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Ramazan Yagci - One of the best experts on this subject based on the ideXlab platform.

  • retinal nerve fiber layer thickness and retinal vessel calibers in children with Thalassemia Minor
    Sage Open Medicine, 2016
    Co-Authors: Semra Acer, Tt Ongun, Yasemin Isik Balci, Gokhan Pekel, Aziz Polat, Ebru Nevin Cetin, Ramazan Yagci
    Abstract:

    OBJECTIVES Evaluation of the peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements in children with Thalassemia Minor. METHODS In this cross-sectional and comparative study, 30 Thalassemia Minor patients and 36 controls were included. Heidelberg spectral domain optical coherence tomography was used for peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements. RESULTS There was no statistically significant difference in retinal nerve fiber layer thickness and subfoveal choroidal thickness between the two groups (p > 0.05). There was no correlation between retinal nerve fiber layer thickness and hemoglobin values. Both the arterioral and venular calibers were higher in Thalassemia Minor group (p < 0.05). CONCLUSION There is increased retinal arterioral and venular calibers in children with Thalassemia Minor compared with controls.

  • Retinal nerve fiber layer thickness and retinal vessel calibers in children with Thalassemia Minor.
    SAGE open medicine, 2016
    Co-Authors: Semra Acer, Tt Ongun, Yasemin Isik Balci, Gokhan Pekel, Aziz Polat, Ebru Nevin Cetin, Ramazan Yagci
    Abstract:

    OBJECTIVES Evaluation of the peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements in children with Thalassemia Minor. METHODS In this cross-sectional and comparative study, 30 Thalassemia Minor patients and 36 controls were included. Heidelberg spectral domain optical coherence tomography was used for peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements. RESULTS There was no statistically significant difference in retinal nerve fiber layer thickness and subfoveal choroidal thickness between the two groups (p > 0.05). There was no correlation between retinal nerve fiber layer thickness and hemoglobin values. Both the arterioral and venular calibers were higher in Thalassemia Minor group (p 

Semra Acer - One of the best experts on this subject based on the ideXlab platform.

  • retinal nerve fiber layer thickness and retinal vessel calibers in children with Thalassemia Minor
    Sage Open Medicine, 2016
    Co-Authors: Semra Acer, Tt Ongun, Yasemin Isik Balci, Gokhan Pekel, Aziz Polat, Ebru Nevin Cetin, Ramazan Yagci
    Abstract:

    OBJECTIVES Evaluation of the peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements in children with Thalassemia Minor. METHODS In this cross-sectional and comparative study, 30 Thalassemia Minor patients and 36 controls were included. Heidelberg spectral domain optical coherence tomography was used for peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements. RESULTS There was no statistically significant difference in retinal nerve fiber layer thickness and subfoveal choroidal thickness between the two groups (p > 0.05). There was no correlation between retinal nerve fiber layer thickness and hemoglobin values. Both the arterioral and venular calibers were higher in Thalassemia Minor group (p < 0.05). CONCLUSION There is increased retinal arterioral and venular calibers in children with Thalassemia Minor compared with controls.

  • Retinal nerve fiber layer thickness and retinal vessel calibers in children with Thalassemia Minor.
    SAGE open medicine, 2016
    Co-Authors: Semra Acer, Tt Ongun, Yasemin Isik Balci, Gokhan Pekel, Aziz Polat, Ebru Nevin Cetin, Ramazan Yagci
    Abstract:

    OBJECTIVES Evaluation of the peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements in children with Thalassemia Minor. METHODS In this cross-sectional and comparative study, 30 Thalassemia Minor patients and 36 controls were included. Heidelberg spectral domain optical coherence tomography was used for peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements. RESULTS There was no statistically significant difference in retinal nerve fiber layer thickness and subfoveal choroidal thickness between the two groups (p > 0.05). There was no correlation between retinal nerve fiber layer thickness and hemoglobin values. Both the arterioral and venular calibers were higher in Thalassemia Minor group (p 

Mehran Karimi - One of the best experts on this subject based on the ideXlab platform.

  • Prevalence of Delta Beta Thalassemia Minor in
    2012
    Co-Authors: Mehran Karimi, Mohaghegh P, Abdolreza Afrasiabi, Javad Dehbozorgian, Asghar Bazrafshan
    Abstract:

    Hb A2 is elevated in subjects with beta Thalassemia Minor but small percent of carriers have normal Hb A2 with elevated levels of HbF (2-10%). This type of Thalassemia is called delta beta Thalassemia, and can be missed in pre-marriage hematologic consults or screening which leads to increased risk of child birth with beta Thalassemia major. Materials and Methods: In this prospective descriptive study, 17768 subjects participated from January 2007 to January 2008. Complete blood count was checked for subjects. If MCV was below 80 fl or MCH was below 27pg, HbA2 was checked with column chromatography. If HbA2 was higher than 3.4 %, subject was labelled as beta Thalassemia Minor. If HbA2 was normal, 45 days of iron therapy were started for patients whom serum iron, serum ferritin and total iron-binding capacity were in favour of iron deficiency anemia. CBC was rechecked after iron therapy and if MCV or MCH still was below normal range, HbF was checked using alkaline denaturation method as well as Hb electrophoresis. Patients with HbF in the range of 2-10% were diagnosed as delta beta Thalassemia Minor. Results: 17768 subjects were recruited in this study and 1326 subjects (7.4%) were diagnosed as beta Thalassemia Minor. 1133 of 1326 Thalassemia Minor subjects (85.4%) had MCV below 70 fl and 193 subjects (14.6%) had MCV between 70 fl and 80 fl. Three subjects from 17768 (0.01%) had normal HbA2 with HbF between 2% and 10% (delta beta Thalassemia). Conclusion: It is very important to use Hb electrophoresis and check HbF by alkaline denaturation method for all people coming for pre-marriage hematologic consultation to detect delta beta Thalassemia or other hemoglobinopathies.

  • Beta Thalassemia Minor as a Risk Factor for Suicide and Violence: A Failure to Replicate
    Psychology, 2010
    Co-Authors: Alireza Fotouhi Ghiam, Alireza Hashemi, Mohammadreza Bordbar, Mehran Karimi
    Abstract:

    The aim of present study was to evaluate the association of Thalassemia Minor with suicide, impulsivity and ag-gression. The study group consisted of 293 suicidal subjects, 300 violent criminals and 300 control subjects. Thalas-semia trait was slightly more common in criminals (7.3%) than in controls (6.67%), this difference was not statistically significant (p = 0.75). Similarly, carrier trait was observed more in suicidal subjects (8.87%) though this difference was not statistically significant (p = 0.3). Despite a plausible biological hypothesis, our study results do not support that Thalassemia Minor could be a risk factor for suicidal, impulsivity and aggressive behaviors.

  • Insulin-like growth factor-1 levels in children with Beta-Thalassemia Minor.
    Turkish journal of haematology : official journal of Turkish Society of Haematology, 2008
    Co-Authors: Hamdollah Karamifar, Mehran Karimi, Nargrs Sobhani
    Abstract:

    Objective Growth retardation in children with b-Thalassemia major is multifactorial. Some etiologies described for this condition are hemochromatosis, disturbed growth hormone (GH) / insulin growth factor-1 (IGF-1) axis, undernutrition and hypermetabolism. It has also been proven that growth retardation is present in b-Thalassemia major children despite regular transfusion and chelation. Our aim was to evaluate the level of IGF-1 in b-Thalassemia Minor subjects and compare it with that in healthy children. Methods Fifty children aged 6 months to 15 years with b-Thalassemia Minor (32 males, 18 females) and 50 age- and sex-matched normal healthy children were selected. Medical history was taken and complete physical examination was done in each case; IGF-1 level was checked in all cases. This study was done in Shiraz, southern Iran, during 2005. Results IGF-1 levels were significantly lower in b-Thalassemia Minor children than normal children (P = 0.015). This result demonstrates that some etiologies of growth failure in b-Thalassemia major other than those described to date can exist, which may be shared with b-Thalassemia Minor in feature or may be transformed by genes that are either expressed or not. Conclusion We conclude that in addition to that observed in b-Thalassemia major, IGF-1 level is also decreased in b-Thalassemia Minor, and these two may have similar etiologies.

  • Prevalence of hepatosplenomegaly in beta Thalassemia Minor subjects in Iran
    European journal of radiology, 2007
    Co-Authors: Mehran Karimi, Mohammad Hadi Bagheri, Mehdi Tahmtan, Alireza Shakibafard, Murtaza Rashid
    Abstract:

    Abstract Introduction Thalassemia is the most common hereditary blood disorder in the world. Iran is located on the thalassemic belt and there is a high prevalence of the hepatosplenomegaly in beta Thalassemia Minor patients which is reported to be very variable. The goal of this research was to study the frequency of these signs in the cases with beta Thalassemia Minor patients in Iran. Materials and methods Two hundred and fifty-nine cases that referred to center for pre-marriage tests were divided into two groups according to their MCV, MCH, and HbA2 (beta Thalassemia Minor cases and control groups). Liver and spleen sizes were determined by ultrasonographic method and the two groups were compared with each other. Results Average spleen volumes in case and control groups were 163.48 ± 133.97 and 126.29 ± 53.98 mm3, respectively. Average spleen lengths in case and control groups were 10.71 ± 1.52 and 10.60 ± 5.4 cm, respectively. Conclusion In the regions with high frequency of beta Thalassemia, in case of finding large spleen size in the ultrasonography, a probable harmless differential diagnosis will be beta Thalassemia Minor that is not indicative of any serious disease. Volumetric measurement of spleen is more reliable for detection of splenomegaly in these patients.

  • short stature in beta Thalassemia Minor subjects
    Medical Science Monitor, 2004
    Co-Authors: Mehran Karimi, Hamdallah Karamifar
    Abstract:

    BACKGROUND Numerous disturbances in growth and development have been observed and demonstrated in homozygote beta-Thalassemia patients. However, short stature in Thalassemia Minor subjects, who have a Minor defect in hemoglobin chain synthesis, has not yet been studied. MATERIAL/METHODS In this cross-sectional study, the heights of 100 Thalassemia Minor subjects in the age group of 2-18 years and their parents were measured and analyzed. If the subject were in the 3-10 percentile range of height based on standardized sex and age curves, several follow-ups with complete history and physical examinations for a period of one year were preformed. If the healthy carrier's height was below the 3rd percentile, history, physical examination, and paraclinical examinations, including BUN, creatinine, electrolytes, serum alkaline phosphatase, thyroid function tests, growth hormone and cortisol levels, arterial blood gas, radiography of the left hand and wrist, etc, were also checked. One hundred healthy children were randomly chosen as a control group and matched for demographic characteristics with our healthy carrier subjects. RESULTS Mean +/- standard deviation for the age of our subjects was 6.62+/-3.63 years old. Twenty-seven (27%) of the patients had short stature. Except for hemoglobin (with a mean of 11.5 g/l), all other paraclinical data were normal. CONCLUSIONS We concluded that short stature was significantly more prevalent in the healthy beta Thalassemia Minor subjects than in the control group (p<0.001). Therefore, Thalassemia Minor can cause short stature.

Fatih Bulucu - One of the best experts on this subject based on the ideXlab platform.

  • Renal Tubular Dysfunction in -Thalassemia Minor
    2003
    Co-Authors: Türker Çetin, Cagatay Oktenli, Taner Ozgurtas, Mujdat Yenicesu, S. Yavuz Sanisoglu, Yusuf Oguz, Oguzhan Yildiz, Ismail Kurt, Ugur Musabak, Fatih Bulucu
    Abstract:

    ● Background: Persons with -Thalassemia Minor usually are symptomless. However, we previously reported renal tubular dysfunction in a patient with -Thalassemia Minor. The aim of this study is to investigate renal function in patients with -Thalassemia Minor. Methods: Forty-one subjects with -Thalassemia Minor and 20 sex- and age-matched healthy subjects were enrolled in the study. For analysis, patients were divided into 2 groups: group A, all patients with anemia (n 19), and group B, patients without anemia (n 22). Blood and 24-hour urine samples were obtained for hematologic and biochemical analysis. Results: Anemic patients had increased urinary zinc excretion (Uzinc) and fractional excretion of sodium (FENa) and uric acid (FEUA) compared with both controls and patients without anemia. Hemoglobin levels correlated significantly in a negative manner with Uzinc ,F E Na, and FEUA in patients with -Thalassemia Minor. However, serum lactate dehydrogenase levels correlated significantly in a positive manner with the same parameters. In addition, 6 of 41 patients (14.6%) with -Thalassemia Minor showed significant signs of renal tubulopathy, such as hypercalciuria, decreased tubular reabsorption of phosphorus with hypophosphatemia, hypomagnesemia with renal magnesium wasting, hypouricemia with renal uric acid wasting, and tubular proteinuria. Conclusion: Proximal renal tubular dysfunction is not rare in patients with -Thalassemia Minor. Am J Kidney Dis 42:1164-1168. © 2003 by the National Kidney Foundation, Inc.

  • Renal tubular dysfunction in β-Thalassemia Minor
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2003
    Co-Authors: Türker Çetin, Cagatay Oktenli, Taner Ozgurtas, Mujdat Yenicesu, S. Yavuz Sanisoglu, Yusuf Oguz, Oguzhan Yildiz, Ismail Kurt, Ugur Musabak, Fatih Bulucu
    Abstract:

    Abstract Background: Persons with β-Thalassemia Minor usually are symptomless. However, we previously reported renal tubular dysfunction in a patient with β-Thalassemia Minor. The aim of this study is to investigate renal function in patients with β-Thalassemia Minor. Methods: Forty-one subjects with β-Thalassemia Minor and 20 sex- and age-matched healthy subjects were enrolled in the study. For analysis, patients were divided into 2 groups: group A, all patients with anemia (n = 19), and group B, patients without anemia (n = 22). Blood and 24-hour urine samples were obtained for hematologic and biochemical analysis. Results: Anemic patients had increased urinary zinc excretion (U zinc ) and fractional excretion of sodium (FE Na ) and uric acid (FE UA ) compared with both controls and patients without anemia. Hemoglobin levels correlated significantly in a negative manner with U zinc , FE Na , and FE UA in patients with β-Thalassemia Minor. However, serum lactate dehydrogenase levels correlated significantly in a positive manner with the same parameters. In addition, 6 of 41 patients (14.6%) with β-Thalassemia Minor showed significant signs of renal tubulopathy, such as hypercalciuria, decreased tubular reabsorption of phosphorus with hypophosphatemia, hypomagnesemia with renal magnesium wasting, hypouricemia with renal uric acid wasting, and tubular proteinuria. Conclusion: Proximal renal tubular dysfunction is not rare in patients with β-Thalassemia Minor.

  • Renal tubular dysfunction in a patient with beta-Thalassemia Minor.
    Nephron, 2002
    Co-Authors: Cagatay Oktenli, Fatih Bulucu
    Abstract:

    β-Thalassemia Minor is a hemoglobinopathy which has been known as a symptomless carrier state. Although there are many causes leading to renal tubular dysfunction, β-Thalassemia Minor has not been rep

Tt Ongun - One of the best experts on this subject based on the ideXlab platform.

  • children with Thalassemia Minor
    'SAGE Publications', 2016
    Co-Authors: Acer S, Yi Balci, Pekel G, Tt Ongun, Polat A, En Cetin, Yagci R
    Abstract:

    Objectives: Evaluation of the peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements in children with Thalassemia Minor.Methods: In this cross-sectional and comparative study, 30 Thalassemia Minor patients and 36 controls were included. Heidelberg spectral domain optical coherence tomography was used for peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements.Results: There was no statistically significant difference in retinal nerve fiber layer thickness and subfoveal choroidal thickness between the two groups (p > 0.05). There was no correlation between retinal nerve fiber layer thickness and hemoglobin values. Both the arterioral and venular calibers were higher in Thalassemia Minor group (p < 0.05).Conclusion: There is increased retinal arterioral and venular calibers in children with Thalassemia Minor compared with controls

  • retinal nerve fiber layer thickness and retinal vessel calibers in children with Thalassemia Minor
    Sage Open Medicine, 2016
    Co-Authors: Semra Acer, Tt Ongun, Yasemin Isik Balci, Gokhan Pekel, Aziz Polat, Ebru Nevin Cetin, Ramazan Yagci
    Abstract:

    OBJECTIVES Evaluation of the peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements in children with Thalassemia Minor. METHODS In this cross-sectional and comparative study, 30 Thalassemia Minor patients and 36 controls were included. Heidelberg spectral domain optical coherence tomography was used for peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements. RESULTS There was no statistically significant difference in retinal nerve fiber layer thickness and subfoveal choroidal thickness between the two groups (p > 0.05). There was no correlation between retinal nerve fiber layer thickness and hemoglobin values. Both the arterioral and venular calibers were higher in Thalassemia Minor group (p < 0.05). CONCLUSION There is increased retinal arterioral and venular calibers in children with Thalassemia Minor compared with controls.

  • Retinal nerve fiber layer thickness and retinal vessel calibers in children with Thalassemia Minor.
    SAGE open medicine, 2016
    Co-Authors: Semra Acer, Tt Ongun, Yasemin Isik Balci, Gokhan Pekel, Aziz Polat, Ebru Nevin Cetin, Ramazan Yagci
    Abstract:

    OBJECTIVES Evaluation of the peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements in children with Thalassemia Minor. METHODS In this cross-sectional and comparative study, 30 Thalassemia Minor patients and 36 controls were included. Heidelberg spectral domain optical coherence tomography was used for peripapillary retinal nerve fiber layer thickness, subfoveal choroidal thickness, and retinal vessel caliber measurements. RESULTS There was no statistically significant difference in retinal nerve fiber layer thickness and subfoveal choroidal thickness between the two groups (p > 0.05). There was no correlation between retinal nerve fiber layer thickness and hemoglobin values. Both the arterioral and venular calibers were higher in Thalassemia Minor group (p