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Artificial Cell

The Experts below are selected from a list of 315 Experts worldwide ranked by ideXlab platform

Kazuhiko Ishihara – 1st expert on this subject based on the ideXlab platform

  • Cytocompatible and multifunctional polymeric nanoparticles for transportation of bioactive molecules into and within Cells
    Science and Technology of Advanced Materials, 2016
    Co-Authors: Kazuhiko Ishihara, Weixin Chen, Yihua Liu, Yoshihiro Tsukamoto, Yuuki Inoue

    Abstract:

    © 2016 The Author(s). Published by National Institute for Materials Science in partnership with Taylor & Francis. Multifunctional polymeric nanoparticles are materials with great potential for a wide range of biomedical applications. For progression in this area of research, unfavorable interactions of these nanoparticles with proteins and Cells must be avoided in biological environments, for example, through treatment of the nanoparticle surfaces. Construction of an Artificial Cell membrane structure based on polymers bearing the zwitterionic phosphorylcholine group can prevent biological reactions at the surface effectively. In addition, certain bioactive molecules can be immobilized on the surface of the polymer to generate enough affinity to capture target biomolecules. Furthermore, entrapment of inorganic nanoparticles inside polymeric matrices enhances the nanoparticle functionality significantly. This review summarizes the preparation and characterization of cytocompatible and multifunctional polymeric nanoparticles; it analyzes the efficiency of their fluorescence function, the nature of the Artificial Cell membrane structure, and their performance as in-Cell devices; and finally, it evaluates both their chemical reactivity and effects in Cells.

  • integrated functional nanocolloids covered with Artificial Cell membranes for biomedical applications
    Nano Today, 2011
    Co-Authors: Ryosuke Matsuno, Kazuhiko Ishihara

    Abstract:

    Summary The functionality of nanocolloids used in biomedical applications are subject to strong interference arising from significant interactions with biological components such as proteins and Cells. Among the known examples of surface treatment of nanocolloids, the construction of an Artificial Cell membrane structure based on phospholipid polymers has proven effective in preventing the occurrence of biological reactions at the surface. Furthermore, certain bioactive molecules can be immobilized on the surface of the phospholipid polymer platform to generate bioaffinity for other biomolecules. This review describes preparation and characterization of integrated functional nanocolloids covered by Artificial Cell membrane structures and their performance in biomedical applications.

  • Integrated functional nanocolloids covered with Artificial Cell membranes for biomedical applications
    Nano Today, 2011
    Co-Authors: Ryuichi Matsuno, Kazuhiko Ishihara

    Abstract:

    The functionality of nanocolloids used in biomedical applications are subject to strong interference arising from significant interactions with biological components such as proteins and Cells. Among the known examples of surface treatment of nanocolloids, the construction of an Artificial Cell membrane structure based on phospholipid polymers has proven effective in preventing the occurrence of biological reactions at the surface. Furthermore, certain bioactive molecules can be immobilized on the surface of the phospholipid polymer platform to generate bioaffinity for other biomolecules. This review describes preparation and characterization of integrated functional nanocolloids covered by Artificial Cell membrane structures and their performance in biomedical applications. © 2010 Elsevier Ltd.

Thomas Ming Swi Chang – 2nd expert on this subject based on the ideXlab platform

  • Artificial Cell evolves into nanomedicine biotherapeutics blood substitutes drug delivery enzyme gene therapy cancer therapy Cell stem Cell therapy nanoparticles liposomes bioencapsulation replicating synthetic Cells Cell encapsulation scaffold bioso
    Artificial Cells Nanomedicine and Biotechnology, 2019
    Co-Authors: Thomas Ming Swi Chang

    Abstract:

    AbstractIt is only in the last 20 years that many of the original ideas on Artificial Cells are being increasingly applied and extended by researchers around the world. Artificial Cell has now evolved into nanomedicine, biotherapeutics, blood substitutes, drug delivery, enzyme/gene therapy, cancer therapy, Cell/stem Cell therapy, nanoparticles, liposomes, bioencapsulation, replicating synthetic Cells, Cell encapsulation/scaffold, biosorbent/immunosorbent haemoperfusion/plasmapheresis, regenerative medicine, encapsulated microbe, nanobiotechnology, nanotechnology and other areas. More futuristic research includes nanorobot, nanocomputer, multimodal locomotion delivery robot and others. This review starts with a general overview followed by specific examples in more details.

  • present status of modified hemoglobin as blood substitutes and oral therapy for end stage renal failure using Artificial Cells containing genetically engineered Cells
    Annals of the New York Academy of Sciences, 2006
    Co-Authors: Thomas Ming Swi Chang

    Abstract:

    : Artificial Cell or bioencapsulation has been developed for use in bioArtificial organs, drug delivery, blood substitutes, and other areas. Recent rapid advances in modified hemoglobin blood substitutes have resulted in advance stages of Phase III clinical trials. Another area of use is in oral therapy, using Artificial Cells microencapsulated with genetically engineered Cells for use in end stage renal failure and other conditions.

  • Artificial Cells for Blood Substitutes, Enzyme Therapy, Cell Therapy and Drug Delivery
    Applications of Cell Immobilisation Biotechnology, 2005
    Co-Authors: Thomas Ming Swi Chang

    Abstract:

    Artificial Cells are being actively investigated for medical and biotechnological applications. The earliest routine clinical use of Artificial Cells is in the form of coated activated charcoal for haemoperfusion. Implantation of encapsulated Cells are being studied for the treatment of diabetes, liver failure and the use of encapsulated genetically engineered Cells for gene therapy. Blood substitutes based on modified haemoglobin are already in Phase III clinical trials in patients with as much as 20 units infused into each patient during trauma surgery. Artificial Cells containing enzymes are being developed for clinical trial in hereditary enzyme deficiency diseases and other diseases. Artificial Cell is also being investigated for drug delivery and for other uses in biotechnology, chemical engineering and medicine.

Ryuichi Matsuno – 3rd expert on this subject based on the ideXlab platform

  • Integrated functional nanocolloids covered with Artificial Cell membranes for biomedical applications
    Nano Today, 2011
    Co-Authors: Ryuichi Matsuno, Kazuhiko Ishihara

    Abstract:

    The functionality of nanocolloids used in biomedical applications are subject to strong interference arising from significant interactions with biological components such as proteins and Cells. Among the known examples of surface treatment of nanocolloids, the construction of an Artificial Cell membrane structure based on phospholipid polymers has proven effective in preventing the occurrence of biological reactions at the surface. Furthermore, certain bioactive molecules can be immobilized on the surface of the phospholipid polymer platform to generate bioaffinity for other biomolecules. This review describes preparation and characterization of integrated functional nanocolloids covered by Artificial Cell membrane structures and their performance in biomedical applications. © 2010 Elsevier Ltd.