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Rikard Landberg – 1st expert on this subject based on the ideXlab platform
Dietary intake of whole grains and plasma alkylresorcinol concentrations in relation to changes in anthropometry: the Danish diet, cancer and health cohort studyEuropean Journal of Clinical Nutrition, 2017Co-Authors: C Kyrø, Rikard Landberg, M Kristensen, M U Jakobsen, J Halkjær, Hb(as) Bueno-de-mesquita, J Christensen, I Romieu, A Tjønneland, A OlsenAbstract:
Background/Objectives: Whole grain intake has been associated with a small but significant lower body weight gain in observational studies, but there is limited knowledge about the associations with specific whole grain types. The objective was to investigate the association between whole grains, different sources of whole grains and biomarkers of whole grain intake (Alkylresorcinols) in relation to subsequent changes in waist circumference (WC) and body weight. Subjects/Methods: Cohort study of 57 053 participants with baseline information on whole grain intake from questionnaires (FFQ) and biomarkers of whole grain rye and wheat intake, plasma Alkylresorcinols, for a subset. WC and body weight were measured at baseline and again at follow-up. The associations were estimated using multiple linear regression analyses and logistic regression. Results: For women, overall whole grain intake was not related to changes in WC or body weight. For men, total whole grain intake was associated with gains in WC (ΔWC per 25 g increment: 0.44 cm, 95% CI: 0.34 cm; 0.54 cm) and body weight (Δweight per 25 g increment: 150 g, 95% CI: 78 g; 222 g), but the results changed to null or changed direction when adjusting for baseline anthropometry. For the different sources of whole grains, rye (women) and crispbread was significantly associated with gains in WC and body weight. Plasma alkylresorcinol concentration was associated with reduced WC, but not body weight, for women (ΔWC per 50 nmol/l increment: −0.69 cm, 95% CI:−1.26 cm;−0.13 cm), but no association was found for men. Conclusions: Overall, no strong relationship between whole grain intake, measured from questionnaires or using biomarkers was found in relation to changes in body weight and WC.
carotenoids and Alkylresorcinols as objective biomarkers of diet quality when assessing the validity of a web based food record tool and a food frequency questionnaire in a middle aged populationBMC Nutrition, 2016Co-Authors: Sanna Nybacka, Rikard Landberg, Elisabet Wirfält, Anna Karin Lindroos, Per Leanderson, Ulrika Ericson, Ingrid Larsson, Eva Warensjo Lemming, Goran BergstromAbstract:
Recently, two web-based dietary assessment tools were developed; a 4-day food record tool (the Riksmaten method), and a food frequency questionnaire (MiniMeal-Q). The aim of this study was to use objective biomarkers to examine the ability of the two methods to capture habitual dietary intake. In total, 200 individuals from the pilot study of the Swedish CArdioPulmonary bioImage Study (SCAPIS) participated. Plasma concentration of carotenoids were determined with high-performance liquid chromatography (HPLC) and used as biomarkers of fruit and vegetable intake. A gas chromatography mass spectrometry (GC-MS) method was used to quantify alkylresorcinol homologues, which were used as biomarkers of whole grain wheat and rye intake. The correlations between energy-adjusted fruit and vegetable intakes and plasma carotenoid concentrations (except lycopene) were stronger amongst women than men (r = 0.46 and r = 0.20 for the Riksmaten method, and r = 0.50 and r = 0.31 for MiniMeal-Q, respectively). For whole grains, the correlations of energy-adjusted intakes and Alkylresorcinols were higher using the Riksmaten method (r = 0.30 and r = 0.29 for women and men) than the MiniMeal-Q (r = 0.25 and r = 0.20, respectively). In regression analyses between plasma carotenoids (except lycopene) and reported intake of fruits and vegetables, the R2 were 21.6 % and 5.1 % for women and men by the Riksmaten method, and correspondingly, 18.0 % and 6.6 % by the MiniMeal-Q. In the final full models, adjusted for smoking and BMI, all regression models remained statistically significant. The regression analyses of plasma Alkylresorcinols and reported intake of whole grains showed an R2 of 9.4 % and 9.7 % for women and men by the Riksmaten method, and correspondingly, 5.3 % and 8.4 % by the MiniMeal-Q. In the final full models, adjusted for smoking and age, all regression models remained statistically significant, except for women in MiniMeal-Q. Both dietary assessment methods were able to capture dietary intake based on food groups with a similar precision. Agreements with objective biomarkers ranged from low to moderate, depending on sex and diet quality indicator. While the ability to capture whole grain intake was weak for both methods and sexes, the assessment of vegetable and fruit intake performed in a satisfactory manner for women in both methods.
Alkylresorcinols in adipose tissue biopsies as biomarkers of whole grain intake an exploratory study of responsiveness to advised intake over 12 weeksEuropean Journal of Clinical Nutrition, 2015Co-Authors: H Wu, Rikard Landberg, Kaisa Poutanen, Marjukka Kolehmainen, Hannu Mykkanen, Matti Uusitupa, Ursula Schwab, Alicja WolkAbstract:
Alkylresorcinols in adipose tissue biopsies as biomarkers of whole-grain intake: an exploratory study of responsiveness to advised intake over 12 weeks
Arkadiusz Kozubek – 2nd expert on this subject based on the ideXlab platform
Isolation of Alkylresorcinols: Classical and supercritical CO2 extraction methods, 2020Co-Authors: José Da Cruz Francisco, Bengt Danielsson, Arkadiusz KozubekAbstract:
This chapter focuses on the use of different methods for isolation of Alkylresorcinols. Alkylresorcinols are members of a lipid group called non-isoprenoid phenolic lipids. Different aspects of the extraction by classical methods and supercritical CO2 are discussed. Supercritical CO2 extraction of Alkylresorcinols from rye bran is discussed for the first time. As compared to the classical extraction methods, supercritical CO2 gives higher yields and it allows the separation of the crude extrac into long- and short-chain alkylresorcinol homologues.
Alkylresorcinols in the family FabaceaeActa Societatis Botanicorum Poloniae, 2020Co-Authors: R. Zarnowski, E. D. Zarnowska, Arkadiusz KozubekAbstract:
The Fabaceae are a large family, members occurence of which is very common at various latitudes. The characteristic feature of this plant family is the symbiosis with the bacteria genus Rhizobium and Bradyrhizobium . The analysis of acetone extracts from dried seeds of the subfamily Papilinioideae revealed the occurrence of Alkylresorcinols in about 85% of the examined samples. Unfortunately, it was not possible to verify this observation in the second subfamily of Fabaceae-Caesalpinioideae . It was partly because there is merely one species belonging to this subfamily, in Poland.In reference to the common occurence of Alkylresorcinols in Papilinioideae some interspecific differences were indicated. This survey is a basis for further studies on the Fabaceae family.
Various effects of the photosystem II–inhibiting herbicides on 5-n-alkylresorcinol accumulation in rye seedlings.Pesticide Biochemistry and Physiology, 2014Co-Authors: Elżbieta G. Magnucka, Arkadiusz Kozubek, Stanislaw J. Pietr, Robert ZarnowskiAbstract:
Abstract The effect of three PSII-inhibiting herbicides, lenacil, linuron, and pyrazon, on the accumulation of 5- n –Alkylresorcinols in rye seedlings ( Secale cereale L.) grown under various light and thermal conditions was studied. All used chemicals increased resorcinolic lipid content in both green and etiolated plants grown at 29 °C. At 22 °C pyrazon and lenacil decreased the content of Alkylresorcinols in plants kept in the darkness and increased their amount in the light-grown seedlings. In turn, level of resorcinolic lipids was decreased by linuron in both etiolated and green plants. At the lowest tested temperature lenacil enhanced production of Alkylresorcinols only in etiolated rye seedlings, whereas the light-independent stimulatory action of pyrazon on alkylresorcinol accumulation in rye grown at 15 °C was observed. Additionally, only the latter did not exert a negative effect on rye seedling growth under any of tested conditions. Compared with respective controls, the herbicides used also markedly modified the qualitative pattern of resorcinolic homologs. Interestingly, the observed changes generally favored the enhanced antifungal activity of these compounds. Our study provides novel information on the influence of PSII inhibitors on alkylresorcinol metabolism in rye seedlings. The unquestionable achievement of this work is the observation that low dose of pyrazon mainly stimulated both growth and alkylresorcinol synthesis in rye seedlings, a non-target plant. Moreover, our experimental work showed unambiguously that the observed pyrazon-driven accumulation and homolog pattern modification of Alkylresorcinols dramatically improved the resistance of winter rye to infections caused by Rhizoctonia cerealis .
Alastair B. Ross – 3rd expert on this subject based on the ideXlab platform
Serum Alkylresorcinols as Biomarkers of Dietary Gluten Exposure in Celiac diseaseThe FASEB Journal, 2020Co-Authors: Alastair B. Ross, Rok Seon Choung, Eric V Marietta, Carol T Van Dyke, Joseph A MurrayAbstract:
Background Therapy for celiac disease (CD) mainly relies on following a gluten-free diet (GFD); however, a serum marker for gluten intake has yet to be established.
Aims To evaluate the utility of alkylresorcinol concentrations for detecting gluten intake in studies of human and mouse.
Methods Alkylresorcinol concentrations were compared among treated CD patients (n=34), untreated CD patients (n=36), and controls (n=33). Furthermore, 7 additional CD patients whose serum samples were available at diagnosis and after GFD were evaluated. In mice studies, alkylresorcinol concentrations were compared in the serum of 5 mice fed a regular chow and 10 mice fed lifelong with a gluten-free chow. In addition, the effect of adding gluten on changes of alkylresorcinol concentrations was also evaluated.
Results Total alkylresorcinol concentrations were significantly lower in treated CD patients (median [IQR], 3 (2–8) nmol/L), compared to untreated CD patients (median [IQR], 32 [11–74] nmol/L; P
identification and quantification of even and odd chained 5 n Alkylresorcinols branched chain Alkylresorcinols and methylAlkylresorcinols in quinoa chenopodium quinoaFood Chemistry, 2017Co-Authors: Alastair B. Ross, Cecilia Svelander, Goran Karlsson, Otto SavolainenAbstract:
Quinoa is a pseudocereal grown in the Andean region of South America that is of increasing interest worldwide as an alternative staple food. We have detected a complex mixture of both odd- and even-alkyl chain Alkylresorcinols (AR), branched-chain Alkylresorcinols (bcAR) and methylAlkylresorcinols (mAR) in ethyl acetate extracts of quinoa. We quantified the content of AR in 17 commercial samples of quinoa, and found that the mean±SD content of AR was 58±16μg/g, bcAR was 182±52μg/g, and mAR was 136±40μg/g. AR from quinoa could also be detected in plasma after eating quinoa, indicating that some of these unique AR could be used as biomarkers of quinoa intake in humans. Further work is required to understand the role of these ARs in the quinoa plant and whether any of the novel ARs may be of particular interest in human nutrition.
serum Alkylresorcinols as biomarkers of dietary gluten exposure in coeliac diseaseAlimentary Pharmacology & Therapeutics, 2017Co-Authors: Rok Seon Choung, Joseph A Murray, Eric V Marietta, Carol T Van Dyke, Alastair B. RossAbstract:
Therapy for coeliac disease (CD) mainly relies on following a gluten-free diet (GFD); however, a serum marker for gluten intake has yet to be established. Aim: To evaluate the utility of alkylresorcinol concentrations for detecting gluten intake in studies of human and mouse. Methods: Alkylresorcinol concentrations were compared among treated patients with coeliac disease (n = 34), untreated coeliac disease patients (n = 36) and controls (n = 33). Furthermore, seven additional coeliac disease patients whose serum samples were available at diagnosis and after GFD were evaluated. In mice studies, alkylresorcinol concentrations were compared in the serum of five mice fed a regular chow and 10 mice fed lifelong with a gluten-free chow. In addition, the effect of adding gluten on changes of alkylresorcinol concentrations was also evaluated. Results: Total alkylresorcinol concentrations were significantly lower in treated with coeliac disease [median (IQR), 3 (2–8) nmol/L], compared to untreated patients [median (IQR), 32 (11–74) nmol/L; P < 0.0001] or healthy controls [median (IQR), 54 (23–112) nmol/L; P < 0.0001]. Moreover, alkylresorcinol concentrations in coeliac disease patients significantly decreased after introduction of a GFD (median, 34 nmol/L at diagnosis vs. 5 nmol/L after GFD, P = 0.02). In the mice, median (IQR) total alkylresorcinol concentrations in serum samples of mice fed lifelong with a gluten-free chow was 1.8 (1.6–2.3) nmol/L, which was further significantly increased to 16 (11–22) nmol/L after 8 days of feeding with the gluten-free chow that had gluten added to it. (P = 0.008). Conclusion: Serum alkylresorcinol concentrations could be a useful marker for dietary gluten in coeliac disease.