The Experts below are selected from a list of 189 Experts worldwide ranked by ideXlab platform
Joao Palermoneto - One of the best experts on this subject based on the ideXlab platform.
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effects of monosialoganglioside on dopaminergic supersensitivity
Life Sciences, 1995Co-Authors: Roberto Frussafilho, Joao PalermonetoAbstract:Abstract The effects of monosialoganglioside (GM1) treatment on dopaminergic supersensitivity induced by long-term haloperidol administration were studied; both general activity of rats observed in an open-field and apomorphine-induced Stereotyped Behavior were used as experimental parameters. GM1 per se (5.0 mg/kg, twice daily, for 30 days) did not modify rat Behavior, but when given in combination with haloperidol (1.0 mg/kg, twice daily, for 30 days) it increased neuroleptic withdrawal Symptoms as detected in both models. When GM1 (5.0 mg/kg, twice daily) was administered after abrupt withdrawal from haloperidol (1.0 mg/kg, twice daily, for 30 days), it attenuated the increases in both general activity of rats observed in the open-field and apomorphine-induced Stereotyped Behavior. These results suggest that GM1 may affect synaptic plasticity, facilitating the induction of the adaptative changes in receptor function (up and down-regulation), following long-term haloperidol treatment and withdrawal.
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effects of single and long term droperidol administration on open field and Stereotyped Behavior of rats
Physiology & Behavior, 1991Co-Authors: Roberto Frussafilho, Joao PalermonetoAbstract:The effects of single and long-term droperidol administration on rat open-field and apomorphine-induced Stereotyped Behavior were studied. A single dose of droperidol decreased dose dependently not only locomotion and rearing frequencies in the open-field but also the apomorphine effects. Long-term droperidol administration induced significant tolerance to all parameters of activity recorded in the open-field. Unlike other dopamine blockers, droperidol withdrawn from long-term droperidol administration wasn't able to increase rats' open-field parameters significantly. However, like other dopamine blockers, droperidol withdrawn produced an augmented responsiveness to apomorphine-induced Stereotyped Behavior. These results suggest that the supersensitivity of central dopamine receptors developed after droperidol treatment may have peculiar characteristics.
C Marin - One of the best experts on this subject based on the ideXlab platform.
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differential nigral expression of bcl 2 protein family in chronically haloperidol and clozapine treated rats role in neurotoxicity and Stereotyped Behavior
Experimental Neurology, 2007Co-Authors: M Saldana, M Bonastre, E Aguilar, C MarinAbstract:Tardive dyskinesia (TD) is a syndrome characterized by repetitive involuntary movements induced by the administration of typical neuroleptics such as haloperidol. TD generally persists after haloperidol withdrawal indicating that haloperidol produces long-lasting changes in brain function. In contrast to the typicals, atypical medications, such as clozapine, have very low rates of TD. The mechanisms underlying drug-induced TD are poorly understood. We have investigated the role of nigral expression of the bcl-2 family of proteins on haloperidol-induced neurotoxicity. Rats were treated for 21 days with the following drugs: haloperidol (1 mg/kg), clozapine (1 mg/kg) or saline. After a 3-day washout period, apomorphine-induced Stereotyped Behavior was scored. Western blotting was performed to evaluate the nigral expression of the dopamine transporter (DAT), bax, bcl-x(L) and bcl-2 proteins. Haloperidol administration, but not clozapine, increased Stereotyped Behavior (p<0.01) in association with a decrease in striatal DAT expression (p<0.05). Haloperidol and clozapine treatment significantly decreased the nigral expression of bax (p<0.05, p<0.01, respectively). Neither treatment modified bcx(L) expression. Haloperidol increased (p<0.05), whereas clozapine did not significantly modify the nigral expression of bcl-2. Our results suggest that the increase in bcl-2 expression in the haloperidol-treated animals might be a compensatory mechanism that may reflect cellular damage induced by haloperidol in the dopaminergic neurons in the pars compacta of the substantia nigra.
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role of nigral nfκb p50 and p65 subunit expression in haloperidol induced neurotoxicity and Stereotyped Behavior in rats
European Neuropsychopharmacology, 2006Co-Authors: M Saldana, M Bonastre, E Aguilar, C MarinAbstract:Long-term use of typical neuroleptics such as haloperidol may be limited by unwanted motor side effects like tardive dyskinesia (TD) characterized by repetitive involuntary movements, involving the mouth, face and tongue. TD generally persists after haloperidol withdrawal indicating long lasting changes in brain function that are no longer related to the presence of the drug. The precise mechanisms of the neuronal toxicity induced by haloperidol are poorly understood. Haloperidol has been shown to induce the expression of the transcription factor nuclear factor-kappaB (NFkappaB). NFkappaB resembles a heterodimer protein composed of a 50 and a 65 kDa subunits and the role of the NFkappaB subunits on haloperidol-induced toxicity remains still unknown. The aim of the present study is to investigate the role of the p65 and p50 subunits of NFkappaB on the toxicity induced by chronic haloperidol administration in an experimental model of TD. Rats were treated for 21 days with: haloperidol (1mg/kg), clozapine (1mg/kg) or saline. Apomorphine-induced Stereotyped Behavior was evaluated. Striatal expression of the dopamine transporter (DAT) and the nigral expression of the NFkappaB p65 and p50 subunits were measured by Western Blot. Haloperidol, but not clozapine, increased Stereotyped Behavior associated to a decreased striatal DAT expression (p<0.01). Haloperidol did not modify the nigral expression of the p65 subunit whereas clozapine decreased it (p<0.01). Both drugs induced a significant decrease in the nigral expression of the NFkappaB p50 (p<0.05 and p<0.01, respectively). The decrease in nigral expression of the p50 subunit may increase the vulnerability of the dopaminergic neurons to a possible neurotoxic effect of p65 subunits in the haloperidol-treated rats.
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effect of long term haloperidol treatment on striatal neuropeptides relation to Stereotyped Behavior
Brain Research, 1996Co-Authors: M Bonastre, C Marin, Thomas M Engber, Thomas N Chase, Eduardo TolosaAbstract:Abstract Behavioral and biochemical responses to D 1 and D 2 dopamine (DA) agonists were used to evaluate the participation of striatal peptidergic mechanisms in the motor function alterations that attend chronic neuroleptic treatment. Rats, given haloperidol (1 mg/kg, s.c.) for 21 consecutive days, were randomly allocated to one of the following treatments: the D 1 agonist SKF 38393, the D 2 agonist quinpirole, their combination or saline. Stereotyped Behavior and neuropeptide levels were evaluated after 5 days treatment and 4 days washout. Haloperidol increased most oral Behaviors including licking, chewing and biting as well as striatal enkephalin and somatostatin levels. Subsequent treatment with SKF 38393 diminished the haloperidol-induced increase in licking and chewing; quinpirole reduced chewing Behavior. The administration of both agonists together decreased chewing and biting. Neither DA agonist alone, nor their combination, reduced the haloperidol-induced increase in enkephalin levels. Both SKF 38393 and quinpirole, when given alone, tended to decrease the haloperidol-induced increase in somatostatin levels; when both the D 1 and D 2 agonists were administered together, somatostatin levels declined significantly. These results suggest that somatostatin- but not enkephalin-containing striatal neurons contribute to the expression of haloperidol-induced stereotypies.
Lane J Wallace - One of the best experts on this subject based on the ideXlab platform.
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importance of environmental context in the development of amphetamine or apomorphine induced Stereotyped Behavior after single and multiple doses
Pharmacology Biochemistry and Behavior, 2000Co-Authors: John J Battisti, Norman J Uretsky, Lane J WallaceAbstract:The present study was designed to determine whether single and repeated pretreatment regimens with amphetamine or apomorphine differ in the context-dependency of sensitization of Stereotyped Behavior. Male CF-1 mice that were pretreated with a single high dose of amphetamine (14 mg/kg intraperitoneally [IP]) or apomorphine (40 mg/kg subcutaneously [SC]) only became sensitized to a lower test dose of amphetamine (7 mg/kg IP) or apomorphine (3 mg/kg SC) when placed in an environment that was the same as the pretreatment environment. However, animals pretreated with 3 high doses (24-h apart) of amphetamine (14 mg/kg IP) or apomorphine (40 mg/kg SC) did demonstrate sensitization to a lower test dose of amphetamine (7 mg/kg IP) or apomorphine (3 mg/kg SC) when placed in an environment that was different from the pretreatment environment. Context-dependent sensitization, but not context-independent sensitization, was extinguished by pairing the test environment with saline injections instead of drug injections. In addition, it was determined that neither sensitization model could be related to pharmacokinetic factors. Therefore, the results indicate that repeated exposure to amphetamine or apomorphine overcomes the context-dependent component of sensitization of amphetamine- or apomorphine-induced Stereotyped Behavior.
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sensitization of apomorphine induced Stereotyped Behavior in mice is context dependent
Psychopharmacology, 1999Co-Authors: John J Battisti, Norman J Uretsky, Lane J WallaceAbstract:Rationale: The role of the environment in the sensitization of the Stereotyped Behavioral effects of apomorphine is unclear, since sensitization of this drug effect has either been difficult to demonstrate or has been shown to occur with a low but not a higher dose of apomorphine. Objectives: The present study was designed to determine whether sensitization of the Stereotyped Behavioral effects induced by a single dose of apomorphine is dependent on environmental context. Methods: CF-1 mice were pretreated with apomorphine or vehicle under different environmental conditions and tested for Stereotyped Behavior after apomorphine challenge. Animals were scored positively for Stereotyped Behavior if they remained stationary and exhibited repetitive head and/or fore-limb movements, and data are reported as the percentage of mice rated as positive for Stereotyped Behavior. Results: When mice were pretreated with 40 mg/kg apomorphine and later tested in the same environment, the dose–response curve for Stereotyped Behavior elicited by apomorphine was shifted threefold to the left 48 h after pretreatment, and this sensitization persisted for at least 28 days after pretreatment. Mice pretreated with apomorphine did not have higher brain levels of apomorphine after administration of the test dose of apomorphine. When the pretreatment environment was different from the test environment, mice did not exhibit sensitization to apomorphine. Conclusions: These results show that pre-exposure to a single high dose of apomorphine induces a long-lasting sensitization of apomorphine-induced Stereotyped Behavior that is context dependent. Since apomorphine directly activates dopamine receptors, these observations suggest that a mechanism located postsynaptic to dopamine neurons may be responsible for sensitization of Stereotyped Behavior.
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sensitization of Stereotyped Behavior to amphetamine is context and response dependent
Pharmacology Biochemistry and Behavior, 1999Co-Authors: John J Battisti, Norman J Uretsky, Chenghuan Chang, Lane J WallaceAbstract:The present study was designed to determine whether the environmental context in which amphetamine is administered plays a role in the development of sensitization to the Stereotyped Behavioral effects of amphetamine in mice. In male CF-1 mice, the dose–response curve for Stereotyped Behavior elicited by amphetamine was shifted 1.9-fold to the left 48 h after pretreatment with 14 mg/kg amphetamine. Behavioral sensitization only developed in mice that were pretreated in the same or a similar environment as that of the test environment. In addition, when mice were placed in an environment that attenuated the acute expression of Stereotyped Behavior elicited by the pretreatment dose of amphetamine, sensitization never developed. A further experiment showed that 96% of the mice that expressed stereotypy after the ED50 pretreatment dose of 10 mg/kg amphetamine showed a Stereotyped Behavioral response to the lesser dose of 7 mg/kg 48 h later, indicating sensitization. In contrast, mice that did not express stereotypy after the ED50 dose of amphetamine failed to show a significant Stereotyped Behavioral response to amphetamine challenge compared to vehicle-pretreated controls. Therefore, the results indicate that preexposure to a single high dose of amphetamine produces context- and response-dependent sensitization to amphetamine-induced Stereotyped Behavior.
Johannes Rojahn - One of the best experts on this subject based on the ideXlab platform.
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Stereotyped Behaviors predicting self injurious Behavior in individuals with intellectual disabilities
Research in Developmental Disabilities, 2015Co-Authors: Lucy Barnardbrak, Johannes Rojahn, David M Richman, Steven R Chesnut, Tianlan WeiAbstract:We examined the relation between Stereotyped Behavior and self-injurious Behavior (SIB) for 1871 individuals with intellectual disabilities who had a score of >0 on the Behavior Problem Inventory (BPI-01; Rojahn et al., 2001). We report three main findings: First, structural equation modeling techniques (SEM) revealed that the BPI-01Stereotyped Behavior subscale scores predicted BPI-01 SIB subscale scores. Second, when Stereotyped Behavior was modeled as a predictor of SIB, mixture-modeling techniques revealed two groups of individuals: one in which Stereotyped Behavior was a strong, statistically significant predictor of SIB (69% of the sample), and another one in which Stereotyped Behavior was not a predictor of SIB (31%). Finally, two specific Stereotyped Behavior topographies (i.e., body rocking and yelling) were identified that significantly predicted five different SIB topographies (i.e., self-biting, head hitting, body hitting, self-pinching, and hair pulling). Results are discussed in terms of future research needed to identify bio-Behavioral variables correlated with cases of SIB that can, and cannot, be predicted by the presence of Stereotyped Behavior.
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the Behavior problems inventory an instrument for the assessment of self injury Stereotyped Behavior and aggression destruction in individuals with developmental disabilities
Journal of Autism and Developmental Disorders, 2001Co-Authors: Johannes Rojahn, Johnny L. Matson, Denise Lott, Anna J. Esbensen, Yemonja SmallsAbstract:The Behavior Problems Inventory (BPI-01) is a 52-item respondent-based Behavior rating instrument for self-injurious, stereotypic, and aggressive/destructive Behavior in mental retardation and other developmental disabilities. Items are rated on a frequency scale and a severity scale. The BPI-01 was administered by interviewing direct care staff of 432 randomly selected residents from a developmental center between the ages of 14 to 91 years. For 73% of those selected, at least one problem was endorsed on the BPI-01. A total of 43% showed self-injury, 54% Stereotyped Behavior, and 38% aggressive/destructive Behavior. Confirmatory factor analysis and item-total correlations supported the three a priori factors. Analyses of variance (ANOVA) showed that of the variables age, sex, and level of mental retardation, only the latter had a significant effect on the BPI-01 total score, the SIB subscale score, and the Stereotyped Behavior subscale score. Aggression/destruction was not significantly related to any of the three variables. Individuals with a diagnosis of pervasive developmental disorder had higher scores on all three subscales than those without, whereas residents with a diagnosis of Stereotyped movement disorder had higher Stereotyped Behavior scale scores than those without. The BPI-01 was found to be a reliable (retest reliability, internal consistency, and between-interviewer-agreement) and valid (factor and criterion validity) Behavior rating instrument for problem Behaviors in mental retardation and developmental disabilities with a variety of potentially useful applications. Strengths and limitations of the instrument are discussed.
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The Behavior Problems Inventory: An Instrument for the Assessment of Self-Injury, Stereotyped Behavior, and Aggression/Destruction in Individuals with Developmental Disabilities
Journal of Autism and Developmental Disorders, 2001Co-Authors: Johannes Rojahn, Johnny L. Matson, Denise Lott, Anna J. Esbensen, Yemonja SmallsAbstract:The Behavior Problems Inventory (BPI-01) is a 52-item respondent-based Behavior rating instrument for self-injurious, stereotypic, and aggressive/destructive Behavior in mental retardation and other developmental disabilities. Items are rated on a frequency scale and a severity scale. The BPI-01 was administered by interviewing direct care staff of 432 randomly selected residents from a developmental center between the ages of 14 to 91 years. For 73% of those selected, at least one problem was endorsed on the BPI-01. A total of 43% showed self-injury, 54% Stereotyped Behavior, and 38% aggressive/destructive Behavior. Confirmatory factor analysis and item-total correlations supported the three a priori factors. Analyses of variance (ANOVA) showed that of the variables age, sex, and level of mental retardation, only the latter had a significant effect on the BPI-01 total score, the SIB subscale score, and the Stereotyped Behavior subscale score. Aggression/destruction was not significantly related to any of the three variables. Individuals with a diagnosis of pervasive developmental disorder had higher scores on all three subscales than those without, whereas residents with a diagnosis of Stereotyped movement disorder had higher Stereotyped Behavior scale scores than those without. The BPI-01 was found to be a reliable (retest reliability, internal consistency, and between-interviewer-agreement) and valid (factor and criterion validity) Behavior rating instrument for problem Behaviors in mental retardation and developmental disabilities with a variety of potentially useful applications. Strengths and limitations of the instrument are discussed.
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the Stereotyped Behavior scale psychometric properties and norms
Research in Developmental Disabilities, 2000Co-Authors: Johannes Rojahn, Scott T Matlock, Marc J TasseAbstract:The Stereotyped Behavior Scale (SBS) is an empirically developed Behavior rating scale for adolescents and adults with mental retardation (Rojahn, Tasse & Sturmey, 1997). Since the original publication, one item was deleted and two items were merged, leaving 24 items. In an additional change, severity scales were added to the frequency scales. In this paper, psychometric properties and (relative) norms for the new SBS are presented. In the psychometric study, 45 adults with mental retardation from a residential facility participated. Of these, 15 were selected for high-rates or very severe forms of Stereotyped Behaviors, 15 for mild to moderate rates or less severe stereotypies, and 15 for the low rates or absence of Stereotyped Behaviors. Direct care staff familiar with the participants completed the SBS and the "Stereotypy" subscale of the Aberrant Behavior Checklist-Residential (ABC-R) (Aman, Singh, Stewart & Field, 1985). For 15 participants, two raters independently completed the SBS. In addition, 45-min direct Behavior observations were conducted on 16 participants. After approximately four weeks, the instruments were completed a second time by the same raters. As for reliability, the SBS frequency and severity scale total scores yielded test-retest intraclass coefficients (ICC) of 0.93 and 0.71, ICC interrater agreement of 0.76 and 0.75, and each had an internal consistency a of 0.91. For criterion validity, the SBS frequency and severity scores correlated with the ABC-R "Stereotypy" score at 0.80 and 0.84 (Pearson r), with systematic Behavior observations at 0.50 and 0.65 (Pearson r), and with the a priori classification at 0.50 and 0.65 (Spearman p). From a previous data set of 550 individuals with stereotypic Behavior, normative data (percentile ranks and T-scores) were derived. The data were presented in two tables, one showing a breakdown of gender by age groups, and the second one of age groups by level of functioning.
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the Stereotyped Behavior scale for adolescents and adults with mental retardation
American Journal on Mental Retardation, 1997Co-Authors: Johannes Rojahn, Marc J Tasse, Peter SturmeyAbstract:Abstract The development of the Stereotyped Behavior Scale for adolescents and adults with mental retardation was described. Service provider staff in three states selected 600 clients known for stereotypic Behaviors and then used 66 items to rate the frequency of occurrence of these Behaviors. Items with test-retest reliability less than .45 and/or interrater agreement less than 30 were deleted. The remaining 30 items were subjected to a principal component analysis with varimax rotation. A single-factor solution emerged, which explained 24.9% of the variance. After eliminating 4 items with low factor loadings, we found that the final 26-item Stereotyped Behavior Scale had an internal consistency alpha of .88, test-retest reliability was pI = .90, and interrater reliability was pI =.76.
Roberto Frussafilho - One of the best experts on this subject based on the ideXlab platform.
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effects of monosialoganglioside on dopaminergic supersensitivity
Life Sciences, 1995Co-Authors: Roberto Frussafilho, Joao PalermonetoAbstract:Abstract The effects of monosialoganglioside (GM1) treatment on dopaminergic supersensitivity induced by long-term haloperidol administration were studied; both general activity of rats observed in an open-field and apomorphine-induced Stereotyped Behavior were used as experimental parameters. GM1 per se (5.0 mg/kg, twice daily, for 30 days) did not modify rat Behavior, but when given in combination with haloperidol (1.0 mg/kg, twice daily, for 30 days) it increased neuroleptic withdrawal Symptoms as detected in both models. When GM1 (5.0 mg/kg, twice daily) was administered after abrupt withdrawal from haloperidol (1.0 mg/kg, twice daily, for 30 days), it attenuated the increases in both general activity of rats observed in the open-field and apomorphine-induced Stereotyped Behavior. These results suggest that GM1 may affect synaptic plasticity, facilitating the induction of the adaptative changes in receptor function (up and down-regulation), following long-term haloperidol treatment and withdrawal.
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effects of single and long term droperidol administration on open field and Stereotyped Behavior of rats
Physiology & Behavior, 1991Co-Authors: Roberto Frussafilho, Joao PalermonetoAbstract:The effects of single and long-term droperidol administration on rat open-field and apomorphine-induced Stereotyped Behavior were studied. A single dose of droperidol decreased dose dependently not only locomotion and rearing frequencies in the open-field but also the apomorphine effects. Long-term droperidol administration induced significant tolerance to all parameters of activity recorded in the open-field. Unlike other dopamine blockers, droperidol withdrawn from long-term droperidol administration wasn't able to increase rats' open-field parameters significantly. However, like other dopamine blockers, droperidol withdrawn produced an augmented responsiveness to apomorphine-induced Stereotyped Behavior. These results suggest that the supersensitivity of central dopamine receptors developed after droperidol treatment may have peculiar characteristics.
