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Frank Lobbezoo - One of the best experts on this subject based on the ideXlab platform.
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Self-reported Sleep Bruxism among Finnish symphony orchestra musicians: Associations with perceived Sleep-related problems and psychological stress.
Cranio : the journal of craniomandibular practice, 2020Co-Authors: Maurits K. A. Van Selms, Daniele Manfredini, Frank Lobbezoo, Janine Kroon, Henri Tuomilehto, Miikka Peltomaa, Aslak Savolainen, Jari AhlbergAbstract:Objective: This study aimed to evaluate whether self-reported Sleep Bruxism among musicians is associated with Sleep-related problems and/or psychological stress. Methods: Eight hundred-thirty-one Finnish orchestra musicians completed a questionnaire that covered, among others, indicators of Sleep-related problems, possible Sleep Bruxism, and stress. Results: In total, 488 questionnaires were completed. The single variable ordinal logistic regression models revealed at least moderate associations between frequency of Sleep Bruxism and female gender, shorter Sleep duration, longer Sleep latency, problems in Sleeping during concert season, feeling more often tired during the daytime, restless legs, a poor self-rated Sleep quality, and more stress experience. The variables that remained in the final model were Sleep duration, gender, and stress. Conclusion: Musicians who Sleep 7 hours or less per night report more Sleep Bruxism, as compared to those who Sleep 8 hours or more. Female gender and high-stress experience were associated with more Sleep Bruxism.
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The prevalence of awake Bruxism and Sleep Bruxism in the Dutch adult population.
Journal of oral rehabilitation, 2020Co-Authors: P. Wetselaar, Frank Lobbezoo, Erik Vermaire, Annemarie SchullerAbstract:Background Awake Bruxism and Sleep Bruxism are common conditions amongst adult populations, although prevalence data are scarce. Objective This study aimed to assess the prevalence of awake Bruxism and Sleep Bruxism in the Dutch adult population. Methods As part of a large epidemiologic survey on oral health of the general Dutch adult population, a total of 1209 subjects were asked about their Bruxism behaviour during the day and during their Sleep. The collected data were subjected to stratified analysis by five age groups (25‐34, 35‐44, 45‐54, 55‐64 and 65‐74 years), socioeconomic status, and gender. Results A prevalence of 5.0% of the total population was found for awake Bruxism and of 16.5% for Sleep Bruxism. Regarding the five age groups, prevalence of 6.5%, 7.8%, 4.0%, 3.2% and 3.0%, respectively, were found for awake Bruxism, and of 20.0%, 21.0%, 16.5%, 14.5% and 8.3%, respectively, for Sleep Bruxism. Women reported both awake Bruxism and Sleep Bruxism more often than men. These differences were statistically significant. Concerning socioeconomic status (SES), both awake Bruxism and Sleep Bruxism were more often found in high SES groups, being statistically significant for awake Bruxism only. Conclusion Sleep Bruxism is a common condition in the Dutch adult population, while awake Bruxism is rarer.
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Medications and addictive substances potentially inducing or attenuating Sleep Bruxism and/or awake Bruxism.
Journal of oral rehabilitation, 2020Co-Authors: Cees De Baat, M.c. Verhoeff, Jari Ahlberg, Daniele Manfredini, Ephraim Winocur, P G M A Zweers, Fred Rozema, Arjan Vissink, Frank LobbezooAbstract:Bruxism is a repetitive jaw-muscle activity characterised by clenching or grinding of the teeth and/or by bracing or thrusting of the mandible. It can occur during Sleep, indicated as Sleep Bruxism, or during wakefulness, indicated as awake Bruxism. Exogenous risk indicators of Sleep Bruxism and/or awake Bruxism are, among others, medications and addictive substances, whereas also several medications seem to have the potential to attenuate Sleep Bruxism and/or awake Bruxism. The objective of this study was to present a narrative literature on medications and addictive substances potentially inducing or aggravating Sleep Bruxism and/or awake Bruxism and on medications potentially attenuating Sleep Bruxism and/or awake Bruxism. Literature reviews reporting evidence or indications for Sleep Bruxism and/or awake Bruxism as an adverse effect of several (classes of) medications as well as some addictive substances and literature reviews on medications potentially attenuating Sleep Bruxism and/or awake Bruxism were used as starting point and guidelines to describe the topics mentioned. Additionally, two literature searches were established on PubMed. Three types of Bruxism were distinguished: Sleep Bruxism, awake Bruxism and non-specified Bruxism. Generally, there are insufficient evidence-based data to draw definite conclusions concerning medications and addictive substances inducing or aggravating Sleep Bruxism and/or awake Bruxism as well as concerning medications attenuating Sleep Bruxism and/or awake Bruxism. There are insufficient evidence-based data to draw definite conclusions concerning medications and addictive substances inducing or aggravating Sleep Bruxism and/or awake Bruxism as well as concerning medications attenuating Sleep Bruxism and/or awake Bruxism.
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Effect of experimental temporomandibular disorder pain on Sleep Bruxism: a pilot study in males.
Clinical oral investigations, 2019Co-Authors: Konstantin Muzalev, Corine M Visscher, Michail Koutris, Frank LobbezooAbstract:Sleep Bruxism (SB) is considered to play an important role in the provocation of temporomandibular disorder (TMD) pain. However, clinical studies investigating this relation yielded contradictory results. These contradictory results can, at least in part, be explained by a possible influence of TMD pain on SB activity. The aim of this experimental study was to assess the effect of TMD pain on SB. Nine male participants with clinical signs of SB underwent two subsequent baseline ambulatory polysomnographic (PSG) recordings before undergoing an experimental pain provocation protocol. Thirty-two hours after the pain provocation part a third ambulatory PSG recording was obtained to study the effect of pain on SB. Decrease for all Bruxism parameters was found between the recording after the provocation part and the second baseline recording. Experimentally induced TMD pain causes a reduction in SB activity in healthy individuals. A reduction in Sleep Bruxism activity was recorded in all participants who experienced jaw-muscle pain. This is in line with the pain adaptation model. It supports the negative association between Sleep Bruxism and jaw muscle pain reported by numerous polysomnographic studies.
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Associations between Sleep Bruxism and (peri-) implant complications: a prospective cohort study
BDJ Open, 2017Co-Authors: Magdalini Thymi, Corine M Visscher, Eiko Yoshida-kohno, Wim Crielaard, Daniel Wismeijer, Frank LobbezooAbstract:Objectives/Aims: To describe the protocol of a prospective cohort study designed to answer the question: ‘Is Sleep Bruxism a risk factor for (peri-)implant complications?’. Materials and Methods: Our study is a single-centre, double-blind, prospective cohort study with a follow-up time of 2 years. Ninety-eight participants fulfilling inclusion criteria (planned treatment with implant-supported fixed suprastructure(s) and age 18 years or older) will be included. Sleep Bruxism will be monitored at several time points as masticatory muscle activity during Sleep by means of a portable single-channel electromyographic device. Our main outcomes are biological complications (i.e., related to peri-implant bleeding, probing depth, marginal bone height, quality of submucosal biofilm and loss of osseointegration) and technical complications (i.e., suprastructure, abutment, implant body or other). Results: The study is currently ongoing, and data are being gathered. Discussion: The results of this prospective cohort study will provide important information for clinicians treating bruxing patients with dental implants. Furthermore, it will contribute to the body of evidence related to the behaviour of dental implants and their complications under conditions of high mechanical loadings that result from Sleep Bruxism activity. Conclusion: The protocol of a prospective cohort study designed to investigate possible associations between Sleep Bruxism and (peri-) implant complications was presented.
Júnia Maria Serra-negra - One of the best experts on this subject based on the ideXlab platform.
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Association of gender, oral habits, and poor Sleep quality with possible Sleep Bruxism in schoolchildren.
Brazilian oral research, 2020Co-Authors: Josiane Pezzini Soares, Júnia Maria Serra-negra, Angela Giacomin, Mariane Cardoso, Michele BolanAbstract:The aim of this study was to verify the oral habits, symptoms, and characteristics of some children aged 8 to 10 years that could be associated with possible Sleep Bruxism. A cross-sectional study was performed. Questionnaires were sent to parents to obtain information on sex, age, school shift, Sleep quality, parents' perception of children's behavior, and children's oral habits (nail biting, object biting, and lip biting), and symptoms such as headache or earache. In addition, parents reported the frequency of Sleep Bruxism (no day to 7 days a week). Descriptive analysis and multinomial logistic regression were performed and the level of significance was set at 5%. A total of 1,554 parents of children aged 8 to 10 years participated in this study. Possible Sleep Bruxism was reported as mild for 65.7%, moderate for 25.3%, and severe for 9% of the children. In the adjusted multinomial logistic regression, boys were 79% more likely to have Sleep Bruxism (OR: 1.79; 95%CI 1.23-2.60) and were 2.06 more times at risk of being in the habit of lip biting (OR: 2.06; 95%CI 1.26-3.37). Children with possible severe Sleep Bruxism were 61% more likely to develop object biting (OR: 1.61; 95%CI 1.09-2.39), 52% more likely to have headaches (OR: 1.52; 95%CI 1.01-2.28), and 3.29 more times at risk of poor Sleep quality (OR: 3.29; 95%CI 2.25-4.82). Based on the report, boys with lip and object biting habits, headaches, and poor Sleep quality presented a higher chance of possible severe Sleep Bruxism.
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Study of Associated Factors With Probable Sleep Bruxism Among Adolescents.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018Co-Authors: Ivana Meyer Prado, Saul Martins Paiva, Sheyla Márcia Auad, Daniele Manfredini, Lucas Guimarães Abreu, Karen Simon Rezende Da Silveira, Júnia Maria Serra-negraAbstract:Study Objectives:To evaluate the prevalence of probable Sleep Bruxism (SB) and its association with Sleep features, orthodontic fixed appliance wearing, and extraoral and intraoral clinical signs a...
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Respiratory disorders and the prevalence of Sleep Bruxism among schoolchildren aged 8 to 11 years.
Sleep & breathing = Schlaf & Atmung, 2017Co-Authors: Clarissa Lopes Drumond, Júnia Maria Serra-negra, Maria Letícia Ramos-jorge, Leandro Silva Marques, Débora Souto Souza, Joana Ramos-jorgeAbstract:The aim of this study was to evaluate the association between respiratory disorders and Sleep Bruxism, with an evaluation of demographic/socioeconomic factors and childhood stress as confounding variables. A cross-sectional study was performed in the city of Diamantina, Brazil, with 448 randomly selected schoolchildren aged 8 to 11 years. The schoolchildren underwent an oral examination for the evaluation of Bruxism. Parents/caregivers answered a questionnaire for the assessment of Sleep Bruxism; socioeconomic-demographic factors; and respiratory disorders, such as rhinitis, sinusitis, and bronchitis. The schoolchildren filled out the Children’s Stress Scale. Poisson regression models were constructed separately for each respiratory disorder to determine prevalence ratios (PRs) and 95% confidence intervals (CIs). Sleep Bruxism was more prevalent among children with rhinitis (PR = 1.45; 95%CI 1.08–1.93; p = 0.012) and sinusitis (PR = 1.58; 95%CI 1.06–2.36; p = 0.023). No significant association was found between Sleep Bruxism and bronchitis. A greater frequency of Sleep Bruxism was found among children whose mothers had a higher level of schooling and those who reported stress in the resistance/exhaustion phase. Rhinitis and sinusitis were associated with Sleep Bruxism. Moreover, Sleep Bruxism was more prevalent among children whose mothers had a higher level of schooling and those with higher degrees of stress.
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Association between possible Sleep Bruxism and Sleep characteristics in children
Cranio : the journal of craniomandibular practice, 2016Co-Authors: Júnia Maria Serra-negra, Saul Martins Paiva, Ivana Meyer Prado, Mariana Batista Ribeiro, Isabela Almeida PordeusAbstract:AbstractAims: To evaluate the relationship between possible Sleep Bruxism and Sleep characteristics in children.Methodology: A cross-sectional study was conducted through data collection of a pre-tested questionnaire answered by 111 parents on behalf of their children in the waiting room during their appointment at the Pediatric Dentistry Clinic of a public Brazilian university. The diagnosis of possible Sleep Bruxism was based on the international classification of Sleep disorders (ICSD) criteria. The Chi-square test and logistic multinomial regression test were used in the statistical analysis.Results: The final model of logistic multinomial regression demonstrated that children with muscle pain in the mouth region (OR = 19.70 95% IC = 1.82–212.69), snoring (OR = 8.25 95% IC = 2, 56–26, 54), and those with parents with possible Sleep Bruxism have more of a probability of Sleep Bruxism.Conclusion: Potential Sleep Bruxism tends to be hereditary. Muscle pain, snoring, and mouth breathing were important sig...
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Sleep Bruxism and Orthodontic Appliance among Children and Adolescents: A Preliminary Study
Journal of Sleep Disorders & Therapy, 2016Co-Authors: Ivana Meyer Prado, Saul Martins Paiva, Isabela Almeida Pordeus, Marcela Oliveira Brant, Sheyla Márcia Auad, Júnia Maria Serra-negraAbstract:Objective: The aim of this study was to evaluate the association between Sleep Bruxism and orthodontic treatment in children and adolescents. Methods: Analysis was performed both before and during such treatment. A retrospective cross-sectional study was undertaken in two groups of seven to 15-year-old patients from the orthodontic clinic of a public university in Belo Horizonte, Brazil. The first group contained 22 patients with a mean age of ten years (SD = 2.058) who were awaiting orthodontic treatment. The second group contained 44 patients with a mean age of nine years (SD = 1.79) undergoing orthodontic treatment. Data collection was performed using a questionnaire completed by parents/caregivers and data from the medical records of the clinic. Diagnosis of Bruxism was determined in accordance with American Academy of Sleep Medicine criteria. Descriptive analysis and Chi-square test were used for statistical analysis. Results: Sleep Bruxism was observed in 27.3% of patients who were awaiting orthodontic treatment. Regarding the group undergoing treatment, 36.4% had Sleep Bruxism prior to the start of treatment and 25% continued to suffer from the Para function following placement of an orthodontic appliance. Among those who had Sleep Bruxism before treatment, 75% reported that the Para function ceased after placement of the appliance. There was an association between the presence of Sleep Bruxism among parents/ caregivers and among patients (p = 0.035). Interceptive orthodontics was associated in 77% of Sleep Bruxism stop during treatment (p = 0.029). The corrective orthodontics was in 22.8% patients with Sleep Bruxism only after fitting orthodontic appliance compared to 9% with interceptive orthodontic treatment (p = 0.002). Conclusion: There was an association between Sleep Bruxism in parents/caregivers and the presence of the Para function among children/adolescents. The type of orthodontic treatment influenced the time that Sleep Bruxism appeared. The interceptive orthodontic treatment was associated with the cases which Sleep Bruxism stopped during treatment.
Isabela Almeida Pordeus - One of the best experts on this subject based on the ideXlab platform.
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Association between possible Sleep Bruxism and Sleep characteristics in children
Cranio : the journal of craniomandibular practice, 2016Co-Authors: Júnia Maria Serra-negra, Saul Martins Paiva, Ivana Meyer Prado, Mariana Batista Ribeiro, Isabela Almeida PordeusAbstract:AbstractAims: To evaluate the relationship between possible Sleep Bruxism and Sleep characteristics in children.Methodology: A cross-sectional study was conducted through data collection of a pre-tested questionnaire answered by 111 parents on behalf of their children in the waiting room during their appointment at the Pediatric Dentistry Clinic of a public Brazilian university. The diagnosis of possible Sleep Bruxism was based on the international classification of Sleep disorders (ICSD) criteria. The Chi-square test and logistic multinomial regression test were used in the statistical analysis.Results: The final model of logistic multinomial regression demonstrated that children with muscle pain in the mouth region (OR = 19.70 95% IC = 1.82–212.69), snoring (OR = 8.25 95% IC = 2, 56–26, 54), and those with parents with possible Sleep Bruxism have more of a probability of Sleep Bruxism.Conclusion: Potential Sleep Bruxism tends to be hereditary. Muscle pain, snoring, and mouth breathing were important sig...
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Sleep Bruxism and Orthodontic Appliance among Children and Adolescents: A Preliminary Study
Journal of Sleep Disorders & Therapy, 2016Co-Authors: Ivana Meyer Prado, Saul Martins Paiva, Isabela Almeida Pordeus, Marcela Oliveira Brant, Sheyla Márcia Auad, Júnia Maria Serra-negraAbstract:Objective: The aim of this study was to evaluate the association between Sleep Bruxism and orthodontic treatment in children and adolescents. Methods: Analysis was performed both before and during such treatment. A retrospective cross-sectional study was undertaken in two groups of seven to 15-year-old patients from the orthodontic clinic of a public university in Belo Horizonte, Brazil. The first group contained 22 patients with a mean age of ten years (SD = 2.058) who were awaiting orthodontic treatment. The second group contained 44 patients with a mean age of nine years (SD = 1.79) undergoing orthodontic treatment. Data collection was performed using a questionnaire completed by parents/caregivers and data from the medical records of the clinic. Diagnosis of Bruxism was determined in accordance with American Academy of Sleep Medicine criteria. Descriptive analysis and Chi-square test were used for statistical analysis. Results: Sleep Bruxism was observed in 27.3% of patients who were awaiting orthodontic treatment. Regarding the group undergoing treatment, 36.4% had Sleep Bruxism prior to the start of treatment and 25% continued to suffer from the Para function following placement of an orthodontic appliance. Among those who had Sleep Bruxism before treatment, 75% reported that the Para function ceased after placement of the appliance. There was an association between the presence of Sleep Bruxism among parents/ caregivers and among patients (p = 0.035). Interceptive orthodontics was associated in 77% of Sleep Bruxism stop during treatment (p = 0.029). The corrective orthodontics was in 22.8% patients with Sleep Bruxism only after fitting orthodontic appliance compared to 9% with interceptive orthodontic treatment (p = 0.002). Conclusion: There was an association between Sleep Bruxism in parents/caregivers and the presence of the Para function among children/adolescents. The type of orthodontic treatment influenced the time that Sleep Bruxism appeared. The interceptive orthodontic treatment was associated with the cases which Sleep Bruxism stopped during treatment.
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Sleep Bruxism, awake Bruxism and Sleep quality among Brazilian dental students: a cross-sectional study
Brazilian dental journal, 2014Co-Authors: Júnia Maria Serra-negra, Isabela Almeida Pordeus, Ana Carolina Scarpelli, Debora Tirsa-costa, Flávia Helena Guimarães, Saul Martins PaivaAbstract:The aim of the study was to evaluate the association of Sleep Bruxism, awake Bruxism and Sleep quality among dental students of the Federal University of Minas Gerais, Belo Horizonte, Brazil. A cross-sectional study was performed including 183 Brazilian dental students aged from 17 to 46 years old. The complete course curriculum consists of 9 semesters. Students enrolled in the first semester, the middle semester and the final semester of the course participated in the survey. The PSQI-BR (the Brazilian version of the Pittsburgh Sleep Questionnaire Index) was used for data collection. The PSQI-BR was distributed during lecture classes. Sleep Bruxism and awake Bruxism diagnosis was based on self-reported data. Descriptive analysis, Kruskal-Wallis, Mann-Whitney and Poisson regression with robust estimator were the statistical tests used. Sleep Bruxism prevalence was 21.5% and awake Bruxism prevalence was 36.5%. Sleep duration components were associated with Sleep Bruxism (PR=1.540; 95% CI: 1.00-2.37) and awake Bruxism (PR=1.344; 95% CI: 1,008-1,790). There was an association between awake Bruxism and habitual Sleep efficiency component (PR=1.323; 95% CI: 1.03-1.70). Sleep disturbance component and awake Bruxism were associated (PR=1.533; 95% CI: 1.03-2.27). Poor Sleep quality was an important factor among dental students, who reported Sleep Bruxism as well as among those who presented awake Bruxism.
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Association among stress, personality traits, and Sleep Bruxism in children.
Pediatric dentistry, 2012Co-Authors: Júnia Maria Serra-negra, Saul Martins Paiva, Carmen Flores-mendoza, Maria Letícia Ramos-jorge, Isabela Almeida PordeusAbstract:Purpose The purpose of this study was to determine the association among stress levels, personality traits, and Sleep Bruxism in children. Methods A population-based case control study (proportion=1:2) was conducted involving 120 7- to 11-year-olds with Sleep Bruxism and 240 children without Sleep Bruxism. The sample was randomly selected from schools in Belo Horizonte, Minas Gerais, Brazil. The following instruments were used for data collection: questionnaire administered to parents; child stress scale; and neuroticism and responsibility scales of the big five questionnaire for children. Psychological tests were administered and evaluated by psychologists. Sleep Bruxism was diagnosed from parents' reports. The chi-square test, as well as binary and multivariate logistic regression, was applied for statistical analysis. Results In the adjusted logistic model, children with a high level of stress, due to psychological reactions (odds ratio=1.8; confidence interval=1.1-2.9) and a high sense of responsibility (OR=1.6; CI=1.0-2.5) vs those with low levels of these psychological traits, presented a nearly 2-fold greater chance of exhibiting the habit of Sleep Bruxism. Conclusion High levels of stress and responsibility are key factors in the development of Sleep Bruxism among children.
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Signs, symptoms, parafunctions and associated factors of parent-reported Sleep Bruxism in children: a case-control study
Brazilian dental journal, 2012Co-Authors: Júnia Maria Serra-negra, Saul Martins Paiva, Maria Letícia Ramos-jorge, Sheyla Márcia Auad, Isabela Almeida PordeusAbstract:Bruxism is the non-functional clenching or grinding of the teeth that may occur during Sleep or less commonly in daytime. The aim of this study was to investigate the association between clinical signs and symptoms, parafunctions and associated factors of Sleep Bruxism in children. A population-based case-control study was carried out involving 120 children, 8 years of age, with Sleep Bruxism and 240 children without Sleep Bruxism. The sample was randomly selected from public and private schools in the city of Belo Horizonte, MG, Brazil. Groups were matched by gender and social class. The Social Vulnerability Index (SVI) drawn up by the city of Belo Horizonte was employed for social classification. Data collection instruments included clinical forms and pre-tested questionnaires. The diagnosis of Sleep Bruxism was supported by the American Association of Sleep Medicine (AASM) criteria. The McNemar test, binary and multivariate logistic regression models were used for statistical analysis. The risk factors associated with Sleep Bruxism included: primary canine wear (OR=2.3 IC 95% 1.2-4.3), biting of objects like pencils or pens (OR=2.0 IC 95% 1.2-3.3) and wake-time Bruxism (tooth clenching) (OR=2.3 IC 95% 1.2-4.3). Children that present the parafunctions of object biting and wake-time Bruxism were more susceptible to Sleep Bruxism.
Gilmar Fernandes Do Prado - One of the best experts on this subject based on the ideXlab platform.
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The Cochrane Library - Pharmacotherapy for Sleep Bruxism
The Cochrane database of systematic reviews, 2014Co-Authors: Cristiane R Macedo, Ademir Baptista Silva, Elizeu Coutinho De Macedo, Maria Regina Torloni, Gilmar Fernandes Do PradoAbstract:Background Sleep Bruxism is an oral activity characterized by involuntary teeth grinding or clenching during Sleep. Several forms of treatment have been proposed for this disorder, including behavioural, dental and pharmacological strategies. Objectives To evaluate the effectiveness and safety of pharmacological therapy for the treatment of Sleep Bruxism compared with other drugs, no treatment or placebo. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (Issue 8, 2014), MEDLINE (1966 to August 2014), EMBASE (1980 to August 2013) and LILACS (1982 to August 2014). We identified additional reports from the reference lists of retrieved reports and from reviews on treatment of Sleep Bruxism. We applied no language restrictions. Selection criteria We selected randomized controlled trials (RCTs) or quasi-RCTs that compared drugs with other drugs, no treatment or placebo in people with Sleep Bruxism. Data collection and analysis Review authors carried out data extraction and quality assessment of the included trials independently and in duplicate. We discussed discrepancies until we reached consensus. We consulted a third review author in cases of persistent disagreement. We contacted authors of primary studies when necessary. Main results We identified 18 potentially relevant RCTs, but only seven met the inclusion criteria. All studies had a small number of participants, ranging from seven to 16 people per study and had a cross-over design. Three studies were of low risk of bias, while four were of uncertain risk. Amitriptyline (three studies), bromocriptine (one study), clonidine (one study), propranolol (one study), levodopa (Prolopa®) (one study) and tryptophan (one study) were compared with placebo. Studies evaluating bromocriptine, clonidine, propranolol and levodopa reported our primary outcome of indices of Bruxism motor activity. Results were imprecise and consistent with benefit, no difference or harm. These were the specific findings for each of the drugs according to specific outcomes: 1. Amitriptyline versus placebo for masseteric electromyography (EMG) activity per minute: standardized mean difference (SMD) -0.28 (95% confidence interval (CI) -0.91 to 0.34; P value = 0.37), 2. bromocriptine versus placebo for Bruxism episodes per hour: mean difference (MD) 0.60 (95% CI -2.93 to 4.13), Bruxism bursts per hour: MD -2.00 (95% CI -53.47 to 49.47), Bruxism bursts per episode: MD 0.50 (95% CI -1.85 to 2.85) or number of episodes with grinding noise: MD 2.40 (95% CI -24.00 to 28.80), 3. clonidine versus placebo for number of Bruxism episodes per hour: MD -2.41 (95% CI -4.84 to 0.02), 4. propranolol versus placebo for the number of Bruxism episodes per hour: MD 1.16 (95% CI -1.89 to 4.21), 5. L-tryptophan versus placebo for masseteric EMG activity per second: SMD 0.08 (95% CI -0.90 to 1.06) and 6. levodopa versus placebo for Bruxism episodes per hour of Sleep: MD -1.47 (95% CI -3.64 to 0.70), for Bruxism bursts per episode: MD 0.06 (95% CI -2.47 to 2.59). We combined several secondary outcomes (Sleep duration, masseteric EMG activity per minute and pain intensity) in a meta-analysis for comparison of amitriptyline with placebo. The results for most comparisons were uncertain because of statistical imprecision. One study reported that clonidine reduced rapid eye movement (REM) Sleep stage and increased the second stage of Sleep. However, results for other Sleep-related outcomes with clonidine were uncertain. Adverse effects were frequent in people who took amitriptyline (5/10 had drowsiness, difficulty awakening in the morning, insomnia or xerostomia compared with 0/10 in the placebo group), as well as in people who received propranolol (7/16 had moderate-to-severe xerostomia compare with 2/16 in the placebo group). Clonidine was associated with prolonged morning hypotension in three of 16 participants. The use of preventive medication avoided any adverse effects in people treated with levodopa and bromocriptine. Authors' conclusions There was insufficient evidence on the effectiveness of pharmacotherapy for the treatment of Sleep Bruxism. This systematic review points to the need for more, well-designed, RCTs with larger sample sizes and adequate methods of allocation, outcome assessment and duration of follow-up. Ideally, parallel RCTs should be used in future studies to avoid the bias associated with cross-over studies. There is a need to standardize the outcomes of RCTs on treatments for Sleep Bruxism.
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occlusal splints for treating Sleep Bruxism tooth grinding
Cochrane Database of Systematic Reviews, 2007Co-Authors: Cristiane R Macedo, Ademir Baptista Silva, Marco Antonio Cardoso Machado, Humberto Saconato, Gilmar Fernandes Do PradoAbstract:Background Sleep Bruxism is an oral activity characterised by teeth grinding or clenching during Sleep. Several treatments for Sleep Bruxism have been proposed such as pharmacological, psychological, and dental. Objectives To evaluate the effectiveness of occlusal splints for the treatment of Sleep Bruxism with alternative interventions, placebo or no treatment. Search methods We searched the Cochrane Oral Health Group's Trials Register (to May 2007); the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2007, Issue 1); MEDLINE (1966 to May 2007); EMBASE (1980 to May 2007); LILACS (1982 to May 2007); Biblioteca Brasileira de Odontologia (1982 to May 2007); Dissertation, Theses and Abstracts (1981 to May 2007); and handsearched abstracts of particular importance to this review. Additional reports were identified from the reference lists of retrieved reports and from article reviews about treating Sleep Bruxism. There were no language restrictions. Selection criteria We selected randomised or quasi-randomised controlled trials (RCTs), in which splint therapy was compared concurrently to no treatment, other occlusal appliances, or any other intervention in participants with Sleep Bruxism. Data collection and analysis Data extraction was carried out independently and in duplicate. Validity assessment of the included trials was carried out at the same time as data extraction. Discrepancies were discussed and a third review author consulted. The author of the primary study was contacted when necessary. Main results Thirty-two potentially relevant RCTs were identified. Twenty-four trials were excluded. Five RCTs were included. Occlusal splint was compared to: palatal splint, mandibular advancement device, transcutaneous electric nerve stimulation, and no treatment. There was just one common outcome (arousal index) which was combined in a meta-analysis. No statistically significant differences between the occlusal splint and control groups were found in the meta-analyses. Authors' conclusions There is not sufficient evidence to state that the occlusal splint is effective for treating Sleep Bruxism. Indication of its use is questionable with regard to Sleep outcomes, but it may be that there is some benefit with regard to tooth wear. This systematic review suggests the need for further investigation in more controlled RCTs that pay attention to method of allocation, outcome assessment, large sample size, and sufficient duration of follow up. The study design must be parallel, in order to eliminate the bias provided by studies of cross-over type. A standardisation of the outcomes of the treatment of Sleep Bruxism should be established in the RCTs.
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The Cochrane Library - Occlusal splints for treating Sleep Bruxism (tooth grinding)
The Cochrane database of systematic reviews, 2007Co-Authors: Cristiane R Macedo, Ademir Baptista Silva, Marco Antonio Cardoso Machado, Humberto Saconato, Gilmar Fernandes Do PradoAbstract:Background Sleep Bruxism is an oral activity characterised by teeth grinding or clenching during Sleep. Several treatments for Sleep Bruxism have been proposed such as pharmacological, psychological, and dental. Objectives To evaluate the effectiveness of occlusal splints for the treatment of Sleep Bruxism with alternative interventions, placebo or no treatment. Search methods We searched the Cochrane Oral Health Group's Trials Register (to May 2007); the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2007, Issue 1); MEDLINE (1966 to May 2007); EMBASE (1980 to May 2007); LILACS (1982 to May 2007); Biblioteca Brasileira de Odontologia (1982 to May 2007); Dissertation, Theses and Abstracts (1981 to May 2007); and handsearched abstracts of particular importance to this review. Additional reports were identified from the reference lists of retrieved reports and from article reviews about treating Sleep Bruxism. There were no language restrictions. Selection criteria We selected randomised or quasi-randomised controlled trials (RCTs), in which splint therapy was compared concurrently to no treatment, other occlusal appliances, or any other intervention in participants with Sleep Bruxism. Data collection and analysis Data extraction was carried out independently and in duplicate. Validity assessment of the included trials was carried out at the same time as data extraction. Discrepancies were discussed and a third review author consulted. The author of the primary study was contacted when necessary. Main results Thirty-two potentially relevant RCTs were identified. Twenty-four trials were excluded. Five RCTs were included. Occlusal splint was compared to: palatal splint, mandibular advancement device, transcutaneous electric nerve stimulation, and no treatment. There was just one common outcome (arousal index) which was combined in a meta-analysis. No statistically significant differences between the occlusal splint and control groups were found in the meta-analyses. Authors' conclusions There is not sufficient evidence to state that the occlusal splint is effective for treating Sleep Bruxism. Indication of its use is questionable with regard to Sleep outcomes, but it may be that there is some benefit with regard to tooth wear. This systematic review suggests the need for further investigation in more controlled RCTs that pay attention to method of allocation, outcome assessment, large sample size, and sufficient duration of follow up. The study design must be parallel, in order to eliminate the bias provided by studies of cross-over type. A standardisation of the outcomes of the treatment of Sleep Bruxism should be established in the RCTs.
Jacques Montplaisir - One of the best experts on this subject based on the ideXlab platform.
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high separation anxiety trajectory in early childhood is a risk factor for Sleep Bruxism at age 7
Sleep, 2020Co-Authors: Elham Garmroudinezhad Rostami, Evelyne Touchette, Nelly Huynh, Jacques Montplaisir, Richard E Tremblay, Marco Battaglia, Michel BoivinAbstract:STUDY OBJECTIVES The evolution of Sleep Bruxism manifestations and their co-occurrence with separation anxiety in early childhood remain unclear. Our threefold aim was to: (1) describe developmental Sleep Bruxism trajectories in early childhood, (2) investigate co-occurrences between trajectories of Sleep Bruxism and separation anxiety, and (3) determine whether distinct trajectories of separation anxiety increase the risk of presenting Sleep Bruxism during the first year of elementary school. METHODS This study is part of the Quebec Longitudinal Study of Child Development. Sleep Bruxism scores were assessed from age 1.5 to 7 years with the Self-Administered Questionnaire for Mother (n = 1946). Separation anxiety scores were measured from age 1.5 to 6 years with the Interviewer-Completed Computerized Questionnaire (n = 2045). RESULTS We identified four Sleep Bruxism trajectories from age 1.5 to 6 years: High-Increasing Sleep Bruxism at age 1.5 (14.1%), High-Increasing Sleep Bruxism at age 4 (18.3%), Low-Persistent Sleep Bruxism (12.1%), and Never-Persistent Sleep Bruxism (55.5%); and four separation anxiety trajectories from age 1.5 to 6 years: Low-Persistent separation anxiety (60.2%), High-Increasing separation anxiety (6.9%), High-Decreasing separation anxiety (10.8%), and Low-Increasing separation anxiety (22.1%). Sleep Bruxism and separation anxiety trajectories were weakly associated (X2 = 37.84, p < 0.001). Compared with preschoolers belonging to the Low-Persistent separation anxiety trajectory, preschoolers in the High-Increasing separation anxiety trajectory had almost double the risk of presenting Sleep Bruxism at age 7 (95% CI = 1.25-3.22, p = 0.04). CONCLUSION When separation anxiety issues are detected in early childhood, it would be useful to target Sleep Bruxism during the first year of elementary school.
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Identification of a Sleep Bruxism Subgroup with a Higher Risk of Pain
Journal of dental research, 2007Co-Authors: Pierre H. Rompré, Jacques Montplaisir, F. Guitard, D. Daigle-landry, G.j. LavigneAbstract:Sleep Bruxism research diagnostic criteria (SB-RDC) have been applied since 1996. This study was performed to validate these criteria and to challenge the hypothesis that pain is associated with lower frequencies of orofacial activities. Polygraphic recordings were made of 100 individuals presenting with a clinical diagnosis of Sleep Bruxism and 43 control individuals. TwoStep Cluster analyses (SPSS) were performed with Sleep Bruxism variables to reveal groupings among Sleep bruxers and control individuals. Participants completed questionnaires during screening, diagnosis, and recording sessions. Cluster analysis identified three subgroups of Sleep bruxers. Interestingly, 45 of the 46 Sleep bruxers with values below SB-RDC were classified in the low-frequency cluster. These individuals were more likely to complain of pain and fatigue of masticatory muscles than were the higher-frequency Sleep bruxers (odds ratios > 3.9, p < 0.01). Sleep bruxers were distributed among three heterogeneous groups. Sleep bruxers with low frequencies of orofacial activities were more at risk of reporting pain.
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The effect of 2 sympatholytic medications--propranolol and clonidine--on Sleep Bruxism: experimental randomized controlled studies.
Sleep, 2006Co-Authors: Nelly Huynh, Jacques Montplaisir, G.j. Lavigne, Paola Lanfranchi, Jacques De ChamplainAbstract:STUDY OBJECTIVE To examine whether 2 sympatholytic medications decrease Sleep Bruxism and prevent the rise in sympathetic activity preceding the onset of Sleep Bruxism: propranolol, a nonselective adrenergic beta-blocker, and clonidine, a selective alpha2-agonist. DESIGN Experimental randomized controlled crossover studies with placebo and active treatments (propranolol 120 mg; clonidine 0.3 mg). SETTING Hospital-based Sleep research laboratory. PATIENTS Twenty-five subjects with a history and diagnosis of Sleep Bruxism (11 men, 14 women; age range, 21 to 31 years). INTERVENTION Polygraphic study. MEASUREMENTS AND RESULTS Polygraphic Sleep laboratory recordings were done for 4 nights: the first night was habituation, the second, Sleep Bruxism diagnosis; and 3 and 4 were study nights. The Sleep Bruxism index was estimated using masseter muscle activity. Heart rate variability was estimated with spectral analysis of RR intervals. Sleep and Sleep Bruxism variables were not significantly influenced by propranolol. A reduction of the mean RR intervals and of the sympathetic dominance (p < .05) was seen. Under clonidine, duration of Sleep stage 2 was prolonged, whereas REM Sleep was suppressed in 14 of 16 subjects with Sleep Bruxism. The Sleep Bruxism index was reduced by 61% (p < .05). Under clonidine, a reduction in heart rate and sympathetic dominance was observed in stable Sleep and in the minute preceding the onset of Sleep Bruxism (p < .05). CONCLUSION Although propranolol did not affect Sleep Bruxism, clonidine decreased sympathetic tone in the minute preceding the onset of Sleep Bruxism, thus reducing Sleep Bruxism by preventing the sequence of autonomic to motor activation of Sleep Bruxism. This further supports the role of sympathetic activity in the pathophysiology of Sleep Bruxism. Because morning hypotension was seen in 19% of patients, further dose-dependant research is required to assess the safety of clonidine for the management of Sleep Bruxism.
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Association between Sleep Bruxism, swallowing-related laryngeal movement, and Sleep positions.
Sleep, 2003Co-Authors: Shouichi Miyawaki, Jacques Montplaisir, Gilles Lavigne, Pierre Mayer, F. Guitard, Takafumi KatoAbstract:STUDY OBJECTIVE To describe the relationships of Sleep Bruxism to swallowing and Sleep positions. DESIGN Controlled descriptive study. SETTING Polysomnography and audio-video recordings were done in a hospital Sleep laboratory. PARTICIPANTS Nine patients with Sleep Bruxism and 7 normal subjects were matched for age and sex. INTERVENTIONS n/a. MEASUREMENTS AND RESULTS During Sleep, patients with Sleep Bruxism showed a higher frequency of rhythmic masticatory muscle activity episodes (6.8 +/- 1.0 [SEM]/h) than did normals (0.5 +/- 0.1/h, p < 0.01). Swallowing-related laryngeal movements occurred more frequently in Sleep of patients with Sleep Bruxism (6.8 +/- 0.8/h) than in normals (3.7 +/- 0.3/h, p < 0.01). In both groups, during Sleep, close to 60% of rhythmic masticatory muscle activity episodes were associated with swallowing. In Sleep Bruxism patients, 68% of swallowing events occurred during rhythmic masticatory muscle activity episodes, while only 10% of swallowing events were associated with rhythmic masticatory muscle activity in normal subjects. Sleep Bruxism patients and normals spent 95.5% and 87.3% of Sleeping time in the supine and lateral decubitus positions, respectively. In both groups, up to 96% of rhythmic masticatory muscle activity and swallowing were observed in the supine and lateral decubitus position. In Sleep Bruxism patients, although Sleeping time did not differ between the 2 Sleeping body positions, 74% of rhythmic masticatory muscle activity and swallowing events were scored in the supine position compared to 23% in the lateral decubitus position. CONCLUSIONS During Sleep, rhythmic masticatory muscle activity is often associated with swallowing. In Sleep Bruxism patients, most of these oromotor events are observed in the supine position. The physiologic link between rhythmic masticatory muscle activity and swallowing and the clinical relevance of Sleep position in Sleep Bruxism management need to be investigated.
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Double-blind, crossover, placebo-controlled trial of bromocriptine in patients with Sleep Bruxism.
Clinical neuropharmacology, 2001Co-Authors: Gilles Lavigne, Frank Lobbezoo, Christiane Manzini, Jean-paul Soucy, Pierre J. Blanchet, Jacques MontplaisirAbstract:This study was designed to assess the effects of bromocriptine, a dopamine D2 receptor agonist, on Sleep Bruxism. Seven otherwise healthy patients with severe and frequent Sleep Bruxism participated in this randomized, double-blind, placebo-controlled study. The study used a crossover design that included 2 weeks of active treatment or placebo with a washout period of 1 week. To further evaluate whether bromocriptine influences striatal D2 receptor binding, we used iodine-123-iodobenzamide single photon emission computed tomography (SPECT) under both placebo and bromocriptine regimens. Bromocriptine did not reduce the frequency of episodes of Bruxism during Sleep (mean +/- SEM, 9.0 +/- 1.0 and 9.6 +/- 1.5 Bruxism episodes per hour for placebo and bromocriptine, respectively) or the amplitude of masseter muscle contractions (root mean square values, 48.2 +/- 15.5 microV and 46.9 +/- 12.7 microV for placebo and bromocriptine, respectively). SPECT also failed to reveal that either treatment had any influence on striatal D2 binding (values for total binding in counts/pixel, 1.80 [1.72-1.93] and 1.79 [1.56-1.87] for placebo and bromocriptine, respectively). This study shows that a nightly dose of bromocriptine does not exacerbate or reduce Sleep Bruxism motor activity.
