not receiving stimulation were taken as blank control.The brain stem proteins of Seasickness adaptive and Seasickness non-adaptive rats(n=6) were isolated by two-dimensional electrophoresis;the differentially expressed proteins were identified by peptide mass fingerprint(PMF).Results: During a 21-day stimulation,the amount of kaolin consumption in Seasickness adaptive rats experienced an increasing phase and a subsequent decreasing phase;Seasickness nonadaptive rats consumed significantly more kaolin during the whole 21-day stimulation than the blank control rats did(P0.01 or P0.05).Nine Seasickness adaptive proteins were identified by PMF: peroxiredoxinⅠ,peroxiredoxinⅡ,light molecular-weight neurofilament,ubiquitin carboxyl-terminal hydrolase PGP9.5,and glutamine synthetase were highly expressed;carbonic anhydraseⅡ,triosephosphate isomerase Ⅰ,phosphoglycerate mutase isozyme B and mitochondrial voltage dependent anion channel were lowly expressed.Conclusion: Adaptation to Seasickness can induce changes in the protein expression pattern of brain stem in the Seasickness adaptive rats,which may be associated with energy metabolism,neurotransmitter adjustment and oxidative stress.

Ilana Doweck - One of the best experts on this subject based on the ideXlab platform.

  • Evaluation of betahistine for the prevention of Seasickness: effect on vestibular function, psychomotor performance and efficacy at sea.
    Journal of vestibular research : equilibrium & orientation, 2003
    Co-Authors: Carlos R. Gordon, Ilana Doweck, Zohar Nachum, Orna Spitzer, Adi Gonen, Avi Shupak
    Abstract:

    Betahistine was evaluated for the prevention of Seasickness in a laboratory and sea study. The effect of 48 mg betahistine on the vestibulo-ocular reflex (VOR) and on psychomotor performance was evaluated in twelve young healthy subjects in a double-blind, placebo controlled, randomized, crossover design. The vestibulo-ocular reflex was evaluated by the Sinusoidal Harmonic Acceleration (SHA) test at frequencies of 0.01, 0.02, 0.04, 0.08 and 0.16 Hz. Psychomotor performance was assessed by both computerized and paper and pencil test batteries. No significant differences in VOR gain or phase were found between betahistine and placebo treatment for any of the frequencies tested. No significant differences were found between treatments for any of the psychomotor performance tests or other possible side effects. The effect of 48 mg betahistine on Seasickness severity was evaluated in 83 subjects during a voyage in rough seas. Betahistine had a borderline non-statistically significant effect on the prevention of Seasickness in comparison with placebo (p = 0.053), with no notable side effects. Although our results are insufficient to recommend betahistine as an anti-Seasickness drug, further studies are required to determine its possible effectiveness in less provocative motion sickness situations.

  • The vestibulo-ocular reflex and Seasickness susceptibility.
    J. Vestib. Res.-Equilib. Orientat., 1996
    Co-Authors: C.r. Gordon, O Spitzer, Ilana Doweck, Avi Shupak, Natan Gadoth
    Abstract:

    VOR parameters were compared in subjects at the extremes of the Seasickness susceptibility scale. Thirty-nine subjects highly susceptible to Seasickness and 30 nonsusceptible subjects participated in the study. The VOR was evaluated by the Sinusoidal Harmonic Acceleration (SHA) test at frequencies of 0.01, 0.02, 0.04, 0.08, and 0.16 Hz. In subjects susceptible to Seasickness, VOR gain was significantly higher at 0.02 and 0.04 Hz, and phase lead was significantly lower at 0.01, 0.02, 0.04, and 0.08 Hz, than in nonsusceptible subjects. Our findings are in agreement with the notion that the vestibular response will be more intense in subjects susceptible to motion sickness. The present results support the contention that a natural insusceptibility, or increased resistance to Seasickness produced by adaptive responses to repeated sea exposures, may be reflected by lower VOR gain and higher phase lead.

  • Cinnarizine in the prophylaxis of Seasickness: Laboratory vestibular evaluation and sea study
    Clinical pharmacology and therapeutics, 1994
    Co-Authors: Avi Shupak, Ilana Doweck, Carlos R. Gordon, Orna Spitzer
    Abstract:

    Cinnarizine was evaluated for the prevention of Seasickness in a laboratory and sea study. The effects of 25 mg cinnarizine on the vestibulo-ocular reflex were investigated in 13 subjects. Significant reduction of the gain in response to sinusoidal oscillations at 0.02, 0.08, and 0.16 Hz (p < 0.05) and increased phase lead at 0.16 Hz (p < 0.01) were observed. The effect of 25 and 50 mg cinnarizine on Seasickness severity was examined in 95 subjects during a voyage in rough seas. Seasickness symptoms were improved in 69% of the subjects by 50 mg cinnarizine versus 35% and 31% in the groups receiving 25 mg cinnarizine and placebo (p < 0.05 and p < 0.01, respectively). The percentage of vomiting protection provided by 50 mg cinnarizine was 63% (p < 0.05). We conclude that 50 mg cinnarizine is an effective drug for the prevention of Seasickness. The reduction in vestibular sensitivity observed even after administration of 25 mg cinnarizine may explain the potency of cinnarizine in the prevention of Seasickness. Clinical Pharmacology and Therapeutics (1994) 55, 670–680; doi:10.1038/clpt.1994.84

  • Effect of cinnarizine in the prevention of Seasickness
    Aviation space and environmental medicine, 1994
    Co-Authors: Ilana Doweck, Carlos R. Gordon, Orna Spitzer, Yehuda Melamed, Avi Shupak
    Abstract:

    In a double-blind, placebo-controlled study, we evaluated the effect of two different doses of cinnarizine in the prevention of Seasickness in very rough seas. We divided 95 healthy male subjects into 3 groups which received: cinnarizine 50 mg, cinnarizine 25 mg, and placebo. Seasickness susceptibility and severity were evaluated by a standard questionnaire concerning the subject's condition on previous voyages (Seasickness susceptibility), and the subject's condition immediately after a 4-6-h voyage in very rough seas with 3.5 m waves (Seasickness severity). Possible side effects of the drug were also evaluated by filling in a further questionnaire. Of the 31 subjects who received cinnarizine 50 mg, 65% felt better during the present voyage than on previous voyages, compared to 41% of the 32 subjects who received cinnarizine 25 mg and 31% of the 32 who received placebo. A significant difference (p < 0.05) was found between the cinnarizine 50 mg and placebo groups, while cinnarizine 25 mg was no more effective than placebo. No notable side effects were found for any drug group. In conclusion, cinnarizine 50 mg was found to be effective in the prevention of Seasickness in rough seas.

  • Salivary secretion and Seasickness susceptibility.
    Aviation space and environmental medicine, 1992
    Co-Authors: Carlos R. Gordon, Ilana Doweck, Orna Spitzer, Y. Jackman, H. Ben-aryeh, R. Szargel, Avi Shupak
    Abstract:

    The salivary flow rate and composition of 2 groups of 31 subjects, one group at each extreme of the Seasickness susceptibility scale, were compared. No significant differences were found between the two groups in flow rates and electrolyte concentrations of whole resting and stimulated saliva. Amylase activity and rate of secretion in resting saliva were significantly higher in subjects susceptible to Seasickness as compared with nonsusceptible subjects